Article
Chemistry, Multidisciplinary
Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke-Layland, Peter Loskill
Summary: Obesity and associated diseases have become epidemic globally. Researchers have developed a microphysiological in vitro model of human white adipose tissue, leveraging Organ-on-Chip technology, which can recapitulate crucial adipose tissue functions and offers advantages such as low inter-donor variability and controllability, making it a valuable tool for metabolism research and personalized medicine applications.
Review
Biochemistry & Molecular Biology
J. Michael Sorrell, Arnold Caplan
Summary: White adipose tissues are crucial endocrine organs that release adipokines, affecting other major organ systems. The development and functions of adipose tissues rely heavily on the glycosaminoglycan heparan sulfate, which regulates cellular physiology and communication. Understanding the role of heparan sulfates in the regulation of adipokine production and release could provide valuable insights into tissue engineering and experimental studies.
Article
Pharmacology & Pharmacy
Sarra Mohammed Attia, Sandra Concepcion Das, Kavitha Varadharajan, Hamda A. Al-Naemi
Summary: This study investigates the effect of low-dose chronic Cd exposure on genes involved in adipose tissue (AT) functions. The results show that Cd accumulates in different adipose depots, and chronic exposure to low Cd doses leads to downregulation of adiponectin and leptin gene expression levels. SUB-AT shows the most significant response to Cd exposure, indicating different responses based on the location of AT depots.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Luzhou Wang, Heba Zabri, Simone Gorressen, Dominik Semmler, Christian Hundhausen, Jens W. Fischer, Katharina Bottermann
Summary: The incidence of heart failure after a heart attack is high, and the underlying causes are not fully understood. This study investigates the interaction between the heart and adipose tissue and the activation of lipolysis as a potential driver of heart failure. Using a mouse model, the researchers found that in subcutaneous adipose tissue, the size of adipocytes gradually decreased after reperfusion, indicating conversion to a different phenotype. They also observed decreased lipogenesis and increased infiltration of macrophages. The study suggests that targeted interference with lipolysis in subcutaneous adipose tissue may be a promising approach to promote cardiac healing after ischemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medical Laboratory Technology
Juan Reyes-Barrera, Aida X. Medina-Urrutia, Esteban Jorge-Galarza, Horacio Osorio-Alonso, Abraham S. Arellano-Buendia, Gabriela Olvera-Mayorga, Nestor A. Sanchez-Ortiz, Margarita Torres-Tamayo, Armando R. Tovar Palacio, Ivan Torre-Villalvazo, Juan G. Juarez-Rojas
Summary: Results indicate that uric acid concentration is associated with dysfunctional adipose tissue. Despite the subjects being apparently healthy, the study demonstrates that uric acid is an early instigator of adipose tissue dysfunction.
CLINICA CHIMICA ACTA
(2022)
Review
Endocrinology & Metabolism
Yakun Ren, Hao Zhao, Chunyan Yin, Xi Lan, Litao Wu, Xiaojuan Du, Helen R. Griffiths, Dan Gao
Summary: Chronic low-grade inflammation in adipose tissue is a key characteristic of obesity and contributes to various metabolic disorders. This inflammation is regulated by adipokines, hepatokines, and myokines secreted from different organs, which play either pro-inflammatory or anti-inflammatory roles in adipose tissue inflammation. Understanding these organokines and their mechanisms could lead to potential therapeutic targets for obesity-induced inflammation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lorena Doretto-Silva, Marcelo Luis Steiner, Juliana Mora Veridiano, Giuliana Petri, Maria Claudia de Brito Luz, Bianca Neofiti-Papi, Bianca Bianco, Fernando Luiz Affonso Fonseca, Olga Maria Szymanski de Toledo, Cesar Eduardo Fernandes, Luciano de Melo Pompei
Summary: The high caloric diet group of mice showed greater weight gain in fat sites, while the DHEA + HFD group exhibited more insulin intolerance; DHEA affects adipose tissue growth.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Immunology
John R. Koethe, Carlee Moser, Todd T. Brown, James H. Stein, Theodoros Kelesidis, Michael Dube, Judith Currier, Grace A. McComsey
Summary: In persons with HIV initiating antiretroviral therapy, higher circulating leptin levels are associated with increased insulin resistance and systemic inflammation, independent of fat depot size. This suggests that adipocyte lipid content may contribute to impaired glucose tolerance and systemic inflammation in this population. Serum leptin level is a stronger determinant of insulin resistance and systemic inflammation compared to measurements of regional adiposity.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Endocrinology & Metabolism
Kristy A. Brown, Philipp E. Scherer
Summary: Adipose tissue, as the largest endocrine organ, has been strongly linked to cancer development due to the metabolic dysfunction and insulin resistance caused by increased adiposity. Adipose tissue also directly impacts the development and progression of specific cancers, such as breast cancer. Changes in factor secretion and adipose tissue remodeling contribute to the obesity-cancer link. Additionally, adipose tissue provides essential nutrients for tumor cells through increased lipolysis and aerobic glycolysis. This article aims to provide an update on the role of adipose tissue in cancer initiation and progression.
