Review
Gastroenterology & Hepatology
Athena L. Sheppard, Martha M. C. Elwenspoek, Lauren J. Scott, Victoria Corfield, Hazel Everitt, Peter M. Gillett, Alastair D. Hay, Hayley E. Jones, Susan Mallett, Jessica Watson, Penny F. Whiting
Summary: This study aimed to assess the diagnostic accuracy of serological tests for coeliac disease in both children and adults. The results showed that anti-tissue transglutaminase has sufficient sensitivity to rule out coeliac disease in children, while endomysial antibody has high specificity to rule in coeliac disease in adults.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Public, Environmental & Occupational Health
Xiaoyan Zheng, Rui hua Duan, Fen Gong, Xiaojing Wei, Yu Dong, Rouhao Chen, Ming Yue Liang, Chunzhi Tang, Liming Lu
Summary: The study evaluated the diagnostic accuracy of serological tests for COVID-19, finding that ELISA and CLIA tests performed better in terms of sensitivity than LFIA. IgG-based tests had higher sensitivity than IgM-based tests, with combined IgG/IgM test-based CLIA tests showing the best overall diagnostic test accuracy.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Dermatology
Keisuke Anan, Yuki Kataoka, Shinji Okabayashi, Ryohei Yamamoto, Ho Namkoong, Yosuke Yamamoto
Summary: This study provides evidence on the diagnostic accuracy of different Aspergillus antibodies for chronic pulmonary aspergillosis. The results suggest a preference for IgG over other antibody tests in CPA screening, although most studies have a high risk of bias and the precipitin test showed imprecision and instability in sensitivity analysis.
Review
Infectious Diseases
Anna S. Andrew, Tholasi Nadhan Navien, Tzi Shien S. Yeoh, Marimuthu Citartan, Ernest S. Mangantig, Magdline S. H. Sum, Ewe Seng S. Ch'ng, Thean-Hock Tang
Summary: This study conducted a systematic review and meta-analysis to evaluate the diagnostic accuracy of serological tests for Chikungunya virus (CHIKV) infection. The results showed that antigen or antibody-based serological tests can be reliably used to diagnose CHIKV infection depending on the time of sample collection. Antigen tests are suitable for acute-phase samples, while IgM and IgG tests can be used for convalescent-phase samples, distinguishing recent and past infections.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Review
Infectious Diseases
Vitor Falcao de Oliveira, Guilherme Diogo Silva, Mariane Taborda, Anna S. Levin, Marcello Mihailenko Chaves Magri
Summary: This study evaluated the diagnostic performance of serum and bronchoalveolar lavage (BAL) galactomannan (GM) and proposed a cutoff value. The results showed that BAL GM performed better than serum, with higher sensitivity and accuracy.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Review
Public, Environmental & Occupational Health
W. H. Chong, K. P. Neu
Summary: CAPA is defined as invasive pulmonary aspergillosis occurring in COVID-19 patients, with a high mortality rate of 48.4%. The diagnosis is limited by lack of standardized criteria, necessitating further research to determine the optimal diagnostic approach.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Allergy
Bernardo Sousa-Pinto, Isabel Tarrio, Kimberly G. Blumenthal, Luis Araujo, Luis Filipe Azevedo, Luis Delgado, Joao Almedia Fonseca
Summary: The diagnostic accuracy of skin tests and specific IgE quantification in identifying patients reporting a penicillin/B-lactam allergy is low, with low sensitivity and high specificity. More research is needed to assess the role of these tests in stratifying patients for delabeling.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Infectious Diseases
Basilua Andre Muzembo, Kei Kitahara, Anusuya Debnath, Keinosuke Okamoto, Shin-Ichi Miyoshi
Summary: This study systematically evaluated the accuracy of cholera rapid diagnostic tests (RDTs) and found that they have moderate sensitivity and specificity, especially when enriched with alkaline peptone water (APW). Although they are less useful for clinical management, the current generation of RDTs can be valuable for surveillance efforts if used in a principled manner.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Parasitology
Carmen Phang Romero, Rodolfo Castro, Pedro Emmanuel A. do Brasil, Daniella R. Pereira, Roberta Olmo Pinheiro, Cristiana M. Toscano, Maria Regina Fernandes de Oliveira
Summary: This systematic review evaluates the accuracy of rapid point-of-care (POC) tests for diagnosis of leprosy. The results show that these tests have high sensitivity and specificity in multibacillary and paucibacillary cases.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2022)
Review
Virology
Daniel Mekonnen, Hylemariam Mihiretie Mengist, Awoke Derbie, Endalkachew Nibret, Abaineh Munshea, Hongliang He, Bofeng Li, Tengchuan Jin
Summary: This study evaluated the diagnostic test accuracy of SARS-COV-2 serological tests and the kinetics of antibody positivity through systematic review and meta-analysis. Results showed that CLIA assays targeting antibodies against RBD had the highest sensitivity and varied over time. The antibody positivity rate increased with days post-symptom onset, but decreased when transitioning from acute phase to convalescent phase.
REVIEWS IN MEDICAL VIROLOGY
(2021)
Review
Infectious Diseases
Jessica V. L. Macedo, Isaac A. M. Frias, Maria D. L. Oliveiraz, Fernando Zanghelini, Cesar A. S. Andrade
Summary: This systematic review evaluates the accuracy of rapid dengue diagnostic tests. The results show that the combination of anti-dengue IgM, IgG, and NS1 antigen tests has the highest sensitivity.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Review
Oncology
Leibo Wang, Wei He, Guanyu Shi, Guoqiang Zhao, Zhuangding Cen, Feng Xu, Wu Tian, Xin Zhao, Chishou Mo
Summary: This study conducted a network meta-analysis to compare the diagnostic value of different urinary markers for prostate cancer. The results showed that Selectmdx and MIPS were the most suitable urine markers for prostate cancer screening and diagnosis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Public, Environmental & Occupational Health
W. H. Chong, B. K. Saha, C. K. Tan
Summary: Invasive pulmonary aspergillosis, known as 'influenza-associated pulmonary aspergillosis' (IAPA), is increasingly recognized as a complication of influenza, leading to higher morbidity and mortality rates among critically ill patients. Patients with IAPA require more respiratory support, have longer ICU stays, and experience more severe disease compared to those without IAPA.
JOURNAL OF HOSPITAL INFECTION
(2022)
Review
Infectious Diseases
Woon Hean Chong, Biplab K. Saha, Kristoffer P. Neu
Summary: Patients with CAPA are typically older with underlying COPD and received long-term corticosteroid treatment. Furthermore, CAPA is associated with higher SOFA scores, mortality, and earlier onset of ICU admission from illness onset.
Review
Microbiology
Lydia M. P. Bukkems, Laura van Dommelen, Marta Regis, Edwin van den Heuvel, Laurens Nieuwenhuizen
Summary: This article conducts a systematic review and meta-analysis to determine the optimal cut-off values of the optical density index (ODI) for galactomannan antigen assays (GM) in diagnosing invasive pulmonary aspergillosis in hematological patients. The study found that a serum ODI of 0.5 and BAL ODI of 1.0 were the most suitable cut-off values for clinical practice. However, the evidence for the use of GM in clinical practice for hematological malignancy patients is currently insufficient.
Article
Biotechnology & Applied Microbiology
L. M. P. S. Braga, B. A. A. Saad, C. T. F. de Oliveira, C. E. Volpe-Chaves, M. L. G. G. Lacerda, S. J. Forsythe, J. Venturini, S. M. V. L. de Oliveira, A. M. M. Paniago, L. da Costa, R. V. S. L. de Miranda, C. M. F. dos Reis, M. L. L. Brandao
Summary: This study investigated an uncertain species identification for an infection located on a catheter tip of a patient with Covid-19. The strain, initially identified as Cronobacter spp. by VITEK (R) 2, was later confirmed to be Curtobacterium spp. through polyphasic analysis. The misidentification occurred due to the Gram-variable characteristic of the strain. Additional techniques are required for species-level identification.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Oncology
Eliana C. A. de Brito, Thiago Franca, Thalita Canassa, Simone S. Weber, Anamaria M. M. Paniago, Cicero Cena
Summary: PCM is a systemic mycosis with high incidence in Latin America, and Brazil is considered the endemic center of this disease. Various diagnostic methods, such as microbiological, immunological, histopathological, and molecular, are used for PCM. This study evaluated a new strategy for PCM diagnosis using blood serum FTIR spectra and achieved a high accuracy rate through machine learning algorithms.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Review
Cardiac & Cardiovascular Systems
Saniya Tandon, Antonio Jose Grande, Alexis Karamanos, John Kennedy Cruickshank, Leonardo Roever, Ian Stanley Mudway, Frank James Kelly, Salma Ayis, Seeromanie Harding
Summary: This study systematically reviewed the association between ambient air pollution and blood pressure in adolescents. The analysis of eight studies with approximately 15,000 adolescents revealed generally positive but non-significant associations between long-term exposure to PM10, PM2.5, and NO2 and blood pressure. However, at age 12, significant positive associations were found between long-term exposure to PM2.5 and PM10 and diastolic blood pressure.
