Article
Clinical Neurology
Herbert L. DuPont, Jessika Suescun, Zhi-Dong Jiang, Eric L. Brown, Heather T. Essigmann, Ashley S. Alexander, Andrew W. DuPont, Tehseen Iqbal, Netanya S. Utay, Michael Newmark, Mya C. Schiess
Summary: This pilot clinical study investigated the safety and efficacy of fecal microbiota transplantation (FMT) in patients with Parkinson's disease. The results showed that FMT treatment increased the diversity of the intestinal microbiome and improved constipation and gut function associated with Parkinson's disease. This suggests that the intestinal microbiome may play a significant role in the pathogenesis of Parkinson's disease and offers new opportunities for treatment.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, Research & Experimental
Tapani Salonen, Elina Jokinen, Reetta Satokari, Perttu Lahtinen
Summary: This study evaluated the effect of faecal microbiota transplantation (FMT) on fatigue severity and health-related quality of life (HRQOL) in patients with chronic fatigue syndrome (CFS). The results showed that FMT did not relieve symptoms or improve the HRQOL of patients with CFS. It is important to note that the small number of study subjects limits the generalizability of these results.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Cong He, Yong Xie, Yin Zhu, Kun Zhuang, Lijuan Huo, Yong Yu, Qiang Guo, Xu Shu, Zhijuan Xiong, Zhenyu Zhang, Bin Lyu, Nonghua Lu
Summary: This study not only demonstrated the beneficial effect of probiotics implementation on side events during H. pylori eradication but also provided a comprehensive profile of microbiome alterations along the gastrointestinal tract that is modulated by probiotics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Mehran Rahimlou, Shima Nematollahi, Durdana Husain, Nasrin Banaei-Jahromi, Nastaran Majdinasab, Seyed Ahmad Hosseini
Summary: The study aimed to investigate the effect of probiotic supplementation on systemic inflammation in patients with multiple sclerosis (MS). The results showed that probiotic supplementation significantly reduced serum levels of CRP, TNF-alpha, and IFN-gamma, while increasing levels of FOXP3 and TGF-beta. This indicates that probiotic supplementation has beneficial effects in reducing systemic inflammation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Gastroenterology & Hepatology
Yi Cheng, Guohua Tan, Qihui Zhu, Chun Wang, Guangcong Ruan, Senhong Ying, Jinlong Qie, Xiaofei Hu, Zhifeng Xiao, Fenghua Xu, Lu Chen, Minjia Chen, Yang Pei, Hao Zhang, Yuting Tian, Dongfeng Chen, Xingyin Liu, Heqing Huang, Yanling Wei
Summary: The study demonstrates that fecal microbiota transplantation (FMT) can improve symptoms and gastrointestinal disorders in Parkinson's disease (PD) patients.
Article
Cell Biology
Alvina Widhani, Samsuridjal Djauzi, Franciscus Dhyanagiri Suyatna, Beti Ernawati Dewi
Summary: This study investigated the effects of synbiotic supplementation on gut microbiota and systemic inflammation in lupus patients. The results showed that synbiotics can improve dysbiosis in the gut microbiota, reduce systemic inflammation, and improve disease activity in lupus patients.
Article
Oncology
Nicolien C. de Clercq, Tom van den Ende, Andrei Prodan, Robert Hemke, Mark Davids, Helle K. Pedersen, Henrik B. Nielsen, A. K. Groen, Willem M. de Vos, Hanneke W. M. van Laarhoven, Max Nieuwdorp
Summary: A study on fecal microbiota transplantation in cachectic patients with gastroesophageal cancer showed that allogenic FMT did not improve cachexia, but led to better disease control rate, overall survival, and progression-free survival. Patients in the allogenic group also experienced significant changes in fecal microbiota composition after FMT. This suggests a potential benefit of FMT in improving treatment response and survival in advanced gastroesophageal cancer patients.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sergio Serrano-Villar, Alba Talavera-Rodriguez, Maria Jose Gosalbes, Nadia Madrid, Jose A. Perez-Molina, Ryan J. Elliott, Beatriz Navia, Val F. Lanza, Alejandro Vallejo, Majdi Osman, Fernando Dronda, Shrish Budree, Javier Zamora, Carolina Gutierrez, Monica Manzano, Maria Jesus Vivancos, Raquel Ron, Javier Martinez-Sanz, Sabina Herrera, Uxua Ansa, Andres Moya, Santiago Moreno
Summary: This study demonstrates the safety and efficacy of fecal microbiota transplantation in HIV-infected individuals, showing successful engraftment of transplanted microbiota and improvement of HIV-associated dysbiosis.
