Article
Chemistry, Analytical
Aman K. K. Bhasin, Pooja Chauhan, Savita Chaudhary
Summary: In the recent decade, coumarin and its congeners have been extensively evaluated for their biological potency in drug-like molecules. However, there are relatively fewer reports on their utility as a pincer-type ligand against biochemical analytes. This study reports the synthesis and characterization of a potentially novel coumarin-derived schiff base (M) as a sensor of Zn2+ in semi-aqueous medium, showing significant fluorescence enhancement in the presence of Zn2+ compared to other competitive cations like Cd2+. The coordination stoichiometry of M: Zn2+ was found to be 1:1 with a low detection limit, indicating effective sensing capabilities towards Zn2+ in environmental water samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Physical
Wataru Inoue, Kotoha Kazama, Masaki Tsuboi, Makoto Miyasaka
Summary: The novel Schiff base chiral macrocycle C-1, synthesized by self-condensation reaction, exhibited significant fluorescence enhancement in the presence of metal ions, particularly Zn2+, with a very low detection limit. The fluorescence enhancement was achieved through PET and CHEF mechanisms, making it a promising candidate for Zn2+ ion detection.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Food Science & Technology
Mana Ayari, Ali Banitalebi Dehkordi, Ghodsi Mohammadi Ziarani, Jahan B. Ghasemi, Mohammad Reza Ganjali, Meisam Soleimani, Alireza Badiei, Elena Niculina Dragoi, Hassan Rokni
Summary: Europium-doped boron phosphate nanoparticles were prepared by doping europium ions into BPO4 host crystal using an ultrasonic method and calcination process. The doping was confirmed by various characterization techniques, and the doped nanoparticles showed excellent selectivity and sensitivity as a fluorescence sensor for the quantification of Zn2+ cation.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
Guo Tian, Yin-Zhu Han, Qian Yang
Summary: A fluorescent probe was designed and synthesized for sensitive and selective detection of Zn2+ and Cd2+. The probe exhibited selective fluorescence in the presence of other metal ions and changed the color of the solution. The fluorescence intensity of the probe showed a linear relationship with the concentration of Zn2+ and Cd2+, with low detection limits.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Zikai Zhou, Jieying Qian, Kai Liu, Yunjiao Zhang, Meng Gao, Ben Zhong Tang
Summary: Compared with traditional closed-shell fluorophores, pyrrole radical cations offer the advantage of smaller size and easier preparation. However, most reported radical cations are unstable in water and have low emission. To overcome this challenge, researchers have developed a deep-red emissive and water-stable pyrrole radical cation, which can be easily generated from P-DPA-Zn through air oxidation. This discovery shows promise for cancer theranostic applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Pramsak Patawanich, Anuwut Petdum, Jitnapa Sirirak, Kamonwan Chatree, Adisri Charoenpanich, Waraporn Panchan, Krit Setthakarn, Anyanee Kamkaew, Thanasat Sooksimuang, Phornphimon Maitarad, Nantanit Wanichacheva
Summary: A novel fluorescence sensor with high selectivity for zinc ion recognition was successfully designed and synthesized. The sensor showed a low detection limit and could be used for practical applications by detecting zinc ions through fluorescence signal changes.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Physical
Sanjay Yadav, Nishu Choudhary, Alok Ranjan Paital
Summary: In this study, a modified approach was used to prepare high-quality graphene oxide, which was then used to create a functional composite for selective fluorescence detection and adsorption of zinc-ion and adenosine triphosphate. The material showed high adsorption capacities and recyclability, enabling accurate quantification of zinc and ATP.
Article
Biochemistry & Molecular Biology
Xiaoping Zhang, Guiyong Jin, Zeshao Chen, Yunjie Wu, Qian Li, Pengfei Liu, Gaolei Xi
Summary: Mitochondria-targetable fluorescent chemosensors, Rhodamine-B and rhodamine 6G bearing syringaldehyde based receptors, were designed and synthesized for efficient chemosensing of Zinc(II) ions. These probes showed selective color change and fluorescence enhancement upon addition of Zinc(II) ions, making them applicable for the detection and quantification of Zinc(II) ions in mitochondria.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Chemistry, Analytical
Arul Pundi, Chi-Jung Chang, Jemkun Chen, Shih-Rong Hsieh, Ming-Ching Lee
Summary: The chiral carbazole based sensor (CCS) was prepared and shown to effectively detect Fe3+, L-tryptophan (Trp), and L-histidine (His) with low limits of detection in a high water-content environment. The CCS Fe3+ complex based chemosensor was successfully used to quantify the L-tryptophan content in commercial capsules with accurate results.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Materials Science, Multidisciplinary
V. Ramkumar, P. Kamachiyappan, R. Manjunath, S. Balamurugan, A. Ashokkumar, M. K. Ashraf Ali, S. C. Kim
Summary: A highly selective and sensitive receptor for Al3+ and Cu2+ ions was synthesized and characterized. The receptor exhibited solvatochromism and keto-enol tautomerism properties in different solvents. It was found to be a highly selective colorimetric sensor for Al3+ ions, and a turn-off sensor for Cu2+ ions. The highlight of this work is its effectiveness as a naked-eye sensor for both Al3+ and Cu2+ ions.
Article
Chemistry, Analytical
Hui Xu, Xin You, Yue Lu, Peng Liang, Zhihui Luo, Yiwei Wang, Shaoxiao Zeng, Hongliang Zeng
Summary: A convenient and efficient method using red carbon dots as a fluorescent probe was developed for high-sensitivity detection of Mn and Zn contents in macroalgae. The method showed a good linear relationship and determined the detection limits.
Article
Chemistry, Physical
Guo Tian, Yin -Zhu Han, Qian Yang
Summary: A colorimetric and ratiometric fluorescent probe, probe 1, was designed and synthesized for the sensitive and selective detection of Zn2+ and Cd2+ in methanol, test paper, and actual water samples. Probe 1 exhibited sensitive fluorescence selectivity to Zn2+ and Cd2+ in the presence of various metal ions. The detection limits for Zn2+ and Cd2+ were 0.11 μM, and the probe showed potential application prospects in environmental ion recognition.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Analytical
Jinrong Wen, Qianying Hua, Sha Ding, Aokui Sun, Yong Xia
Summary: Zinc is a crucial metal element with wide applications in various fields, and its deficiency can lead to multiple diseases. Selective recognition and effective detection of free zinc ions are highly important. Fluorescent probes, with their high sensitivity, selectivity, real-time monitoring capability, and ease of operation, have been widely used for metal ion detection, including convenient and low-cost methods for Zn2+ detection. This article reviews the latest research advances in fluorescent chemosensors for Zn2+ detection from 2019 to 2023, discussing various mechanisms such as PET, ESIPT, ICT, FRET, CHEF, and AIE. The use of these mechanisms in detecting zinc ions is explored through specific cases, some of which have been validated through theoretical calculations.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Ambigapathi Anandababu, Sambandam Anandan, Asad Syed, Najat Marraiki, Muthupandian Ashokkumar
Summary: This study describes the synthesis of a novel sensor capable of selectively detecting Zn2+ in solution, with fluorescence changes that can be visually observed and a high detection sensitivity.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Applied
Duygu Aydin, Sinan Dinckan, Sukriye Nihan Karuk Elmas, Tahir Savran, Fatma Nur Arslan, Ibrahim Yilmaz
Summary: In this study, a turn-on fluorogenic chemosensor HMBP was designed to detect Al3+. The chemosensor showed high sensitivity and binding capacity towards Al3+, with a stoichiometric ratio of 1:2 and a binding constant of 1.21 x 10(8) M-1. The response of the chemosensor to Al3+ was attributed to blocking the PET and C=N isomerisation mechanisms. The sensor was successfully employed for the determination of Al3+ in real food samples, drinking waters, and herbal teas.
Article
Chemistry, Physical
Onder Alici, Duygu Aydin
Summary: A novel phenolphthalein-derived Schiff base fluorescence probe FF2H has been synthesized and utilized for the fluorescence "turn-on" detection of Al3+ in aceto-nitrile: HEPES system. The probe showed high sensitivity and selectivity towards Al3+ detection, making it a promising tool for metal ion sensing.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2021)
Article
Chemistry, Applied
Duygu Aydin, Sinan Dinckan, Sukriye Nihan Karuk Elmas, Tahir Savran, Fatma Nur Arslan, Ibrahim Yilmaz
Summary: In this study, a turn-on fluorogenic chemosensor HMBP was designed to detect Al3+. The chemosensor showed high sensitivity and binding capacity towards Al3+, with a stoichiometric ratio of 1:2 and a binding constant of 1.21 x 10(8) M-1. The response of the chemosensor to Al3+ was attributed to blocking the PET and C=N isomerisation mechanisms. The sensor was successfully employed for the determination of Al3+ in real food samples, drinking waters, and herbal teas.
Article
Biochemical Research Methods
Duygu Aydin, Meliha Kutluca Alici
Summary: A new phenolphthalein derivative, FFIZNA, was successfully prepared and utilized to selectively monitor Al3+ and Zn2+ through turn-on emission response in EtOH:HEPES media. Confirmation of 1:2 reaction stoichiometry between FFIZNA and Al3+ and Zn2+ was achieved through emission spectroscopy, Job's plot and H-1-NMR titration. Time-response study showed rapid and stable emission enhancement of FFIZNA with Al3+ and Zn2+ in less than 3.0 and 4.0 min, respectively, indicating successful dual recognition of these ions in solutions.
JOURNAL OF FLUORESCENCE
(2021)
Article
Chemistry, Analytical
Sukriye Nihan Karuk Elmas, Duygu Aydin, Tahir Savran, Eray Caliskan, Kenan Koran, Fatma Nur Arslan, Gokhan Sadi, Ahmet Orhan Gorgulu, Ibrahim Yilmaz
Summary: This study successfully developed a fluorene-based fluorescent turn-off sensor FLPG for the highly selective and sensitive detection of Cu2+ and Fe3+ ions, with successful bio-imaging experiments in living cells, providing a simple, inexpensive, fast, and easy-to-use detection platform for routine analysis.
CURRENT ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Serkan Erdemir, Onder Alici, Duygu Aydin, Ozcan Kocyigit
Summary: A new chemosensor SP was designed to sensitively and selectively recognize Fe3+ in aqueous solution, with the sensing mechanism successfully proven through various analytical methods. The SP can be effectively recycled and used for visualizing Fe3+ in low-cost smartphone sensor applications.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Optics
Duygu Aydin, Ibrahim Berk Gunay, Onder Alici
Summary: The research has developed a new benzothiazole-based fluorescent sensor, TAPOH, for detecting Cu2+ ions in the environment, with good specificity and rapid response, generating strong signals in a short period of time. Experimental results demonstrate the potential application value of this sensor in tracking Cu2+ in solutions.
JOURNAL OF LUMINESCENCE
(2022)
Article
Chemistry, Multidisciplinary
Tahir Savran, Sukriye Nihan Karuk Elmas, Duygu Aydin, Sumeyye Arslan, Fatma Nur Arslan, Ibrahim Yilmaz
Summary: A novel multiple-target chemoprobe CTH has been designed and synthesized for the detection of Hg2+ and Fe3+ ions. It shows high sensitivity and selectivity towards Hg2+ and Fe3+ and can quantitatively detect trace amounts of these ions in water samples. A silica-coated test paper and a smartphone application have also been developed for convenient on-site detection.