Article
Nutrition & Dietetics
Katrin Schmitz, Eva-Maria Turnwald, Tobias Kretschmer, Ruth Janoschek, Inga Bae-Gartz, Kathrin Vossbrecher, Merlin D. Kammerer, Angela Koeninger, Alexandra Gellhaus, Marion Handwerk, Maria Wohlfarth, Dirk Gruendemann, Eva Hucklenbruch-Rother, Joerg Doetsch, Sarah Appel
Summary: With the increasing prevalence of obesity, the risks associated with pregnancy are also rising. Inflammation and oxidative stress are identified as key mechanisms in white adipose tissue (WAT) that contribute to obesity-associated complications and diseases. The anti-diabetic drug metformin has known systemic effects, but its effects on WAT are not well understood. This study investigated the effects of metformin treatment during pregnancy using a mouse model of diet-induced maternal obesity. The results showed that metformin treatment reduced weight gain and visceral fat accumulation, and regulated several potential adipokines to mediate anti-diabetic, anti-inflammatory, and oxidative stress-modulating effects.
Review
Medical Laboratory Technology
Xuan Xiao, Yi-Zhang Liu, Zhe-Bin Cheng, Jia-Xiang Sun, Yi-Duo Shao, Shun-Lin Qu, Liang Huang, Chi Zhang
Summary: Adipokines, as important endocrine factors, play crucial roles in regulating glycolipid metabolism and inflammatory response. They can connect obesity with cardiovascular diseases by promoting vascular calcification. Chronic hypoxia caused by adipocyte hypertrophy leads to imbalanced adipokine generation, contributing to the occurrence of vascular calcification.
CLINICA CHIMICA ACTA
(2021)
Review
Oncology
Pawel Dec, Agata Poniewierska-Baran, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Adipocytes in visceral adipose tissue release omentin-1, which is associated with type 2 diabetes and plays a role in the development and progression of various cancers. Omentin-1 functions as an anti-inflammatory and pro-apoptotic adipokine, regulating glucose and fat metabolism. Understanding the effects of omentin-1 on carcinogenesis is important in exploring new therapeutic strategies.
Review
Immunology
Jorge Correale, Mariano Marrodan
Summary: This paper explores the relationship between Multiple Sclerosis (MS) and obesity, as well as the potential underlying biological mechanisms shared by both conditions. The paper highlights the role of adipokines, a family of soluble factors produced by adipose tissue, in both obesity and MS, suggesting their involvement as immune response mediators. The findings of this study are significant for further understanding and treating MS and obesity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Anna Stochmal, Anna Waskiel-Burnat, Sylwia Chrostowska, Michal Zaremba, Adriana Rakowska, Joanna Czuwara, Lidia Rudnicka
Summary: The study found significantly lower concentrations of adiponectin and resistin in patients with alopecia areata compared to healthy controls, with a negative correlation between adiponectin levels and hair loss severity. Adiponectin concentrations were significantly lower in patients with alopecia universalis than in those with patchy alopecia areata. The results suggest that adiponectin may serve as a marker of hair loss severity in patients with alopecia areata.
SCIENTIFIC REPORTS
(2021)
Article
Peripheral Vascular Disease
Mustafa Celik, Rukiye Nar, Gokay Nar, Erdogan Sokmen, Guven Gunver
Summary: Omentin-1, a glucoprotein with anti-inflammatory effects, is associated with various diseases. Research shows that circulating Omentin-1 levels are significantly lower in patients with hypertension compared to healthy normotensive controls.
JOURNAL OF HUMAN HYPERTENSION
(2021)
Review
Medicine, General & Internal
Nadro Biborka, Sztanek Ferenc, Lorincz Hajnalka, Pall Denes, Paragh Gyorgy, Harangi Mariann
Review
Endocrinology & Metabolism
Eszter Berta, Inez Lengyel, Sandor Halmi, Miklos Zrinyi, Annemaria Erdei, Mariann Harangi, Denes Pall, Endre Nagy, Miklos Bodor
FRONTIERS IN ENDOCRINOLOGY
(2019)
Review
Medicine, General & Internal
Sztanek Ferenc, Jebelovszki Eva, Gaszner Balazs, Zrinyi Miklos, Pall Denes, Kempler Peter, Harangi Mariann
Article
Genetics & Heredity
Laszlo Madar, Lilla Juhasz, Zsuzsanna Szucs, Lorant Kerkovits, Mariann Harangi, Istvan Balogh
Summary: This study presents the clinical and molecular data of 44 unrelated individuals with suspected familial hypercholesterolemia (FH) in Hungary. Variants in LDLR and APOB genes were found to be the most common, with the c.10580G>A p.(Arg3527Gln) alteration in APOB gene being the most frequent. Several missense variants in the LDLR gene were detected in multiple index patients. The LDLR variants in the Hungarian population largely overlap with those detected in neighboring countries.
Article
Biochemistry & Molecular Biology
Imre Juhasz, Szilvia Ujfalusi, Ildiko Seres, Hajnalka Lorincz, Viktoria Evelin Varga, Gyoergy Paragh, Sandor Somodi, Mariann Harangi, Gyoergy Paragh
Summary: This study found that in non-diabetic, obese patients, Afamin levels were significantly higher and correlated with markers of metabolic syndrome. After multiple regression analysis, HbA1c levels and small HDL subfractions were identified as independent predictors of Afamin.
Review
Medicine, General & Internal
Beata Kovacs, Orsolya Cseprekal, Agnes Dioszegi, Szabolcs Lengyel, Laszlo Maroda, Gyorgy Paragh, Mariann Harangi, Denes Pall
Summary: Cardiovascular diseases, mainly caused by atherosclerosis, are the leading cause of mortality worldwide. Patients with familial hypercholesterolemia are at a high cardiovascular risk, and non-invasive measurement of arterial stiffness can be used to screen for vascular dysfunction in this genetic disorder. Statin treatment has a beneficial effect on arterial stiffness in these patients. If conventional drug therapy fails, PCSK9 inhibitor therapy or selective LDL apheresis can be considered.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Biborka Nadro, Hajnalka Lorincz, Lilla Juhasz, Anita Szentpeteri, Ferenc Sztanek, Eva Varga, Denes Pall, Gyorgy Paragh, Mariann Harangi
Summary: This study found significant correlations between PGRN concentrations and triglyceride, inflammatory markers, sVCAM-1, and HDL subfractions in patients with FH. Furthermore, PGRN may exert its anti-atherogenic effect by altering HDL composition and improving inflammation.
Review
Genetics & Heredity
Eszter Berta, Noemi Zsiros, Miklos Bodor, Istvan Balogh, Hajnalka Lorincz, Gyorgy Paragh, Mariann Harangi
Summary: Familial hypercholesterolemia (FH) is a common monogenic metabolic disorder with wide phenotypic heterogeneity, posing challenges in cardiovascular risk prediction and therapeutic strategy determination. Beyond lifetime low-density lipoprotein cholesterol (LDL-C) accumulation, other genetic and non-genetic risk factors may exacerbate the development of the disease. This review summarizes the most important genetic and non-genetic factors that might affect the risk prediction and therapeutic strategy in FH, emphasizing the need for an interdisciplinary approach in finding the best treatment methods.
Article
Medicine, General & Internal
Akos Nemeth, Mariann Harangi, Balint Daroczy, Lilla Juhasz, Gyorgy Paragh, Peter Fulop
Summary: This study aimed to assess the prevalence of familial chylomicronemia syndrome (FCS) in Central Europe and evaluate the diagnostic applicability of the FCS score. Through the analysis of medical records and machine learning models, it was found that FCS has a higher prevalence in the region, and additional features can improve the accuracy of the FCS score calculation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lilla Juhasz, Hajnalka Lorincz, Anita Szentpeteri, Biborka Nadro, Eva Varga, Gyorgy Paragh, Mariann Harangi
Summary: In untreated patients with HeFH, elevated levels of serum S1P and ApoM showed correlations with HDL subfractions and inflammatory markers, suggesting their possible role in endothelial protection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Balazs Ratku, Sara Csiha, Ildiko Seres, Zoltan Szabo, Gyorgy Paragh, Mariann Harangi, Sandor Somodi
Summary: Altered organokine expression contributes to increased cardiometabolic risk in obesity. This study aimed to evaluate the associations of serum afamin with glucose homeostasis, atherogenic dyslipidemia, and other adipokines in severe obesity to clarify the early metabolic alterations. The results showed that afamin and PAI-1 were significantly higher in obese subjects compared to controls, while RBP4 was unexpectedly lower. Afamin was negatively correlated with mean LDL size and RBP4, but positively correlated with anthropometric, glucose/lipid parameters, and PAI-1. BMI, glucose, intermediate HDL, and small HDL were predictors of afamin. This suggests that afamin may serve as a biomarker for the severity of cardiometabolic disturbances in obesity and draws attention to the diverse spectrum of obesity-related comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lilla Juhasz, Hajnalka Lorincz, Anita Szentpeteri, Nora Toth, Eva Varga, Gyorgy Paragh, Mariann Harangi
Summary: This study found that serum SDF-1 levels were significantly lower in HeFH patients compared to healthy controls, and showed correlations with lipid fractions and subfractions, highlighting potential common pathways of SDF-1 and lipoprotein metabolism and supporting its role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Beata Kovacs, Akos Nemeth, Balint Daroczy, Zsolt Karanyi, Laszlo Maroda, Agnes Dioszegi, Mariann Harangi, Denes Pall
Summary: Cardiovascular diseases are a leading cause of death worldwide, and hypertension is a preventable risk factor for major cardiovascular events. A comprehensive study was conducted to investigate the complex metabolic status of hypertensive patients in Central and Eastern Europe. The study found a prevalence of hypertension of 32.2%, similar to international findings, and highlighted the extensive association of metabolic abnormalities. Early recognition and immediate treatment of cardiometabolic abnormalities are crucial for improving the quality of life and life expectancy of hypertensive patients.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Hajnalka Lorincz, Sara Csiha, Balazs Ratku, Sandor Somodi, Ferenc Sztanek, Ildiko Seres, Gyorgy Paragh, Mariann Harangi
Summary: This study investigates the association between betatrophin and lipoprotein subfractions. The results show that betatrophin concentrations are significantly higher in obese patients with type 2 diabetes (T2D) and nondiabetic obese (NDO) subjects compared to healthy controls, particularly in females. The findings highlight the importance of measuring serum betatrophin for cardiovascular risk assessment in obese patients, with consideration of gender differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Lilla Juhasz, Istvan Balogh, Laszlo Madar, Beata Kovacs, Mariann Harangi
CUREUS JOURNAL OF MEDICAL SCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)