Review
Biochemistry & Molecular Biology
Vlad Sever Neculicioiu, Ioana Alina Colosi, Carmen Costache, Dan Alexandru Toc, Alexandra Sevastre-Berghian, Horatiu Alexandru Colosi, Simona Clichici
Summary: Sleep deprivation is a widespread issue in modern society, with unclear effects on oxidative stress. This review analyzed experimental data from studies on rat models conducted between 2015 and 2022, and found that sleep deprivation appears to affect oxidative stress parameters, indicating a potential antioxidant role of sleep. The effects of sleep deprivation were observed in different protocols and rat strains, and extended beyond the central nervous system to other body sites. Sleep recovery exhibited variability, with some parameters normalizing and others showing long-lasting changes. The presence of a stress response following sleep deprivation was also noted, but its origin and impact remain unclear.
Article
Engineering, Biomedical
Motika Geethika, Namrata Singh, Sagar Kumar, Somanathapura K. Naveen Kumar, Govindasamy Mugesh
Summary: The conversion of nitric oxide (NO) into peroxynitrite (ONOO-) in a superoxide (O-2(.-))-rich environment is a major cause of reduced NO levels in vascular walls, leading to cardiovascular complications. Superoxide dismutase (SOD) mimetics that can selectively catalyze the dismutation of O-2(.-) in the presence of NO are challenging to design but have therapeutic relevance. In this study, the authors show that SOD mimetic cerium vanadate (CeVO4) nanozymes effectively regulate the bioavailability of NO and O-2(.-) even in the absence of cellular SOD enzyme, leading to improved endothelial function and potential applications in biological treatments.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Plant Sciences
Jovana Sucur Elez, Kristina Petrovic, Marina Crnkovic, Slobodan Krsmanovic, Milos Rajkovic, Zeljko Kaitovic, Dorde Malencic
Summary: The study evaluated oxidative stress and lesion length in soybean seedlings infected with the fungus Macrophomina phaseolina to determine the most tolerant soybean cultivar. Superoxide anion radical production and superoxide-dismutase (SOD) activity were highest in the Favorit cultivar, indicating its tolerance to M. phaseolina. In contrast, the Victoria cultivar showed high radical production, low SOD activity, and enhanced lipid peroxidation, suggesting its susceptibility to the pathogen. No significant differences were observed in the oxidative stress parameters of the Atlas and Rubin cultivars compared to the control. The Victoria cultivar had the longest lesion length, while the Atlas and Rubin cultivars displayed the shortest lengths, indicating their tolerance to the pathogen.
Review
Medicine, General & Internal
Ting-ting Li, Hong-ying Wang, Hui Zhang, Ping-ping Zhang, Ming-chen Zhang, Hai-yang Feng, Xiao-yong Duan, Wen-bo Liu, Xiao-wen Wang, Zhong-guang Sun
Summary: This meta-analysis systematically evaluated the effects of breathing exercises on oxidative stress biomarkers in humans and provided evidence for clinical application. The results showed that participants who performed breathing exercises had greater changes in the biomarkers, suggesting that these can be used to evaluate oxidative stress after respiratory interventions.
FRONTIERS IN MEDICINE
(2023)
Article
Health Care Sciences & Services
Irina A. Mednova, Liudmila P. Smirnova, Alisa R. Vasilieva, Daria Kazantseva, Elena Epimakhova, Nina M. Krotenko, Arkadiy Semke, Svetlana A. Ivanova
Summary: This study demonstrates that patients with schizophrenia have SOD activity in their IgG, and the highest activity is observed in patients in therapeutic remission. The mechanism of SOD activity in IgG is similar to classical enzyme catalysis, with a higher affinity for the substrate than classical SOD enzyme.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Shaimaa M. M. Saleh, A. Bakr Mahmoud, M. Bassam Al-Salahy, Fatma Ahmed Mohamed Moustafa
Summary: This study aimed to determine the effect of gallic acid (GA) on ameliorating bisphenol A (BPA) nephrotoxicity in male rat kidneys. The results revealed morphological, immunohistochemical, and biochemical alterations in the kidney. Most of these changes showed a satisfactory improvement of kidney damage when BPA-administered rats were treated with GA at both doses.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Fanrong Yao, Abdel A. Abdel-Rahman
Summary: The study reveals a protective role of tetrahydrobiopterin (BH4) against ethanol-induced cardiac dysfunction, and increasing BH4 levels can alleviate the adverse effects of ethanol.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Y. Lakshmisha Rao, B. Ganaraja, Aradhana Marathe, Poornima A. Manjrekar, Teresa Joy, Sheetal Ullal, Mangala M. Pai, B. V. Murlimanju
Summary: The study found that the MDA level was elevated in the AD induced group, indicating a poor oxidative stress-defence mechanism. The RS and DPZ treatment groups showed higher SOD activity, suggesting an improved oxidative stress-defence mechanism. The RS + DPZ group exhibited higher SOD activity, indicating a synergistic effect between DPZ and RS.
