Article
Psychology, Clinical
Tamara Oliveira dos Reis, Fernanda de Magalhaes Oliveira, Fabiana Martins Kattah, Natalia Fenner Pena, Maria Marta Sarquis Soares, Henrique Oswaldo da Gama Torres
Summary: The body mass index (BMI) may not accurately reflect changes in body composition during recovery from anorexia nervosa. A study investigated different parameters in recovering anorexia nervosa patients, focusing on the phase angle (PA) obtained from bioimpedance measurements. It was found that the phase angle can play an important role in assessing the nutritional status of recovering anorexia nervosa patients.
JOURNAL OF EATING DISORDERS
(2022)
Article
Multidisciplinary Sciences
C. A. Gonzalez-Correa, S. A. Jaimes, J. Cardenas-Jimenez
Summary: This study tests a geometrical parameterization method for Electrical Bio-Impedance Spectroscopy (EBIS) readings and compares it with other methods. The results show that the method performs well with low noise levels but poorly with high noise levels.
SCIENTIFIC REPORTS
(2022)
Article
Geriatrics & Gerontology
Yasunori Akamatsu, Toru Kusakabe, Hiroshi Arai, Yuji Yamamoto, Kazuwa Nakao, Kentaro Ikeue, Yuki Ishihara, Tetsuya Tagami, Akihiro Yasoda, Kojiro Ishii, Noriko Satoh-Asahara
Summary: This study examined the relationship between phase angle (PhA) and muscle quality, as well as other body composition parameters. It found that age, skeletal muscle mass index (SMI), and muscle quality were independently associated with PhA. PhA demonstrated good predictive ability for sarcopenia, indicating its potential as an easily measurable index for muscle quality assessment and sarcopenia diagnosis.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Nutrition & Dietetics
Mariana Garcia Branco, Carlota Mateus, Manuel Luis Capelas, Nuno Pimenta, Teresa Santos, Antti Makitie, Susana Ganhao-Arranhado, Carolina Trabulo, Paula Ravasco
Summary: This scoping review evaluates the scientific and clinical evidence on the use of BIA for body composition assessment in oncology patients. The findings suggest that BIA is a suitable and valid method for body composition assessment in cancer patients and has potential clinical value in preoperative risk evaluation, reducing postoperative complications and hospital stay, and predicting prognosis.
Article
Nutrition & Dietetics
Sylvia Ryz, Larissa Nixdorf, Juergen Puchinger, Andrea Lassnigg, Dominik Wiedemann, Martin H. Bernardi
Summary: This study showed that PhA in cardiac surgery patients decreased postoperatively, with patients with lower preoperative PhA being older, frailer, and having longer ICU stays. Preoperative PhA was influenced by frailty and cardiac function, while postoperative PhA decline was influenced by fluid balances and cardiopulmonary bypass times. Perioperative PhA measurement is crucial for risk evaluation in cardiac surgery patients.
Article
Environmental Sciences
Catarina N. Matias, Francesco Campa, Catarina L. Nunes, Ruben Francisco, Filipe Jesus, Miguel Cardoso, Maria J. Valamatos, Pedro Mil Homens, Luis B. Sardinha, Paulo Martins, Claudia Minderico, Analiza M. Silva
Summary: The phase angle (PhA) is associated with skeletal muscle mass, upper- and lower-body strength, and maximal aerobic capacity (VO2max) in overweight/obese and inactive former athletes. Adjusting for age, sex, and fat mass, PhA remained significantly associated with muscle mass and strength, indicating its potential as an indicator for muscle quantity and functionality.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Anna Maria Sacco, Giuliana Valerio, Paola Alicante, Ada Di Gregorio, Rocco Spera, Giada Ballarin, Luca Scalfi
Summary: The study explored the association between musculoskeletal fitness and body composition, finding a strong correlation between musculoskeletal fitness and raw bioelectrical impedance analysis (BIA) variables. Bioimpedance index, phase angle, and impedance ratio were more effective predictors of hand grip strength than BIA-derived estimates, suggesting a new approach for reliable assessment of muscle quality.
