Journal
PEDIATRICS
Volume 145, Issue 4, Pages -Publisher
AMER ACAD PEDIATRICS
DOI: 10.1542/peds.2019-2114
Keywords
-
Categories
Funding
- National Institutes of Health [R01 HL121230]
- National Heart, Lung, and Blood Institute [R01 HL121230]
- Australian National Health and Medical Research Council Project [APP1098369]
- National Heart Foundation of Australia Future Leader Fellowship [100849]
- Academy of Finland [126925, 121584, 124282, 129378, 117787, 41071]
- Social Insurance Institution of Finland
- Kuopio University Hospital medical fund
- Tampere University Hospital medical fund
- Turku University Hospital medical fund
- Juho Vainio Foundation
- Paavo Nurmi Foundation
- Finnish Foundation of Cardiovascular Research
- Finnish Cultural Foundation
- Sigrid Juselius Foundation
- Yrjo Jahnsson Foundation
- Commonwealth Department of Sport, Recreation, and Tourism
- Commonwealth Department of Health
- National Heart Foundation
- Commonwealth Schools Commission
- National Health and Medical Research Council [APP211316]
- National Heart Foundation [GOOH 0578]
- Tasmanian Community Fund [D0013808]
- Veolia Environmental Services
- Sanitarium
- ASICS
- Target
- National Institutes of Health (NIH)
Ask authors/readers for more resources
BACKGROUND: Elevated non-high-density lipoprotein cholesterol (HDL-C) levels are used to identify children at increased cardiovascular risk, but the use of non-HDL-C in childhood to predict atherosclerosis is unclear. We examined whether the National Heart, Lung, and Blood Institute classification of youth non-HDL-C status predicts high common carotid artery intima-media thickness in adulthood. METHODS: We analyzed data from 4 prospective cohorts among 4582 children aged 3 to 19 years who were remeasured as adults (mean follow-up of 26 years). Non-HDL-C status in youth and adulthood was classified according to cut points of the National Heart, Lung, and Blood Institute and the National Cholesterol Education Program Adult Treatment Panel III. High carotid intima-media thickness (cIMT) in adulthood was defined as at or above the study visit-, age-, sex-, race-, and cohort-specific 90th percentile of intima-media thickness. RESULTS: In a log-binomial regression analysis adjusted with age at baseline, sex, cohort, length of follow-up, baseline BMI, and systolic blood pressure, children with dyslipidemic non-HDL-C were at increased risk of high cIMT in adulthood (relative risk [RR], 1.29; 95% confidence interval [CI], 1.07-1.55). Compared with the persistent normal group, the persistent dyslipidemia group (RR, 1.80; 95% CI, 1.37-2.37) and incident dyslipidemia (normal to dyslipidemia) groups (RR, 1.45; 95% CI, 1.07-1.96) had increased risk of high cIMT in adulthood, but the risk was attenuated for the resolution (dyslipidemia to normal) group (RR, 1.17; 95% CI, 0.97-1.41). CONCLUSIONS: Dyslipidemic non-HDL-C levels predict youth at risk for developing high cIMT in adulthood. Those who resolve their non-HDL-C dyslipidemia by adulthood have normalized risk of developing high cIMT in adulthood.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available