Review
Toxicology
Thomas Kralj, Kim L. R. Brouwer, Darren J. Creek
Summary: Drug-induced liver injury (DILI) is a significant clinical issue, with an annual impact on 1-1.5 million patients, and is a major challenge during drug development. Greater understanding of the biological mechanisms behind DILI can help minimize its future prevalence. Qualitative and quantitative analytical techniques, as well as omics-based analytical techniques, are vital for characterizing and investigating DILI.
TOXICOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Tsuyoshi Yokoi, Shingo Oda
Summary: Drug-induced liver injury (DILI) is a major concern during drug development and post-marketing, with both intrinsic and idiosyncratic classifications. Predicting idiosyncratic DILI, associated with severe liver damage, is challenging due to its low incidence and complex nature. Animal models have been used to study DILI mechanisms and predict potential risks.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Gastroenterology & Hepatology
Naga Chalasani, Yi-Ju Li, Andrew Dellinger, Victor Navarro, Herbert Bonkovsky, Robert J. Fontana, Jiezhun Gu, Huiman Barnhart, Elizabeth Phillips, Craig Lammert, Tae-Hwi Schwantes-An, Paola Nicoletti, David E. Kleiner, Jay H. Hoofnagle
Summary: This study describes the clinical characteristics, outcomes, and HLA risk factors for nitrofurantoin-induced liver injury (NTF-DILI) among individuals enrolled in the Drug Induced Liver Injury Network (DILIN). Long-term use of NTF can result in parenchymal necrosis, bridging fibrosis, cirrhosis, and death or liver transplantation, and is associated with HLA-DRB1*11:04. Regulators should revise the prescribing information and consider other mitigation strategies.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Hk Bjornsson, Es Bjornsson
Summary: Drug-induced liver injury (DILI) is an important adverse event that can range from mild enzyme elevations to severe liver failure or death. Different types of DILI and the role of the immune system in its pathogenesis have been identified. The diagnosis of DILI remains a challenge due to varying biochemical profiles and multiple clinical signatures of different drugs. Multicenter studies and public websites have provided tools for physicians to investigate suspected DILI cases.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Naga Chalasani, Herbert L. Bonkovsky, Jonathan G. Stine, Jiezhun Gu, Huiman Barnhart, Elin Jacobsen, Einar Bjornsson, Robert J. Fontana, David E. Kleiner, Jay H. Hoofnagle
Summary: A study in the United States showed a decrease in the proportion of liver injury caused by antiepileptic drugs in recent years, which is more common in non-seizure indications and allergic skin reactions, and more common in African Americans.
JOURNAL OF HEPATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuan-kai Sun, Ya-fei Zhang, Li Xie, Fan Rong, Xing-yu Zhu, Jing Xie, Huan Zhou, Tao Xu
Summary: Drug-induced liver injury (DILI) is a major cause of liver disease worldwide, and many drugs can cause this condition. Traditional Chinese medicine (TCM) has shown effectiveness in treating DILI, but reducing the toxicity of TCM remains a challenge. Hydrogel-based nanocomposite materials may serve as excellent carriers for TCM. This review provides new insights for further exploration of TCM in the treatment of DILI.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Chemistry, Analytical
Jianfei Liu, Manfen Zhao, Fangfang Zhao, Xiangzhi Song, Yong Ye
Summary: We designed a new fluorogenic ONOO--triggered H2S donor (Z-1) for mitigating liver injury caused by toxic active substances. Z-1 can scavenge harmful ONOO- and release H2S to relieve DILI in cellular and mice models. Additionally, we found that the ferroptosis inhibitor Ferrostatin 1 can reduce ROS in mitochondria during acetaminophen (APAP)-induced liver injury, suggesting a potential therapeutic opportunity for preventing ferroptosis in DILI and other related pathologies.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Review
Environmental Sciences
Rebecca Allison, Asha Guraka, Isaac Thom Shawa, Gyan Tripathi, Wolfgang Moritz, Ali Kermanizadeh
Summary: This review primarily focuses on the mechanisms, risk factors, and the impact of the coronavirus pandemic on idiosyncratic drug-induced liver injury (DILI). Although some molecular mechanisms are known, the underlying mechanisms responsible for DILI are still unknown. Prevention strategies are crucial due to limited treatment options once the injury has occurred.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Hui Qian, Xiaojuan Chao, Jessica Williams, Sam Fulte, Tiangang Li, Ling Yang, Wen-Xing Ding
Summary: The liver is a crucial metabolic organ, where autophagy plays a significant role in maintaining cellular and metabolic homeostasis. Autophagy in the liver fluctuates with hormonal cues, nutrient availability, and circadian activities. Dysfunctional autophagy may lead to various liver diseases.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ming-Gui Wang, Shou-Quan Wu, Meng-Meng Zhang, Jian-Qing He
Summary: This study demonstrated that potential markers for the early prediction of ATB-DILI can be found through plasma metabolomics and lipidomics. The random forest model showed good clinical predictive value for ATB-DILI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad Alshabeeb, Fadhel A. Alomar, Amjad Khan
Summary: The study did not find an association between the SLCO1B1 rs4149056 (T521C) polymorphism and liver injury induced by flucloxacillin and co-amoxiclav. However, a slightly lower frequency of positive cases was noticed in the flucloxacillin cases compared to the control group.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Olof Nibell, Henrik Svanstrom, Malin Inghammar
Summary: This study found that fluoroquinolone treatment is associated with an increased risk of acute liver injury in the first two months after starting the treatment.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Harshad Devarbhavi, Marwan Ghabril, Huiman Barnhart, Mallikarjun Patil, Sujata Raj, Jiezhun Gu, Naga Chalasani, Herbert L. Bonkovsky
Summary: Leflunomide-induced liver injury is predominantly hepatocellular. Leflunomide hepatotoxicity is more likely accompanied by severe cutaneous adverse reactions, a short latency, and a higher mortality rate in Indian patients, with a predominance of females. Differences in skin involvement, immunoallergic features, and outcomes between Indian and US patients suggest that genetic or environmental factors play an important role in the pathogenesis of liver injury.
LIVER INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Marta Moreno-Torres, Guillermo Quintas, Jose Castell
Summary: Metabolomics as a tool holds great potential in DILI biomarker research, although there are limitations and inconsistencies that hinder the translation of research findings into general clinical practice, notable progress has been made in identifying promising novel metabolite biomarkers.
Article
Immunology
Shuang Zhao, Haoshuang Fu, Tianhui Zhou, Minghao Cai, Yan Huang, Qinyi Gan, Chenxi Zhang, Cong Qian, Jiexiao Wang, Zhenglan Zhang, Xiaolin Wang, Xiaogang Xiang, Qing Xie
Summary: The study found that bile acids and polyunsaturated fatty acids may be important markers for the severity and chronicity of DILI, and the combination of AdA and Asp can predict the risk of chronicity in the acute stage of DILI. In addition, gut microbiota may maintain the homeostasis of bile acids and PUFAs through a negative feedback mechanism.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)