Review
Clinical Neurology
Vera Ong, Ashley B. Zhang, Bayard Wilson, Nolan J. Brown, Brian V. Lien, Shane Shahrestani, Isaac Yang
Summary: This study provides a bibliometric analysis of hearing preservation in treating vestibular schwannomas, revealing a lack of prospective studies and novel treatment options in the current literature.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Zane Schnurman, Jason Gurewitz, Eric Smouha, Sean O. McMenomey, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: Through propensity score matching, this study found no significant difference in the loss of class A or serviceable hearing between patients managed with SRS or observation alone when controlling for potential confounders.
Review
Clinical Neurology
Amey R. Savardekar, Danielle Terrell, Saudamini J. Lele, Ryan Diaz, Praneeth Reddy Keesari, Krystle Trosclair, Jennifer Kosty, Chiachien Jake Wang, Gale Gardner, Bharat Guthikonda
Summary: A meta-analysis comparing the outcomes of sporadic vestibular schwannoma patients treated with stereotactic radiosurgery (SRS) or microsurgery (MS) revealed comparable results in hearing preservation and tumor control, but a higher occurrence of facial nerve dysfunction in the microsurgery group.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Assaf Berger, Juan Diego Alzate, Kenneth Bernstein, Reed Mullen, Sean McMenomey, Daniel Jethanemest, David R. Friedmann, Eric Smouha, Erik P. Sulman, Joshua S. Silverman, J. Thomas Roland, John G. Golfinos, Douglas Kondziolka
Summary: This study evaluates hearing outcomes in patients with vestibular schwannoma (VS) during the modern era of cochlear dose restriction. The results show that factors such as age, baseline GR score, cochlear dose, and biological effective dose are correlated with hearing preservation. Increased tumor-free canal space is associated with better outcomes. Furthermore, patients who meet specific criteria have higher hearing preservation rates compared to the rest of the population.
Article
Otorhinolaryngology
Cynthia M. Chweya, Nicole M. Tombers, Christine M. Lohse, Michael J. Link, Matthew L. Carlson
Summary: This study examines the impact of treatment on disease-specific health-related quality of life among patients with sporadic vestibular schwannoma. The findings suggest that differences in HRQOL among treatment modalities are small and may be less significant compared to the impact of the VS diagnosis itself.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Clinical Neurology
Max Whitmeyer, Bledi C. Brahimaj, Andre Beer-Furlan, Sameer Alvi, Madeline J. Epsten, Fred Crawford, Richard W. Byrne, R. Mark Wiet
Summary: This study focused on evaluating the outcomes of salvage microsurgery (MS) after stereotactic radiosurgery (SRS) for vestibular schwannomas (VS) based on a review of 20 studies and 300 cases. The primary indication for salvage surgery was tumor growth after an average of 39.4 months post-radiation. The study found no significant differences in outcomes based on surgical approach, but patients who underwent subtotal resection (STR) showed better House-Brackmann outcomes compared to those who had gross-total resection (GTR).
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Elie Massaad, Nima Hamidi, Jacalynn Goetz, Varun Padmanaban, Christine Mau, Derek Tsang, Fabio Y. de Moraes, Caroline Chung, Brad E. Zacharia, Alireza Mansouri
Summary: The evidence collected demonstrates that radiosurgery for cystic vestibular schwannomas exhibits effective tumor control probabilities similar to solid counterparts. It is necessary to establish consensus definitions and standard criteria in the future to better understand tumor growth patterns, treatment response, as well as long-term neurological and functional outcomes following radiosurgery for cystic vestibular schwannomas.
