Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Fariza Cheldieva, Maria Cherkasova, Alexander Lila, Evgeny Nasonov
Summary: This study investigates the role of IgA antibodies to cardiolipin (aCL) and IgA antibodies to beta-2 glycoprotein 1 (anti-beta(2)-GP1) in the development of vascular complications in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE). The results show that the levels of IgA aCL and IgA anti-beta(2)-GP1 are significantly higher in APS patients compared to SLE patients and the control group. These antibodies are closely associated with thrombosis in APS, demonstrating high specificity but low sensitivity for the diagnosis of APS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tatiana Reshetnyak, Kamila Nurbaeva, Ivan Ptashnik, Anna Kudriaeva, Alexey Belogurov Jr, Aleksandr Lila, Evgeny Nasonov
Summary: This study aimed to assess the role of neutrophil extracellular traps (NETs) markers, MPO-DNA complex and nucleosomes, in the diagnosis of systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). The study found that levels of MPO-DNA complex were higher in SLE patients and associated with SLE activity and lupus glomerulonephritis. Lower levels of nucleosomes were observed in SLE patients and associated with SLE activity and arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Rheumatology
Yevgeniya Gartshteyn, John Conklin, Michelle A. Petri, Vasileios C. Kyttaris, Daniel W. Goldman, Anja Kammesheidt, Anca D. Askanase, Roberta Vezza Alexander
Summary: The study found that PC4d levels in SLE patients are correlated with history of thrombosis and can assess the risk of future thrombosis events. Patients with a PC4d level above the cutoff of 13 MFI are at a higher risk of arterial thrombosis and all types of thrombosis.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Immunology
Ines Bernardoff, Alexandre Picq, Pierre Loiseau, Thomas Foret, Virginie Dufrost, Thomas Moulinet, Ozan Unlu, Doruk Erkan, Denis Wahl, Stephane Zuily
Summary: This study conducted a systematic review and meta-analysis to evaluate the association of antiphospholipid antibodies (aPL) with autoimmune hemolytic anemia in systemic lupus erythematosus (SLE) patients. The results showed a strong association between the presence of aPL and the occurrence of hemolytic anemia in SLE patients, with lupus anticoagulant and anti beta 2Glycoprotein I antibodies having the highest risk. IgM isotypes also indicated an increased risk of hemolytic anemia in SLE.
AUTOIMMUNITY REVIEWS
(2022)
Article
Rheumatology
Nicola Farina, Jemma Webster, Weike Luo, Daniela Garelick, Sara Moreira Pinto, David Isenberg, Anisur Rahman
Summary: The study revealed that patients with SLE have a high prevalence of cardiovascular disease, and certain factors such as antiphospholipid antibody positivity, glucocorticoid therapy, and diagnosis before 2000 are associated with an increased risk of cardiovascular events. These findings are important for predicting and managing cardiovascular risk in patients with SLE.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Immunology
Yevgeniya Gartshteyn, Adam Mor, Daichi Shimbo, Leila Khalili, Teja Kapoor, Laura Geraldino-Pardilla, Roberta V. Alexander, John Conklin, Thierry Dervieux, Anca D. Askanase
Summary: Elevated levels of PC4d are associated with arterial events in SLE patients, independent of antiphospholipid status, smoking, and prednisone use. PC4d levels are correlated with abnormalities in platelet function and may serve as a mechanistic marker for vascular disease in SLE.
CLINICAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Dong-Jin Park, Chang-Seok Yoon, Sung-Eun Choi, Haimuzi Xu, Ji-Hyoun Kang, Shin-Seok Lee
Summary: This study identified hypertension, APS, higher mean daily dose of prednisolone, and higher SDI score as risk factors for TE in SLE patients, while the use of ACEi or ARB was associated with a reduced risk of TE development in these patients.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Juan J. Fierro, Jelmer R. Prins, Gwenny M. Verstappen, Hendrika Bootsma, Johanna Westra, Karina de Leeuw
Summary: This study aimed to identify preconception clinical factors associated with adverse pregnancy outcomes (APO) in patients with systemic lupus erythematosus (SLE) or primary Sjogren's syndrome (pSS). A retrospective cohort study was conducted, and data on demographic characteristics, comorbidities, disease duration, disease activity, APO, laboratory parameters, and treatment regimens were recorded. No preconception risk factors related to APO were found in SLE pregnancies, whereas preconception complement levels were associated with APO development in patients with pSS.
Review
Immunology
Aleida Susana Castellanos Gutierrez, Francesc Figueras, Diana M. Morales-Prieto, Ekkehard Schleussner, Gerard Espinosa, Nuria Banos
Summary: Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease that mainly affects women of childbearing age. During pregnancy, SLE is associated with a higher risk of perinatal morbidity and mortality. Several studies have suggested that placental dysfunction may play a crucial role in this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Jozelio Freire de Carvalho, Felipe Freire Silva, Yehuda Shoenfeld
Summary: This article describes a rare case of a young patient with cAPS who later developed SLE. Treatment included methylprednisolone, heparin, and immunoglobulin, leading to a good outcome and discharge from the hospital. The patient was later diagnosed with SLE and successfully treated with prednisone, azathioprine, and hydroxychloroquine, currently managing symptoms well with these medications.
Article
Pediatrics
Lingjuan Liu, Liqun Liu, Lu Zhang, Peng Huang, Xiqiang Dang, Lanjun Shuai, Xingfang Li, Yongzhen Li, Dingan Mao, Xiaochuan Wu, Yan Cao
Summary: Systemic lupus erythematosus (SLE) is an autoimmune disease with complex clinical features. SLE patients are at significantly increased risk of thrombotic events. Antiphospholipid syndrome (APS) is a rare autoimmune disorder characterized by recurrent thrombosis and pregnancy-related complications. This paper reports a school-age patient diagnosed with SLE coexisting with APS, which started with renal contusion and later developed into pulmonary embolism.
FRONTIERS IN PEDIATRICS
(2023)
Article
Medicine, General & Internal
Savino Sciascia, Massimo Radin, Irene Cecchi, Elena Rubini, Silvia Grazietta Foddai, Alice Barinotti, Antonella Vaccarino, Daniela Rossi, Dario Roccatello
Summary: This study prospectively investigated the incidence of first thromboembolic events in SLE patients positive for aPS/PT antibodies, finding that the cumulative incidence of TEs increased over time and patients with IgG aPS/PT positivity were at significantly higher risk for TEs.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Katarzyna Fischer, Hanna Przepiera-Bedzak, Iwona Brzosko, Marcin Sawicki, Anna Walecka, Marek Brzosko
Summary: This study found that levels of anti-phosphatidylethanolamine (aPE) and anti-phosphatidylserine (aPS) antibodies are significantly higher in patients with systemic lupus erythematosus (SLE) compared to controls, and they are associated with increased cardiovascular risk and organ involvement. The presence of aPE may be a marker of disease activity and risk of renal injury development in this patient group. Classical atherosclerotic markers, including lipid indices, play an important role in analyzing the cardiovascular risk in lupus patients.
Article
Immunology
Savino Sciascia, Rory Bloch, Tyler O'Malley, Anja Kammesheidt, Roberta Vezza Alexander
Summary: High titers of aPL often remain positive, allowing for earlier diagnosis and risk assessment at the initial screening. Low titers may require retesting. There is a high correlation between aCL and aB2GP1 measured using two different technologies. The correlation between PC4d and aPL is low to moderate, suggesting a possible additional value in evaluating the association with thrombosis in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ryo Hisada, Tatsuya Atsumi
Summary: Despite advances in treatment, thrombosis remains the leading cause of death in SLE. aPL are the main triggers of thrombosis in SLE patients, with a frequency of approximately 30-40%. Lupus anticoagulant, anticardiolipin, anti-beta 2-glycoprotein I antibodies, and non-criteria aPL are risk factors for thrombosis in SLE. Multiple positivity for aPL and calculated scores can predict the risk of thrombosis. Treatment with anticoagulants and/or low-dose aspirin may be appropriate for aPL-positive SLE patients.
