Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis

Calculus Bovis Sativus Improves Bile Acid Homeostasis via Farnesoid X Receptor-Mediated Signaling in Rats With Estrogen-Induced Cholestasis

(2019) Dong Xiang et al.   Frontiers in Pharmacology

FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury

(2019) Bo Kong et al.   DIGESTIVE AND LIVER DISEASE

Current Treatment of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis

(2018) Chun Kit Hung et al.   Clinics in Liver Disease

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

(2018) Phillipp Hartmann et al.   HEPATOLOGY

Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future

(2018) Ana Ruth Araújo et al.   LIVER INTERNATIONAL

Bile acid regulation: A novel therapeutic strategy in non-alcoholic fatty liver disease

(2018) Qinwei Yu et al.   PHARMACOLOGY & THERAPEUTICS

Yangonin protects against non-alcoholic fatty liver disease through farnesoid X receptor

(2018) Renchao Dong et al.   PHYTOMEDICINE

Comparison of the Effects and Inhibitory Pathways of the Constituents from Gynostemma pentaphyllum against LPS-Induced Inflammatory Response

(2018) Chun-Yan Shen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice

(2018) Ning Jia et al.   Nutrition & Metabolism

Geniposide and Chlorogenic Acid Combination Ameliorates Non-alcoholic Steatohepatitis Involving the Protection on the Gut Barrier Function in Mouse Induced by High-Fat Diet

(2018) Jing-hua Peng et al.   Frontiers in Pharmacology

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice

(2017) Vittoria Massafra et al.   GASTROENTEROLOGY

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD

(2017) Na Jiao et al.   GUT

Hepatic bile acid uptake in humans and mice: Multiple pathways and expanding potential role for gut-liver signaling

(2017) Paul A. Dawson   HEPATOLOGY

Gypenosides Reduced the Risk of Overweight and Insulin Resistance in C57BL/6J Mice through Modulating Adipose Thermogenesis and Gut Microbiota

(2017) Jie Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Further New Gypenosides from Jiaogulan (Gynostemma pentaphyllum)

(2017) Jun Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Serum bile acid level and fatty acid composition in Chinese children with non-alcoholic fatty liver disease

(2017) Li Ping Lu et al.   Journal of Digestive Diseases

Luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/JAK2/STAT3 pathway in cardiomyocytes

(2017) Huiyan Qu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Xyloketal B Attenuates Fatty Acid-Induced Lipid Accumulation via the SREBP-1c Pathway in NAFLD Models

(2017) Youying Zhang et al.   Marine Drugs

Altenusin, a Nonsteroidal Microbial Metabolite, Attenuates Nonalcoholic Fatty Liver Disease by Activating the Farnesoid X Receptor

(2017) Zhihui Zheng et al.   MOLECULAR PHARMACOLOGY

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Calycosin attenuates triglyceride accumulation and hepatic fibrosis in murine model of non-alcoholic steatohepatitis via activating farnesoid X receptor

(2017) Xingping Duan et al.   PHYTOMEDICINE

Chinese medicine CGA formula ameliorates DMN-induced liver fibrosis in rats via inhibiting MMP2/9, TIMP1/2 and the TGF-β/Smad signaling pathways

(2016) Xue-mei Li et al.   ACTA PHARMACOLOGICA SINICA

Key Role for the 12-Hydroxy Group in the Negative Ion Fragmentation of Unconjugated C24 Bile Acids

(2016) Ke Lan et al.   ANALYTICAL CHEMISTRY

Beneficial effects of voglibose administration on body weight and lipid metabolism via gastrointestinal bile acid modification

(2016) Hyun Ju Do et al.   ENDOCRINE JOURNAL

Bile acids and nonalcoholic fatty liver disease: Molecular insights and therapeutic perspectives

(2016) Juan P. Arab et al.   HEPATOLOGY

Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis

(2016) Guoxiang Xie et al.   INTERNATIONAL JOURNAL OF CANCER

Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway

(2016) Runbin Sun et al.   MOLECULAR PHARMACOLOGY

Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet–fed mice

(2016) Anuradha Rao et al.   Science Translational Medicine

Nuclear Receptor Modulation for the Treatment of Nonalcoholic Fatty Liver Disease

(2016) Claudia Fuchs et al.   SEMINARS IN LIVER DISEASE

Nonalcoholic Fatty Liver Disease

(2015) Mary E. Rinella   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

The story of HCC in NAFLD: from epidemiology, across pathogenesis, to prevention and treatment

(2015) Cristina Margini et al.   LIVER INTERNATIONAL

Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats

(2015) Qin He et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration

(2015) Guodong Li et al.   Acta Pharmaceutica Sinica B

Nuclear bile acid signaling through the farnesoid X receptor

(2014) Claire Mazuy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Anticancer and immunoregulatory activity of Gynostemma pentaphyllum polysaccharides in H22 tumor-bearing mice

(2014) Jun Liu et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Bile acid receptors in non-alcoholic fatty liver disease

(2013) Yuanyuan Li et al.   BIOCHEMICAL PHARMACOLOGY

Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice

(2012) Bo Kong et al.   HEPATOLOGY

A Mouse Model of Metabolic Syndrome: Insulin Resistance, Fatty Liver and Non-Alcoholic Fatty Pancreas Disease (NAFPD) in C57BL/6 Mice Fed a High Fat Diet

(2010) Julio C. Fraulob et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Histopathology of Non-Alcoholic Fatty Liver Disease

(2009) Elizabeth M. Brunt   Clinics in Liver Disease

Bile Acids and Metabolic Regulation: Mechanisms and clinical responses to bile acid sequestration

(2009) B. Staels et al.   DIABETES CARE

Obesity and nonalcoholic fatty liver disease: Biochemical, metabolic, and clinical implications

(2009) Elisa Fabbrini et al.   HEPATOLOGY

FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats

(2009) Sabrina Cipriani et al.   JOURNAL OF LIPID RESEARCH