Article
Rheumatology
Matej Sapina, Marijan Frkovic, Mario Sestan, Sasa Srsen, Aleksandar Ovuka, Mateja Batnozic Varga, Karolina Kramaric, Dario Brdaric, Kresimir Milas, Alenka Gagro, Marija Jelusic
Summary: Research on the spatial variability of IgA vasculitis (IgAV) in children and its associated nephritis (IgAVN) in Croatia showed non-random distribution, with clustering patterns differing between IgAV and IgAVN. This spatial analysis provides insight for investigating potential environmental risk factors and genetic diversity in non-communicable diseases.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Immunology
Xueli Hu, Ru Fan, Wenzhu Song, Jianbo Qing, Xiaoyan Yan, Yaheng Li, Qi Duan, Yafeng Li
Summary: By screening and analyzing the differential intestinal flora between the three disease groups of IgAN, Kawasaki disease, and IgA vasculitis and their healthy controls, common differential flora were found, which may provide new insights into the pathogenesis of these three diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Rheumatology
Alper Han Cebi, Ferhat Demir, Mevlit Ikbal, Mukaddes Kalyoncu
Summary: In children with IgAV, miRNA-33 and miRNA-34 expression levels significantly increase during the active period, while miRNA-122 and miRNA-204 levels decrease. The study suggests that miRNA-204 may serve as a significant biomarker in autoimmune diseases, but further research is needed to validate this relationship.
CLINICAL RHEUMATOLOGY
(2021)
Article
Immunology
Zhao-wei Gao, Lan Yang, Chong Liu, Xi Wang, Wen-tao Guo, Hui-zhong Zhang, Ke Dong
Summary: This study explores the roles of ADA1 and ADA2 in cancers. The results show that ADA1 is significantly increased in several tumor tissues, while ADA2 is significantly increased in other tumor tissues. High ADA1 expression is associated with poor prognosis, while high ADA2 expression is associated with favorable prognosis. ADA1 shows a moderate positive correlation with multiple infiltrating immune cells, while ADA2 is positively correlated with some immune cells and negatively correlated with others. These findings reveal the distinct roles of ADA1 and ADA2 in cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Evangeline Pillebout, Cord Sunderkoetter
Summary: IgA vasculitis is an inflammation of small vessels caused by IgA deposition and neutrophil activation, which can present as systemic vasculitis or be limited to the skin or kidneys. Clinical features include palpable purpura, joint pain, gastrointestinal symptoms, and glomerulonephritis. Treatment is not well-established, and long-term prognosis is often related to the severity of nephritis.
SEMINARS IN IMMUNOPATHOLOGY
(2021)
Review
Pediatrics
Marija Jelusic, Mario Sestan, Teresa Giani, Rolando Cimaz
Summary: This article summarizes the current knowledge about the epidemiology, pathogenesis, diagnosis, and treatment of non-granulomatous systemic vasculitis, specifically focusing on IgA vasculitis (IgAV). The article highlights the importance of an integrative approach in understanding IgAV and discusses the impact of geographical and environmental factors on the disease.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Donald Y. M. Leung, Patrick M. Schlievert
Summary: Kawasaki syndrome is an acute vasculitis in children that can lead to heart disease, with unclear etiology and lack of diagnostic tests. High dose intravenous immunoglobulin therapy is effective in reducing cardiovascular complications, but some patients are resistant to this treatment. The disease may be caused by multiple infectious agents and influenced by environmental, genetic, and immunologic responses.
Article
Biochemistry & Molecular Biology
Yusuke Motoji, Ryuji Fukazawa, Ryosuke Matsui, Noriko Nagi-Miura, Yasuo Miyagi, Yasuhiko Itoh, Yosuke Ishii
Summary: This study found that Kawasaki disease may promote the development of atherosclerosis in adulthood. Long-term treatment with HMG-CoA inhibitors (statins) effectively suppressed the occurrence of atherosclerosis and inflammatory cell infiltration. Therefore, statin treatment may be used for secondary prevention of cardiovascular events during the chronic phase of Kawasaki disease.
Review
Medicine, General & Internal
Evangeline Pillebout
Summary: Many authors have suggested that IgA Vasculitis and IgA Nephropathy may be two different clinical manifestations of the same disease, but larger clinical studies are needed to explore further. Limited studies have been conducted on these two diseases, and therapeutic trials often exclude patients with both conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Yan Song, Xiaohan Huang, Guizhen Yu, Jianjun Qiao, Jun Cheng, Jianyong Wu, Jianghua Chen
Summary: IgA vasculitis, also known as Henoch-Schonlein purpura, is a common small-vessel vasculitis in children, characterized by symptoms such as purpura, arthritis, abdominal pain, and abnormal urine. Recent advances have shed light on the pathogenesis of IgAV, including environmental factors, genetics, and immune reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Ali Simsek, Mehmet Tekin
Summary: The choroidal and RNFL thicknesses were significantly increased in children with IgA vasculitis compared to healthy controls. However, there was no correlation between ESR or CRP levels and choroidal and RNFL thicknesses.
Review
Rheumatology
Lina Du, Panpan Wang, Chang Liu, Shaojing Li, Shuang Yue, Yan Yang
Summary: Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schonlein Purpura, is a common systemic vasculitis in children, presenting with palpable skin purpura, arthritis, gastrointestinal tract involvement, and kidney damage. Rare systemic manifestations include neurological symptoms, scrotal involvement, and cardiopulmonary disease. Prompt diagnosis and adequate treatment are crucial for optimal outcomes.
CLINICAL RHEUMATOLOGY
(2021)
Review
Immunology
Liyun Xu, Yongzhen Li, Xiaochuan Wu
Summary: Immunoglobulin A vasculitis (IgAV), also known as Henoch-Schonlein purpura, is a common systemic vasculitis in children with diverse clinical manifestations. Its incidence varies geographically and ethnically, suggesting the involvement of genetic and environmental factors. The pathogenesis of IgAV involves the formation of Gd-IgA1 and immune complexes, as well as neutrophil activation through IgA binding, leading to systemic inflammation and tissue damage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Ilaria Maccora, Giovanni Battista Calabri, Silvia Favilli, Alice Brambilla, Sandra Trapani, Edoardo Marrani, Gabriele Simonini
Summary: The study described the clinical and epidemiological characteristics of a Kawasaki syndrome cohort, identified risk factors for coronary artery lesions, and demonstrated the benign course of the syndrome with timely treatment in long-term follow-up over 36 years.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Hitomi Sugino, Yu Sawada, Motonobu Nakamura
Summary: IgA, previously known as Henoch-Schonlein vasculitis, is an important immune component that can respond flexibly to various microorganisms, but may also cause autoreactive responses in the host human body, leading to IgA vasculitis and other autoimmune diseases. Bacterial and viral infections are often triggers of IgA vasculitis, while recent research has found that drugs and COVID-19 can also trigger this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Rheumatology
Kubra Yuksel, Erdal Sag, Selcan Demir, Semanur Ozdel, Ummusen Akca Kaya, Erdal Atalay, Muserref Kasap Cuceoglu, Rezan Topaloglu, Yelda Bilginer, Seza Ozen
Summary: The study found Galectin-9 and IL-2R alpha to be good markers for disease activity in childhood SLE, with significant correlations between SLEDAI scores and IL-2R alpha, Gal-9, and PDL1. Additionally, checkpoint protein levels did not differ significantly among different clinical clusters in SLE.
Article
Rheumatology
Erdal Sag, Selcan Demir, Yelda Bilginer, Beril Talim, Goknur Haliloglu, Haluk Topaloglu, Seza Ozen
Summary: The study analyzed the clinical features, laboratory tests, treatment response, and long-term outcomes of 58 patients with JDM. Dermatological manifestations and muscle weakness were key diagnostic elements, while calcinosis was the most common long-term complication. The presence of TIF1g and NXP2 may indicate a severe disease course.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Genetics & Heredity
Ummusen Kaya Akca, Pelin Ozlem Simsek Kiper, Gizem Urel Demir, Erdal Sag, Erdal Atalay, Gulen Eda Utine, Mehmet Alikasifoglu, Koray Boduroglu, Yelda Bilginer, Seza Ozen
Summary: The study examined genetic diagnoses in patients presenting with musculoskeletal complaints to the rheumatology department, finding that a significant proportion of cases were due to genetic disorders. It highlights the importance of considering genetic factors in the differential diagnosis of musculoskeletal symptoms in pediatric rheumatology patients.
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2021)
Article
Rheumatology
Ummusen K. Akca, Ezgi D. Batu, Aysenur P. Kisaarslan, Hakan Poyrazoglu, Nuray A. Ayaz, Betul Sozeri, Erdal Sag, Erdal Atalay, Selcan Demir, Serife G. Karadag, Ferhat Demir, Yelda Bilginer, Fatma Gumruk, Seza Ozen
Summary: The study revealed that hematological abnormalities are commonly encountered in pediatric patients with SLE, with anemia being the most common abnormality. The main treatment modalities include corticosteroids and IVIG, with rituximab being preferred for resistant cases. Positive antiphospholipid antibodies and high SLEDAI scores are independently associated with hematological involvement.
Article
Pediatrics
Ummusen Kaya Akca, Elif Arslanoglu Aydin, Hayrettin Hakan Aykan, Oguzhan Serin, Erdal Sag, Selcan Demir, Erdal Atalay, Muserref Kasap, Ezgi Deniz Batu, Tevfik Karagoz, Yelda Bilginer, Seza Ozen
Summary: The study compared ten different scoring systems to predict IVIG resistance in Turkish children, finding that these systems had low sensitivity and were unable to differentiate IVIG-resistant patients effectively. Factors like increased serum GGT levels and low platelet counts were identified as risk factors for predicting IVIG resistance.
PEDIATRIC RESEARCH
(2022)
Article
Rheumatology
Ummusen Kaya Akca, Erdal Sag, Sule Unal, Muserref Kasap Cuceoglu, Yelda Bilginer, Seza Ozen
Summary: This study aimed to assess the role of vascular inflammatory factors in the pathogenesis of deficiency of adenosine deaminase 2 (DADA2) and to compare these markers among DADA2 patients with different phenotypes. The results showed significant differences in markers among DADA2 patients with various features, suggesting potential biomarkers for neuropathy and distinguishing DADA2 patients with PAN-like features from PAN patients.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Rheumatology
Ummusen Kaya Akca, Bayram Farisogullari, Gozde Kubra Yardimci, Erdal Sag, Erdal Atalay, Muserref Kasap Cuceoglu, Ozge Basaran, Levent Kilic, Seza Ozen, Yelda Bilginer
Summary: The study showed a higher prevalence of Methotrexate intolerance in pediatric patients compared to adults, with a stronger correlation between Miss and VAS scores in patients receiving parenteral MTX. Younger age was identified as an independent risk factor for Methotrexate intolerance.
CLINICAL RHEUMATOLOGY
(2021)
Article
Rheumatology
Selcan Demir, Fatma Bilge Ergen, Onur Taydas, Erdal Sag, Yelda Bilginer, Ustun Aydingoz, Seza Ozen
Summary: The study evaluated the frequency and spectrum of MRI findings of spine involvement in patients with JIA, finding that both ERA and non-ERA patients can have spinal involvement despite clinical symptoms or lack thereof.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Allergy
Sule Buyuk Yaytokgil, Ilknur Kulhas Celik, Betul Karaatmaca, Tayfur Ginis, Selma Alim Aydin, Muge Toyran, Emine Dibek Misirlioglu, Ersoy Civelek
Summary: Approximately one-third of children with food-induced anaphylaxis develop tolerance within three years. Risk factors for persistent food-induced anaphylaxis include multiple food anaphylaxis, total IgE levels greater than 100 kU/L, and skin-prick test wheal size larger than 10 mm.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Article
Rheumatology
Abdullah Agin, Sibel Kadayifcilar, Ata Baytaroglu, Ozge Deliktas, Selcan Demir, Erdal Sag, Yelda Bilginer, Jale Karakaya, Seza Ozen, Bora Eldem
Summary: The study aimed to evaluate the retina and choroid in children with juvenile idiopathic arthritis (JIA) using optical coherence tomography (OCT). The choroid was found to be thicker in JIA patients compared to healthy controls, possibly indicating subclinical choroidal inflammation. Ophthalmologic examination, including choroidal imaging, in a larger cohort may help clarify this aspect.
RHEUMATOLOGY INTERNATIONAL
(2022)
Correction
Rheumatology
Abdullah Agin, Sibel Kadayifcilar, Ata Baytaroglu, Ozge Deliktas, Selcan Demir, Erdal Sag, Yelda Bilginer, Jale Karakaya, Seza ozen, Bora Eldem
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Pediatrics
Sibel Lacinel Gurlevik, Yasemin Ozsurekci, Erdal Sag, P. Derin Oygar, Selman Kesici, Ummusen Kaya Akca, Muserref Kasap Cuceoglu, Ozge Basaran, Sultan Goncu, Jale Karakaya, Ali Bulent Cengiz, Seza Ozen
Summary: This study investigates the cytokine and chemokine profiles of children with MIS-C and compares them to severe/critical COVID-19 cases and healthy controls. The results suggest that IL-1 and IFN-gamma pathways play a significant role in the pathophysiology of MIS-C. These findings contribute to our understanding of immune responses in children with MIS-C and severe/critical COVID-19.
PEDIATRIC RESEARCH
(2022)
Article
Allergy
Sule Buyuk Yaytokgil, Azize Pinar Metbulut, Tayfur Ginis, Muge Toyran, Ersoy Civelek, Emine Dibek Misirlioglu
Summary: This study found an increase in the prevalence of cat allergies among children during the COVID-19 pandemic. Symptoms associated with cat exposure and cat ownership were more common in this period.
ALLERGY AND ASTHMA PROCEEDINGS
(2022)
Meeting Abstract
Rheumatology
Betul Sozeri, Kenan Barut, Erdal Atalay, Aysenur Pac Kisaarslan, Semanur Ozdel, Ozge Altug, Ferhat Demir, Balahan Makay, Nuray Aktay Ayaz, Ersen Acar, Fatih Haslak, Erdal Sag, Mehmet Yildiz, Ummusen Kaya Akca, Amra Adrovic, Yelda Bilginer, Hakan Poyrazoglu, Erbil Unsal, Ozgur Kasapcopur, Seza Ozen
ARTHRITIS & RHEUMATOLOGY
(2021)
Retraction
Rheumatology
Ummusen K. Akca, Ezgi D. Batu, Aysenur P. Kisaarslan, Hakan Poyrazoglu, Nuray A. Ayaz, Betul Sozeri, Erdal Sag, Erdal Atalay, Selcan Demir, Serife G. Karadag, Ferhat Demir, Fatma Gumruk, Seza Ozen
