Article
Gastroenterology & Hepatology
Shun Kato, Shin-ei Kudo, Yosuke Minegishi, Yuki Miyata, Yasuharu Maeda, Takanori Kuroki, Yuki Takashina, Kenichi Mochizuki, Eri Tamura, Masahiro Abe, Yuta Sato, Tatsuya Sakurai, Yuta Kouyama, Kenta Tanaka, Yushi Ogawa, Hiroki Nakamura, Katsuro Ichimasa, Noriyuki Ogata, Tomokazu Hisayuki, Takemasa Hayashi, Kunihiko Wakamura, Hideyuki Miyachi, Toshiyuki Baba, Fumio Ishida, Tetsuo Nemoto, Masashi Misawa, Collaborators
Summary: This study evaluated the additional diagnostic value of computer-aided characterization in colonoscopy practice. It found that this technique improves the sensitivity and negative predictive value for colorectal polyps and enhances the high-confidence diagnosis rate.
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Aasma Shaukat, David R. Lichtenstein, Samuel C. Somers, Daniel C. Chung, David G. Perdue, Murali Gopal, Daniel R. Colucci, Sloane A. Phillips, Nicholas A. Marka, Timothy R. Church, William R. Brugge
Summary: This study evaluated the clinical benefit and safety of using a computer-aided detection (CADe) device in colonoscopy procedures. The results showed that the use of CADe device significantly increased adenoma detection rate without increasing the resection of non-neoplastic lesions.
Article
Gastroenterology & Hepatology
Jooyoung Lee, Jung Ho Bae, Su Jin Chung, Hae Yeon Kang, Seung Joo Kang, Min-Sun Kwak, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Eun Hyo Jin, Ji Min Choi, Yoo Min Han, Joo Sung Kim
Summary: Comprehensive optical diagnosis training with WASP classification significantly increased the overall SDR of expert endoscopists, while it did not have a significant impact on ADR.
DIGESTIVE ENDOSCOPY
(2022)
Article
Oncology
Da-Huan Li, Xue-Ying Liu, Chao Huang, Chao-Nan Deng, Jia-Lu Zhang, Xiao-Wen Xu, Liang-Bi Xu
Summary: This study aimed to analyze the endoscopic and pathological characteristics of colorectal laterally spreading tumors (LSTs) to assist in malignant risk stratification. Findings revealed that LST malignancy was correlated with lesion diameter, location, and morphological appearance. Endoscopic submucosal dissection is the preferred treatment for LSTs with a diameter >= 20 mm and cancerization mainly in the rectum with a morphology of LST-G-M.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sangeeta Jaiswal, Bishnu Joshi, Jing Chen, Fa Wang, Michael K. Dame, Jason R. Spence, Gina M. Newsome, Erica L. Katz, Yatrik M. Shah, Sadeesh K. Ramakrishnan, Gaoming Li, Miki Lee, Henry D. Appelman, Rork Kuick, Thomas D. Wang
Summary: The study identified that Prdx1 is overexpressed on the cell surface in the presence of oxidative stress and can serve as an imaging biomarker for in vivo detection of SSAs.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Gastroenterology & Hepatology
Jun Li, Di Zhang, Yunlei Wei, Kan Chen, Ruijin Wu, Kangsheng Peng, Xiaojia Hou, Lei Li, Chao Huang, Yuxin Wang, Linjuan Xun, Hongwei Xu, Jianhua Wang, Zhirong Chen, Ming Shen, Feng Liu
Summary: This study aims to compare the detection of colorectal sessile serrated lesions (SSL) using linked color imaging (LCI) with white light imaging (WLI). The study found that the SSL detection rate was significantly higher in the LCI group compared to the WLI group. LCI also improved the polyp and adenoma detection rate. Therefore, LCI can be recommended as a routine method for colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jun Li, Kan Chen, Yunlei Wei, Di Zhang, Yuxin Wang, Xiaojia Hou, Ruijin Wu, Kangsheng Peng, Lei Li, Chao Huang, Yilong Wang, Linjuan Xun, Feng Liu
Summary: This study compared the effectiveness of LCI and NBI in detecting colorectal SSLs, and found no significant difference between the two methods. Both LCI and NBI were equally effective in detecting polyps and adenomas. Factors associated with SSL detection were bowel preparation score, withdrawal time, and operator experience.