NATURE COMMUNICATIONS
(2021)
Article
Engineering, Multidisciplinary
Yang Liu, Xinjie Yu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Zhengqing Xue, Qixiao Zhai, Wei Chen
Summary: This study aimed to investigate the IBS-D-alleviating effects of Lactobacillus plantarum CCFM8610, and the results showed that this probiotic significantly alleviated clinical symptoms and gut microbiota dysbiosis.
Article
Nutrition & Dietetics
Dooheon Son, Youn Jung Choi, Min Young Son, Won Moon, Seun Ja Park, Sanghyun Lim, Jae Hyun Kim
Summary: The study aimed to evaluate the effects of probiotic pretreatment on gut microbiota alteration and recovery after bowel preparation and its correlation with minor complications. In a randomized, double-blind, placebo-controlled pilot trial with participants aged 40-65, probiotics or placebo were given for 1 month before colonoscopy. The results showed that probiotic pretreatment had beneficial effects on gut microbiota alteration and recovery, as well as a significant reduction in the duration of minor complications.
Article
Nutrition & Dietetics
MinAh Jung, Susie Jung, NamKyu Kim, HeeYoon Ahn, HyunSun Yun, Kyu-Nam Kim
Summary: This study aimed to evaluate the effects of Lactobacillus plantarum CJLP243 in patients with FD. The results showed that the probiotic group experienced significant relief in FD symptoms, decreased FC values, and increased levels of Leuconostoc in the gut microbiota composition.
Article
Nutrition & Dietetics
Mayuko Takahashi, Yoshihiro Kadota, Yuki Shiko, Yohei Kawasaki, Kenichi Sakurai, Chisato Mori, Naoki Shimojo
Summary: Constipation is a common issue in children that can negatively impact their quality of life. Prebiotics, such as 1-kestose, have been found to be helpful for constipation in adults. This study examined the effect of 1-kestose on constipation in kindergarten children and found that daily intake for 8 weeks did not change stool properties but significantly increased the number of defecations per week.
Article
Gastroenterology & Hepatology
Essi K. Karjalainen, Laura Renkonen-Sinisalo, Reetta Satokari, Harri Mustonen, Ari Ristimaki, Perttu Arkkila, Anna H. Lepisto
Summary: The fecal microbiota transplantation treatment did not show efficacy in treating chronic pouchitis, however the safety profile was good. Among patients who were using continuous antibiotics before the study, the relapse-free survival was shorter in the intervention group.
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Medicine, General & Internal
Camille Amadieu, Luca Maccioni, Sophie Leclercq, Audrey M. Neyrinck, Nathalie M. Delzenne, Philippe de Timary, Peter Staerkel
Summary: This study aimed to evaluate the effects of inulin supplementation on liver parameters in alcohol use disorder (AUD) patients. The results showed that, at the end of the study, AST, ALT, and IL-18 levels were significantly higher in the inulin group compared to the placebo group in the whole sample. In the subgroup with early alcohol-associated liver disease, inulin supplementation led to specific changes in the gut microbiota, but AST and ALT levels were still higher compared to the placebo group. The treatment was well tolerated without important adverse events or side effects.
Article
Biochemistry & Molecular Biology
Valentin Mocanu, Zhengxiao Zhang, Edward C. Deehan, Dina H. Kao, Naomi Hotte, Shahzeer Karmali, Daniel W. Birch, Kalutota K. Samarasinghe, Jens Walter, Karen L. Madsen
Summary: The study demonstrated that a single-dose oral FMT combined with daily low-fermentable fiber supplementation significantly improved insulin sensitivity in patients with severe obesity and metabolic syndrome.
