From Acylethynylpyrroles to Pyrrolo[1,2-a]pyrazines in One Step

Design, Synthesis, and Biological Evaluation of Novel Pyrrolo[1,2-a]pyrazine Derivatives

(2019) Jinwoo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2- a ]indol-1(2 H )-ones as potential anticancer agents effecting the reactive oxygen species production

(2018) Bahaa G.M. Youssif et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

(2018) James J. Crawford et al.   JOURNAL OF MEDICINAL CHEMISTRY

An antibiotic agent pyrrolo[1,2-a]pyrazine-1,4-dione,hexahydro isolated from a marine bacteria Bacillus tequilensis MSI45 effectively controls multi-drug resistant Staphylococcus aureus

(2018) George Seghal Kiran et al.   RSC Advances

Transition-Metal-Free Synthesis of Pyrrolo[1,2-a]pyrazines via Intramolecular Cyclization of N-Propargyl(pyrrolyl)enaminones

(2017) Boris Trofimov et al.   SYNTHESIS-STUTTGART

Combating Enhanced Intracellular Survival (Eis)-Mediated Kanamycin Resistance of Mycobacterium tuberculosis by Novel Pyrrolo[1,5-a]pyrazine-Based Eis Inhibitors

(2017) Atefeh Garzan et al.   ACS Infectious Diseases

Anticancer potential of pyrrole (1, 2, a) pyrazine 1, 4, dione, hexahydro 3-(2-methyl propyl) (PPDHMP) extracted from a new marine bacterium, Staphylococcus sp. strain MB30

(2016) P. Lalitha et al.   APOPTOSIS

Pyrrole: An emerging scaffold for construction of valuable therapeutic agents

(2016) Somnath S. Gholap   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

An Update on Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors: Opportunities and Challenges in Cancer Therapy

(2016) Ying-Qing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-based discovery of potent ERK2 pyrrolopyrazine inhibitors

(2015) Daniel J. Burdick et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors

(2015) Peng-Hui Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design of Pyrazolo-pyrrolo-pyrazines and Pyrazolo-pyrrolo-diazepines via AuCl3-Catalyzed and NaH-Supported Cyclization of N-Propargyl Pyrazoles

(2015) Sinan Basceken et al.   JOURNAL OF ORGANIC CHEMISTRY

Deorphaning Pyrrolopyrazines as Potent Multi-Target Antimalarial Agents

(2014) Daniel Reker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel fluorinated pyrrolo[1,2-a]pyrazine-2,6-dione derivatives: Synthesis and anticonvulsant evaluation in animal models of epilepsy

(2014) Maciej Dawidowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationships of the aromatic site in novel anticonvulsant pyrrolo[1,2-a]pyrazine derivatives

(2013) Maciej Dawidowski et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pyrrolopyrazines as Selective Spleen Tyrosine Kinase Inhibitors

(2013) Fernando Padilla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, anti-inflammatory, and antiproliferative activity evaluation of isoindole, pyrrolopyrazine, benzimidazoisoindole, and benzimidazopyrrolopyrazine derivatives

(2013) Sandeep Kumar et al.   MOLECULAR DIVERSITY

3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models

(2012) Michael Soth et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of pyrrolo[1,2-a]pyrazines and pyrazino[1,2-a]indoles by Curtius reaction in Morita–Baylis–Hillman derivatives

(2011) Maloy Nayak et al.   TETRAHEDRON

Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: Novel, potent, and selective series of Vasopressin1b receptor antagonists

(2010) Roberto Arban et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Domino Approach for the Synthesis of Pyrrolo[1,2-α]pyrazine from Vinyl Azides

(2010) Wenteng Chen et al.   ORGANIC LETTERS

Microwave-Promoted Synthesis ofN-Heterocycles by Tandem Imination/Annulation of γ- and δ-Ketoalkynes in the Presence of Ammonia

(2009) Maria Alfonsi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Phenylethynyl-pyrrolo[1,2-a]pyrazine: A new potent and selective tool in the mGluR5 antagonists arena

(2008) Fabrizio Micheli et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS