Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element

Supraphysiological androgens suppress prostate cancer growth through androgen receptor–mediated DNA damage

(2019) Payel Chatterjee et al.   JOURNAL OF CLINICAL INVESTIGATION

The androgen receptor malignancy shift in prostate cancer

(2018) Ben T. Copeland et al.   PROSTATE

Genomic analysis of DNA repair genes and androgen signaling in prostate cancer

(2018) Kasey Jividen et al.   BMC CANCER

Molecules targeting the androgen receptor (AR) signaling axis beyond the AR-Ligand binding domain

(2018) N. G. R. Dayan Elshan et al.   MEDICINAL RESEARCH REVIEWS

Evolution of weak cooperative interactions for biological specificity

(2018) Ang Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationale for the development of alternative forms of androgen deprivation therapy

(2017) Sangeeta Kumari et al.   ENDOCRINE-RELATED CANCER

Androgen Receptor Rearrangement and Splicing Variants in Resistance to Endocrine Therapies in Prostate Cancer

(2017) Yeung Ho et al.   ENDOCRINOLOGY

Bipolar Androgen Therapy: A Paradoxical Approach for the Treatment of Castration-resistant Prostate Cancer

(2017) Michael T. Schweizer et al.   EUROPEAN UROLOGY

Selective Glucocorticoid Receptor Modulators (SGRMs) Delay Castrate-Resistant Prostate Cancer Growth

(2017) Jacob Kach et al.   MOLECULAR CANCER THERAPEUTICS

Acquired resistance to the second-generation androgen receptor antagonist enzalutamide in castration-resistant prostate cancer

(2016) Steven Kregel et al.   Oncotarget

Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines

(2016) Stephen Wilson et al.   Scientific Reports

Determinants of Receptor- and Tissue-Specific Actions in Androgen Signaling

(2015) Päivi Pihlajamaa et al.   ENDOCRINE REVIEWS

The use of exome capture RNA-seq for highly degraded RNA with application to clinical cancer sequencing

(2015) Marcin Cieslik et al.   GENOME RESEARCH

5α-Reductase Inhibition Coupled with Short Off Cycles Increases Survival in the LNCaP Xenograft Prostate Tumor Model on Intermittent Androgen Deprivation Therapy

(2015) Laura E. Pascal et al.   JOURNAL OF UROLOGY

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression

(2015) J. L. Schaefer-Klein et al.   PLoS One

Androgen receptor: structure, role in prostate cancer and drug discovery

(2014) MH Eileen Tan et al.   ACTA PHARMACOLOGICA SINICA

Combination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim

(2014) Hye-Kyung Park et al.   BMC CANCER

Conversion of Androgen Receptor Signaling From a Growth Suppressor in Normal Prostate Epithelial Cells to an Oncogene in Prostate Cancer Cells Involves a Gain of Function in c-Myc Regulation

(2014) Donald J. Vander Griend et al.   International Journal of Biological Sciences

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Androgen receptor uses relaxed response element stringency for selective chromatin binding and transcriptional regulation in vivo

(2014) Biswajyoti Sahu et al.   NUCLEIC ACIDS RESEARCH

Targeting the androgen receptor pathway in castration-resistant prostate cancer: progresses and prospects

(2014) R Ferraldeschi et al.   ONCOGENE

Castration-resistant prostate cancer: Adaptive responses in the androgen axis

(2013) Alison Egan et al.   CANCER TREATMENT REVIEWS

Doxorubicin Enhances Nucleosome Turnover around Promoters

(2013) Fan Yang et al.   CURRENT BIOLOGY

Targeting Alternative Sites on the Androgen Receptor to Treat Castration-Resistant Prostate Cancer

(2013) Nada Lallous et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Hormone-DNA Repair Circuit Governs the Response to Genotoxic Insult

(2013) J. F. Goodwin et al.   Cancer Discovery

FoxA1 Specifies Unique Androgen and Glucocorticoid Receptor Binding Events in Prostate Cancer Cells

(2012) B. Sahu et al.   CANCER RESEARCH

Genome-wide structure and organization of eukaryotic pre-initiation complexes

(2012) Ho Sung Rhee et al.   NATURE

Persistent androgen receptor-mediated transcription in castration-resistant prostate cancer under androgen-deprived conditions

(2012) Keith F. Decker et al.   NUCLEIC ACIDS RESEARCH

DREME: motif discovery in transcription factor ChIP-seq data

(2011) Timothy L. Bailey   BIOINFORMATICS

Small Molecule Inhibitors Targeting the “Achilles' Heel” of Androgen Receptor Activity: Figure 1.

(2011) Marianne D. Sadar   CANCER RESEARCH

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers

(2011) Russell Z. Szmulewitz et al.   PROSTATE

A Noncompetitive Small Molecule Inhibitor of Estrogen-regulated Gene Expression and Breast Cancer Cell Growth That Enhances Proteasome-dependent Degradation of Estrogen Receptor α

(2010) Nicole M. Kretzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Steroid Receptor Coactivator (SRC) Family: Masters of Systems Biology

(2010) Brian York et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer

(2010) Karen E. Knudsen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Differential expression analysis for sequence count data

(2010) Simon Anders et al.   GENOME BIOLOGY

Androgen regulation of the prostatic tumour suppressorNKX3.1is mediated by its 3′ untranslated region

(2009) Marc A. Thomas et al.   BIOCHEMICAL JOURNAL

Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy

(2009) M. P. Steinkamp et al.   CANCER RESEARCH

Androgen Receptor Regulates a Distinct Transcription Program in Androgen-Independent Prostate Cancer

(2009) Qianben Wang et al.   CELL

Differential Presentation of Protein Interaction Surfaces on the Androgen Receptor Defines the Pharmacological Actions of Bound Ligands

(2009) John David Norris et al.   CHEMISTRY & BIOLOGY

Discovery of selective glucocorticoid receptor modulators by multiplexed reporter screening

(2009) A. N. Gerber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA