Article
Multidisciplinary Sciences
A. H. Ayesha Lavell, Jonne J. Sikkens, Arthur W. D. Edridge, Karlijn van der Straten, Ferdyansyah Sechan, Melissa Oomen, David T. P. Buis, Michiel Schinkel, Judith A. Burger, Meliawati Poniman, Jacqueline van Rijswijk, Menno D. de Jong, Godelieve J. de Bree, Edgar J. G. Peters, Yvo M. Smulders, Rogier W. Sanders, Marit J. van Gils, Lia van der Hoek, Marije K. Bomers
Summary: A study in the Netherlands found that healthcare workers with high levels of HCoV-OC43 nucleocapsid antibodies had a lower risk of SARS-CoV-2 infection, which may support the development of pancoronavirus vaccines.
Review
Medicine, General & Internal
Mariam Nikolaishvili, Ani Pazhava, Vito Di Lernia
Summary: Henoch-Schonlein purpura, also known as IgA vasculitis, is a common type of vasculitis in children and adults. It affects small blood vessels and can cause skin and systemic symptoms, with some patients developing kidney failure. The specific pathophysiology of this disorder is not well understood, but it is believed to be related to abnormally glycosylated IgA1. Various factors, including infections, drugs, and vaccines, can trigger the condition. In the context of the COVID-19 pandemic, SARS-CoV-2 infection and COVID-19 immunization have been identified as significant triggers for IgA vasculitis. This review provides insights into the relationship between viral infections, viral vaccines, and Henoch-Schonlein purpura.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Jerome H. Check, Diane L. Check
Summary: Cancer and the fetal-placental semi-allograft have similarities in their characteristics, and the progesterone induced blocking factor (PIBF) may play a crucial role in cell cycle regulation, aiding both the fetus and malignant tumors in evading immune surveillance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Matthew Cotten, My V. T. Phan
Summary: The SARS-CoV-2 virus has evolved over the years and our study reveals significant changes in the spike protein of the virus. These changes may affect the survival and transmission of the virus, and should be targeted in future vaccine and therapeutic development.
Article
Immunology
Yingli Liu, Dan Si, Pingping Bai, Li Zhu, Lili Zhang, Qi Chen, Yong Qi
Summary: This study identified common genes shared by COVID-19 and PE, and identified CXCL10 as a potential cause of susceptibility to PE in COVID-19 patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Review
Immunology
Ying Wang, Pengfei Huo, Rulin Dai, Xin Lv, Shaofei Yuan, Yang Zhang, Yiming Guo, Rui Li, Qian Yu, Kun Zhu
Summary: The effectiveness of convalescent plasma (CP) immunotherapy for COVID-19 in reducing mortality and improving clinical symptoms remains controversial based on current evidence, but it may have a positive impact on treating COVID-19 patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Leyuan Liu, Xiaoxiao Wang, Xiaoguang Li, Nan Li
Summary: The study shows that COVID-19 vaccination can reduce public anxiety and promote willingness for future antibody testing, with those experiencing higher levels of anxiety more likely to undergo antibody testing.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Gastroenterology & Hepatology
Giuseppe Losurdo, Milena Di Leo, Edoardo Santamato, Monica Arena, Maria Rendina, Carmelo Luigiano, Enzo Ierardi, Alfredo Di Leo
Summary: The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition has approved new criteria for diagnosing celiac disease in children, allowing for biopsy avoidance in specific antibody value and positivity cases, while adults still require histological biopsy for diagnosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Jungchan Park, Seung-Hwa Lee, Seng Chan You, Jinseob Kim, Kwangmo Yang
Summary: The study found that the use of NSAIDs in Covid-19 patients was not associated with all-cause mortality or the need for ventilator care, indicating that NSAIDs can be safely used to alleviate symptoms in patients suspected of having Covid-19.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Roger A. De Souza, Dennis Kemp, Matthew J. Wolf, Amr H. H. Ramadan
Summary: The activation energies of defect migration in ABX3 perovskite halides obtained through static supercell calculations are unreliable, particularly at temperatures relevant to device operation, due to the adoption of higher symmetry structures and local structural modifications in addition to ion relaxation around the point defects. We propose a robust test to determine the reliability of static supercell calculations for point defect processes in ABX3 perovskite systems.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Physical
Roger A. De Souza, Dennis Kemp, Matthew J. Wolf, Amr H. H. Ramadan
Summary: The activation energies of defect migration in ABX3 perovskite halides obtained through static supercell calculations may be unreliable at temperatures relevant to device operation due to local structural modifications. A robust test method is proposed to determine the reliability of static supercell calculations in point defect processes in perovskite systems.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Evolutionary Biology
Peter A. Biro, Frederic Thomas, Beata Ujvari, Christa Beckmann
Summary: High energy expenditure may have a net protective effect against cancer, despite increased production of reactive oxygen species. Individuals with high energy expenditure have greater energetic capacity, allowing allocation of energy to multiple cancer-fighting mechanisms with minimal trade-offs.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2022)
Article
Immunology
Ying Shao, Jason Saredy, Keman Xu, Yu Sun, Fatma Saaoud, Charles Drummer, Yifan Lu, Jin J. Luo, Jahaira Lopez-Pastrana, Eric T. Choi, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Summary: Transcriptomic changes in endothelial cells (ECs) infected by coronaviruses and stimulated by DAMPs lead to upregulation of innate immune regulatomic genes (IGs), contributing to various aspects including COVID-19, cardiovascular diseases, inflammation, transplantation, autoimmune diseases, and cancers. The activation of nucleic acid sensors and modulation of gene expression by various PAMPs and DAMPs play crucial roles in the immune response of ECs. The findings suggest a novel function of ECs in promoting myelopoiesis and trained immunity, which may drive cytokine storms and increase thromboembolic potential in COVID-19.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Zeljko Kikic, Benjamin A. Adam, Anna Buxeda Porras, Carmen Lefaucheur, Alexandre Loupy, Heinz Regele, Daniel Cejka, Mark Haas, Robert B. Colvin, Michael Mengel
Summary: Antibody-mediated rejection (ABMR) is a major cause of kidney allograft failure. The current scoring system for measuring ABMR progression, known as the Banff transplant glomerulopathy (TG) scoring system, has limitations due to crude and arbitrary grades and low inter-observer concordance. A novel quantitative method using digital pathology was developed that accurately assessed progression of TG in ABMR and showed better predictive capability for graft failure.
KIDNEY INTERNATIONAL
(2023)
Article
Surgery
Megan Jenkins, Gabrielle Maranga, G. Craig Wood, Christopher M. Petrilli, George Fielding, Christine Ren-Fielding
Summary: The study suggests that a history of bariatric surgery significantly reduces the risk of hospitalization, mechanical ventilation, prolonged ICU stay, and death in COVID-19 patients. Even after adjusting for BMI and obesity-related comorbidities, patients with a history of bariatric surgery still have a lower risk of emergency room admission.
SURGERY FOR OBESITY AND RELATED DISEASES
(2021)