Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium

Human gut derived-organoids provide model to study gluten response and effects of microbiota-derived molecules in celiac disease

(2019) Rachel Freire et al.   Scientific Reports

Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function

(2019) Gizem Altay et al.   Scientific Reports

Three lysophosphatidic acids with a distinct long chain moiety differently affect cell differentiation of human colon epithelial cells to goblet cells

(2018) Mayumi Hidaka et al.   LIFE SCIENCES

Deriving functional human enteroendocrine cells from pluripotent stem cells

(2018) Katie L. Sinagoga et al.   DEVELOPMENT

SCFAs strongly stimulate PYY production in human enteroendocrine cells

(2018) P. Larraufie et al.   Scientific Reports

Butyrate Stimulates Histone H3 Acetylation, 8-Isoprostane Production, RANKL Expression, and Regulated Osteoprotegerin Expression/Secretion in MG-63 Osteoblastic Cells

(2018) Mei-Chi Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Intestinal in vitro and ex vivo Models to Study Host-Microbiome Interactions and Acute Stressors

(2018) Sarah C. Pearce et al.   Frontiers in Physiology

Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons

(2017) Tran Van Hung et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

(2017) Leon Zheng et al.   JOURNAL OF IMMUNOLOGY

Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model

(2017) Tingting Chen et al.   Food & Function

Development and Characterization of a Human and Mouse Intestinal Epithelial Cell Monolayer Platform

(2017) Kenji Kozuka et al.   Stem Cell Reports

Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli

(2017) Sayali S. Karve et al.   PLoS One

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway

(2017) Hui Yan et al.   PLoS One

Differing roles for short chain fatty acids and GPR43 agonism in the regulation of intestinal barrier function and immune responses

(2017) Warren N. D’Souza et al.   PLoS One

Deregulation of transcription factors controlling intestinal epithelial cell differentiation; a predisposing factor for reduced enteroendocrine cell number in morbidly obese individuals

(2017) Bettina K. Wölnerhanssen et al.   Scientific Reports

The SCFA butyrate stimulates the epithelial production of retinoic acid via inhibition of epithelial HDAC

(2016) Ronald Schilderink et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium

(2016) Takeshi Tsuruta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

(2016) Gerard E. Kaiko et al.   CELL

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

TLR ligands and butyrate increasePyyexpression through two distinct but inter-regulated pathways

(2016) Pierre Larraufie et al.   CELLULAR MICROBIOLOGY

Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut

(2016) Phoom Chairatana et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

(2016) Jennifer Foulke-Abel et al.   GASTROENTEROLOGY

Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites

(2016) François Gerbe et al.   NATURE

Promotion of Intestinal Epithelial Cell Turnover by Commensal Bacteria: Role of Short-Chain Fatty Acids

(2016) Jung-ha Park et al.   PLoS One

Tuft Cells: New Players in Colitis

(2016) Shaun P. Steele et al.   TRENDS IN MOLECULAR MEDICINE

Butyrate and bioactive proteolytic form of Wnt-5a regulate colonic epithelial proliferation and spatial development

(2016) Kazuhiko Uchiyama et al.   Scientific Reports

Colonic crypts are natural gatekeepers of microbial metabolites to protect stem cells

(2016) Praveen Kumar Vemula et al.   Translational Cancer Research

Soluble RANKL expression in Lactococcus lactis and investigation of its potential as an oral vaccine adjuvant

(2015) Jeong-In Kim et al.   BMC IMMUNOLOGY

Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

(2015) Roni Nowarski et al.   CELL

Short-Chain Fatty Acids Regulate Secretion of IL-8 from Human Intestinal Epithelial Cell Linesin vitro

(2015) M. Asarat et al.   IMMUNOLOGICAL INVESTIGATIONS

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

(2014) S. Lukovac et al.   mBio

Colonic bacterial metabolites and human health

(2013) Wendy R Russell et al.   CURRENT OPINION IN MICROBIOLOGY

Epithelial Cell Proliferation Arrest Induced by Lactate and Acetate from Lactobacillus casei and Bifidobacterium breve

(2013) Takahiro Matsuki et al.   PLoS One

Brief Report: Dclk1 Deletion in Tuft Cells Results in Impaired Epithelial Repair After Radiation Injury

(2013) Randal May et al.   STEM CELLS

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

(2012) Jean Guy LeBlanc et al.   CURRENT OPINION IN BIOTECHNOLOGY

Regulation of antimicrobial peptide gene expression by nutrients and by-products of microbial metabolism

(2012) Yan Campbell et al.   EUROPEAN JOURNAL OF NUTRITION

The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates

(2012) Erwin G Zoetendal et al.   ISME Journal

Short-Chain Fatty Acids Induce Pro-Inflammatory Cytokine Production Alone and in Combination with Toll-Like Receptor Ligands

(2011) Paria Mirmonsef et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Antibacterial Lectin RegIII  Promotes the Spatial Segregation of Microbiota and Host in the Intestine

(2011) S. Vaishnava et al.   SCIENCE

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

(2010) Rosalba Salcedo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

KLF4 positively regulates human ghrelin expression

(2009) Hyo Jung Lee et al.   BIOCHEMICAL JOURNAL

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

The dietary histone deacetylase inhibitor sulforaphane induces human β-defensin-2 in intestinal epithelial cells

(2008) Markus Schwab et al.   IMMUNOLOGY

Innate immune response mechanisms in the intestinal epithelium: potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis

(2008) P. A. KNIGHT et al.   PARASITOLOGY