Article
Environmental Sciences
Evelyn Krawczyk-Baersch, Andreas C. Scheinost, Andre Rossberg, Katharina Mueller, Frank Bok, Lotta Hallbeck, Jana Lehrich, Katja Schmeide
Summary: The microaerophilic iron(II) oxidizer Gallionella ferruginea forms stalks and has a high sorption capacity towards radionuclides, with the ability to form inner-sphere complexes. The rapid iron precipitation in G. ferruginea-dominated systems makes more ferrihydrite available for immobilization processes of heavy metals and radionuclides in contaminated environments.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Physical
Michele Carosso, Eleonora Vottero, Sara Morandi, Maela Manzoli, Davide Ferri, Thibault Fovanna, Riccardo Pellegrini, Andrea Piovano, Elena Groppo
Summary: The decomposition of ethanol over two Pd/Al2O3 catalysts was investigated using transmission FT-IR and ATR-IR spectroscopies. The regularity of Pd particles and initial Pd oxidation state were found to significantly impact the products formed, with ethanol oxidation to acetates being the kinetically favored reaction path. The presence of a solvent also dampened the decarbonylation process due to competition for surface sites.
Article
Engineering, Environmental
Natalia Mayordomo, Diana M. Rodriguez, Andre Rossberg, Harald Foerstendorf, Karsten Heim, Vinzenz Brendler, Katharina Mueller
Summary: This study comprehensively investigates the retention of Fe(II)-Al(III)-Cl LDH towards pertechnetate (TcO4-), showing that Tc retention yield is higher than 80% from pH 3.5 to pH 10.5, especially at low NaCl concentrations. Molecular scale structural information on the retention mechanism is provided through a combination of vibrational and X-ray absorption spectroscopy. XANES confirms Tc(VII) reduction to Tc(IV) and consecutive Tc(IV) interaction with the solid, while EXAFS reveals two different mechanisms of Tc(IV) interaction with hematite.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Instruments & Instrumentation
James M. Cameron, Christopher Rinaldi, Samantha H. Rutherford, Alexandra Sala, Ashton G. Theakstone, Matthew J. Baker
Summary: This review paper discusses the advancements in biomedical Raman and infrared spectroscopy, as well as the challenges towards utilizing these technologies as reliable clinical tools. Despite the potential shown in proof-of-concept studies, there are still barriers such as technical limitations, lack of understanding of clinical pathways, and funding applications that need to be addressed in order for vibrational spectroscopy to be clinically effective. The current outlook emphasizes the need for overcoming these hurdles in order to push spectroscopic technologies towards medical diagnostics and various clinical applications in the future.
APPLIED SPECTROSCOPY
(2022)
Article
Cell Biology
Francesca Perut, Gabriela Graziani, Laura Roncuzzi, Nicoletta Zini, Sofia Avnet, Nicola Baldini
Summary: This study identified subpopulations of osteosarcoma-derived extracellular vesicles (EVs) by Fourier transform infrared spectroscopy (FT-IR) and defined a specific spectral signature for sensitive and multidrug-resistant (MDR) EVs.
Article
Biochemical Research Methods
Ewelina Mistek-Morabito, Igor K. Lednev
Summary: This study successfully differentiated menstrual and peripheral bloodstains using ATR FT-IR spectroscopy combined with chemometrics, achieving excellent separation in internal validation and 100% accuracy in external validation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Medicine, Legal
Sweety Sharma, Harpreet Kaur, Rajinder Singh
Summary: This study demonstrates the use of ATR FT-IR spectroscopy as a non-destructive, non-invasive, and confirmatory technique for sex discrimination from dry urine traces, achieving high accuracy rates.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Chong-Yuan Zhang, Qiang Wu, Ying-Dong Wang, Jin-Tao Fan, Zi-Zong Zhu
Summary: In this study, carbonization experiments were conducted on cokes produced from Jurassic and Carboniferous coking coals. The quality of cokes from Jurassic coals was found to be inferior to that from Carboniferous coals. Analyzing the coal samples, it was discovered that the excessive oxygen-containing functional groups in the Jurassic coals led to the poor quality of the cokes.