Article
Geriatrics & Gerontology
S. J. Ko, J. Cho, S. M. Choi, Y. S. Park, C. -H. Lee, S. -M. Lee, C. -G. Yoo, Y. W. Kim, J. Lee
Summary: The study revealed that high PhA above 3.5 was associated with lower in-hospital mortality and a shorter duration of ICU stay, while frailty was associated with more mechanical ventilation days.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Endocrinology & Metabolism
Fernando De Benedetto, Stefano Marinari, Francesco De Blasio
Summary: Phase angle (PhA) is a raw variable measured with bioelectrical impedance analysis (BIA) and is used to assess malnutrition in various diseases, including chronic obstructive pulmonary disease (COPD). Reduced PhA is associated with older age, hypoxia, hypercapnia, reduced cell mass, muscle depletion, and worsening gas exchange in COPD patients. PhA degrees have significance in estimating muscle strength and respiratory muscles function, and are related to all-cause mortality in COPD patients.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Nutrition & Dietetics
Cristina Garcia-Garcia, Isabel Maria Vegas-Aguilar, Rosalia Rioja-Vazquez, Isabel Cornejo-Pareja, Francisco J. Tinahones, Jose Manuel Garcia-Almeida
Summary: This study evaluates the prognostic value of classic and emerging nutritional assessments in cancer patients. The results show that low PhA and RFCSA values are significant predictors of mortality. These findings are important for nutritional assessment and predicting clinical outcomes in cancer patients.
Article
Medicine, General & Internal
Hamidullah Salimi, Shoichiro Ohyama, Hidetomi Terai, Yusuke Hori, Shinji Takahashi, Masatoshi Hoshino, Akito Yabu, Hasibullah Habibi, Akio Kobayashi, Tadao Tsujio, Shiro Kotake, Hiroaki Nakamura
Summary: This study found that bioelectrical impedance analysis is a reliable method to assess trunk muscle mass and correlates with traditional quantitative and functional assessments of trunk muscles.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Sandra Unterberger, Rudolf Aschauer, Patrick A. Zoehrer, Agnes Draxler, Mirjam Aschauer, Benno Kager, Bernhard Franzke, Eva-Maria Strasser, Karl-Heinz Wagner, Barbara Wessner
Summary: In recent years, the phase angle (PhA) has been studied as a variable to assess cell integrity and physical performance. However, there is limited data on healthy older adults. This retrospective analysis examined the relationship between PhA, body composition, physical performance, and macronutrient intake in older adults and found that PhA was associated with physical performance but not protein intake. Age, sex, BMI, and PhA were predictors of performance test outcomes.
Article
Nutrition & Dietetics
Emilio Minano Garrido, Laura Di Lodovico, Marika Dicembre, Maeva Duquesnoy, Haykanush Ohanyan, Jean-Claude Melchior, Mouna Hanachi
Summary: This study examined muscle strength and peak expiratory flow (PEF) in severely undernourished patients with anorexia nervosa at admission and after 5 weeks of refeeding through tube feeding. Results showed a significant association between severity of undernourishment and muscle weakness, with partial recovery observed after enteral nutrition.
