Journal
PHARMACOLOGY & THERAPEUTICS
Volume 213, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2020.107584
Keywords
Microbiome; MACCE; Myocardial infarction; Platelet aggregation; TMAO
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Funding
- Forschungskommission of the Medical Faculty of the Heinrich Heine University [46-2016, 29-2019, 16-2014, 19-2019]
- German Research Foundation [LE 940/7-1, PO 2247/2-1, SFB1116]
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The human gut microbiota is the most important active part of the intestinal micro-ecosystem. Lifestyle modification, drug intake and nutrition have an impact on the composition of the gut microbiota and its metabolites. This review focuses on the effects of changes in the gut microbiota as well as the important metabolite Trimethylamine-N-oxide (TMAO). Furthermore, relevant therapeutic options to target the human microbiome in patients with cardiovascular disease are presented. (C) 2020 Elsevier Inc. All rights reserved.
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