RESEARCH ON CHEMICAL INTERMEDIATES
(2022)
Article
Biochemical Research Methods
Ruveyda Kilic Boz, Duygu Aydin, Salli Kocak, Bianka Golba, Rana Sanyal, Amitav Sanyal
Summary: This study successfully prepared redox-responsive hydrogels with a well-defined network structure, and tuned the release of encapsulated drugs by varying the molecular weight of the polymers. The hydrogels can undergo complete degradation and rapidly release drugs upon treatment. The results demonstrated the non-toxicity of the hydrogels and their degradation products, as well as the cytocompatibility of the materials.
BIOCONJUGATE CHEMISTRY
(2022)
Article
Chemistry, Applied
Fatma Nur Arslan, Duygu Aydin, Sukriye Nihan Karuk Elmas
Summary: In this research, a novel colorimetric and ratiometric fluorescence chemoprobe (NAPH) based on 1,8-naphthalimide was developed for the recognition of copper (II) in different vegetables and drinkable water samples. NAPH exhibited a ratiometric turn-on fluorescent response and a colorimetric response towards Cu2+ with low detection limit. It showed excellent selectivity towards Cu2+ without interference from other metal ions, anions, and amino acids. The study also validated the spectral data of NAPH and demonstrated its potential as a powerful tool for Cu2+ monitoring using a smartphone.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Chemistry, Applied
Duygu Aydin, Sukriye Nihan Karuk Elmas, Fatma Nur Arslan
Summary: A new cyanobiphenyl-based compound PEBP was successfully synthesized and characterized as a Cu2+ detection sensor. PEBP exhibited extremely fast response and highly selective fluorescence to Cu2+ in water and acetonitrile. The study demonstrated the potential of using PEBP for on-site Cu2+ detection without the need for sophisticated instruments, supported by validation experiments and density functional theory analysis.
Article
Chemistry, Physical
Duygu Aydin, Fatma Nur Arslan, Sukriye Nihan Karuk Elmas, Aykut Bostanci, Gonul Akin Geyik, Tahir Savran, Gokhan Sadi, Ibrahim Yilmaz
Summary: The development of selective and sensitive fluorescence probes for specific recognition of cysteine is important. A new chemoprobe, BUNB, was synthesized and showed excellent selectivity and low detection limit for cysteine. The thiol-propiolate cyclization/addition mechanism between BUNB and cysteine was verified using various experimental methods. BUNB was successfully used for monitoring cysteine in living cells.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Physical
Huseyin Kucukbasmaci, Duygu Aydin
Summary: Accurate tracking of Cu2+ plays a significant role in various fields, and there is a special demand for well-organized, sensitive, and accurate Cu2+ recognition methods in solutions. In this study, a novel phenolphthalein-based fluorogenic probe was developed by integrating a phenolphthalein-based building block with an amine-containing molecule. The probe acted as a switch-off fluorogenic sensor for Cu2+ signaling, showing perfect selectivity and sensitivity towards Cu2+ and faster equilibrium response time compared to other reported probes. As a sensing platform, the probe exhibited a moderately experimental limit of detection (LOD) of 84.0 nM Cu2+ in HEPES:CH3CN (v:v, 1:1, pH = 7). Binding affinity tests, MALDI-TOF MS techniques, and DFT computations confirmed the coordination bonding between Cu2+ and phenolic hydroxyl and -CH = N groups of the probe (FPAB). The probe was successfully applied for Cu2+ sensing on FPAB-coated silica plates and cotton swabs.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Physical
Duygu Aydin, Sukriye Nihan Karuk Elmas, Fatma Nur Arslan
Summary: The phenolphthalein-based compound PHAB was synthesized and characterized, and its fluorescence sensing properties for Al3+ were studied. PHAB showed high sensitivity and specificity towards Al3+ over other competitive cations. The stoichiometry between PHAB and Al3+ was confirmed to be 1:2 using various analytical methods. The fluorescence sensing performance of PHAB makes it a promising candidate for practical applications in water and food analysis.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2024)
Article
Materials Science, Multidisciplinary
Serkan Erdemir, Duygu Aydin, Ozcan Kocyigit
Summary: This study introduces a highly selective fluorescent probe FP for the rapid and sensitive recognition of toxic heavy metal Hg2+. The probe exhibits high sensitivity and specificity, and can efficiently recognize Hg2+ in biological systems.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Chemistry, Analytical
Sukriye Nihan Karuk Elmas, Fatma Nur Arslan, Duygu Aydin
Summary: A novel chemical sensor BUDIN based on 1,8-naphthalimide has been developed, which exhibits ratiometric fluorescence behavior and naked-eye response for sensitive and specific determination of Cu2+ at nanomolar levels. BUDIN shows continuous emission variations with the addition of different amounts of Cu2+, resulting in color changes from yellow to blue. The detection limit for Cu2+ is 17 nM.
