Article
Biochemistry & Molecular Biology
Dalil Hannani, Estelle Leplus, David Laurin, Benjamin Caulier, Caroline Aspord, Natacha Madelon, Ekaterina Bourova-Flin, Christian Brambilla, Elisabeth Brambilla, Anne-Claire Toffart, Karine Laulagnier, Laurence Chaperot, Joel Plumas
Summary: The purpose of ICI-based therapies is to help the patient's immune system combat tumors. Therapeutic vaccines with dendritic cells have not shown significant benefit, so a new vaccine based on an allogeneic dendritic cell line has been developed. This new vaccine demonstrates efficient activation of specific T cells and the synergistic effect of anti-PD-1 antibodies, showing potential for NSCLC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Canling Lin, Yonghui Chen, Liji Shi, Huarong Lin, Hongmei Xia, Weihua Yin
Summary: Prostate cancer is a significant disease worldwide, and its incidence is increasing in China. Despite the efficacy of chemotherapy agents, treatment failure can occur, leading to castration-resistant prostate cancer. Due to limited treatment options, bio-immunotherapy targeting the prostate microenvironment has become an important option for advanced prostate cancer. This study investigates the role of three types of bio-immunotherapies in castrate-resistant prostate cancer, providing insights for clinical treatment.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Alireza Hassani Najafabadi, Zeynab Izadi Najaf Abadi, Marisa E. Aikins, Kathryn E. Foulds, Mitzi M. Donaldson, Wenmin Yuan, Emeka B. Okeke, Jutaek Nam, Yao Xu, Priyan Weerappuli, Taryn Hetrick, David Adams, Patrick A. Lester, Andres M. Salazar, Dan H. Barouch, Anna Schwendeman, Robert A. Seder, James J. Moon
Summary: This study confirmed that sHDL combined with polyICLC is a strong vaccine platform for inducing CD8+ T cell responses. While the CpG B and CpG C classes generated strong responses in mice, their efficacy was mixed in non-human primates.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Dieter Stevens, Joline Ingels, Sandra Van Lint, Bart Vandekerckhove, Karim Vermaelen
Summary: Immune therapy plays a significant role in the treatment of lung cancer patients, with potential for further exploration. Combining immune checkpoint blockade with other strategies may be a way to fully harness the immune system's anti-tumor potential. Dendritic cells, with their unique ability to initiate and regulate T cell responses, show promise as tools for immunotherapy in lung cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Zhongyuan Guo, Ilkoo Noh, Audrey T. T. Zhu, Yiyan Yu, Weiwei Gao, Ronnie H. H. Fang, Liangfang Zhang
Summary: Cell membrane-based nanovaccines incorporating adjuvants have shown promising features for antitumor vaccination. This study presents cellular nanodiscs made from cancer cell membranes and a lipid-based adjuvant. The nanodiscs are efficiently taken up by antigen-presenting cells and stimulate the immune system, leading to effective control of tumor growth in both prophylactic and therapeutic settings, especially when combined with checkpoint blockades. These multiantigenic nanovaccines hold potential for activating antitumor immune responses in a wide range of cancers.
Review
Chemistry, Multidisciplinary
Salma B. Abdelbaky, Mayar Tarek Ibrahim, Hebatallah Samy, Menatalla Mohamed, Hebatallah Mohamed, Mahmoud Mustafa, Moustafa M. Abdelaziz, M. Laird Forrest, Islam A. Khalil
Summary: Cancer immunotherapy has shown promise in eradicating cancer cells and overcoming multidrug resistance with fewer side effects compared to traditional cytotoxic therapies, utilizing agents such as checkpoint inhibitors and monoclonal antibodies to help immune cells target tumor cells. However, concerns remain around off-target side effects and poor pharmacokinetics in immunotherapeutics. Nanomedicine offers potential solutions by improving drug delivery, release control, and pharmacokinetic profiles, enhancing therapeutic outcomes and minimizing side effects.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Chemistry, Multidisciplinary
Asal Barshidi, Vahid Karpisheh, Fatemeh Karimian Noukabadi, Fariba Karoon Kiani, Mohammad Mohammadi, Negin Afsharimanesh, Farbod Ebrahimi, Seyed Hossein Kiaie, Jamshid Gholizadeh Navashenaq, Mohammad Hojjat-Farsangi, Naime Majidi Zolbanin, Ata Mahmoodpoor, Hadi Hassannia, Sanam Nami, Pooya Jalali, Reza Jafari, Farhad Jadidi-Niaragh
Summary: This study suggests that nanoparticles loaded with siRNA can effectively inhibit the expression of immune checkpoints, leading to increased efficiency of T cells in response to vaccines. Furthermore, the combination of these nanoparticles and DC vaccines has shown promising results in inhibiting tumor growth and improving survival in mice. These findings highlight the potential of combination therapy targeting immune checkpoints for cancer treatment.
