Article
Medical Laboratory Technology
Sepideh Sadighbathi, Ahmad Mobed
Summary: MicroRNAs are small non-coding RNAs, with miR21 being highly expressed in many mammalian cells and regulating various biological functions. Accurate detection of miR-21 is crucial, and conventional methods have limitations. Advanced techniques such as nanotechnology and biosensors have gained attention in recent years.
CLINICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Tao Wang, Yangyang Guan, Jintao Pang, Ning Li, Jing Nie, Jin Xie
Summary: This paper designs dew point sensors based on MEMS technology and proposes a piecewise function fitting method for dew point identification, which can accurately detect dew point with reduced errors. Experimental results demonstrate that the sensor has good accuracy and stability.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Engineering, Electrical & Electronic
Tao Wang, Enfu Li, Jin Xie
Summary: This paper proposes a TCF compensation recognition method using a MEMS piezoelectric cantilever as a dew point sensor to improve the accurate measurement performance. This method analyzes the sources of previous errors, identifies the dew point using only the influence of TCF and relative humidity on the resonant frequency, and determines the dew point by iteratively calculating the intersection point. Experimental results demonstrate a measurement error of 0.33 degrees Celsius for this method.
SENSORS AND ACTUATORS A-PHYSICAL
(2023)
Review
Chemistry, Multidisciplinary
Tao Dong, Nuno Miguel Matos Pires, Zhaochu Yang, Zhuangde Jiang
Summary: The focus on precise medicine has increased the demand for timely diagnosis and frequent monitoring of chronic diseases. The recent pandemic of severe acute respiratory syndrome coronavirus 2 has also created a need for rapid detection and surveillance of viral infections. Electrochemical biosensors based on nanomaterials have shown great potential in detecting biomarkers in point-of-care settings. This study critically reviews the recent advances in electrochemical sensors for salivary protein detection, emphasizing the role of nanomaterials in enhancing analytical performance and reliability of the test. It also identifies the critical factors for further modernization of nanomaterial-based electrochemical sensors.
Article
Optics
Xue Wang, Chang Wang, Xiaojuan Sun, Xin Li, Hongyao Liu, Xuqing Sun, Fei Wang, Xinchao Lu, Chengjun Huang
Summary: The study introduces a method of objective-coupled locally excited SPR sensing with high sensitivity and high resolution for refractive index measurement. Through experimental and theoretical analysis, successful achievement of sensitivity and spatial resolution for the refractive index measurement of the medium was demonstrated.
Review
Biotechnology & Applied Microbiology
Gowhar A. Naikoo, Fareeha Arshad, Israr U. Hassan, Tasbiha Awan, Hiba Salim, Mona Z. Pedram, Waqar Ahmed, Vaishwik Patel, Ajay S. Karakoti, Ajayan Vinu
Summary: With the lack of an effective and safest vaccine to combat COVID-19 and its variants, there is an urgent need for the development of rapid and selective diagnostic devices. Nanomaterial-based biosensors show immense potential in detecting the virus in real-time with noninvasive and cost-effective properties. This review provides an overview of existing and potential nanomaterial-based biosensors, as well as the practical tools and techniques required for their development.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Horticulture
Wilson Thau Lym Yong, Aswaneeza Khairul Aswandy, Bo Eng Cheong, Kenneth Francis Rodrigues
Summary: The study utilized EMS to induce mutations in Solanum lycopersicum and identified mutations in several genes through PCR and sequencing. The results showed changes in the translated amino acid sequences of multiple genes, accompanied by a wide range of phenotypic variants.
SCIENTIA HORTICULTURAE
(2021)
Article
Chemistry, Analytical
Ming-Hao Cheng, Adam J. Chicco, Daniel Ball, Thomas W. Chen
Summary: Mitochondria are vital for oxygen consumption and energy metabolism in cells, but also produce reactive oxygen species (ROS) with various effects. This paper presents a sensitive multi-sensor device capable of measuring ROS production and oxygen consumption rate (OCR) simultaneously in biological samples. The device has been validated in scarce biological samples and shows potential utility in studying cellular metabolism and mitochondrial function.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
Fabio A. Kraft, Katherina Harwardt, Jan Schardt, Dirk Nowotka, Martina Gerken
Summary: Photonic crystal slabs (PCS) are a promising platform for optical biosensing. We demonstrate the suppression of the mechanochromism effect for flexible PCS, by obtaining flexible PCS with a high refractive index layer and a nanostructured polydimethylsiloxane (PDMS) substrate. These stabilized PCS (sPCS) show less than 0.5 nm resonance shift for 4% strain, compared to a much larger resonance shift observed in a mechanochromatic PCS (mPCS).