Article
Chemistry, Analytical
Qian Wu, Li Tian, Xiangyu Shan, Huiling Li, Chao Li, Juan Lu
Summary: A novel ECL sensor was developed by modifying Fe3CuO4-Ru(bpy)3+ and GO-CdS@ZnS on the electrode for the detection of permethrin. The sensor exhibited high sensitivity and a wide detection range.
Article
Chemistry, Analytical
Tingting Gong, Lei Liao, Bingying Jiang, Ruo Yuan, Yun Xiang
Summary: In this study, a fluorescent biosensing system for high sensitivity detection of MT was established using a new Ag+-stabilized DNA triplex probe (Ag+-SDTP) combined with catalytic hairpin assembly (CHA) and CRISPR/Cas12a signal enhancements. The sensing method is able to selectively detect MT from other non-specific molecules and can achieve low level detection of MT in diluted human serums, demonstrating its potential for monitoring disease-specific MT biomarker at trace levels.
Article
Chemistry, Analytical
Estrella Sanz Rodriguez, Kyra Wood, Paul R. Haddad, Brett Paull
Summary: This study presents a simple, rapid, and reliable method for determining boron in aqueous solutions using suppressed ion chromatography coupled to electrospray ionisation-triple quadrupole mass spectrometry. The method achieved a low limit of detection and demonstrated excellent analytical performance.
Article
Chemistry, Analytical
Aline Cournut, Paul Moustiez, Yannick Coffinier, Christine Enjalbal, Claudia Bich
Summary: Alzheimer's disease is a major cause of senile dementia and is characterized by the aggregation of neurofibrillary tangles and amyloid plaques in the brain. The A beta 1-42 peptide is considered the primary cause of neurotoxicity due to its insolubility and subsequent aggregation. A beta 1-42 and A beta 1-40 have been identified as relevant biomarkers for AD diagnosis, and SurfaceAssisted Laser Desorption/Ionization Mass Spectrometry (SALDI-MS) was used to monitor the A beta 1-42/A beta 1-40 ratio without prior sample treatment.
Article
Chemistry, Analytical
Dotse Selali Chormey, Buse Tugba Zaman, Tulay Borahan Kustanto, Sezin Erarpat Bodur, Suleyman Bodur, Elif Ozturk Er, Sezgin Bakirdere
Summary: This review provides an overview of the harmful effects of endocrine disrupting chemicals (EDCs) on human health and introduces the methods for analyzing EDCs. Recent research has focused on using green chemicals, such as deep eutectic solvents (DESs), for microextraction to ensure environmental safety.
Article
Chemistry, Analytical
Yan Zhang, Renfeng Xu, Jingjing Wu, Zhenghong Zhang, Yuhuang Wang, Hongqin Yang, Sheng Zhang
Summary: This study visualized the pore-like structures in prostate cancer cell membranes after treatment with the anticancer drug paclitaxel, demonstrating its mechanism of action related to oxidative damage.