Article
Multidisciplinary Sciences
Alan Espinosa-Marron, Aquiles Rubio-Blancas, Christian Anibal Quinones-Capistran, Anais Camacho-Zamora, Itzel Salcedo-Grajales, Ana Paula Bravo-Garcia, Maria T. Bourlon, Ricardo A. Castillejos-Molina, Julie-Alexia Dias, Maria del Pilar Milke-Garcia
Summary: This study evaluated muscle mass and function in Mexican men with prostate cancer and found that muscle wasting is highly prevalent and presumably associated with aging rather than cancer and its treatment. Due to limited availability of equipment, simplistic techniques such as left-arm handgrip dynamometry can be used as surrogate measurements for muscle wasting. The study also developed a model to identify elderly patients with prostate cancer at risk of muscle depletion and impairment.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Luis B. Sardinha, Gil B. Rosa
Summary: The biophysical response of the human body to electric current, particularly the phase angle (PhA), is considered as an indicator of cell health and mass. Despite the effectiveness of resistance training (RT) in improving PhA, the underlying biological mechanisms are still not fully understood. This review provides a theoretical explanation for the responsiveness of PhA determinants to RT and summarizes the evidence on the effects of RT on PhA in different age groups. The findings suggest that RT modulates cell volume and leads to changes in electrical resistance and capacitance, ultimately affecting PhA.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Medicine, General & Internal
Iwona Bojar, Radoslaw Mlak, Iwona Homa-Mlak, Monika Prendecka, Alfred Owoc, Teresa Malecka-Massalska
Summary: This study examined the relationship between body fat level and serum concentration of myostatin protein in peri- and postmenopausal women. The results showed that a decreased level of myostatin is associated with higher body fat in these women.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Tomasz Powrozek, Dominika Pigon-Zajac, Marcin Mazurek, Michael Ochieng Otieno, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study aimed to evaluate the impact of inflammatory conditions on the expression of long non-coding RNAs (lncRNAs) in a mouse skeletal muscle cell line. Three lncRNAs (Gm4117, Ccdc41os1, and 5830418P13Rik) were found to be significant in inflammatory-related myotube atrophy. The expression of lncRNAs varied depending on the concentration of the inflammatory factor and the treatment time. Bioinformatics analysis identified potential target genes and miRNAs for these lncRNAs, further implicating their involvement in molecular processes related to muscle atrophy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Jaromir Jarecki, Teresa Malecka-Masalska, Ewa Kosior-Jarecka, Wojciech Widuchowski, Piotr Krasowski, Martina Gutbier, Maciej Dobrzynski, Tomasz Blicharski
Summary: The aim of this study was to evaluate the levels of MMPs and osteocalcin in the serum and synovial fluid of obese women with osteoarthritis and their correlations with clinical status. The results showed that the levels of MMP3, MMP9, and pro-MMP13 were increased in more advanced stages of osteoarthritis, indicating an underlying inflammatory process.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Oncology
Iwona Homa-Mlak, Radoslaw Mlak, Marcin Mazurek, Anna Brzozowska, Tomasz Powrozek, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: This study found that the TT genotype of the TNFRSF1A gene (-610 T > G) is independently associated with a higher risk of nutritional disorders in head and neck cancer patients undergoing radiotherapy. This suggests that this genetic polymorphism may be useful in assessing the risk of nutritional deficiencies in these patients.
Review
Nutrition & Dietetics
Marcin Mazurek, Radoslaw Mlak, Agata Kot, Mansur Rahnama-Hezavah, Teresa Malecka-Massalska
Summary: The research suggests that HPV infection may increase the risk of malnutrition, significant weight loss, and the need for gastrostomy in head and neck cancer patients. However, the data on the influence of HPV infection on the occurrence and severity of nutritional disorders in HNC patients is still limited and inconclusive.
Article
Medicine, Research & Experimental
Iwona Homa-Mlak, Radoslaw Mlak, Anna Brzozowska, Marcin Mazurek, Tomasz Powrozek, Monika Prendecka-Wrobel, Aneta Szudy-Szczyrek, Piotr Dreher, Katarzyna Kaminska, Teresa Malecka-Massalska, Alicja Wojcik-Zaluska
Summary: This study found that there is a correlation between malnutrition and weight loss with the increase in irisin concentration in patients with head and neck cancers. Higher levels of irisin may serve as a useful marker for malnutrition in HNC patients.
MEDICAL SCIENCE MONITOR
(2022)
Article
Cell Biology
Weronika Domerecka, Anna Kowalska-Kepczynska, Iwona Homa-Mlak, Agata Michalak, Radoslaw Mlak, Marcin Mazurek, Halina Cichoz-Lach, Teresa Malecka-Massalska
Summary: This study investigated the role of Extended Inflammation Parameters (EIP) and systemic inflammatory response markers in diagnosing autoimmune hepatitis (AIH). Results showed higher values in AIH patients compared to controls, indicating potential diagnostic value. Additionally, certain markers were also found to be important in detecting liver fibrosis in the course of AIH.