Article
Genetics & Heredity
Shalaw Rassul Sallah, Jamie M. Ellingford, Panagiotis Sergouniotis, Simon C. Ramsden, Nicholas Lench, Simon C. Lovell, Graeme C. Black
Summary: The study developed an algorithm ProSper that combines genetic and protein structural data to predict the pathogenicity of missense variants in genes associated with X linked disorders, showing superior performance over existing tools; gene-specific pathogenicity thresholds were determined to enhance the performance of other prediction tools.
JOURNAL OF MEDICAL GENETICS
(2022)
Article
Nanoscience & Nanotechnology
Feng Gao, Amine Bermak, Sarah Benchabane, Laurent Robert, Abdelkrim Khelif
Summary: This article introduces an acoustic radiation-free gravimetric biosensor based on a locally resonant surface phononic crystal, which improves quality factor and reduces frequency noise by confining energy near the electrode surface. Experimental results demonstrate that this method effectively enhances the quality factor in liquid.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Chemistry, Analytical
Zahra Soltanabadi, Akbar Esmaeili, Bijan Bambai
Summary: Biosensors analytical devices, consisting of a diagnostic element with a physical converter, are useful for on-site analysis of biomarkers. The biosensor oscillator in this study was made from a 20 MHz piezoelectric modified gold nano-layer, whose response was based on frequency change caused by the effect of morphine on the anti-morphine monoclonal antibody. The stability of the biosensor at different temperatures was confirmed through FE-SEM and XRD analysis. The device demonstrated fast detection speed and small sample volume, making it compatible with clinical measurements.
MICROCHEMICAL JOURNAL
(2022)
Review
Chemistry, Analytical
Chuljin Hwang, Won-June Lee, Su Dong Kim, Sungjun Park, Joo Hee Kim
Summary: Human urine samples are valuable for diagnosing common clinical conditions due to their non-invasiveness and availability. However, traditional methods like the dipstick test have limitations, which can be overcome by biosensor technologies for point-of-care applications in urinalysis.
Article
Engineering, Biomedical
Samia Adrar, Mohammed El Gibari, Philippe Saillant, Jean-Christophe Thomas, Raynald Seveno
Summary: This article discusses a system designed for monitoring and analyzing patients' gait remotely in their own homes, with an aim to detect foot anomalies related to chronic diseases. The system includes pressure sensitive piezoelectric sensors developed at the IETR laboratory, which can transform the sensor data into medically exploitable information. The collaboration with a podiatrist ensures accurate analysis and interpretation of the data.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Multidisciplinary Sciences
Chunlin Tan, Ping Xu, Fei Tao
Summary: Rationally controlling cellular metabolism is challenging due to its complex and chaotic nature. In this study, a global metabolic reprogramming platform was developed using sensory proteins and gene interference technology. The platform enables the decoding of gene interactions and has been shown to effectively reduce antibiotic resistance and increase metabolite production in bacteria. A web-based service platform has also been provided for easy implementation of this strategy in various cells.
Review
Chemistry, Analytical
Claudia Campanale, Silvia Galafassi, Francesca Di Pippo, Iulian Pojar, Carmine Massarelli, Vito Felice Uricchio
Summary: Biodegradable plastic mulches (BDMs) have the potential to be an eco-friendly alternative to conventional plastic mulches in agriculture. However, their long-term impacts on soil ecosystems are still uncertain, and further research is needed. Incorporating BDMs into the soil may stimulate microbial activity, but there is also a risk of incomplete degradation and release of residual microplastics and additives.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim
Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Yaxin Cao, Longyi Shao, Timothy P. Jones, Wenjing Deng, M. Santosh, Pengju Liu, Cheng-Xue Yang, Yaowei Li, Daizhou Zhang, Kelly Berube
Summary: The toxicity of fibrous particles in ambient air can be higher than other types of particles. Microfibers can be organic or inorganic and their presence in the atmosphere as a result of human activity raises concerns for environmental and public health. Accurate collection, identification, and understanding of the health hazards associated with these fibers are crucial for mitigation strategies and protection of public health.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Chenchen Xie, Chen Meng, Huilin Liu, Baoguo Sun
Summary: The development of food hazard factor (FHF) detection has been moving towards on-site inspection and mobile law enforcement, calling for simple, fast, and affordable analysis technology to ensure food safety and quality. This review comprehensively summarizes the progress in research on smartphone-assisted MIP optosensors, focusing on the key issues of accuracy and sensitivity.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Guillem Peris-Pastor, Cristian Azorin, Jose Grau, Juan L. Benede, Alberto Chisvert
Summary: Green Analytical Chemistry plays an important role in every stage of method development, including sample preparation. Extraction techniques have evolved from conventional ones to a variety of miniaturized techniques in order to enhance analytical performance and ensure safety for operators and the environment. Green metric tools are used to evaluate the impact and sustainability of methods, with AGREEprep selected as the most suitable tool for evaluating published methods in various applications. The miniaturization of sample preparation strategies has led to the use of less and safer solvents, reduced waste generation and energy consumption, and improved portability and throughput.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Helena Hruskova, Roman Reminek, Frantisek Foret
Summary: This review article summarizes the progress and recent studies in offline electromigration preparative techniques between 2018 and 2023. It covers various techniques including electrophoresis, free-flow electrophoresis, isoelectric focusing, and isotachophoresis, providing theoretical aspects, trends, and solutions to existing limitations in each technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Mayank Garg, Nicole Pamme
Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Ivneet Banga, Anirban Paul, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar, Sriram Muthukumar, Shalini Prasad
Summary: Breathomics is an emerging field that focuses on analyzing exhaled breath to diagnose and monitor respiratory diseases. Electrochemical sensors, with their high sensitivity, selectivity, and low cost, play a significant role in breathomics and can be integrated into portable devices for point-of-care diagnosis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Fabjola Bilo, Paola Cirelli, Laura Borgese
Summary: This review explores the application of X-ray fluorescence (XRF) spectrometry for elemental analysis of particulate matter (PM) in air quality monitoring. It discusses the fundamentals of XRF, experimental configurations, PM sampling devices and substrate, sample preparation strategies, qualitative and quantitative analysis, as well as the challenges faced by XRF in becoming a reliable analytical technique for PM analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hakim Faraji
Summary: The dispersive liquid-liquid microextraction (DLLME) technique is widely popular in analytical chemistry due to its high efficiency, cost-effectiveness, and simplicity. Recent advancements have addressed the limitations of DLLME, incorporating greener solvents, innovative dispersion strategies, and simplified procedures. These changes have made DLLME a more sustainable and efficient technique.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Sherin F. Hammad, Inas A. Abdallah, Alaa Bedair, Reda M. Abdelhameed, Marcello Locatelli, Fotouh R. Mansour
Summary: Carbon nanomaterials (CNMs) have excellent capabilities in terms of adsorption, enhanced oxidation, and photocatalysis, attracting widespread attention in different fields. Metal-organic frameworks (MOFs) have been widely used due to their regular network structure, porous nature, and large specific surface area. However, the instability of MOFs in aqueous solutions limits their applications in chemical sensing. Recent studies have focused on increasing the stability of MOFs in water-based matrices through chemical modifications using CNMs.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Alexandra Pape, Oliver J. Schmitz
Summary: Low temperature plasmas based on dielectric barrier discharges have emerged as a recent development in ion source research. These ion sources are applicable to heat-sensitive analytes and can ionize a wide range of compounds. Despite intensive research on important parameters such as configuration, shape, size, and materials in the past two decades, the actual ionization mechanism for all plasma gases has not been fully elucidated. This review provides an overview of atmospheric pressure ion sources, with a focus on plasma and dielectric barrier discharge based ion sources, summarizing the reactions occurring in the plasma and discussing the applications developed by different research groups.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Hai Xiong, Fengli Li, Linyu Zeng, Qiyu Lei
Summary: This review provides an overview of the emerging trends in the use of functional COF nanomaterials as biosensors for DNA/RNA detection. It summarizes the construction of DNA/RNA hybridized COF nanoprobes and their potential applications in bioanalyte detection, biosensing, biomarker imaging, and clinical biomedicine.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Bing Yan
Summary: This article summarizes the recent progress in logic gate computing and operation based on multiple luminescence response and chemical sensing for lanthanide functionalized MOF hybrid systems. The article first describes multi-color luminescence and the subsequent multiple luminescence response. The basic concept of logic gate operation and the advantages of lanthanide-based hybrid materials are then introduced. Reports on logic gate operation using pure lanthanide MOFs are provided, followed by a detailed summary of logic gate operations using lanthanide functionalized MOF hybrid materials. Additionally, the article discusses the practical luminescent detection of analytes by correlating the luminescence responsive signals and the concentration of different analytes. Finally, the article concludes with a prospect for this topic.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)
Review
Chemistry, Analytical
Brij Mohan, Gurjaspreet Singh, Rakesh Kumar Gupta, Pawan Kumar Sharma, Alexander A. Solovev, Armando J. L. Pombeiro, Peng Ren
Summary: Porous materials, particularly hydrogen-bonded organic frameworks (HOFs), have gained significant attention due to their versatile applications and unique properties such as well-defined crystalline structure and easy regeneration processes. This article provides a comprehensive overview of HOFs, including synthesis methods, hydrogen bonding motifs, recent advancements, and potential applications, offering valuable guidance for further exploration in this dynamic field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2024)