Journal
CHEMISTRY OF NATURAL COMPOUNDS
Volume 52, Issue 4, Pages 624-627Publisher
SPRINGER
DOI: 10.1007/s10600-016-1725-1
Keywords
Selaginella moellendorffii; selaginellin S; hepatitis B virus; HepG2.2.15 cells
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A new compound, selaginellin S (1), was isolated from the whole plants of Selaginella moellendorffii Hieron. Its structure was elucidated on the basis of spectroscopic analysis and ECD calculations. Selaginellin S markedly suppressed the production of HbsAg and HBeAg with IC50 values of 0.026 and 0.032 mu g/mL. The transcript of viral mRNA was significantly suppressed by selaginellin S in HepG2.2.15 cells.
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