PHARMACEUTICAL RESEARCH
(2022)
Review
Chemistry, Multidisciplinary
Elham Masoumi, Sahar Tahaghoghi-Hajghorbani, Leila Jafarzadeh, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: This review provides an overview of the current research status of immune checkpoint blockades in breast cancer and discusses the efficacy and limitations of ICB therapy in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Gastroenterology & Hepatology
Cathrin L. C. Gudd, Lewis Au, Evangelos Triantafyllou, Benjamin Shum, Tong Liu, Rooshi Nathwani, Naveenta Kumar, Sujit Mukherjee, Ameet Dhar, Kevin J. Woollard, You Yone, David J. Pinato, Mark R. Thursz, Robert D. Goldin, Martin E. Gore, James Larkin, Wafa Khamri, Charalambos G. Antoniades, Samra Turajlic, Lucia A. Possamai
Summary: This study reveals that patients with checkpoint inhibitor-related hepatitis exhibit activation of peripheral monocytes and an enhanced cytotoxic, effector CD8(+) T cell phenotype, with the presence of CD163(+)CCR2(+) macrophages and CD8(+) T cells in liver tissue. Targeting these pathways identified in the study may help prevent or manage liver-related side effects of immunotherapy.
JOURNAL OF HEPATOLOGY
(2021)
Article
Oncology
Kathryn M. LaPorte, Rosmely Hernandez, Alicia Santos Savio, Thomas R. Malek
Summary: Researchers tested an IL-2 biologic, mIL-2/CD25, which preferentially stimulates the high-affinity IL-2R, and found that it can effectively support antitumor responses to immunogenic tumors as a monotherapy or in combination with a PD-1 checkpoint blockade. This treatment increases the frequency and function of tumor-specific CD8(+) T effector cells and induces long-term antitumor memory responses in the tumor microenvironment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biotechnology & Applied Microbiology
Morgan E. Janes, Alexander P. Gottlieb, Kyung Soo Park, Zongmin Zhao, Samir Mitragotri
Summary: Vaccines are important tools in immunotherapy for cancer treatment. This article provides an update on the clinical status of cancer vaccines, including analyses of 360 ongoing trials and the introduction of eight globally approved products. The article also discusses current limitations and future applications for clinical translation of cancer vaccines.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Rom Leidner, Kevin Conlon, Douglas G. Mcneel, Andrea Wang-Gillam, Sumati Gupta, Robert Wesolowski, Monica Chaudhari, Nadia Hassounah, Jong Bong Lee, Lang Ho Lee, Jessica A. O'Keeffe, Nancy Lewis, George N. Pavlakis, John A. Thompson
Summary: This study investigated the efficacy and safety of NIZ985 as monotherapy and in combination with spartalizumab in the treatment of advanced solid tumors. The results showed that NIZ985 demonstrated antitumor activity and was well tolerated in patients with advanced solid tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Xuedan He, Shiqi Zhou, Wei-Chiao Huang, Amal Seffouh, Moustafa T. Mabrouk, M. Thomas Morgan, Joaquin Ortega, Scott Abrams, Jonathan F. Lovell
Summary: A new vaccine adjuvant system was developed to induce strong cellular immune responses against multiple tumor cell lines, demonstrating durable immunity. The system showed the importance of stable particle formation for effective immune response induction and could control local and metastatic disease in a therapeutic setting.
Article
Oncology
Yue Liu, Joanna Pagacz, Donald J. Wolfgeher, Kenneth D. Bromerg, Jacob Gorman, Stephen J. Kron
Summary: Antigen presentation may be the limiting factor in the low immune response to radiation therapy, and combining immune checkpoint blockade does not restore cytotoxic T lymphocytes function. Therapeutic vaccines based on senescent tumor cells or SnC-activated dendritic cells have the potential to enhance immune therapies and limit recurrence or metastasis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Xi Zhang, Tianhui He, Yuan Li, Ling Chen, Hongyu Liu, Yu Wu, Hongyan Guo
Summary: Ovarian cancer is characterized by uncertain presentation and poor outcomes, with surgery and chemotherapy being the current basis of treatment. However, there are limitations due to advanced stage at diagnosis and high recurrence rate. The use of anti-VEGF agents, PARP inhibitors, and immunotherapies are being explored to enhance treatment outcomes, but the population that can benefit from these treatments remains limited.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Mohammad Azam Ansari, Farheen Badrealam Khan, Haaris Ahsan Safdari, Ahmad Almatroudi, Mohammad A. Alzohairy, Mohammadreza Safdari, Mehran Amirizadeh, Suriya Rehman, Mohammad Javed Equbal, Mehboob Hoque
Summary: The review collates the pharmacological properties of Tanshinone IIA (Tan IIA) with a special emphasis on its therapeutic potential against diverse diseases, while also discussing possible applications of various therapeutic formulations based on nanotechnology. The convergence of nanomedicine and the therapeutic potential of Tan IIA shows great promise in clinical application.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Adel M. Abuzenadah, Fatin Al-Sayes, Syed Sahajada Mahafujul Alam, Mehboob Hoque, Sajjad Karim, Ibtessam M. R. Hussain, Shams Tabrez
Summary: Angiogenesis is crucial for tumor development, and targeting VEGFR-2 signaling is a promising strategy for cancer treatment. This study identified bioactive compounds from Rauwolfia serpentina that effectively bind with VEGFR-2. Molecular docking results showed strong interactions between these compounds and VEGFR-2, and they possess favorable drug-like properties without significant toxicity. These findings suggest the potential of these compounds for antiangiogenic drug development.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Munazza Tamkeen Fatima, Zeyaul Islam, Ejaj Ahmad, Mehboob Hoque, Marriam Yamin
Summary: The research explored the potential of fibrin-based plasma beads and liposome-PB systems as delivery systems for combating fungal infections. These systems exhibited the ability to sustain the release of antifungal compounds in the bloodstream and gradually accumulate in vital organs, offering safe and effective alternatives for drug delivery.
Article
Biochemistry & Molecular Biology
Shams Tabrez, Torki A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. Khan
Summary: In this study, 12 potent compounds were identified from a traditional Chinese medicine database as potential GLS inhibitors. Among them, ZINC03978829 and ZINC32296657 exhibited higher binding energy values with GLS. Molecular dynamics simulations confirmed that these compounds form stable complexes with GLS, suggesting their potential as therapeutic agents against cancer. Further laboratory testing is required to optimize these compounds as GLS inhibitors.
Article
Cell Biology
Zarnain Jamil, Arif Uddin, Syed Sahajada Mahafujul Alam, Arijit Samanta, Nojood Altwaijry, Mohd Ahmar Rauf, Safdar Ali, Mohd Shahnawaz Khan, Muhammad Nadeem Asghar, Mehboob Hoque
Summary: Autophagy is involved in various human pathologies and is regulated by a set of autophagy-related genes. This study analyzed the nucleotide composition and codon usage pattern of human autophagy genes, revealing an overall low codon usage bias. Both nucleotide composition and evolutionary forces influence the codon usage pattern of these genes.
Article
Genetics & Heredity
Arijit Samanta, Syed Sahajada Mahafujul Alam, Safdar Ali, Mehboob Hoque
Summary: The newly emerged Omicron (B.1.1.529) variant of the SARS-CoV-2 virus shows higher infectivity in humans, raising concerns about possible transmission via intermediate hosts. Through protein-protein interaction analysis, it was found that Omicron interacts with the ACE2 receptor of 122 mammalian hosts with different amino acid residues. This indicates a greater potential for new host transmission and infection.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Correction
Biochemistry & Molecular Biology
Shams Tabrez, Torki A. A. Zughaibi, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Azhar U. U. Khan
Article
Biochemistry & Molecular Biology
Haaris A. Safdari, Sergo Kasvandik, Christine Polte, Zoya Ignatova, Tanel Tenson, Daniel N. Wilson
Summary: The heat shock protein 15 (Hsp15) in bacteria has different binding sites and mechanisms compared to its homolog RqcP in Bacillus subtilis. Our study found that Hsp15 in Escherichia coli binds to the 50S subunit upon heat shock, stabilizes the peptidyl-tRNA in the P-site, and promotes the release of aberrant nascent polypeptide chains.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Iftikhar Ahmad, Mehboob Hoque, Syed Sahajada Mahafujul Alam, Torki A. Zughaibi, Shams Tabrez
Summary: Cancer development is associated with deregulation of cell signaling pathways caused by genetic and epigenetic alterations. The PI3K/Akt/mTOR pathway is a major deregulated pathway in cancer, and several drug candidates are being investigated to target this pathway. Curcumin and plumbagin are potential anticancer compounds that individually target the PI3K/Akt/mTOR pathway. This study investigates their synergistic effect by employing molecular docking and molecular dynamics analysis. The results show increased binding affinity and decreased inhibition constant when curcumin and plumbagin are sequentially docked against PI3K, Akt, and mTOR. MD simulations and MM-GBSA analyses validate the more stable conformation of target proteins when interacting with the combination of curcumin and plumbagin, indicating their synergistic role against cancer cells. The findings pave the way for further investigation of their combinatorial effect in vitro and in vivo models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Syed Sahajada Mahafujul Alam, Arijit Samanta, Faizan Uddin, Safdar Ali, Mehboob Hoque
Summary: Natural compound Tan IIA derived from the roots of Traditional Chinese Medicine herb Salvia miltiorrhiza exhibits remarkable anticancer properties against various types of cancer by modulating multiple signaling pathways. It inhibits tumor cell growth and proliferation, metastasis, invasion, and angiogenesis, while inducing apoptosis and autophagy. This review focuses on the role of Tan IIA in cancer treatment and its underlying molecular mechanisms.
PHARMACOLOGICAL REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Shams Tabrez, Azhar U. Khan, Mehboob Hoque, Mohd Suhail, Mohammad Imran Khan, Torki A. Zughaibi
Summary: This study biosynthesized ZnO NPs from pumpkin seed extract and demonstrated their anticancer potential in breast cancer cells, showing promise for future applications in cancer treatment.
NANOTECHNOLOGY REVIEWS
(2022)
