Journal
ORGANIC LETTERS
Volume 22, Issue 9, Pages 3551-3556Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c00984
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21772127, 21890723, 21921002]
Ask authors/readers for more resources
A highly efficient enantioselective synthesis of multisubstituted tetrahydrobenzofuran derivatives with four contiguous stereocenters was established by the dual catalysis of a gold(I)/chiral N,N'-dioxide-cobalt(II) complex via a tandem cycloisomerization/Diels-Alder reaction of 2-alkynyl-2-alkenones and electron-deficient olefins. This strategy was not only featured with atom economy, remarkable efficiency and stereoselectivity but also was highlighted by further transformations of the furan-based products into polycyclic molecules. Moreover, a possible transition-state model was proposed to elucidate the origin of stereoselectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available