Article
Cardiac & Cardiovascular Systems
Marios Rossides, Susanna Kullberg, Johan Grunewald, Anders Eklund, Daniela Di Giuseppe, Johan Askling, Elizabeth Arkema
Summary: This study found that the risk of heart failure in patients with sarcoidosis is significantly increased, especially in the first two years after diagnosis. Diabetes, atrial fibrillation, and other arrhythmias were identified as the strongest independent clinical predictors of heart failure in sarcoidosis.
Article
Rheumatology
Sindhu R. Johnson, Dafna D. Gladman, Hermine Brunner, David Isenberg, Ann E. Clarke, Megan R. W. Barber, Laurent Arnaud, Paul R. Fortin, Marta Mosca, Alexandre E. Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S. Alarcon, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica A. English, Guillermo J. Pons-Estel, Bernardo A. Pons-Estel, Rebecca Gilman, Ellen M. Ginzler, John G. Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L. Kamen, Chynace Lambalgen, Alexandra Legge, S. Sam Lim, Anselm Mak, Eric F. Morand, Christine A. Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A. Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F. van Vollenhoven, Heather Waldhauser, Daniel J. Wallace, Asad Zoma, Ian N. Bruce
Summary: The SLICC, ACR, and Lupus Foundation of America are developing a revised SLE damage index (SDI) due to shifts in the concept of damage in SLE. A qualitative study was conducted to evaluate contemporary constructs in SLE damage and develop a conceptual framework for the revised SDI.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Sahwa Elbagir, Lina-Marcela Diaz-Gallo, Giorgia Grosso, Agneta Zickert, Iva Gunnarsson, Michael Mahler, Elisabet Svenungsson, Johan Ronnelid
Summary: HLA-DRB1 alleles are associated with thrombosis and production of aPL in SLE patients. HLA-DRB1*13 increases the risk of aPS-PT production and thrombosis, while HLA-DRB1*03 is associated with reduced thrombotic events and favorable lipid levels in aPL-positive SLE patients.
Article
Rheumatology
Srijana Davuluri, Bhargavi Duvvuri, Christian Lood, Sara Faghihi-Kashani, Lorinda Chung
Summary: This article discusses the pathogenic mechanisms and available treatments for calcinosis. There are currently no widely effective treatments, but various formulations of sodium thiosulfate show potential efficacy in calcinosis treatment. Early aggressive immunosuppression may prevent calcinosis in juvenile dermatomyositis, but the improvement of established calcinosis is limited. Surgical removal is a viable treatment option.
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2022)
Article
Rheumatology
Oscar Plunde, Elisabet Svenungsson, Giulia Ferrannini, Anders Franco-Cereceda, Magnus Back
Summary: The study revealed that antiphospholipid antibodies (aPL) are more common in calcific aortic valve stenosis (CAVS) patients in the general population. The positivity of aPL was associated with altered aortic valve transcriptomics related to interferon pathways. Further research is needed to establish aPL as a possible risk marker and/or causal factor for CAVS and to explore new precision therapeutic targets.
Article
Cardiac & Cardiovascular Systems
Giulia Ferrannini, Mariam Almosawi, Kare Buhlin, Ulf De Faire, Barbro Kjellstrom, Bjorn Klinge, Ake Nygren, Per Nasman, Elisabet Svenungsson, Lars Ryden, Anna Norhammar
Summary: In a long-term follow-up study of patients after their first myocardial infarction (MI) compared with matched controls, it was found that there was a higher risk of cardiovascular events in the MI group, while mortality did not differ significantly. The access to high-quality care and cardiac rehabilitation may contribute to the lower rates of adverse outcomes.
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2022)
Article
Rheumatology
Ting Wang, Andrew Vasconcellos, John Marken, Sladjana Skopelja-Gardner, Christian Lood, Natalia Giltiay
Summary: This study explores the link between immune complex-driven neutrophil activation and B cell responses in systemic lupus erythematosus (SLE). The results show that immune complexes induce the release of B cell pro-survival factor BAFF by neutrophils, and neutrophils directly promote B cell activation and differentiation. The findings suggest that targeting neutrophil-B cell interactions could be a potential approach for inhibiting pathogenic B cell responses in SLE.
LUPUS SCIENCE & MEDICINE
(2022)
Article
Rheumatology
Despina Michailidou, Linda Johansson, Runa Kuley, Ting Wang, Payton Hermanson, Solbritt Rantapaa-Dahlqvist, Christian Lood
Summary: The study aimed to evaluate the increased levels of neutrophil activation markers in PMR patients. The results showed that calprotectin and neutrophil extracellular traps (NETs) were elevated in PMR patients, and neutrophil activation was associated with immune complexes and Fc gamma RIIA. The levels of immune complexes correlated with the expression of CD66b and CD11b, and decreased after glucocorticoid therapy. Calprotectin can be used as a biomarker for treatment response in PMR patients.
Article
Rheumatology
Richard E. Moore, Ting Wang, Bhargavi Duvvuri, Marie L. Feser, Kevin D. Deane, Joshua J. Solomon, J. Lee Nelson, M. Kristen Demoruelle, Christian Lood
Summary: This study investigated the presence and significance of antimitochondrial antibodies (AMAs) in patients with rheumatoid arthritis (RA). The results showed that AMA levels were elevated in RA patients and associated with disease severity and progression.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Medicine, General & Internal
Marios Rossides, Pernilla Darlington, Susanna Kullberg, Elizabeth V. Arkema
Summary: Sarcoidosis is a disease characterized by noncaseating granulomas occurring in various parts of the body, with a higher prevalence in the lungs and/or thoracic lymph nodes. Environmental factors and genetic susceptibility are thought to contribute to the development of sarcoidosis. Diagnosis can be challenging due to the heterogeneous presentation and disease course. Corticosteroids are commonly used for treatment, but there is still a need for sensitive biomarkers and personalized approaches. Further research is required to understand the disease variability and improve patient care.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Rheumatology
Linnea Karlsson, Agneta Zickert, Elisabet Svenungsson, Jan Schmidt-Mende, Francesca Faustini, Iva Gunnarsson
Summary: This study retrospectively analyzed the histopathological findings of first-time kidney biopsies in 139 SLE patients. The results showed that 88.5% of the patients had histopathological findings consistent with lupus nephritis, while 11.5% had other renal diseases. These findings highlight the importance of kidney biopsy in diagnosing and managing inflammatory renal diseases.
CLINICAL RHEUMATOLOGY
(2023)
Letter
Endocrinology & Metabolism
Alicia Nevriana, Marios Rossides, Kyriaki Kosidou, Matthias Pierce, Christina Dalman, Kathryn M. Abel
DIABETES & METABOLISM
(2023)
Article
Oncology
Marios Rossides, Hanna Mogensen, Christina-Evmorfia Kampitsi, Mats Talback, Pernilla Wiebert, Giorgio Tettamanti, Maria Feychting
Summary: A study conducted in Sweden found that maternal occupational exposure to arsenic, cadmium, chromium, nickel, and lead was associated with a 38% increased risk of childhood cancer, particularly lymphoma, central nervous system tumors, and other solid malignancies. There were no associations observed between paternal occupational exposure to these metals and childhood cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Editorial Material
Rheumatology
Lesley Ann Saketkoo, Antonia Valenzuela, Susan Kim, Liza J. McCann, Christian Lood, Dawn M. Wahezi, Victoria P. Werth, Belina Yi, Helene Alexanderson, Susan Maillard, Clarissa Pilkington, Kim Fligelstone, Barbara Limbach, Amir B. Orandi, Malin Regardt, Anne-Marie Russell, Srijana Davuluri, Ingrid deGroot, Floranne Ernste, Julie J. Paik, Carlos A. von Muhlen, Mazen M. Dimachkie, Pedro M. Machado, Elie Naddaf, Barbara M. Shafranski, Latika Gupta, Francesco Zulian, Lorinda Chung
Letter
Rheumatology
Richard Moore, Ting Wang, Marina Barguil Macedo, Christian Lood
ARTHRITIS & RHEUMATOLOGY
(2023)