Elucidation of the Molecular Mechanisms Underlying Sorafenib-Induced Hepatotoxicity

Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy

(2019) Shuang Qin et al.   Journal of Hematology & Oncology

Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma Is Reversed by SIRT1

(2019) Antje Garten et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway

(2019) Hao Yan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities

(2019) Wafa A. AL-Megrin et al.   Antioxidants

Live cell imaging of cytosolic NADH/NAD+ ratio in hepatocytes and liver slices

(2018) Ricard Masia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Metabolomics of Hydrazine-Induced Hepatotoxicity in Rats for Discovering Potential Biomarkers

(2018) Zhuoling An et al.   DISEASE MARKERS

Receptor tyrosine kinases and downstream pathways as druggable targets for cancer treatment: the current arsenal of inhibitors

(2018) Wagner Ricardo Montor et al.   Molecular Cancer

Mechanisms of mitochondrial toxicity of the kinase inhibitors ponatinib, regorafenib and sorafenib in human hepatic HepG2 cells

(2018) Franziska Paech et al.   TOXICOLOGY

Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

(2018) Bee Ling Tan et al.   Frontiers in Pharmacology

Synergistic anti-tumor efficacy of sorafenib and fluvastatin in hepatocellular carcinoma

(2017) Yang Cheng et al.   Oncotarget

Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria

(2016) Jun Zhang et al.   ARCHIVES OF TOXICOLOGY

Molecular mechanisms of ROS production and oxidative stress in diabetes

(2016) P. Newsholme et al.   BIOCHEMICAL JOURNAL

(Secondary) solid tumors in thyroid cancer patients treated with the multi-kinase inhibitor sorafenib may present diagnostic challenges

(2016) Tatiana C. Schneider et al.   BMC CANCER

Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model

(2016) Mohammad Raish et al.   BMC Complementary and Alternative Medicine

Survival and cost-effectiveness of sorafenib therapy in advanced hepatocellular carcinoma: An analysis of the SEER-Medicare database

(2016) Neehar D. Parikh et al.   HEPATOLOGY

Selective use of sorafenib in the treatment of thyroid cancer

(2016) Fabián Pitoia et al.   Drug Design Development and Therapy

The Adverse Effects of Sorafenib in Patients with Advanced Cancers

(2015) Ye Li et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Nuclear factor kappa B-mediated CD47 up-regulation promotes sorafenib resistance and its blockade synergizes the effect of sorafenib in hepatocellular carcinoma in mice

(2015) Jessica Lo et al.   HEPATOLOGY

Albumin in chronic liver disease: structure, functions and therapeutic implications

(2015) Rosaria Spinella et al.   Hepatology International

Targeting RTK Signaling Pathways in Cancer

(2015) Tarik Regad   Cancers

ROS-mediated JNK/p38-MAPK activation regulates Bax translocation in Sorafenib-induced apoptosis of EBV-transformed B cells

(2014) GA BIN PARK et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Alleviation of hepatic injury by chrysin in cisplatin administered rats: Probable role of oxidative and inflammatory markers

(2014) Muneeb U. Rehman et al.   Pharmacological Reports

Sorafenib delays recurrence and metastasis after liver transplantation in a rat model of hepatocellular carcinoma with high expression of phosphorylated extracellular signal-regulated kinase

(2013) Jun Yan et al.   LIVER TRANSPLANTATION

Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis

(2013) Nemat Ali et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sorafenib-Induced Hepatocellular Carcinoma Cell Death Depends on Reactive Oxygen Species Production In Vitro and In Vivo

(2012) R. Coriat et al.   MOLECULAR CANCER THERAPEUTICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats

(2012) Summya Rashid et al.   TOXICOLOGY MECHANISMS AND METHODS

Sorafenib induces preferential apoptotic killing of a drug- and radio-resistant hep G2 cells through a mitochondria-dependent oxidative stress mechanism

(2010) Jeng-Fong Chiou et al.   CANCER BIOLOGY & THERAPY

Sorafenib – a small molecule with big promise?

(2010) Tamar Tadmor et al.   LEUKEMIA & LYMPHOMA

Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways

(2009) Y. O. Ilbey et al.   HUMAN REPRODUCTION

Efficacy of Sunitinib and Sorafenib in Non–Clear Cell Renal Cell Carcinoma: Results From Expanded Access Studies

(2008) Dirk Strumberg   JOURNAL OF CLINICAL ONCOLOGY

Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling

(2008) Scott M. Wilhelm et al.   MOLECULAR CANCER THERAPEUTICS

Selection of agents for prevention of cisplatin-induced hepatotoxicity

(2008) Yingjun Liao et al.   PHARMACOLOGICAL RESEARCH

Alpha-lipoic acid inhibits TNF-α induced NF-κB activation through blocking of MEKK1–MKK4–IKK signaling cascades

(2007) Chang-Keun Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY