Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding

Published 2020 View Full Article

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Title
Antigen-Induced Allosteric Changes in a Human IgG1 Fc Increase Low-Affinity Fcγ Receptor Binding
Authors
Keywords
immunoglobulin, Fc receptor binding, IgG1 LALA variants, antigen binding, Fc-effector function, RFADCC Assay, HDX-MS, conformational allostery, configurational allostery
Journal
STRUCTURE
Volume 28, Issue 5, Pages 516-527.e5
Publisher
Elsevier BV
Online
2020-03-24
DOI
10.1016/j.str.2020.03.001

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