Journal
REGENERATIVE MEDICINE
Volume 15, Issue 2, Pages 1295-1312Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0084
Keywords
custom fabrication; mechanobiology; oligomeric collagen; regeneration; skin and wound care
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Funding
- NIH T32 Bioengineering Interdisciplinary Training for Diabetes Research Program Fellowship [NIDDK T32-DK-101000]
- NSF Graduate Research Fellowship [DGE-1333468]
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Aim: To evaluate dermal regeneration scaffolds custom-fabricated from fibril-forming oligomeric collagen where the total content and spatial gradient of collagen fibrils was specified. Materials & methods: Microstructural and mechanical features were verified by electron microscopy and tensile testing. The ability of dermal scaffolds to induce regeneration of rat full-thickness skin wounds was determined and compared with no fill control, autograft skin and a commercial collagen dressing. Results: Increasing fibril content of oligomer scaffolds inhibited wound contraction and decreased myofibroblast marker expression. Cellular and vascular infiltration of scaffolds over the 14-day period varied with the graded density and orientation of fibrils. Conclusion: Fibril content, spatial gradient and orientation are important collagen scaffold design considerations for promoting vascularization and dermal regeneration while reducing wound contraction.
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