Review
Chemistry, Applied
Martyna Krysa, Monika Szymanska-Chargot, Artur Zdunek
Summary: Flavonoids are secondary metabolites commonly found in plants, known for their antioxidant properties, involvement in plant defense mechanisms, and responsibility for the pigmentation of fruits and flower petals. Consumption of foods rich in flavonoids brings various health benefits such as blood pressure regulation, anti-aging effects, and anti-cancer properties. Infrared and Raman spectroscopy are effective methods for quickly and accurately determining the presence of flavonoid compounds in test samples. These methods have been successfully applied in the food and pharmaceutical industries. The spectroscopic spectra of different flavonoid subgroups (flavones, isoflavones, flavanones, flavonols, and anthocyanins) are compared and described in this review.
Article
Biochemical Research Methods
Signe Vahur, Lisett Kiudorv, Peeter Somelar, Jan-Michael Cayme, Mark Dennis Chico Retrato, Rady Jazmin Remigio, Varun Sharma, Ester Oras, Ivo Leito
Summary: A universal method for quantitative analysis of clay components using ATR-FT-IR spectroscopy combined with PLS regression technique has been developed and tested on a large calibration set covering various natural clay sources and archaeological artefacts. The method proved to be quick, easy to use, and able to quantify the contents of 7 main classes of minerals in different clays with an acceptable level of accuracy.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Polymer Science
Carmen Rizzuto, Dale C. Teeters, Riccardo C. Barberi, Marco Castriota
Summary: This work investigates the electrochemical properties of PMMA-based gel polymer electrolytes, focusing on the effect of salt concentration and plasticizers on the conductivity and stability of the electrolyte. The study utilizes various characterization techniques such as conductivity measurements, thermal analysis, anodic stability testing, and FTIR spectroscopy. The findings reveal that the presence of unreacted PMMA monomer enhances ion conduction, and the addition of plasticizers improves the electrolyte's performance.
Article
Biochemical Research Methods
Elena Possenti, Chiara Colombo, Marco Realini, Cai Li Song, Sergei G. Kazarian
Summary: Metal soaps are formed in paint layers through the reaction of metal ions of pigments and fatty acids of organic binders. This study used micro-ATR-FTIR spectroscopic imaging to analyze the formation of lead soaps in oil-based paint layers in relation to moisture sources. The research provided insights into the different lead white pigments, organic materials, and lead soaps present in authentic samples with complex stratigraphies.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Instruments & Instrumentation
Leigh C. Ward
Summary: Conventional methods for measuring deuterium concentration in body fluids involve isotope ratio mass spectrometry or FT-IR spectroscopy. This study explores an alternative method, ATR FT-IR, which allows for faster analysis with smaller sample volumes. The ATR FT-IR method demonstrated high precision in measuring deuterium in plasma, making it suitable for use in pediatrics where minimal blood sampling is required.
APPLIED SPECTROSCOPY
(2021)
Article
Food Science & Technology
Ahmed Menevseoglu, Didem Peren Aykas, Eda Adal
Summary: Pistachio, being one of the most expensive nuts in Turkey, is vulnerable to adulteration. This study utilized vibrational spectroscopy and chemometric methods to analyze adulterations in pistachio, demonstrating the potential of portable FT-IR and UV-Vis spectrometers in detecting green pea and peanut adulterations.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2021)
Review
Instruments & Instrumentation
Nicole M. Ralbovsky, Igor K. Lednev
Summary: Type II diabetes mellitus is a metabolic disorder with high prevalence and mortality rates worldwide, leading to various dangerous diseases. Current methods for diabetes detection have limitations in terms of fluctuation and accuracy, highlighting the need for more effective diagnostic approaches.