Article
Immunology
M. Gelpi, B. Vestad, S. C. Raju, S. Hyll Hansen, J. Hogh, O. Midttun, P. M. Ueland, T. Ueland, T. Benfield, Klaus F. Kofoed, J. R. Hov, M. Troseid, S. Dam Nielsen
Summary: The study found an association between HIV-related gut microbiota changes, alterations in the kynurenine (Kyn) pathway of tryptophan (Trp) metabolism, and increased visceral adipose tissue. The results suggest a potential role for gut microbiota and Kyn pathway in the context of HIV infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Medicine, General & Internal
Beate Vestad, Thor Ueland, Tori Vigeland Lerum, Tuva Borresdatter Dahl, Kristian Holm, Andreas Barratt-Due, Trine Kasine, Anne Ma Dyrhol-Riise, Birgitte Stiksrud, Kristian Tonby, Hedda Hoel, Inge Christoffer Olsen, Katerina Nezvalova Henriksen, Anders Tveita, Ravinea Manotheepan, Mette Haugli, Ragnhild Eiken, Ase Berg, Bente Halvorsen, Tove Lekva, Trine Ranheim, Annika Elisabeth Michelsen, Anders Benjamin Kildal, Asgeir Johannessen, Lars Thoresen, Hilde Skudal, Bard Reiakvam Kittang, Roy Bjorkholt Olsen, Carl Magnus Ystrom, Nina Vibeche Skei, Raisa Hannula, Saad Aballi, Reidar Kvale, Ole Henning Skjonsberg, Pal Aukrust, Johannes Roksund Hov, Marius Troseid
Summary: Respiratory dysfunction after COVID-19 is associated with altered gut microbiota and persistently elevated LBP levels. Our results suggest a potential gut-lung axis that should be further investigated in relation to long-term pulmonary dysfunction and long COVID.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Muyiwa Awoniyi, Jeremy Wang, Billy Ngo, Vik Meadows, Jason Tam, Amba Viswanathan, Yunjia Lai, Stephanie Montgomery, Morgan Farmer, Martin Kummen, Louise Thingholm, Christoph Schramm, Corinna Bang, Andre Franke, Kun Lu, Huiping Zhou, Jasmohan S. Bajaj, Phillip B. Hylemon, Jenny Ting, Yury Popov, Johannes Roksund Hov, Heather L. Francis, Ryan Balfour Sartor
Summary: By studying the microbial composition in germ-free and antibiotic-treated mice and PSC patients, we identified different bacterial species with functional protective and detrimental effects in these animals and patients, which are associated with clinical risk scores. These findings are important for the development of personalized therapeutic approaches.
Article
Gastroenterology & Hepatology
Mikal Jacob Hole, Kristin Kaasen Jorgensen, Kristian Holm, Peder R. Braadland, Malin Holm Meyer-Myklestad, Asle Wilhelm Medhus, Dag Henrik Reikvam, Alexandra Gotz, Krzysztof Grzyb, Kirsten Muri Boberg, Tom Hemming Karlsen, Martin Kummen, Johannes R. Hov
Summary: This study investigated the characteristics of the gut microbiota in patients with primary sclerosing cholangitis (PSC) and found several features associated with PSC, including an expansion of Proteobacteria and increased variability. Furthermore, certain genera and the presence of the pathobiont Klebsiella were associated with reduced survival in PSC patients, and concomitant inflammatory bowel disease (IBD) was associated with reduced levels of Akkermansia.
Article
Allergy
Mari Kaarbo, Mingyi Yang, Johannes R. Hov, Kristian Holm, Mirta Mittelstedt Leal de Sousa, Magnhild E. Macpherson, Henrik M. Reims, Anne-Marte Bakken Kran, Bente Halvorsen, Tom H. Karlsen, Pal Aukrust, Knut E. A. Lundin, Borre Fevang, Magner Bjoras, Silje Fjellgard Jorgensen
Summary: This study aimed to investigate the role of the duodenal microenvironment in the pathogenesis of duodenal inflammation in CVID. The findings suggest altered functions of the duodenal epithelium, particularly in response to lipopolysaccharide and viruses. Viruses, rather than gluten sensitivity, could be related to duodenal inflammation in CVID.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jostein H. Ibsen, Adity Chopra, Eline Benno Vaage, John T. Vaage, Fridtjof Lund-Johansen, Knut E. A. Lundin
Summary: This study investigated the humoral response to SARS-CoV-2 vaccines in patients with celiac disease (CeD) and compared it with healthy controls. The results showed that the humoral response in CeD patients is similar to that observed in healthy controls.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Ayodeji Awoyemi, Johannes R. Hov, Marius Troseid
CIRCULATION-HEART FAILURE
(2023)
Review
Gastroenterology & Hepatology
Johannes R. Hov, Tom H. Karlsen
Summary: This Review explores the links between Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), and the mechanisms related to the gut-liver axis. It is found that the gut microbiota in people with PSC differs from that of healthy individuals, but the specific microbial factors that differentiate PSC from IBD without PSC are poorly understood. The potential existence of a specific unknown factor related to the gut-liver axis as a cause of PSC is postulated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Rheumatology
Noemi Strahm, Henriette Didriksen, Havard Fretheim, Oyvind Molberg, Oyvind Midtvedt, Inger Nina Farstad, Tore Midtvedt, Knut E. A. Lundin, Lars Aabakken, Przemyslaw Blyszczuk, Oliver Distler, Gabriela Kania, Anna-Maria Hoffmann-Vold
Summary: This study aims to investigate the effects of fecal microbiota transplantation (FMT) on duodenal biopsies of SSc patients using immunohistochemistry and transcriptome profiling. The results showed a decrease in podoplanin- and CD64-expressing cells in the mucosa of patients receiving FMT, which correlated with improved lower gastrointestinal symptoms. Transcriptome analysis revealed activation of disease-relevant pathways after FMT treatment. This study highlights the potential therapeutic effects of FMT in SSc patients with gastrointestinal involvement.
Article
Multidisciplinary Sciences
Marketa Chlubnova, Asbjorn O. Christophersen, Geir Kjetil F. Sandve, Knut E. A. Lundin, Jorgen Jahnsen, Shiva Dahal-Koirala, Ludvig M. Sollid
Summary: 42 wheat gluten-reactive T cell clones with different phenotypes and no reactivity to known epitopes were screened. Synthetic peptides were identified bioinformatically from a wheat gluten protein database and tested against the T cell clones. Reactivity of 10 T cell clones was assigned, and 5 previously uncharacterized gliadin/glutenin epitopes with a 9-nucleotide oligomer core region were identified. This work represents an advance in identifying CeD-driving gluten epitopes.
Article
Nutrition & Dietetics
Frida van Megen, Maria Fossli, Gry I. Skodje, Monica H. Carlsen, Lene F. Andersen, Marit B. Veierod, Knut E. A. Lundin, Christine Henriksen
Summary: A study on women with celiac disease and ongoing symptoms revealed that their dietary intake was unbalanced, with higher intake of fat and lower intake of protein and dietary fiber. This highlights the importance of nutritional follow-up for celiac patients and the development of nutrient-dense gluten-free products.
CLINICAL NUTRITION ESPEN
(2023)
Article
Nutrition & Dietetics
Anne Mari Herfindal, Frida van Megen, Mari K. O. Gilde, Jorgen Valeur, Knut Rudi, Gry I. I. Skodje, Knut E. A. Lundin, Christine Henriksen, Siv Kjolsrud Bohn
Summary: Individuals with CeD often experience gastrointestinal symptoms despite adherence to a GFD. The LFD may lead to changes in the faecal microbiota profile, but does not significantly affect gut integrity and inflammation markers in GFD-treated CeD patients.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Biology
Flora Mikaeloff, Marco Gelpi, Rui Benfeitas, Andreas D. Knudsen, Beate Vestad, Julie Hogh, Johannes R. Hov, Thomas Benfield, Daniel Murray, Christian G. Giske, Adil Mardinoglu, Marius Troseid, Susanne D. Nielsen, Ujjwal Neogi, Niel Hens
Summary: Multiomics technologies were used to stratify and characterize the metabolic risk profile in people living with HIV (PWH) on antiretroviral therapy. Through network analysis and similarity network fusion (SNF), three groups of PWH were identified: healthy-like, mild at-risk, and severe at-risk. PWH in the severe at-risk group had a high incidence of metabolic syndrome and dysregulated metabolic traits, despite having higher CD4(+) T-cell counts. The microbiome profile differed between the healthy-like group and the at-risk groups, potentially contributing to systemic inflammation and cardiometabolic risk.
Article
Critical Care Medicine
Marius Troseid, Jan Cato Holter, Kristian Holm, Beate Vestad, Taisiia Sazonova, Beathe K. Granerud, Anne Ma Dyrhol-Riise, Aleksander R. Holten, Kristian Tonby, Anders Benjamin Kildal, Lars Heggelund, Anders Tveita, Simen Boe, Karl Erik Muller, Synne Jenum, Johannes R. Hov, Thor Ueland
Summary: The gut microbiota of hospitalized COVID-19 patients is altered, with reduced diversity and a different composition in those requiring intensive care unit (ICU) admission. This altered gut microbiota is associated with ICU admission and 60-day mortality. These findings suggest that gut microbiota alterations during hospitalization may be related to poor prognosis in severe COVID-19.
Article
Food Science & Technology
Lisa Garnweidner-Holme, Monica Hellmann, Christine Henriksen, Elisabeth Austad, Solveig Ivara Watters, Line Gaundal, Knut E. A. Lundin, Mari C. W. Myhrstad, Vibeke H. Telle-Hansen, Jana Pexova Kalinova
Summary: This study investigated the experiences of people with coeliac disease (CeD) with gluten-free bread, and found that they preferred fibre-rich gluten-free bread that is satiating and has a good texture.