Article
Orthopedics
H. S. Hwang, I. Y. Park, J. I. Hong, J. R. Kim, H. A. Kim
Summary: This study found that joint damage develops similarly in both male and female mice after DMM, but the damage progresses less in females. There were subtle sex differences in pain behaviors and the analgesic efficacy of a TRPV1 antagonist, accompanied by a differential regulation of TPRV1.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Rheumatology
Ricardo Grieshaber-Bouyer, Tarik Exner, Nicolaj S. Hackert, Felix A. Radtke, Scott A. Jelinsky, Olha Halyabar, Alexandra Wactor, Elham Karimizadeh, Joseph Brennan, Jorge Schettini, Helena Jonsson, Deepak A. Rao, Lauren A. Henderson, Carsten Muller-Tidow, Hanns-Martin Lorenz, Guido Wabnitz, James A. Lederer, Angela Hadjipanayis, Peter A. Nigrovic
Summary: Neutrophils in the blood of healthy individuals and patients with arthritis have similar transcriptional signatures, but those in synovial fluid exhibit significant differences, involving over 1600 differentially expressed genes. The gene signatures indicate a strong response to interferon gamma (IFN-gamma), as well as to tumor necrosis factor, interleukin-6, and hypoxia. Mass cytometry analysis confirmed that healthy and arthritic blood neutrophils are similar, but synovial fluid neutrophils show unique protein expression related to various factors such as CXCR1, Fc gamma RI, HLA-DR, PD-L1, ICAM-1, and CXCR4.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Nanoscience & Nanotechnology
Wei Wei, Yuanzhu Ma, Xianzhu Zhang, Wenyan Zhou, Hongwei Wu, Jingwei Zhang, Junxin Lin, Chenqi Tang, Youguo Liao, Chenglin Li, Xiaozhao Wang, Xudong Yao, Yi Wen Koh, Wenwen Huang, Hongwei Ouyang
Summary: A biomimetic joint paint was designed for repairing intractable partial-thickness cartilage defects, showing restoration of smooth cartilage surface and preservation of normal glycosaminoglycan content in rabbit and pig models. The treatment functions by prohibiting chondrocyte apoptosis, maintaining chondrocyte phenotype, and preserving glycosaminoglycan content in the defects, illustrating its effectiveness as a revolutionary therapeutics for noncurable partial-thickness cartilage defects.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Kai Zhou, Chengli Yang, Kun Shi, Yue Liu, Danrong Hu, Xinlong He, Yun Yang, Bingyang Chu, Jinrong Peng, Zongke Zhou, Zhiyong Qian
Summary: This study demonstrates that repolarizing macrophages can reduce inflammation in osteoarthritis, providing a promising therapeutic strategy.
Article
Immunology
Kristina Zec, Barbora Schonfeldova, Zhichao Ai, Erinke Van Grinsven, Gabriela Pirgova, Hayley L. Eames, Dorothee L. Berthold, Moustafa Attar, Ewoud B. Compeer, Tal I. Arnon, Irina A. Udalova
Summary: Using the AIA model, Zec et al. demonstrate that synovial lining macrophages are activated by IRF5 and secrete CXCL1 upon antigen recognition, leading to preferential recruitment of neutrophils in the synovial lining niche at the onset of inflammation. This study utilizes advanced microscopy techniques to reveal that synovial inflammation is initiated by the activation of lining macrophages, challenging the previously held view of these cells as immunosuppressive. The findings highlight the importance of synovial macrophages in instigating synovial inflammation and recruiting immune cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Natalie K. Yoshioka, Gregory M. Young, Deepak Kumar Khajuria, Vengadeshprabhu Karuppagounder, William J. Pinamont, Julie C. Fanburg-Smith, Thomas Abraham, Reyad A. Elbarbary, Fadia Kamal
Summary: This study investigated the changes in collagen fibers in osteoarthritis using a mouse model. The researchers found that the thickness and formation of collagen fibers were altered in the articular cartilage, subchondral bone, and menisci of mice with osteoarthritis. They also observed changes in the expression of collagen I and II in these tissues. These findings provide a comprehensive understanding of the microarchitectural changes in the extracellular matrix during osteoarthritis and can guide future studies on therapies targeting collagen changes to halt the progression of the disease.
