Unraveling the complexity of amyloid polymorphism using gold nanoparticles and cryo-EM

Consolidation alters motor sequence-specific distributed representations

(2019) Basile Pinsard et al.   eLife

Structural Insights into α-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations

(2019) Xiaodan Ni et al.   JOURNAL OF MOLECULAR BIOLOGY

Cryo-EM structure of a transthyretin-derived amyloid fibril from a patient with hereditary ATTR amyloidosis

(2019) Matthias Schmidt et al.   Nature Communications

Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts

(2019) Timo Strohäker et al.   Nature Communications

Amyloid Polymorphism in the Protein Folding and Aggregation Energy Landscape

(2018) Jozef Adamcik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

The invasin D protein fromYersinia pseudotuberculosisselectively binds the Fab region of host antibodies and affects colonization of the intestine

(2018) Pooja Sadana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

(2018) Chao Peng et al.   NEUROBIOLOGY OF DISEASE

Detection of amyloid fibrils in Parkinson’s disease using plasmonic chirality

(2018) Jatish Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths

(2017) John B. Warner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Polymorphism of Amyloid Fibrils In Vivo

(2016) Karthikeyan Annamalai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systemic amyloidosis

(2016) Ashutosh D Wechalekar et al.   LANCET

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau Assembly: The Dominant Role of PHF6 (VQIVYK) in Microtubule Binding Region Repeat R3

(2015) Pritam Ganguly et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Amyloid Polymorphism: Structural Basis and Neurobiological Relevance

(2015) Robert Tycko   NEURON

Universal Behavior in the Mesoscale Properties of Amyloid Fibrils

(2015) Salvatore Assenza et al.   PHYSICAL REVIEW LETTERS

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity

(2014) Julia Gath et al.   PLoS One

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Negatively Charged Gold Nanoparticles Inhibit Alzheimer's Amyloid-β Fibrillization, Induce Fibril Dissociation, and Mitigate Neurotoxicity

(2012) Yi-Hung Liao et al.   Small

Fibril Structure of Human Islet Amyloid Polypeptide

(2011) Sahar Bedrood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Diversity of Assembly Mechanisms of a Generic Amyloid Fold

(2011) Timo Eichner et al.   MOLECULAR CELL

Recent progress in understanding Alzheimer's β-amyloid structures

(2011) Marcus Fändrich et al.   TRENDS IN BIOCHEMICAL SCIENCES

Aβ(1–40) Forms Five Distinct Amyloid Structures whose β-Sheet Contents and Fibril Stabilities Are Correlated

(2010) Ravindra Kodali et al.   JOURNAL OF MOLECULAR BIOLOGY

Understanding amyloid aggregation by statistical analysis of atomic force microscopy images

(2010) Jozef Adamcik et al.   Nature Nanotechnology

Synthesis of fluorescent-maghemite nanoparticles as multimodal imaging agents for amyloid-β fibrils detection and removal by a magnetic field

(2009) Hadas Skaat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Seeded growth of  -amyloid fibrils from Alzheimer's brain-derived fibrils produces a distinct fibril structure

(2009) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of maghemite nanoparticles on insulin amyloid fibril formation: Selective labeling, kinetics, and fibril removal by a magnetic field

(2008) Hadas Skaat et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Aβ(1-40) Fibril Polymorphism Implies Diverse Interaction Patterns in Amyloid Fibrils

(2008) Jessica Meinhardt et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA