Sol-gel (template) synthesis of osteoplastic CaSiO3/HAp powder biocomposite: In vitro and in vivo biocompatibility assessment

The paper studies synthetic osteoplastic powder biocomposite, which is bioactive and extremely relevant for bone defect recovery in dentistry and maxillo-facial surgery. Biocomposite fabrication strategy is based on an original sot-gel (template) synthesis of the porous wollastonite containing 30 wt.% of hydroxyapatite. The way to tailor porosity in the material has been proposed involving siloxane-acrylate latex and carbon fibers as pore-forming templates. Phase formation in the composition structure has been investigated by the means of TG/DTA/DSC and XRD. SEM. low temperature nitrogen sorption, and mercury porosimetry has been used to characterize biocomposite's morphology and microstructure. In vitro and In vivo biocompatibility tests have been carried out. Histological analysis and multislice Cr reveal the ability of the biocomposite to integrate into the area of the under-jaw defect (alveolar socket) of the test animal. Blood count assay shows no direct toxic influence of such implants on a living organism. (C) 2020 Elsevier B.V. All rights reserved.