Article
Plant Sciences
Sang Suk Kim, Hyun-Jin Kim, Kyung Jin Park, Seok Beom Kang, YoSup Park, Seong-Gab Han, Misun Kim, Yeong Hun Song, Dong-Shin Kim
Summary: This study analyzed the changes in chemical composition during the fruit development process of Citrus unshiu, revealing the trends in total phenolic content, total carotenoid content, antioxidant activity, and metabolite profiles at different stages, providing important information for understanding these changes.
Article
Horticulture
Dong-Shin Kim, Kee-Jai Park, Jeong Hee Choi, Jeong-Ho Lim, Hyun-Jin Kim
Summary: This study investigated the changes in quality-related metabolites of strawberries at different maturities during postharvest storage. The results showed that the surface color of strawberries changed to red, SSC/TA ratio increased, and firmness slightly increased during storage. Moreover, the metabolite profiles related to strawberry quality also changed, including sugars, acidic compounds, lipids, flavonoids, phenolic acid derivatives, and tannins. The knowledge gained from this study helps in understanding the changes in quality-related metabolites of strawberries according to maturity and postharvest storage.
SCIENTIA HORTICULTURAE
(2023)
Article
Veterinary Sciences
Yunlong Bai, Yuxi Song, Jiang Zhang, Shixin Fu, Ling Wu, Cheng Xia, Chuang Xu
Summary: This study aimed to investigate the metabolic differences in dairy cows with inactive ovaries and estrus, with 30 differentially abundant metabolites identified between the two groups. Serum metabolites were significantly higher in cows with inactive ovaries compared to those in estrus, suggesting abnormalities in glucose metabolism, lipid metabolism, amino acid metabolism, and glutathione metabolism obstructing follicular development in postpartum dairy cows.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemical Research Methods
Hongmei Tang, Tingting Peng, Xubo Yang, Liru Liu, Yunxian Xu, Yiting Zhao, Shiya Huang, Chaoqiong Fu, Yuan Huang, Hongyu Zhou, Jinling Li, Lu He, Wenda Wang, Huiran Niu, Kaishou Xu
Summary: In this study, significant dynamic changes of plasma metabolites were observed in children with cerebral palsy (CP) after botulinum neurotoxin A (BoNT-A) injections. Metabolic pathways associated with energy expenditure and glycine, serine, and threonine metabolism, as well as cysteine and methionine metabolism, might be related to the duration of effect of BoNT-A in children with CP.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hailong Qiu, Chenxiao Shan, Chenghao Fei, Ping Xue, Yongyi Zhou, Jiahuan Yuan, Xin Liu
Summary: This study investigated the geoherbalism of Atractylodes lancea (AL) in Jiangsu Province and found that different geographic environments have an important influence on its chemical constituents. The chemical constituents of AL were analyzed using LC-triple TOF-MS/MS and GC-MS, and the differential metabolomics of AL from different habitats were revealed using OPLS-DA. This study provides valuable information for establishing a comprehensive quality evaluation system for AL.
Article
Agriculture, Multidisciplinary
Mingjin Li, Yunzhi Zhang, Jiawei Yan, Fengjiao Ding, Chunmei Chen, Sitong Zhong, Minxuan Li, Yanyu Zhu, Panpan Yue, Pengchun Li, Shijun You, Shan Jin
Summary: Beauty tea was made from fresh leaves of Camellia sinensis Jinxuan cultivar, which were punctured by tea green leafhoppers to different extents. The study identified differential metabolites related to tea polyphenols, lipids, and saccharides in the fresh leaves and dry beauty tea. The quality of beauty tea was influenced by the levels of leafhopper puncturing through the presence of specific characteristic volatiles.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
Chao Han, Chaoqun Huang, Qinting Jiang, Li Chen, Yi Li, Chengjie Lou, Hailing Lu, Yan Shen
Summary: A novel and accurate method for the determination of folpet and phthalimide residues in tea has been developed, using solid-phase extraction combined with gas chromatography-tandem mass spectrometry. The method proposes converting all folpet to phthalimide prior to sample extraction and purification, and utilizes an isotopic internal standard for quantification. The study confirms the accurate determination of phthalimide content and its conversion to folpet content.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xin Nie, Hongfan Chen, Lu Xiang, Yulin Zhang, Dayu Liu, Zhiping Zhao
Summary: This study analyzed the metabolites and associated metabolic pathways of different ultra-long-term industrially fermented kohlrabies using metabolomics. The results provide a theoretical basis for targeted regulation of characteristic metabolite biosynthesis in Chinese fermented kohlrabi.