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Article
Chemistry, Analytical
Gang Liang, Jie Zhao, Yufei Gao, Tao Xie, Jianhui Zhen, Ligang Pan, Wenwen Gong
Summary: Molecular docking (MD) analysis is widely used for studying the interaction between aptamers and small molecules. This study established steady-state aptamers of tertiary structures (SATS) using specific aptamers of tetracycline antibiotics as docking models. Molecular docking results revealed multiple binding sites in the SATS of aptamers, with significant variations in binding free energy (BFE) and docking score (DS). The study also proposed a method for MD analysis based on SATS, providing insights into binding mode and predicting binding sites.
Article
Chemistry, Analytical
Yixuan Xu, Changchang Teng, Huiping Dang, Dalong Yin, Lifeng Yan
Summary: Stable organic radical molecules with high NIR fluorescence quantum efficiency have been synthesized and encapsulated into nanoparticles, which show great potential for both photodynamic therapy (PDT) and photothermal therapy (PTT) of tumors.
Article
Chemistry, Analytical
Yu Su, Dandan Yang, Yanjie Wang, Jie Ding, Lan Ding, Daqian Song
Summary: In this study, a highly selective molecularly imprinted polymer Cu-MIPs@CS was designed and synthesized for bisphenol A (BPA). Cu-MIPs@CS showed significantly enhanced imprinting factor and selective factor towards BPA compared to MIPs@CS. It also exhibited superior discrimination ability between BPA and its structural analogue. Additionally, Cu-MIPs@CS were successfully applied as a solid phase extraction adsorbent for the determination of BPA in drinking water samples.
Article
Chemistry, Analytical
Yi Qiao, Qiongdan Zhang, Yukun He, Tianguang Cheng, Jing Tu
Summary: Single cell heterogeneity plays an important role in many biological phenomena, and distinguishing cells with specific mutations is beneficial for clinical diagnosis and drug screening. This study introduces a gel plate platform that can distinguish cell types based on their phenotypes, with low equipment requirement. The gel platform has potential in point-of-care circumstances and single-cell stimulation responses that prioritize efficiency and simplicity.
Article
Chemistry, Analytical
Chengke Wang, Shuyang Sun, Ping Wang, Huawei Zhao, Wenling Li
Summary: The food safety of aquatic products is a global concern. Nanotechnology-based analyses have advantages in the detection of bacteria, metal ions, and small molecule contaminants. This review summarizes the recent advances in biosensing strategies for aquatic products and highlights the application of nanomaterials, lateral flow-based biosensors, surface-enhanced Raman scattering, microfluidic chips, and molecular imprinting technologies.
Article
Chemistry, Analytical
Liping Zhu, Zeng Tang, Xuemei Zhang, Li Zhu, Tian Meng, Linying Yu, Ting Xiao, Shasha Lu, Xiaoli Xiong, Xiurong Yang
Summary: A sensitive off-on electrochemiluminescence DNA sensor was developed using Exo III-assisted cascade amplification system. The sensor achieved high selectivity and ultra-high sensitivity in detecting target DNA by utilizing ECL and SPR effects. This study provides a new perspective for designing highly sensitive and programmable ECL biosensors.
Article
Chemistry, Analytical
Tong Li, Mengxu Sun, Suping Xia, Ting Huang, Rong-Tian Li, Chunrong Li, Zong Dai, Jin-Xiang Chen, Jun Chen, Nuan Jia
Summary: Here, we developed a binary system based on DNA tetrahedron and fluorogenic RNA aptamers for highly specific and label-free mRNA imaging in living cells. This system achieved high specificity label-free detection of nucleic acids with a detection limit of 1.34 nM. The method has potential applications in early disease diagnosis and new drug development.
Article
Chemistry, Analytical
Yao Zhao, Shu Zhang, Wang Yao, Yuxuan Zhu, Jing Qian, Juan Yang, Nianjun Yang
Summary: A new hierarchical nanostructured composite with high conductivity and catalytic activity is synthesized. The sensor exhibits significant catalytic effect and high sensitivity for monitoring the environmental endocrine disruptor bisphenol A (BPA).