CURRENT PROBLEMS IN CARDIOLOGY
(2023)
Review
Psychiatry
Wagner Silva Ribeiro, Antonio Jose Grande, Mauricio Scopel Hoffmann, Carolina Ziebold, David McDaid, Andra Fry, Clayton Peixoto, Claudio Miranda, Derek King, Cristiane Damiani Tomasi, Christine Faustino, Sandra Leone, Silvia Moraes, Antonio Augusto Schafer, Veronica Alves, Maria Ines Rosa, Sara Evans-Lacko
Summary: The study shows that interventions for child and adolescent mental health problems are effective in low- and middle-income countries and have the potential to bridge the mental health care gap in these countries.
COMPREHENSIVE PSYCHIATRY
(2023)
Review
Nutrition & Dietetics
Rosana Emmanuel, Ursula M. M. Read, Antonio Jose Grande, Seeromanie Harding
Summary: Compared with non-Indigenous populations, Indigenous populations have poorer health outcomes, including non-communicable diseases, and higher rates of extreme poverty. A systematic review identified seven studies that examined the content, implementation, and outcomes of interventions in Indigenous communities. The studies reported on acceptability, nutrition knowledge, fruit and vegetable intake, self-efficacy, motivation, and preferences related to diet and gardening. The evidence on the effectiveness of gardening interventions for improving nutrition outcomes was inconclusive, highlighting the need for more robust evaluations. However, using a specific framework revealed strong evidence for the acceptability and feasibility of gardening in Indigenous communities.
Review
Psychiatry
Antonio Jose Grande, Mauricio Scopel Hoffmann, Sara Evans-Lacko, Carolina Ziebold, Claudio Torres de Miranda, David Mcdaid, Cristiane Tomasi, Wagner Silva Ribeiro
Summary: This study aimed to identify school-based interventions that have been tested in treating mental health problems among children and adolescents in low- and middle-income countries. The results showed that overall, interventions delivered in the school environment are effective in reducing mental health problems among children and adolescents.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Nutrition & Dietetics
Ana Claudia Rodrigues Candido, Sarah Dagostin Ferraz, Maria Laura Rodrigues Uggioni, Ivan Rosso Zanevan, Laura Colonetti, Antonio Jose Grande, Tamy Colonetti, Maria Ines da Rosa
Summary: This study aimed to assess the effects of omega-3 supplementation as an adjunct treatment for eating and psychological symptoms in patients with anorexia nervosa. The systematic review of the literature found no evidence of effectiveness of omega-3 supplementation in improving eating and psychological symptoms in patients with anorexia nervosa, regardless of dose, time or association with other components.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Review
Endocrinology & Metabolism
Lidia Rosi Medeiros, Tamy Colonetti, Erickson Cardoso Nagib, Maria Laura Rodrigues Uggioni, Joao Carlos Denoni Junior, Luciane Ceretta, Antonio Jose Grande, Maria Ines Rosa
Summary: This systematic review and meta-analysis evaluated the effect of metformin treatment on Anti-Mullerian Hormone levels in patients with polycystic ovary syndrome. The analysis showed that metformin significantly reduced serum levels of Anti-Mullerian Hormone in both randomized controlled trials and non-randomized studies.
OBESITY RESEARCH & CLINICAL PRACTICE
(2023)
Article
Multidisciplinary Sciences
Paulo T. C. Jardim, Josiliane M. Dias, Antonio J. Grande, Andre B. Veras, Erika K. Ferri, Fatima A. A. Quadros, Clayton Peixoto, Francielle C. S. Botelho, Maria I. M. G. Oliveira, Ieda M. A. V. Dias, Majella O'Keeffe, Christelle Elia, Paola Dazzan, Ingrid Wolfe, Seeromanie Harding
Summary: Latin America and the Caribbean Region have a significant Indigenous population, and there is a need for addressing health inequities and promoting well-being among Indigenous youth. The study involved Indigenous young people and adults in identifying priority actions related to family, education, socio-economic circumstances, nutrition, physical activity, and access to healthcare to improve youth health.