Article
Food Science & Technology
Xiaolei Fang, Yanping Chen, Jie Gao, Zimu Run, He Chen, Ruoqi Shi, Yingqiu Li, Haihua Zhang, Yuan Liu, Shahab A. Shamsi
Summary: GC-TOF/MS and GC x GC-TOF/MS were used to detect VOCs in coffee samples of three different brands at different states. The results showed that most VOCs existed in 2-3 kinds of coffee, and the VOCs detected by GC-TOF/MS could distinguish the coffee samples in different states. GC x GC-TOF/MS was suitable for the identification and differentiation of different brands of coffee samples. Pyridine, pyrrole, alcohols, and phenols contributed greatly to distinguishing coffee in three states, and alcohols greatly contributed to distinguishing the three brands of coffee.
Article
Immunology
Shaoqing Zang, Li-Xia Lv, Chen-Fei Liu, Peng Zhang, Cang Li, Jin-Xing Wang
Summary: The mechanisms of trained immunity in shrimp, a phenomenon identified in invertebrates, were investigated in this study. Metabolomic analysis revealed significant changes in metabolism, including enrichment of glycolysis, pentose phosphate pathway, and AMPK signaling pathway, in shrimp trained with UV-inactivated white spot syndrome virus (UV-WSSV). Histone monomethylation and trimethylation were found to be involved in trained immunity. These findings provide insights for WSSV control in shrimp aquaculture.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Applied
Xuejie Li, Xiangquan Zeng, Huanlu Song, Yu Xi, Yan Li, Bowen Hui, He Li, Jian Li
Summary: GC x GC-O-TOF-MS and GC-IMS have been increasingly used in complex food flavor analysis, but few studies have applied these techniques to identify the aroma components of tomato pastes. This study comprehensively characterized the aroma profiles of cold and hot break tomato pastes using SAFE-GC-O-MS, SAFE-GC x GC-O-TOF-MS, and HS-GC-IMS for the first time. A total of 274 volatile compounds were identified, which is far more than previously reported.
Article
Chemistry, Applied
Yanmei Zhang, Xiaobei Li, Zhiyong Zhao, E. Hengchao, Tingting Fan, Hui Dong, Xiangwei He, Xiaoyan Zhao, Lihua Tang, Changyan Zhou
Summary: This study used a new method to detect and quantify the metabolites in two cultivars of morel mushrooms. The results showed that the flavor differences between the two morel cultivars were closely related to the content of lipids, carbohydrates, amino acids and derivatives, alcohols and ketones.
Article
Chemistry, Applied
A. Zurowietz, Lehr P. Patrick, M. Kleb, N. Merkt, V Goedde, H. Bednarz, K. Niehaus, C. Zoerb
Summary: The study found that different training systems result in distinct metabolomic signatures in wine, which are more pronounced than in leaves. Sensory analysis also showed changes in the aroma of wines from different training systems, indicating that the influence of training systems ranges from the leaf metabolome to the wine metabolome.
Article
Food Science & Technology
Ping Wang, Linlin Zhong, Hongbing Yang, Feng Zhu, Xujie Hou, Cuiyun Wu, Rui Zhang, Yunjiang Cheng
Summary: In this study, the antioxidant activities of fresh walnut kernels and dry walnut kernels were evaluated, and it was found that dry walnut kernels exhibit higher antioxidant activity. Phenolic metabolites and polyunsaturated fatty acids were identified as significant contributors to the antioxidant activity of walnut kernels.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)