WORLD NEUROSURGERY
(2021)
Article
Otorhinolaryngology
Yin Ren, Kareem O. Tawfik, Bill J. Mastrodimos, Roberto A. Cueva
Summary: Radiographic predictors such as tumor size and extension relative to the internal auditory canal play a significant role in hearing preservation after retrosigmoid resection of vestibular schwannomas. Patients with small intracanalicular tumors and good preoperative hearing have the highest rates of hearing preservation, while tumors extending into the cerebellopontine angle may have worse outcomes if they have greater posterior and caudal extension relative to the internal auditory canal.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Oncology
Junhyung Kim, Yukyeng Byeon, Sang Woo Song, Young Hyun Cho, Chang-Ki Hong, Seok Ho Hong, Jeong Hoon Kim, Do Heui Lee, Ji Eun Park, Ho Sung Kim, Young-Hoon Kim
Summary: SRS treatment can adequately control progressive NF2-associated VS, but the short-term effects of this treatment are not highly advantageous in terms of preserving hearing function.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Selcuk Peker, Yavuz Samanci, Inan Erdem Ozdemir, Henricus P. M. Kunst, Danielle B. P. Eekers, Yasin Temel
Summary: The study evaluated the efficacy and safety of upfront Gamma Knife radiosurgery for large cystic vestibular schwannomas. The results suggest that upfront Gamma Knife radiosurgery appears to be a safe and effective treatment option for large cystic vestibular schwannomas, with tumor control rates varying over time and most patients experiencing tumor shrinkage.
NEUROSURGICAL REVIEW
(2022)
Article
Clinical Neurology
Nickalus R. Khan, Turki Elarjani, Aria M. Jamshidi, Stephanie H. Chen, Clifford S. Brown, Josh Abecassis, Michael A. Silva, Victor M. Lu, Eva Wu, Monica Diaz-Kanelidis, Rita Bhatia, Michael E. Hoffer, Adrien A. Eshraghi, Christine T. Dinh, Simon I. Angeli, Fred F. Telischi, Jacques J. Morcos
Summary: This study retrospectively evaluated the clinical and surgical outcomes of a large surgical series of vestibular schwannoma in North America over 20 years. The study found that facial nerve outcomes were correlated with cerebellopontine angle extension, tumor volume, facial nerve stimulation threshold, facial nerve consistency, preoperative facial nerve function, and history of a prior resection. The data supports a continuation of a strategy of gross total resection, modifiable by intraoperative findings and judgment.
WORLD NEUROSURGERY
(2022)
Article
Medicine, Research & Experimental
Christian Scheller, Christian Strauss, Sandra Leisz, Pia Hanel, Ariane Klemm, Simone Kowoll, Iris Boselt, Torsten Rahne, Andreas Wienke
Summary: The study investigated the efficacy and safety of prophylactic nimodipine treatment for hearing preservation in vestibular schwannoma surgery, with potential positive effects on hearing and potential recommendation for routine medication in the future.
Article
Otorhinolaryngology
Emily Kay-Rivest, John G. Golfinos, Sean O. McMenomey, David R. Friedmann, Daniel Jethanamest, Douglas Kondziolka, J. Thomas Roland
Summary: Salvage microsurgery (MS) and salvage stereotactic radiosurgery (SRS) are effective treatment options for vestibular schwannomas (VS) after primary treatment failure. The choice of treatment strategy should be tailored to individual patient's condition to ensure optimal outcomes and facial nerve function preservation.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Medicine, Research & Experimental
Douglas M. M. Hildrew, Philip L. L. Perez, Leila J. J. Mady, Jinhong Li, Marci L. L. Nilsen, Barry E. E. Hirsch
Summary: The objective of this study was to determine tumor control rates and hearing outcomes for treating growing vestibular schwannoma (VS) with CyberKnife stereotactic radiosurgery (CK SRS) and propose a predictive model for hearing outcomes. A retrospective case series review was conducted on 127 patients who received CK SRS for growing VS. The tumor control rate was 94.5% and hearing preservation was achieved in a third of patients. The final predictive model included variables such as age, fundal cap distance (FCD), tumor volume, and maximum radiation dose to the cochlea.
Review
Clinical Neurology
Vinod Kumar Yakkala, Marco Mammi, Nayan Lamba, Renuka Kandikatla, Bhaskar Paliwal, Hoda Elshibiny, C. Eduardo Corrales, Timothy R. Smith, Rania A. Mekary
Summary: Both surgery and stereotactic radiosurgery (SRS) have similar effects on hearing loss, dizziness, and tinnitus in the treatment of vestibular schwannoma. However, there is a higher risk of facial symmetry loss after surgery.
ACTA NEUROCHIRURGICA
(2022)