SCIENTIFIC REPORTS
(2022)
Review
Biotechnology & Applied Microbiology
Zhong Alan Li, Shilpa Sant, Sung Kwon Cho, Stuart B. Goodman, Bruce A. Bunnell, Rocky S. Tuan, Michael S. Gold, Hang Lin
Summary: Synovial joint disorders like osteoarthritis and rheumatoid arthritis are common worldwide, but current clinical management does not fully restore joint function. Organ-on-chip (OoC) technology, which can culture multiple human cell-derived tissues/organs, shows potential in developing better therapies for joint diseases.
TRENDS IN BIOTECHNOLOGY
(2023)
Article
Polymer Science
Mahmoud Amr, Alia Mallah, Samina Yasmeen, Bernard Van Wie, Arda Gozen, Juana Mendenhall, Nehal I. Abu-Lail
Summary: This study examines the efficacy of a biocompatible hydrogel-based scaffold (SA-GEL-GA) in supporting the proliferation, extracellular matrix (ECM) production, and pericellular matrix (PCM) production of bovine articular chondrocytes (bAChs). The results demonstrate that SA-GEL-GA is not cytotoxic, promotes cellular proliferation, and supports ECM and PCM deposition by bAChs.
Review
Engineering, Biomedical
Xiao Xu, Limei Xu, Jiang Xia, Caining Wen, Yujie Liang, Yuanmin Zhang
Summary: Osteoarthritis (OA) is a common disease characterized by cartilage degeneration in middle-aged and elderly people. Currently, there is no effective treatment for OA apart from total joint replacement in advanced stages. Mesenchymal stem cells (MSCs) have shown great potential in regulating the cartilage microenvironment, promoting cartilage regeneration, and alleviating OA symptoms, making them a promising source of cells for OA therapy.
ACTA BIOMATERIALIA
(2023)
Article
Medicine, Research & Experimental
Akshay Vyawahare, Md. Meraj Ansari, Ajay Kumar, Anas Ahmad, Rakesh Kumar Mishra, Chandrashekhar Jori, Ahmed Nadeem, Nahid Siddiqui, Syed Shadab Raza, Rehan Khan
Summary: The study demonstrates that the dual enzyme targeted chlorotoxin conjugated nanomicelles loaded with sivelestat have shown promising results in the treatment of rheumatoid arthritis. The nanomicelles exhibit good drug loading efficiency, cytocompatibility, and potential chondroprotection in in-vivo studies. The inhibition of pro-inflammatory enzymes and mediators of synovial inflammation by the nanomicelles suggests a strong potential for improved treatment and management of RA.
Review
Rheumatology
I Gessl, P. Balint, E. Filippucci, H. Keen, C. Pineda, L. Terslev, B. Wildner, M. A. D'Agostino, P. Mandl
Summary: The systematic literature review identified 149 articles on musculoskeletal ultrasound in assessing structural joint damage in patients with RA. Most studies reported on cross-sectional studies and used OMERACT definitions for ultrasonographic pathology. The results suggest that ultrasound is a sensitive, reliable tool for detecting damage in RA patients, but further research and validation are needed.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Biochemistry & Molecular Biology
Magdalena K. Kaneva, Milind M. Muley, Eugene Krustev, Allison R. Reid, Patricia R. Souza, Francesco Dell'Accio, Jason J. McDougall, Mauro Perretti
Summary: The study demonstrates that AAT possesses anti-inflammatory, analgesic, and chondroprotective properties, reversing joint inflammation and cartilage degradation, promoting the transcription of cartilage-related genes, enhancing chondrogenic differentiation, and acting through CREB signaling pathway and inhibition of Wnt/beta-catenin pathways.
Article
Orthopedics
Daniel Muder, Torbjorn Vedung
Summary: The study investigated the effectiveness of reconstruction of the DRUJ joint with rib perichondrium transplantation, showing significant decrease in pain levels at clinical follow-up, increased range of forearm rotation, and gradual restoration of grip strength to 97% of the contralateral hand. A follow-up survey conducted 7.5 years later showed that ROM and grip strength remained unchanged, with no additional surgeries or complications reported.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Ula von Mentzer, Carmen Corciulo, Alexandra Stubelius
Summary: Articular joint defects are becoming more prevalent due to rising obesity rates and an aging population. Joint replacement is often the last resort for patients with cartilage erosion, and researchers are exploring novel strategies to promote regeneration and healing. The use of decellularized extracellular matrix (dECM) biomaterials shows promise in reducing foreign body responses and enhancing tissue regeneration.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Rheumatology
Edoardo Cipolletta, Peter Mandl, Andrea Di Matteo, Riccardo Mashadi Mirza, Giancarlo Passarini, Walter Grassi, Emilio Filippucci
Summary: This study aimed to validate the OMERACT semi-quantitative score in the assessment of hyaline cartilage at the metacarpal head in patients with rheumatoid arthritis and healthy controls, by comparing it with a quantitative method. The OMERACT semi-quantitative score was found to be quicker to perform than the quantitative method and showed significant correlation with radiographic joint space narrowing score.
Article
Rheumatology
Jamie Soul, Matthew J. Barter, Christopher B. Little, David A. Young
Summary: The study identified 459 genes modulated in animal models of OA, with ageing and post-traumatic models being the most prominent. Ninety-eight of the 143 genes genetically modulated more than once had a consistent effect on OA joint damage severity. By expanding existing annotations and prioritising promising therapeutic targets, the study validated the associations using the latest reported data.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Orthopedics
Gregory Cunningham, Cristina Cocor, Margaret M. Smith, Allan A. Young, Benjamin Cass, Beat K. Moor
Summary: This study reveals the correlation between bone morphology markers GTA and CSA in patients with degenerative rotator cuff tears. The study found that GTA and CSA are independent radiological markers that can reliably predict the presence of degenerative rotator cuff tears. In addition, these markers are not correlated with patient demographic or environmental factors, suggesting that they may be individual risk factors for rotator cuff tear.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Review
Orthopedics
S. Zaki, C. L. Blaker, C. B. Little
Summary: Osteoarthritis is a disease with diverse phenotypes, and the selection and use of animal models in research should align with patient sub-types. This review discusses the importance of selecting animal models based on study objectives, alignment with sub-types, and available resources. It also proposes an experimental design checklist for choosing the optimal model.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Education, Scientific Disciplines
Jaime Gongora, Ingrid van Gelderen, Meg Vost, Sanaa Zaki, Stewart Sutherland, Matthew Pye, Anne Quain, Rosanne Taylor
Summary: Cultural competence is crucial in veterinary and research practice, as it can impact animal health, welfare, and research outcomes. The authors introduced a comprehensive curriculum framework in the University of Sydney veterinary program to cultivate cultural competence in students, achieving integration through aligned learning outcomes, teaching activities, and assessment.
JOURNAL OF VETERINARY MEDICAL EDUCATION
(2023)
Article
Orthopedics
P. Clement-Lacroix, C. B. Little, M. M. Smith, C. Cottereaux, D. Merciris, S. Meurisse, P. Mollat, R. Touitou, F. Brebion, R. Gosmini, F. De Ceuninck, I Botez, L. Lepescheux, E. van der Aar, T. Christophe, N. Vandervoort, R. Blanque, D. Comas, P. Deprez, D. Amantini
Summary: GLPG1972/S201086 is a potent, selective, and orally available ADAMTS5 inhibitor that demonstrates significant protective efficacy on both cartilage and subchondral bone in preclinical OA models.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Article
Orthopedics
S. Zaki, M. M. Smith, C. B. Little
Summary: The study aimed to determine whether osteoarthritis pain characteristics and mechanistic pathways in pre-clinical models are phenotype-specific. The results showed that pain and peripheral sensory neuronal responses in osteoarthritis are phenotype-specific with distinct pathology:pain-outcome:molecular-mechanism relationships.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Orthopedics
Y. Z. Lim, Y. Wang, M. Estee, J. Abidi, M. Udaya Kumar, S. M. Hussain, A. E. Wluka, C. B. Little, F. M. Cicuttini
Summary: Objective: This study systematically reviewed the potential disease-modifying effect of metformin in osteoarthritis based on evidence from pre-clinical and human studies. The results suggest that metformin has chondroprotective, immunomodulatory, and analgesic effects in osteoarthritis, supported by consistent findings in pre-clinical and human studies. Further high-quality clinical trials are needed to confirm these findings.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Editorial Material
Cell & Tissue Engineering
C. B. Little, S. Zaki, C. L. Blaker, E. C. Clarke
BONE & JOINT RESEARCH
(2022)
Article
Orthopedics
Dylan M. Ashton, Carina L. Blaker, Nicholas Hartnell, Patrick Haubruck, Samantha A. Hefferan, Christopher B. Little, Elizabeth C. Clarke
Summary: This study investigated the mechanical properties of a range of human lower leg tendons and their relationship with donor age, sex, and height. The results showed significant differences in mechanical properties among different tendons, with relatively small effects of donor characteristics limited to specific tendons. The findings challenge the exclusion of donors aged >65 years in all tendon grafts, as age only negatively affected the properties of the Achilles tendon (maximum load).
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Editorial Material
Orthopedics
C. B. Little
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Orthopedics
Patrick Haubruck, Raban Heller, Carina L. Blaker, Elizabeth C. Clarke, Susan M. Smith, Daniel Burkhardt, Yolanda Liu, Shihani Stoner, Sanaa Zaki, Cindy C. Shu, Christopher B. Little
Summary: A single slide for evaluating diverse histopathological changes in different joint tissues and disease stages can reduce scoring time and maintain sensitivity and specificity of the analysis.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Multidisciplinary Sciences
Jia Q. Ng, Toghrul H. Jafarov, Christopher B. Little, Tongtong Wang, Abdullah M. Ali, Yan Ma, Georgette A. Radford, Laura Vrbanac, Mari Ichinose, Samuel Whittle, David J. Hunter, Tamsin R. M. Lannagan, Nobumi Suzuki, Jarrad M. Goyne, Hiroki Kobayashi, Timothy C. Wang, David R. Haynes, Danijela Menicanin, Stan Gronthos, Daniel L. Worthley, Susan L. Woods, Siddhartha Mukherjee
Summary: Osteoarthritis is characterized by irreversible degeneration of articular cartilage. Gremlin 1 marks a bipotent cell population on the articular surface, which plays a crucial role in chondrogenic and osteogenic progenitor cells. These cells are affected by injury and aging, leading to the development of osteoarthritis.
NATURE COMMUNICATIONS
(2023)
Review
Engineering, Biomedical
Rouyan Chen, Jasmine Sarah Pye, Jiarong Li, Christopher B. Little, Jiao Jiao Li
Summary: Osteochondral defects result in damage to both articular cartilage and subchondral bone, leading to irreversible joint damage and a higher risk of osteoarthritis. Current treatments only address symptoms and are not curative, necessitating the development of tissue engineering solutions. Scaffold-based approaches, using biomaterials tailored to cartilage and bone properties, show promising results in regenerating osteochondral tissue and minimizing further degeneration.
BIOACTIVE MATERIALS
(2023)