APPLIED SPECTROSCOPY
(2021)
Article
Biochemical Research Methods
Safar M. Alqahtani, Ali Altharawi, Majed Alrobaian, Waleed H. Almalki, Alhumaidi B. Alabbas, Shehla Nasar Mir Najib Ullah, Tanuja Singh, Kamal Younus Thajudeen, Gyas Khan, Rehan A. Rub, Md Abul Barkat, Sarwar Beg, Mahfoozur Rahman
Summary: In this study, a simple, fast, sensitive, and efficient bioanalytical UPLC/MS-MS method was developed to simultaneously estimate diclofenac and resveratrol in mice skin samples. The method showed satisfactory results in terms of detection and quantification limits, precision, and reproducibility. Dermatokinetic evaluation of the dual drugs-loaded liposomal gel formulation showed improved performance compared to the conventional gel. Overall, the developed method proved to be suitable for bioanalytical studies in dermatokinetics.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Khalid M. Alharthy, Hassan N. Althurwi, Faisal F. Albaqami, Ali Altharawi, Sami I. Alzarea, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Imran Kazmi
Summary: This study aimed to investigate the anti-Parkinson's effect of barbigerone, a natural pyranoisoflavone possessing antioxidant activity, in a rotenone-induced rat model of PD. The results demonstrated that barbigerone attenuated rotenone-induced motor deficits and showed improvements in biochemical and neuroinflammatory parameters, suggesting its potential as a therapeutic agent against PD.
Article
Biochemistry & Molecular Biology
Ali Altharawi, Yassine Riadi, Muhammad Tahir ul Qamar
Summary: The emergence of artemisinin resistance by malaria parasites is a major challenge in the fight against malaria. To tackle this, antimalarial drugs with unconventional mechanisms are urgently needed. Blocking the function of hexose transporter 1 (PfHT1) protein, the only known transporter for glucose uptake in Plasmodium falciparum, can selectively starve the parasites and provide an alternative approach to fight drug-resistant malaria.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ali Altharawi, Safar M. Alqahatani, Mohammed M. Alanazi, Muhammad Tahir ul Qamar
Summary: This study utilized a computer aided drug designing approach to search for novel compounds that bind stronger to the MurE ligase enzyme of Acinetobacter baumannii. Three compounds were identified to have promising binding with the MurE enzyme and establish close chemical interactions. Dynamic simulation and energy evaluation methods confirmed the stability of the complexes. The study concludes that these compounds are potential candidates for in vivo and in vitro experimental assays.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ali Altharawi
Summary: Given the limited options for treating toxoplasmosis, discovering new antiparasitic drugs that inhibit TgAPN2 M1 aminopeptidase is highly valuable. Through computer-aided drug design, we identified three promising drug candidates from the Asinex library: LAS_52160953, LAS_51177972, and LAS_52506311. These compounds showed stable conformation and strong binding affinity with TgAPN2, making them suitable for further experimental validation and potential use as drug-like molecules.
Article
Multidisciplinary Sciences
Ali Altharawi, Manal A. Alossaimi, Mohammed M. Alanazi, Safar M. Alqahatani, Muhammad Tahir ul Qamar
Summary: By using computer aided drug design, three potential drug-like compounds with anti-drug resistant tuberculosis activity were identified from Asinex antibacterial compounds. These compounds can be further studied as candidates for developing new drugs against drug-resistant tuberculosis.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Khalid M. Alharthy, Mohamed F. Balaha, Sushma Devi, Ali Altharawi, Hasan S. Yusufoglu, Rana M. Aldossari, Aftab Alam, Viviana Di Giacomo
Summary: The study aimed to determine the antinociceptive effects of isoeugenol and eugenol and their combinations in neuropathic pain resulting from diabetes and neuroinflammation. The results showed that isoeugenol, eugenol, and their combination have therapeutic potential against neuronal and oxidative damage induced by diabetes, particularly in improving behavioral function and providing neuroprotection against diabetic neuropathy with synergistic effects.
Article
Chemistry, Analytical
Ali Altharawi, Safar M. Alqahtani, Sagar Suman Panda, Majed Alrobaian, Alhumaidi B. Alabbas, Waleed Hassan Almalki, Manal A. Alossaimi, Md. Abul Barkat, Rehan Abdur Rub, Shehla Nasar Mir Najib Ullah, Mahfoozur Rahman, Sarwar Beg
Summary: The study explores the therapeutic benefits of combining neratinib and naringenin for treating early-stage hormone-receptor-positive breast cancers. A validated UPLC-MS/MS method was developed for simultaneous estimation of the drugs in rat plasma. The green method has implications for clinical sample analysis and therapeutic drug monitoring (TDM).
Article
Chemistry, Analytical
Sherif A. Abdel-Gawad, Ali Altharawi
Summary: Monitoring and quantifying active pharmaceutical ingredients (APIs) in the environment is crucial for human health. This study successfully isolated and measured four commonly used fluoroquinolones in pharmaceutical industrial wastewater using capillary zone electrophoresis. Solid-phase extraction was used as an efficient sample pretreatment, and the assay was validated and applied to real wastewater samples.
Article
Polymer Science
Obaid Afzal, Abdulamalik S. A. Altamimi, Mubarak A. Alamri, Ali Altharawi, Manal A. Alossaimi, Md Sayeed Akhtar, Fauzia Tabassum, Waleed H. Almalki, Tanuja Singh
Summary: Natural anti-inflammatory nutraceuticals, such as resveratrol and chia seed oil, can help prevent the worsening of rheumatoid arthritis. This study developed and evaluated a resveratrol-loaded chia seed oil-based nanoemulsion gel for its potential therapeutic benefits in inflammatory arthritic conditions. The optimized gel formulation showed significant reversal of arthritic symptoms in rats, indicating increased topical bioavailability and balancing of pro-inflammatory mediators.
Article
Biochemistry & Molecular Biology
Ali Altharawi, Mohammed M. Alanazi, Manal A. Alossaimi, Ashwag S. Alanazi, Safar M. Alqahtani, Mohammed H. Geesi, Yassine Riadi
Summary: The discovery of multi-targeted kinase inhibitors has potential therapeutic implications for multi-genic diseases, such as cancer. This study focuses on the design and synthesis of new quinazolin-4-one derivatives as anti-cancer agents. The most active compound, 5d, exhibits broad-spectrum anti-cancer activities and lower toxicity in normal cells compared to the standard drug doxorubicin.
Article
Acoustics
Weiqi Zhang, Hilde Metzger, Stavros Vlatakis, Amelia Claxton, M. Alejandra Carbajal, Leong Fan Fung, James Mason, K. L. Andrew Chan, Antonios N. Pouliopoulos, Roland A. Fleck, Paul Prentice, Maya Thanou
Summary: Phase-change nanodroplets, composed of a stabilising shell and a perfluorocarbon core, have recently gained attention as ultrasound theranostic nanoparticles. Nanodroplets can vaporise into echogenic microbubbles forming cavitation nuclei when exposed to ultrasound. However, methods to quantify the perfluorocarbon core in nanodroplets are lacking. In this study, nanodroplets were fabricated using lipids shell and perfluorocarbons, and the amount of perfluorocarbon in the core was assessed using 19F NMR and FTIR. The results showed that the fluorine signal accurately correlated with the perfluorocarbon concentration, allowing for quantification of the core. The study also found that different perfluorocarbons had varying rates of content loss and generated cavitation comparable to commercial contrast agent microbubbles.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Emadeldin M. Kamel, Albandari Bin-Ammar, Ashraf A. El-Bassuony, Mohammed M. Alanazi, Ali Altharawi, Ahmad F. Ahmeda, Ashwag S. Alanazi, Al Mokhtar Lamsabhi, Ayman M. Mahmoud
Summary: This study investigated the antioxidant-structure activity relationship of eight flavonoids isolated from Centaurea scoparia. Docking analysis and molecular dynamics simulations revealed the binding modes and interactions of the isolated compounds with xanthine oxidase (XO) and bovine beta-lactoglobulin (BLG). The calculated results showed agreement with the experimental measurements in terms of antioxidant activity.
Article
Multidisciplinary Sciences
Hassan N. Althurwi, Ali Altharawi, Khalid M. Alharthy, Faisal F. Albaqami, Sami I. Alzarea, Fahad A. Al-Abbasi, Muhammad Shahid Nadeem, Imran Kazmi
Summary: This study aimed to evaluate the therapeutic effects of butin on D-GalN-induced liver damage. The experimental results demonstrated that butin had a hepatoprotective effect on rats by reducing liver cell damage, oxidative damage, and pro-inflammatory cytokine levels.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Faisal F. Albaqami, Ameer S. Sahib, Khalid M. Alharthy, Ali Altharawi, Mohammad Y. Alshahrani, Mohammed Abed Jawad, Muath Suliman, Irfan Ahmad
Summary: In this study, two complexes [Ru(mu-tptz)2]Cl2 and [Fe(mu-tptz)2]Cl2 were synthesized and their binding to DNA, molecular docking, and antibacterial activity were investigated.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
