Article
Biochemistry & Molecular Biology
Joshua M. Peterson, Jayson W. Jay, Ye Wang, Alejandro A. Joglar, Anesh Prasai, Alen Palackic, Steven E. Wolf, Amina El Ayadi
Summary: Galunisertib, an inhibitor of ALK5, has anti-fibrotic effects on dermal fibroblasts and enhances in vitro wound closure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Monica L. Brown Lobbins, Andrzej T. Slominski, Karen A. Hasty, Sicheng Zhang, Duane D. Miller, Wei Li, Tae-Kang Kim, Zorica Janjetovic, Robert C. Tuckey, Imara-Safi O. Scott, Linda K. Myers, Arnold E. Postlethwaite
Summary: This study demonstrates that 17,20S(OH)(2)pD can suppress type I collagen synthesis and decrease the expression of fibrosis-related mediators, offering a potential noncalcemic secosteroidal therapeutic approach for treating systemic sclerosis and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hanjing Sheng, Gang Lin, Shengxian Zhao, Weibin Li, Zhaolin Zhang, Weidong Zhang, Li Yun, Xiaoyang Yan, Hongyu Hu
Summary: This study evaluated the anti-fibrotic role of Piceatannol (PIC) in a mouse model of pulmonary fibrosis and found that PIC reduces the number of activated myofibroblasts by promoting autophagy. The study demonstrates for the first time the protective effects of PIC against pulmonary fibrosis and suggests its potential as a candidate compound for pulmonary fibrosis therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Michal Rudnik, Amela Hukara, Ievgeniia Kocherova, Suzana Jordan, Janine Schniering, Vincent Milleret, Martin Ehrbar, Karin Klingel, Carol Feghali-Bostwick, Oliver Distler, Przemyslaw Blyszczuk, Gabriela Kania
Summary: The study identified activated profibrotic features in CD14(+) monocytes and CD14(+) pulmonary macrophages in Systemic sclerosis (SSc) patients, highlighting their capability to produce profibrotic fibronectin. This suggests that tissue-infiltrating CD14(+) monocytes/macrophages play a role in ECM production in the pathogenesis of SSc.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Xi Xie, Haina Gan, Jing Tian, Fen li, Jinwei Chen, Jia Wang, Jiafeng Liao, Shu Li
Summary: T-614 inhibited dermal fibroblasts activation and skin fibrosis in experimental SSc models by regulating TGF-beta 1/smad pathway.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jae-Hyun Lee, Chang-Min Lee, Joyce H. Lee, Mun-Ock Kim, Jin Wook Park, Suchitra Kamle, Bedia Akosman, Erica L. Herzog, Xue Yan Peng, Jack A. Elias, Chun Geun Lee
Summary: This study identified and characterized KSM as a potent CHIT1 inhibitor with strong antifibrotic effects on pulmonary fibrosis. KSM inhibited fibrotic cellular processes and physical association between CHIT1 and TGFBRAP1, suggesting its therapeutic potential by regulating the TGF-beta pathway.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Laura Sartiani, Gianluca Bartolucci, Marco Pallecchi, Valentina Spinelli, Elisabetta Cerbai
Summary: Pirfenidone is a drug approved for the treatment of Idiopathic pulmonary fibrosis, but its mechanism of action is still not well understood. It has attracted attention for its potential therapeutic effects in other pathological fibrotic disorders, but more research is needed to understand its effects on fibroblasts and their interactions with other cell types.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Rheumatology
Fabian A. Mendoza, Sergio A. Jimenez
Summary: Serine/threonine kinases mediate phosphorylation of intracellular protein targets and play a crucial role in regulating cellular functions, including fibrosis development and maintenance in diseases. Drugs targeting and inhibiting these kinases have been developed and may serve as potential therapeutic agents for fibrotic diseases.
Review
Immunology
Kelin Zhao, Chenfei Kong, Naixu Shi, Jinlan Jiang, Ping Li
Summary: This review summarizes the therapeutic effects of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) on systemic sclerosis (SSc) and the mechanisms, providing a theoretical basis for future research on the role of MSC-EVs in treating SSc.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Orthopedics
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Hsiang-Ning Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S. Pang
Summary: The study demonstrated that simultaneous use of PRP and suramin promoted myoblast proliferation, reduced fibronectin expression, and decreased fibronectin expression at the site of muscle injury. In the animal study, the group treated with PRP plus suramin showed better muscle healing and contractile strength compared to the group treated with PRP alone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Medicine, Research & Experimental
Satomi Ozawa, Shigeyuki Mukudai, Yoichiro Sugiyama, Ryan C. Branski, Shigeru Hirano
Summary: This study examined the expression of estrogen receptors in vocal fold fibroblasts and the effects of estrogens on TGF-beta 1 signaling. The results showed that E2 can regulate TGF-beta 1/Smad signaling through estrogen receptors in VFFs, providing insight into potential mechanisms for therapeutic strategies in vocal fold fibrosis.
Article
Multidisciplinary Sciences
Paria Bayati, Mahsa Kalantari, Mohammad-Ali Assarehzadegan, Hadi Poormoghim, Nazanin Mojtabavi
Summary: Systemic sclerosis is a rheumatoid disease characterized by skin tightening or organ dysfunction. MiR-27a, a microRNA associated with fibrosis and cancer, was found to be down-regulated in the blood of SSc patients. It targets factors contributing to SSc and may have potential therapeutic and diagnostic value.
SCIENTIFIC REPORTS
(2022)
Article
Rheumatology
Eleonora Adami, Sivakumar Viswanathan, Anissa A. Widjaja, Benjamin Ng, Sonia Chothani, Nevin Zhihao, Jessie Tan, Pei Min Lio, Benjamin L. George, Umut Altunoglu, Kakaly Ghosh, Bhairav S. Paleja, Sebastian Schafer, Bruno Reversade, Salvatore Albani, Andrea Low Hsiu Ling, Steven O'Reilly, Stuart A. Cook
Summary: This study found that IL11 levels are elevated in patients with SSc and TGF beta induces IL11 secretion in HDFs. IL11 stimulates ERK activation in HDFs, promoting fibrosis phenotypes such as cell migration and extracellular matrix secretion, while inhibiting IL11 signaling reduces TGF beta-induced HDF proliferation and matrix production.
Article
Medicine, Research & Experimental
Jose Alvaro Lomeli-Nieto, Jose Francisco Munoz-Valle, Christian Johana Banos-Hernandez, Jose Eduardo Navarro-Zarza, Juliana Marisol Godinez-Rubi, Samuel Garcia-Arellano, Maria Guadalupe Ramirez-Duenas, Isela Parra-Rojas, Arisbeth Villanueva-Perez, Jorge Hernandez-Bello
Summary: This study demonstrates a joint decrease of the three active TGF-beta isoforms in SSc patients. However, TGF-beta 1, TGF-beta R1, and TGF-beta R2 are possibly increased in clinically involved skin.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Jorge RuizdelRio, Pedro Munoz, Patricia Carreira, David Maestro, Jose L. Pablos, Ana Palanca, Jesus Merino, Anna Serrano-Mollar, Ramon Merino, Esther Tamayo, Marcos Lopez-Hoyos, Federico Diaz-Gonzalez, Victor Martinez-Taboada, Ana V. Villar
Summary: This study investigated the expression and function of Hsp90 alpha in skin fibrosis. The results showed that Hsp90 alpha is overexpressed in fibrotic conditions and is associated with disease severity in SSc patients.
JOURNAL OF IMMUNOLOGY
(2022)