Article
Gastroenterology & Hepatology
Priyanka Kanth, Zhe Yu, Megan B. Keener, Cathryn Koptiuch, Wendy K. Kohlmann, Deborah W. Neklason, Michelle Westover, Karen Curtin
Summary: Patients with serrated polyposis syndrome (SPS) and their relatives, especially first-degree relatives, have an increased risk of colorectal cancer (CRC). In addition, an increased risk of prostate cancer was found in patients with sporadic sessile serrated lesion (SSL). Relatives of patients with both sporadic SSL and adenomas may also have an elevated CRC risk.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Uri Ladabaum, John Shepard, Ajitha Mannalithara
Summary: The study analyzed colonoscopy volumes and lesion detection rates before and after the endorsement of colorectal cancer (CRC) screening at 45-49 years of age. It found that lowering the screening initiation age had a modest effect on colonoscopy volume without compromising screening yield, and the detection rates for lesions in the 45-49 age group were similar to those in older age groups. Further national monitoring is needed to fully assess the impact of this change in screening guidelines.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Mehul Trivedi, Suha Godil, Joshua Demb, Ashley Earles, Ranier Bustamante, Olga Patterson, Andrew J. Gawron, Tonya Kaltenbach, Sumana Mahata, Lin Liu, Samir Gupta
Summary: This study aimed to investigate the clinical characteristics and long-term outcomes associated with traditional serrated adenomas (TSAs). The results showed that TSA patients have an increased risk for colorectal cancer (CRC) and a risk of developing other high-risk neoplasia during follow-up surveillance colonoscopy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Satomi Nishimoto, Takahiro Kudo, Ichitaro Horiuchi, Kiyoaki Yabe, Shingo Kurasawa, Akira Horiuchi
Summary: This study investigated the effectiveness of cap-assisted colonoscopy conducted in the left lateral decubitus position, compared to colonoscopy without a cap conducted in the supine position. The results showed that cap-assisted colonoscopy in the left lateral decubitus position may increase the detection rate of sessile serrated lesions compared to colonoscopy without a cap and supine position at withdrawal.
Review
Medicine, General & Internal
Yu-Hsi Hsieh, Chia-Pei Tang, Chih-Wei Tseng, Tu-Liang Lin, Felix W. Leung
Summary: Randomized control trials and meta-analyses have shown that computer-aided detection (CADe) can significantly increase adenoma detection rates (ADRs) during colonoscopies. However, the issue of false positives (FPs) with CADe is a major limitation, leading to potential user fatigue and increased procedure time. Water exchange (WE) is emerging as a potential method to reduce FPs and improve ADRs through CADe.
Article
Oncology
Liang Wang, Dong Hang, Xiaosheng He, Chun-Han Lo, Kana Wu, Andrew T. Chan, Shuji Ogino, Edward L. Giovannucci, Mingyang Song
Summary: The study indicates that erythrocyte PUFAs in a typical American diet are unlikely to have a substantial influence on the risk of colorectal cancer precursors. However, certain PUFAs may be associated with different types of colorectal polyp risks. Further confirmation is needed for subgroup associations.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
George Tribonias, Angeliki Theodoropoulou, Konstantinos Stylianou, Ioannis Giotis, Afroditi Mpitouli, Dimitrios Moschovis, Yoriaki Komeda, Margarita-Eleni Manola, Gregorios Paspatis, Maria Tzouvala
Summary: The study investigated the use of acetic acid solution for improving the detection of SSLs in the right colon and found that it significantly increased the detection rate of SSLs in a safe, quick, and effective manner. The use of AA solution showed significant improvement in detecting various types and sizes of polyps, providing a promising method for colonoscopy.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Elijah Verheyen, Daniel Castaneda, Seth A. Gross, Violeta Popov
Summary: This meta-analysis compared the effectiveness of currently available mechanical new technology devices and conventional colonoscopy in detecting sessile-serrated adenomas. The results showed that mechanical NTDs, particularly Endocuff, significantly increased the SSADR.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Zoology
Renyi Zhang, Lei Deng, Xiaomei Lv, Qian Tang
Summary: This study investigated and analyzed the mitochondrial genomes of Tachysurus brachyrhabdion and T. gracilis, and found that they have similar genome compositions. The results supported previous research and traditional classification, providing an important basis for future phylogenetic and taxonomic studies of the family Bagridae.
Article
Immunology
Zhenzhan Zhang, Binshu Weng, Yaopeng Qiu, Hao Feng, Renyi Zhang, Jiachen Zhang, Yanfeng Hu, Jiang Yu, Guoxin Li, Hao Liu
Summary: The study found that perioperative serum interleukin-6 (IL6) and tumor necrosis factor-alpha (TNF alpha) levels are negatively associated with 5-year survival outcomes in locally advanced gastric cancer patients, indicating the potential survival benefits from perioperative anti-inflammatory treatment.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Yuichi Mori, Pu Wang, Magnus Loberg, Masashi Misawa, Alessandro Repici, Marco Spadaccini, Loredana Correale, Giulio Antonelli, Honggang Yu, Dexin Gong, Misaki Ishiyama, Shin-ei Kudo, Shunsuke Kamba, Kazuki Sumiyama, Yutaka Saito, Haruo Nishino, Peixi Liu, Jeremy R. Glissen Brown, Nabil M. Mansour, Seth A. Gross, Mette Kalager, Michael Bretthauer, Douglas K. Rex, Prateek Sharma, Tyler M. Berzin, Cesare Hassan
Summary: The use of AI during colonoscopy increases the proportion of patients needing intensive surveillance by approximately 35% in the United States and 20% in Europe. This contributes to improved cancer prevention but adds significant patient burden and healthcare costs.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Chaorui Wu, Yaopeng Qiu, Renyi Zhang, Xiaoqing Li, Huayuan Liang, Minghao Wang, Fengping Li, Mansheng Zhu, Gengtai Ye, Hao Liu, Guoxin Li, Liying Zhao
Summary: This study retrospectively analyzed the association between baseline peripheral basophils and clinical outcomes in gastric cancer patients treated with anti-PD-1 plus chemotherapy. The study found that peripheral basophil count could be a potential biomarker for predicting the efficacy of anti-PD-1 treatment in advanced gastric cancer. The study also revealed that basophils may induce an immune-evasive tumor microenvironment by increasing M2 macrophage infiltration.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Pu Wang, Xiao-Gang Liu, Min Kang, Xue Peng, Mei-Ling Shu, Guan-Yu Zhou, Pei-Xi Liu, Fei Xiong, Ming-Ming Deng, Hong-Fen Xia, Jian-Jun Li, Xiao-Qi Long, Yan Song, Liang-Ping Li
Summary: In colonoscopy screening for colorectal cancer, human vision limitations may lead to higher miss rate of lesions. Artificial intelligence (AI) assistance has been demonstrated to improve polyp detection. This study aimed to compare the effectiveness of AI and human observer during colonoscopy.
GASTROENTEROLOGY REPORT
(2023)
Article
Biodiversity Conservation
Qian Tang, Lei Deng, Qi Luo, Qian Duan, Xue Wang, Renyi Zhang
Summary: Guizhou Province serves as an important ecological barrier in the upper reaches of the Yangtze River and the Pearl River basins, with a rich diversity of fish species. However, anthropogenic activities such as overfishing and habitat destruction pose a threat to these fish. This study used DNA barcoding to assess the fish diversity in the region, revealing the complex nature of fish species in Guizhou Province and providing a reference for their conservation and monitoring.
Article
Gastroenterology & Hepatology
Wei-hui Liu, Xin-yu Huang, Xiao Hu, Pu Wang, Yun-chao Yang, Pei-xi Liu, Xiao-gang Liu
Article
Fisheries
Qi Luo, Qian Tang, Lei Deng, Qian Duan, Renyi Zhang
Summary: A new species called Sinocyclocheilus xingyiensis was discovered in a karst cave in Guizhou Province, China. The authors used both morphological and molecular data to identify the new species as part of the Sinocyclocheilu angularis group, and it differs from other species in the group due to certain distinguishing features. Phylogenetic analyses based on the cyt b gene fragment indicate that S. xingyiensis is closely related to Sinocyclocheilus flexuosdorsalis, with a genetic distance ranging from 1.2% to 15.4% compared to the S. angularis group.
JOURNAL OF FISH BIOLOGY
(2023)
Article
Nutrition & Dietetics
Yaopeng Qiu, Zhou Xu, Qingfeng Xie, Renyi Zhang, Luyao Wang, Liying Zhao, Hao Liu
Summary: This study found that the index derived from LDL-5 Apo-B, LDL-4 Cholesterol, HDL-4 Apo-A2, and HDL-4 Free Cholesterol was significantly associated with overall survival, suggesting that regulating lipid metabolisms might improve the prognosis for gastric cancer patients.
NUTRITION & METABOLISM
(2023)
Article
Genetics & Heredity
Renyi Zhang, Tingting Zhu, Qi Luo
Summary: In this study, the complete mitochondrial genome of Onychostoma ovale was sequenced and characterized. The mitogenome was 16,602 bp in length and contained 13 protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes, and a control region. The nucleotide composition showed a higher A + T content than G + C content. Phylogenetic analysis revealed a close relationship between O. ovale and O. rarum. This study provides valuable information for further phylogeny and population genetic analyses of Onychostoma and Acrossocheilus.
Article
Nanoscience & Nanotechnology
Dan Yang, Jing Ning, Xiaomin Liao, Haixing Jiang, Shanyu Qin
Summary: This study developed a drug delivery system consisting of gemcitabine and thermo-sensitive hydrogel (PPP). The PPP hydrogel demonstrated excellent injectability, biocompatibility, and sustained drug delivery properties. After precise injection using EUS-FNI technology, GEM/PPP hydrogel showed significant therapeutic effects, reducing proliferation, invasion, and migration of cancer cells while promoting apoptosis. The combination of GEM/PPP hydrogel and EUS-FNI technology provides an optimal approach for precise chemotherapy for pancreatic cancer.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Genetics & Heredity
Renyi Zhang, Tingting Zhu, Hongmei Li, Lei Deng
Summary: This study sequenced, annotated, and characterized the complete mitogenome of Linichthys laticeps and conducted phylogenetic analysis with previously published Labeoninae mitogenomes. The results showed that L. laticeps was closely related to the genera Discogobio and Discocheilus, and Labeoninae is not a monophyletic group. This study filled a knowledge gap in Labeoninae and extended understanding of its taxonomy and mitogenomic phylogeny.
Article
Agriculture, Dairy & Animal Science
Renyi Zhang, Qian Duan, Qi Luo, Lei Deng
Summary: This study constructed the full-length transcriptome of Sinocyclocheilus multipunctatus, analyzed its phylogenetic relationships and whole-genome duplication events, and identified positively selected genes involved in adaptation to cave environments. It provides valuable insights into the evolutionary history and genomic characteristics of this species.
Article
Gastroenterology & Hepatology
Shijie Wang, Jinliang Wan, Zhiming Li, Chenyan Long, Renyi Zhang, Yaxin Luo, Zelong Han, Jun Yan
Summary: This study compares the efficacy and safety of endoscopic radial incision and cutting procedure and endoscopic balloon dilation for anastomotic stricture after low anterior resection. The results demonstrate that the endoscopic radial incision and cutting procedure is safer and more efficacious than endoscopic balloon dilation.
DISEASES OF THE COLON & RECTUM
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Yuichi Mori, Pu Wang, Magnus Loberg, Masashi Misawa, Alessandro Repici, Marco Spadaccini, Loredana Correale, Giulio Antonelli, Honggang Yu, Dexin Gong, Misaki Ishiyama, Shinei Kudo, Shunsuke Kamba, Kazuki Sumiyama, Yutaka Saito, Haruo Nishino, Peixi Liu, Jeremy R. Glissen Brown, Nabil M. Mansour, Seth Gross, Mette Kalager, Michael Bretthauer, Douglas K. Rex, Prateek Sharma, Tyler M. Berzin, Cesare Hassan
GASTROINTESTINAL ENDOSCOPY
(2022)