Article
Multidisciplinary Sciences
Mahmoud Abd-Elkareem, Mokhless A. M. Abd El-Rahman, Nasser S. Abou Khalil, Ayman S. Amer
Summary: The study showed that Nigellasativa L. seeds could mitigate testicular impairment caused by monosodium glutamate through antioxidant and cytoprotective activities, alleviating histological disturbances in rats.
SCIENTIFIC REPORTS
(2021)
Article
Green & Sustainable Science & Technology
Hanna Bandurska, Klaudia Borowiak, Malgorzata Zielezinska
Summary: The study observed the response of plants to ozone in different ozone concentration environments, finding that plants exposed to ozone stress increased antioxidant enzyme activity, lipid peroxidation levels, and membrane injury. Although higher ozone concentrations were observed at the forest site, plants in the city site showed a stronger response to ozone.
Review
Biochemistry & Molecular Biology
Paul Guerby, Oriane Tasta, Audrey Swiader, Frederic Pont, Emmanuel Bujold, Olivier Parant, Christophe Vayssiere, Robert Salvayre, Anne Negre-Salvayre
Summary: Preeclampsia is a pregnancy disease exclusive to humans, characterized by gestational hypertension, proteinuria, oxidative stress, and imbalance between NO and ROS production, possibly due to placental abnormalities and oxidative stress.
Article
Horticulture
Esmat Atefepour, Mohammad Saadatian, Moazzam Hassanpour Asil, Babak Rabiei
Summary: The use of silver nanoparticles and 8-hydroxyquinoline citrate as pulse treatment, combined with sucrose, significantly increased the vase life and quality of cut Gerbera flowers.
SCIENTIA HORTICULTURAE
(2021)
Article
Multidisciplinary Sciences
Guanjie Chen, Dianfeng Zheng, Naijie Feng, Hang Zhou, Dewei Mu, Liming Zhao, Xuefeng Shen, Gangshun Rao, Fengyan Meng, Anqi Huang
Summary: The study demonstrated that foliar spraying of abscisic acid (ABA) can regulate the growth quality of rice seedlings under salt stress. ABA treatment reversed the physiological changes induced by salt stress and improved antioxidant enzyme levels in rice varieties. It also increased the content of essential nutrients in leaves and roots and regulated endogenous hormonal balance, providing protection against membrane lipid peroxidation.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Maria Carmina Pau, Arduino Aleksander Mangoni, Elisabetta Zinellu, Gianfranco Pintus, Ciriaco Carru, Alessandro Giuseppe Fois, Pietro Pirina, Angelo Zinellu
Summary: The study found that whole blood SOD concentrations were significantly lower in patients with obstructive sleep apnoea, while serum/plasma SOD concentrations did not show a significant difference. This suggests an impaired antioxidant defence in OSA patients.
Article
Multidisciplinary Sciences
De-wei Mu, Nai-jie Feng, Dian-feng Zheng, Hang Zhou, Ling Liu, Guan-jie Chen, BaoMing Mu
Summary: The study showed that soaking with brassinolide can effectively alleviate the negative impacts of salt stress on rice seedling growth quality by increasing antioxidant enzyme activity and regulating endogenous hormone balance to enhance plant resilience.
SCIENTIFIC REPORTS
(2022)
Article
Psychology, Clinical
Yi-Ling Chien, Wen-Che Tsai, Wen-Hao Chen, Chi-Liang Yang, Susan Shur-Fen Gau, Wei-Tsuen Soong, Elizabeth Laugeson, Yen-Nan Chiu
Summary: This study investigated the effectiveness of the PEERS intervention in Taiwanese young adults with ASD and found that it significantly improved social deficits, autism severity, social interaction anxiety, empathy, and social skills knowledge. The improvements were maintained at 3-month and 6-month follow-ups.
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Psychology, Clinical
Yi-Ling Chien
PSYCHOLOGICAL MEDICINE
(2023)
Editorial Material
Psychology, Clinical
Carmelle Peisah, Carlos A. de Mendonca Lima, Liat Ayalon, Debanjan Banerjee, Diego De Leo, Tzung-Jeng Hwang, Manabu Ikeda, Dilip Jeste, Tomas Leon, Huali Wang, James Warner, Kiran Rabheru
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Psychology, Clinical
Chiao-Erh Chang, Jui Wang, Yi-Ting Lin, Chih-Chiang Chiu, Ming-Hsien Hsieh, Ming-Chyi Huang, Mong-Liang Lu, Hsi-Chung Chen, Wei J. Chen, Po-Hsiu Kuo
Summary: This study compared the clinical features, psychosocial characteristics, and comorbidity patterns between the unipolar mania (UM) and depressive-manic (D-M) subgroups. The results showed that compared to the D-M group, the UM group had more psychotic symptoms, a higher proportion of morningness chronotype, better sleep quality, higher extraversion, lower neuroticism, and less harm avoidance personality traits. Additionally, different lifetime comorbidity patterns were observed between the two groups.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Nursing
Sara Hsin-Yi Liu, Shing-Chia Chen, Ming H. Hsieh, Shu-Jen Shiau, Kuan-Chia Lin, Fei-Hsiu Hsiao
Summary: This study examined the changes in parental functioning of patients with bipolar disorder and major depression from before discharge to 6 months post-discharge. The results showed that positive parenting domains did not fully recover during this period, while negative parenting domains increased at one month post-discharge. Depressive symptoms and social support were associated with positive parenting domains, but manic symptoms were not related to parenting functioning. These findings suggest that a parenting recovery program targeting depressive symptoms and insufficient social support is needed from hospitalization to post-discharge.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Engineering, Biomedical
Yi-Ling Chien, Chia-Hsin Lee, Yen-Nan Chiu, Wen-Che Tsai, Yuan-Che Min, Yang-Min Lin, Jui-Shen Wong, Yi-Li Tseng
Summary: The design goals of recent serious games for autism are improvement of attention, affective recognition, and social interactions. Previous studies mostly used behavioral questionnaires to evaluate effectiveness, but cognitive assessment after intervention is important for assessing improvement. In this study, a game-based social interaction platform with eye-tracking system was developed for autistic children. The eye-tracking results showed atypical gaze patterns in autistic individuals, which can serve as reliable biomarkers for evaluating social and cognitive functions during serious game play. The findings demonstrate the possibility of using eye-tracking signals to evaluate cognitive functions and intervention effectiveness in serious games.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Psychiatry
Yi-Ling Chien, Chen-Chung Liu, Yen-Nan Chiu, Chao-Cheng Lin
Summary: This study aimed to compare the emotional features in Asian autistic adults without intellectual disability to non-autistic comparisons and schizophrenia. The results showed that autistic adults had difficulties in emotion perception and management, which were different from schizophrenia and correlated with autistic features. Autistic adults may need more support and services in emotion perception and management.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Behavioral Sciences
Chi-Shin Wu, Tzu-Hsun Tsai, Wei-Li Chen, Hui-Ju Tsai, Yi-Ling Chien
Summary: Autism spectrum disorder (ASD) is associated with a higher prevalence of visual dysfunction, including amblyopia, refractive errors, and strabismus. This population-based study in Taiwan found that youths with ASD have a significantly increased risk of these ocular abnormalities compared to non-autistic individuals. Sex, ASD subgroup, and co-diagnosis of intelligence disability are important factors influencing the prevalence of these visual problems.
Article
Psychology, Developmental
Yi-Ling Chien, Yueh-Ming Tai, Yen-Nan Chiu, Wen-Che Tsai, Susan Shur-Fen Gau
Summary: The mediators of real-world executive functions in autism during the transition into adulthood were investigated in this study. It was found that the autistic group had lower executive functions compared to the non-autistic group, with lower behavior regulation and metacognition scores. Childhood inattention was identified as a significant mediator for both behavior regulation and metacognition in late adolescence, and peer problems were specific mediators of metacognition.
Article
Psychiatry
Chen-Chung Liu, Ming H. Hsieh, Yi-Ling Chien, Chih-Min Liu, Yi-Ting Lin, Tzung-Jeng Hwang, Hai-Gwo Hwu
Summary: This study aimed to depict and subgroup the trajectories of patients undergoing guided dose reduction and explore factors associated with different dose-reduction patterns. The results showed that the dose-reduction process is dynamic and varies between individuals. Different patients have different ways and effects of reducing medication dosages. Doctors need to choose the appropriate dose reduction method based on the specific situation of each patient.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Tzung-Jeng Hwang, Chia-Ta Chan, Cheng-Yu Hsieh, Chih-Min Liu, Chen-Chung Liu, Yi-Ling Chien, Ming H. H. Hsieh, Yi-Ting Lin, Tai-Li Chou
Summary: It is little known whether aberrant language-related lateralization can be improved after antipsychotic treatment in drug-free patients with first-episode psychosis or ultra-high risk state. This study aimed to investigate the improvement in lateralization of semantic processing after antipsychotic treatment and its correlation with clinical and cognitive changes. The findings demonstrated that aripiprazole treatment significantly increased semantic processing-related lateralization in the inferior frontal gyrus, and a higher baseline accuracy predicted a higher post-treatment lateralization index and greater symptom improvement.
Article
Neuroimaging
Chang-Le Chen, Tzung-Jeng Hwang, Yu-Hung Tung, Li-Ying Yang, Yung-Chin Hsu, Chih-Min Liu, Yi-Tin Lin, Ming-Hsien Hsieh, Chen-Chung Liu, Yi-Ling Chien, Hai-Gwo Hwu, Wen-Yih Isaac Tseng
Summary: Conceptualizing mental disorders as deviations from normative functioning provides a statistical perspective for understanding individual heterogeneity. This study introduces a novel brain age metric based on imaging-derived brain age paradigm combined with normative modeling to investigate advanced brain aging in schizophrenia. The results demonstrate that normative brain age metrics can detect advanced brain aging and associated clinical and neuroanatomical features in schizophrenia.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)