Targeting glycosphingolipid metabolism as a potential therapeutic approach for treating disease in female MRL/lpr lupus mice

Targeting Glucosylceramide Synthesis in the Treatment of Rare and Common Renal Disease

(2018) James A. Shayman   SEMINARS IN NEPHROLOGY

All-Cause and Cause-Specific Mortality Trends of End-Stage Renal Disease due to Lupus Nephritis from 1995 to 2014

(2018) April Jorge et al.   Arthritis & Rheumatology

Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model

(2017) Tejas R. Karhadkar et al.   Scientific Reports

FLI1 Levels Impact CXCR3 Expression and Renal Infiltration of T Cells and Renal Glycosphingolipid Metabolism in the MRL/lpr Lupus Mouse Strain

(2015) Kamala P. Sundararaj et al.   JOURNAL OF IMMUNOLOGY

Glycosphingolipids are modulators of disease pathogenesis in amyotrophic lateral sclerosis

(2015) James C. Dodge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Desialylation is a mechanism of Fc-independent platelet clearance and a therapeutic target in immune thrombocytopenia

(2015) June Li et al.   Nature Communications

A novel insulin receptor-signaling platform and its link to insulin resistance and type 2 diabetes

(2014) Farah Alghamdi et al.   CELLULAR SIGNALLING

Normalizing glycosphingolipids restores function in CD4+ T cells from lupus patients

(2014) Georgia McDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles

(2014) Kerri J. Grove et al.   JOURNAL OF LIPID RESEARCH

Renal Glycosphingolipid Metabolism Is Dysfunctional in Lupus Nephritis

(2014) T. K. Nowling et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mycophenolate Mofetil or Intravenous Cyclophosphamide for Lupus Nephritis With Poor Kidney Function: A Subgroup Analysis of the Aspreva Lupus Management Study

(2013) Michael Walsh et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses

(2013) Samar Abdulkhalek et al.   CELLULAR SIGNALLING

Glycosphingolipids: synthesis and functions

(2013) Giovanni D'Angelo et al.   FEBS Journal

MALDI imaging MS reveals candidate lipid markers of polycystic kidney disease

(2013) Hermelindis Ruh et al.   JOURNAL OF LIPID RESEARCH

Reducing FLI1 Levels in the MRL/lpr Lupus Mouse Model Impacts T Cell Function by Modulating Glycosphingolipid Metabolism

(2013) Erin Morris Richard et al.   PLoS One

Soluble FLT1 Binds Lipid Microdomains in Podocytes to Control Cell Morphology and Glomerular Barrier Function

(2012) Jing Jin et al.   CELL

G-protein coupled receptor agonists mediate Neu1 sialidase and matrix metalloproteinase-9 cross-talk to induce transactivation of TOLL-like receptors and cellular signaling

(2012) Samar Abdulkhalek et al.   CELLULAR SIGNALLING

Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease

(2012) Thomas A. Natoli et al.   HUMAN MOLECULAR GENETICS

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease

(2012) Mario A. Cabrera-Salazar et al.   PLoS One

Where catabolism meets signalling: neuraminidase 1 as a modulator of cell receptors

(2011) Alexey V. Pshezhetsky et al.   GLYCOCONJUGATE JOURNAL

Neu1 Sialidase and Matrix Metalloproteinase-9 Cross-talk Is Essential for Toll-like Receptor Activation and Cellular Signaling

(2011) Samar Abdulkhalek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction

(2011) María José Hernández-Corbacho et al.   PLoS One

Increased Expression of Ganglioside GM1 in Peripheral CD4+ T Cells Correlates Soluble Form of CD30 in Systemic Lupus Erythematosus Patients

(2010) Lingli Dong et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Inhibition of glucosylceramide accumulation results in effective blockade of polycystic kidney disease in mouse models

(2010) Thomas A Natoli et al.   NATURE MEDICINE

Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation

(2010) Schammim R. Amith et al.   Jove-Journal of Visualized Experiments

The 10-year follow-up data of the Euro-Lupus Nephritis Trial comparing low-dose and high-dose intravenous cyclophosphamide

(2009) F A Houssiau et al.   ANNALS OF THE RHEUMATIC DISEASES

Ganglioside GM3 and its biological functions

(2009) N. V. Prokazova et al.   BIOCHEMISTRY-MOSCOW

Dependence of pathogen molecule-induced Toll-like receptor activation and cell function on Neu1 sialidase

(2009) Schammim Ray Amith et al.   GLYCOCONJUGATE JOURNAL

Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers

(2008) Rebecca L. Shaner et al.   JOURNAL OF LIPID RESEARCH