Journal
CHEMISTRY OF MATERIALS
Volume 28, Issue 13, Pages 4661-4669Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemmater.6b01424
Keywords
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Funding
- National Natural Science Foundation of China [51373022, 51503015]
- China Postdoctoral Science Foundation [2015M581176]
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Binding of biomolecules or probes to the plasma membrane is of great importance for investigations of cell morphology and various biological processes. Herein, a water-soluble conjugated polymer is designed as a membrane probe. The probe shows a strong affinity toward lipid membranes owing to the high charge density from abundant imidazolium moieties together with the moderate rigidity and hydrophobicity derived from the conjugated backbone. Upon binding with a membrane, the interchain FRET of the probe was substantially enhanced, which resulted in the emission of both blue and red fluorescence. This is favorable for dual-color imaging. Finally, cellular experiments demonstrate the excellent performance of this macromolecular probe on stable binding with cell membranes without the appearance of cell endocytocysis even after a long retention time.
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