Review
Health Care Sciences & Services
Iwona Homa-Mlak, Dominika Pigon-Zajac, Pawel Wawrejko, Teresa Malecka-Massalska, Radoslaw Mlak
Summary: According to the World Health Organization, cancer remains one of the main causes of mortality globally. Cancer cachexia is a complex disorder characterized by muscle mass loss and inflammation. miRNAs have potential as valuable biomarkers in the diagnosis, treatment, and prognosis of cancer cachexia due to their ability to regulate multiple genes and biological processes.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Joanna Popiolek-Kalisz
Summary: Metabolic syndrome (MetS) is caused by central obesity and leads to chronic inflammation, hypertension, diabetes, and dyslipidemia. This study analyzed the differences in flavonol intake between MetS patients and healthy participants, finding that MetS patients consumed significantly less flavonols, particularly from tomatoes. There was a moderate inverse correlation between flavonol consumption and MetS stage, suggesting a potential protective effect against MetS.
Review
Medicine, General & Internal
Ryszard Sitarz, Dariusz Juchnowicz, Kaja Karakula, Alicja Forma, Jacek Baj, Joanna Rog, Robert Karpinski, Anna Machrowska, Hanna Karakula-Juchnowicz
Summary: The niacin skin flush test (NSFT) is a simple method for assessing fatty acid content in cell membranes and may serve as an indicator of underlying factors in patients. This paper aims to determine the potential usefulness of NSFT in mental disorder diagnostics and identify factors that may affect its results. Research suggests that NSFT can aid in early intervention, psychiatric staging, and the development of new therapeutic methods based on its mechanisms. It can also contribute to personalized diets for patients and has potential benefits in the subclinical phase of the disease. However, further validation of NSFT is needed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Aneta Szudy-Szczyrek, Radoslaw Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michal Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, Teresa Malecka-Massalska, Marek Hus
Summary: The functional single nucleotide polymorphism (SNP) of the KIAA1524 gene (rs2278911, 686C > T) is associated with disease progression and survival in patients with multiple myeloma (MM). The TT genotype is linked to shorter progression-free survival (PFS) and overall survival (OS). Therefore, evaluating the SNP 686C > T of the KIAA1524 gene could serve as a diagnostic tool for identifying MM patients at risk of early disease progression and death.
Review
Biology
Joanna Popiolek-Kalisz, Pawel Glibowski
Summary: Apple peel supplementation shows potential in preventing metabolic syndrome based on in vitro and animal model studies. However, only one human study has been conducted and it showed an effect on endothelial function but not on other clinical parameters. Large-scale human studies are needed to confirm the role of apple peel supplementation in preventing metabolic syndrome.
Review
Cardiac & Cardiovascular Systems
Joanna Popiolek-Kalisz, Karolina Szczygiel
Summary: This paper describes the application of bioelectrical impedance analysis (BIA) in cardiovascular (CV) patients to assess nutritional status and body composition. BIA parameters such as phase angle, Z200/5 parameter, membrane capacitance, fat mass, body cell mass, and total body water can provide valuable information for evaluating the general condition of the body in CV patients. BIA is a noninvasive method that plays a significant role in assessing the nutritional and hydration status of CV patients.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Maciej Pokarowski, Michal Kedra, Justyna Piwinska, Katarzyna Kurek, Karolina Szczygiel, Piotr Denysiuk, Joanna Popiolek-Kalisz
Summary: Sleep is a crucial factor for quality of life, and more than 50% of adults in Poland suffer from sleep disorders, particularly among young adults. Analyzing the predictors of sleep quality, such as sleep hygiene knowledge and dietary knowledge, becomes important, especially after the COVID-19 pandemic. The study found that sleep hygiene knowledge was significantly associated with sleep length and overall sleep quality, while dietary knowledge correlated with time to fall asleep. Decreased sleep quality was observed in participants who used medications or dietary supplements.
Article
Biochemistry & Molecular Biology
Michal Mielnik, Aneta Szudy-Szczyrek, Iwona Homa-Mlak, Radoslaw Mlak, Martyna Podgajna-Mielnik, Aneta Goracy, Teresa Malecka-Massalska, Marek Hus
Summary: This study assessed the correlation between pretreatment serum concentrations of IL-6, IL-8, MCP-1, and VEGF and the clinical outcomes of MM patients. Results showed that IL-8 was significantly correlated with age, staging, performance status, anemia, kidney disease, and VEGF. Chemotherapy responders had lower IL-8, IL-6, and VEGF concentrations compared to non-responders. High levels of IL-6 were associated with a higher risk of disease progression and reduced overall survival.