Article
Multidisciplinary Sciences
Eliana da Costa Alvarenga de Brito, Igor Valadares Siqueira, James Venturini, Vinicius Lopes Teodoro Felix, Alana Oswaldina Gavioli Meira dos Santos, Rinaldo Poncio Mendes, Simone Schneider Weber, Anamaria Mello Miranda Paniago
Summary: This study evaluated the iron metabolism of 39 patients diagnosed with chronic PCM. The results showed that serum ferritin levels decreased and functional iron parameters increased after treatment. The extent of these changes was more pronounced in severe cases.
Article
Multidisciplinary Sciences
Silvia Helena Mendonca de Moraes, Inara Pereira da Cunha, Everton Ferreira Lemos, Lesly Lidiane Ledezma Abastoflor, Maria de Lourdes Oshiro, Rosana Teresinha D. Orio de Athayde Bohrer, Vicente Sarubbi Jr, Fabricia Barros de Souza, Debora Dupas Goncalves do Nascimento, Sandra Maria do Valle Leone de Oliveira
Summary: The COVID-19 pandemic in Brazil had a significant impact on the mental health of healthcare workers. This study aimed to evaluate the mental health of healthcare workers in the central-west region of Brazil during the pandemic. The results showed a high prevalence of mental health disorders, including depression, anxiety, and stress, among healthcare workers. Factors such as professional category, perceived safety, and self-perception of poor mental health were associated with the development of mental health symptoms. Preventative measures are necessary to address this issue.
Review
Medicine, General & Internal
Ana Cristina Macedo, Antonio Jose Grande, Tatiana Figueiredo, Tamy Colonetti, Joao Carlos Goncalves, Eduardo Testoni, Maria Ines da Rosa
Summary: This systematic review evaluates the accuracy of DNA HRHPV, mRNA HPV, DNA HPV16, and p16 biomarkers in identifying anal intraepithelial neoplasia (AIN) 2 or 3 and cancer. The findings suggest that DNA HR HPV can be a useful tool for screening aHSIL and anal cancer, while mRNA HPV shows better performance as an isolated test. Subgroup analysis reveals similar accuracy in MSM with HIV.
Article
Respiratory System
Rafaela Borge Loureiro, Leticia Molino Guidoni, Geisa Carlesso Fregona, Sandra Maria do Valle Leone de Oliveira, Daniel Sacramento, Jair Dos Santos Pinheiro, Denise Gomes, Ethel Leonor Noia Maciel
Summary: This study evaluated the impact of the proportion of annual family income spent on tuberculosis patients before and after diagnosis. The findings showed that the overall average cost of tuberculosis was significantly higher in the post-diagnosis period. The study also revealed an increase in unemployment and a shift towards poverty among the patients after treatment.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2023)
Article
Public, Environmental & Occupational Health
Antonio Jose Grande, Ieda M. A. V. Dias, Paulo T. C. Jardim, Alessandra Aparecida Vieira Machado, Jacks Soratto, Maria Ines da Rosa, Leonardo Roever, Luciane Bisognin Ceretta, Xanthi Zourntos, Seeromanie Harding
Summary: Indigenous university students in Brazil identified the importance of respecting their lands and customs, implementing educational initiatives, guaranteeing basic health rights, and providing culturally appropriate care as actionable priorities for protecting the survival of indigenous peoples from climate change-related impacts.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
Diogo Edele Santos, Tamy Colonetti, Maria Laura Rodrigues Uggioni, Peterson Rech, Mateus Marcelino Baptista, Lidia Rosi Medeiros, Antonio Jose Grande, Maria Ines Rosa
Summary: This systematic review and meta-analysis assessed the effects of SARS-Cov-2 and mRNA vaccines on male reproduction. The results showed significant differences in seminal parameters before and after the COVID-19 pandemic, but the evidence quality was low. However, there were no significant differences in seminal parameters before and after the SARS-Cov-2 vaccine, indicating that mRNA vaccines do not have detrimental effects on male reproductive function.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)