Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability

Mortalin (HSPA9) facilitates BRAF-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability

(2020) Pui-Kei Wu et al.   Science Signaling

ATP Synthase C-Subunit-Deficient Mitochondria Have a Small Cyclosporine A-Sensitive Channel, but Lack the Permeability Transition Pore

(2019) Maria A. Neginskaya et al.   Cell Reports

Mortalin is a distinct bio-marker and prognostic factor in serous ovarian carcinoma

(2019) Ming Xu et al.   GENE

SPG7 targets the m-AAA protease complex to process MCU for uniporter assembly, Ca2+ influx, and regulation of mPTP opening

(2019) Stephen Hurst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Current for the Mitochondrial Permeability Transition

(2019) Massimo Bonora et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oncogenic Kras induces Nix-mediated mitophagy to promote pancreatic cancer

(2019) Timothy J Humpton et al.   Cancer Discovery

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth

(2019) Sarbajeet Nagdas et al.   Cell Reports

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

(2019) Jude Canon et al.   NATURE

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

A Convergence-Based Framework for Cancer Drug Resistance

(2018) David J. Konieczkowski et al.   CANCER CELL

A cellular threshold for active ERK1/2 levels determines Raf/MEK/ERK-mediated growth arrest versus death responses

(2018) Seung-Keun Hong et al.   CELLULAR SIGNALLING

Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein–Protein Interactions with Heat Shock Protein 70 (Hsp70)

(2018) Hao Shao et al.   JOURNAL OF MEDICINAL CHEMISTRY

ERK1/2 inhibitors: New weapons to inhibit the RAS-regulated RAF-MEK1/2-ERK1/2 pathway

(2018) Andrew M. Kidger et al.   PHARMACOLOGY & THERAPEUTICS

Mortalin expression in pancreatic cancer and its clinical and prognostic significance

(2017) Xuelian Cui et al.   HUMAN PATHOLOGY

Persistence of the mitochondrial permeability transition in the absence of subunit c of human ATP synthase

(2017) Jiuya He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mortalin overexpression predicts poor prognosis in early stage of non–small cell lung cancer

(2017) Jie Sun et al.   TUMOR BIOLOGY

Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis

(2016) Y. Na et al.   CANCER RESEARCH

Sp1 regulates Raf/MEK/ERK-induced p21CIP1 transcription in TP53-mutated cancer cells

(2015) Mansi Karkhanis et al.   CELLULAR SIGNALLING

p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells

(2015) J M Bailey et al.   ONCOGENE

Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer

(2014) Matthew J. Sale et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Mitochondrial ion channels as oncological targets

(2014) L Leanza et al.   ONCOGENE

Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells

(2014) D Starenki et al.   ONCOGENE

Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition

(2014) M Bonora et al.   ONCOGENE

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

(2013) Yoshinari Miyata et al.   ACS Chemical Neuroscience

Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF

(2013) Rizwan Haq et al.   CANCER CELL

Elevated levels of mitochondrial mortalin and cytosolic HSP70 in blood as risk factors in patients with colorectal cancer

(2013) Perri Rozenberg et al.   INTERNATIONAL JOURNAL OF CANCER

Mitochondria-Targeted Nitroxide, Mito-CP, Suppresses Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo

(2013) Dmytro Starenki et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Mortalin/HSPA9-Mediated Switch in Tumor-Suppressive Signaling of Raf/MEK/Extracellular Signal-Regulated Kinase

(2013) P.-K. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

(2013) Jonathan M. Ostrem et al.   NATURE

Nelfinavir Inhibits Intra-Mitochondrial Calcium Influx and Protects Brain against Hypoxic-Ischemic Injury in Neonatal Mice

(2013) Irina V. Utkina-Sosunova et al.   PLoS One

p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis

(2012) Angelina V. Vaseva et al.   CELL

Mortalin–p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy

(2011) W-J Lu et al.   CELL DEATH AND DIFFERENTIATION

Allosteric Drugs: The Interaction of Antitumor Compound MKT-077 with Human Hsp70 Chaperones

(2011) Aikaterini Rousaki et al.   JOURNAL OF MOLECULAR BIOLOGY

Adenine nucleotide translocase 2 is a key mitochondrial protein in cancer metabolism

(2010) Arnaud Chevrollier et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Noncatalytic Function of ERK1/2 Can Promote Raf/MEK/ERK-mediated Growth Arrest Signaling

(2009) Seung-Keun Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY