Journal
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Volume 92, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/sji.12895
Keywords
coronavirus disease 19; cytokine storm; inflammation; severe acute respiratory syndrome coronavirus 2
Categories
Funding
- Key Science and Technology Project of Henan Province [192102310333]
- Medical Science and Technology Project Jointly Built of Henan Province [2018020385]
- Key scientific research projects of Henan Colleges and Universities [19B320015]
- Undergraduate Innovation and Entrepreneurship Training Program [S201913505004]
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging coronavirus that belongs to the beta-genus, causing the outbreak of coronavirus disease 19 (COVID-19). SARS-CoV-2 infection can stimulate a pronounced immune response in the host, which embodies in the decrease of lymphocytes and aberrant increase of cytokines in COVID-19 patients. SARS-CoV-2 RNA and proteins interact with various pattern recognition receptors that switch on antiviral immune responses to regulate viral replication and spreading within the host in vivo. However, overactive and impaired immune responses also cause immune damage and subsequent tissue inflammation. This article focuses on the dual roles of immune system during SARS-CoV-2 infection, providing a theoretical basic for identifying therapeutic targets in a situation with an unfavourable immune reaction.
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