Article
Behavioral Sciences
Marja Niiranen, Juha Koikkalainen, Jyrki Lotjonen, Tuomas Selander, Antti Cajanus, Paivi Hartikainen, Sakari Simula, Ritva Vanninen, Anne M. Remes
Summary: This study found differences in brain structures between benign relapsing-remitting multiple sclerosis (BRRMS) and aggressive relapsing-remitting multiple sclerosis (ARRMS), with thalamic volume being the most prominent differentiating measure. In addition, the validation of automated quantification of corpus callosum index (CCI) provides an applicable MRI biomarker to detect brain atrophy in multiple sclerosis.
BRAIN AND BEHAVIOR
(2022)
Editorial Material
Clinical Neurology
Adem Yokus
Summary: Interhemispheric cysts are a rare occurrence in children and infants, and may sometimes be accompanied by agenesis of the corpus callosum. While some patients may be asymptomatic, others may present with symptoms related to the mass effect caused by the cystic lesion. This case report presents the magnetic resonance imaging findings of an 11-month-old girl infant with increased head circumference.
WORLD NEUROSURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claudio Cordani, Paolo Preziosa, Paola Valsasina, Alessandro Meani, Elisabetta Pagani, Tetsu Morozumi, Maria Assunta Rocca, Massimo Filippi
Summary: This study investigates the relationship between altered callosal integrity and disability in multiple sclerosis patients using multiparametric MRI approaches. The results show that structural, rather than functional, abnormalities in white matter fibers predict the severity of global disability and upper limb motor impairment. These predictors appear to be less evident at higher levels of disability.
Article
Neuroimaging
Krista Schendel, Timothy J. Herron, Brian Curran, Nina F. Dronkers, Maria Ivanova, Juliana Baldo
Summary: The white matter pathways play a crucial role in cognition, as demonstrated in this case study where a left lateralized stroke selectively impaired naming abilities on the ipsilesional hand. This highlights the importance of white matter pathways through the body of the corpus callosum. The findings provide fresh insight into alternative strategies for rehabilitating cognitive functioning when structural connectivity may be compromised.
NEUROIMAGE-CLINICAL
(2021)
Article
Behavioral Sciences
Fikret Ari, Canan Kalaycioglu, Hazal Artuvan Korkmaz, Beyza Doganay Erdogan
Summary: This study investigated the differences in callosal transfer speed of verbal and nonverbal stimuli in university students. The results showed that slow readers have slower right-to-left transfer speed at the parietal site related to visual word decoding process, similar to individuals with reading disorders. The difference was not observed with nonverbal stimuli, suggesting that it originates at the orthographic visual lexical level rather than at earlier basic visual processing.
Article
Neurosciences
Lynn K. Paul, Shawneen R. Pazienza, Warren S. Brown
Summary: Research indicates that individuals with AgCC experience difficulty in identifying and describing emotions, as well as vague physical symptoms, compared to neurotypical controls. However, their levels of emotional experience and coping are similar to the control group, suggesting intact emotional processing despite impaired emotional interpretation.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Taylor E. Stansberry, Anne L. Willliams, Toshikazu Ikuta
Summary: The integrity of the interhemispheric auditory white matter tract is associated with impulsivity, especially sensation seeking. Stronger interhemispheric auditory integration is suggested to be related to greater impulsivity and sensation seeking.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Clinical Neurology
Theresa Paul, Valerie M. Wiemer, Lukas Hensel, Matthew Cieslak, Caroline Tscherpel, Christian Grefkes, Scott T. Grafton, Gereon R. Fink, Lukas J. Volz
Summary: This study used diffusion spectrum imaging (DSI) and a novel compartment-wise analysis approach to investigate the structural connectivity between bilateral cortical core motor regions in chronic stroke patients. The results showed that the structural connectivity between these regions is associated with both basal and complex motor control. Specifically, the recovery of basal motor control may be supported by an alternative pathway through the contralesional primary motor cortex (M1) and non-crossing fibers of the contralesional corticospinal tract (CST). These findings help explain conflicting interpretations of the functional role of the contralesional M1 and suggest the potential of cortico-cortical structural connectivity as a biomarker for motor recovery post-stroke.
ANNALS OF NEUROLOGY
(2023)
Article
Clinical Neurology
Michael Platten, Russell Ouellette, Elena Herranz, Valeria Barletta, Constantina A. Treaba, Caterina Mainero, Tobias Granberg
Summary: This study used advanced MRI technology to explore the pathological mechanisms of corpus callosum atrophy. The results showed that both white matter and cortical lesions contribute to regional corpus callosal atrophy, and lobe-specific lesion topology does not fully explain the inhomogeneous atrophy of the corpus callosum.
JOURNAL OF NEUROIMAGING
(2022)
Article
Neurosciences
Benjamin A. Christensen, Bradley Clark, Alexandra M. Muir, Whitney D. Allen, Erin M. Corbin, Tyshae Jaggi, Nathan Alder, Ann Clawson, Thomas J. Farrer, Erin D. Bigler, Michael J. Larson
Summary: Concussion in children and adolescents is a public health concern with a higher incidence than adults. The corpus callosum is vulnerable to concussion-related white matter damage and can have short- and long-term effects. The N1 and P1 components of the scalp-recorded brain event-related potential (ERP) can be used to measure interhemispheric transfer time (IHTT), but studies on IHTT following adolescent concussion are lacking.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Marc H. Bornstein, Clay Mash, Roberto Romero, Amir H. Gandjbakhche, Thien Nguyen
Summary: There is limited anatomical evidence on the connectivity and communication between the two hemispheres of the brain in the first year of life, leading to little empirical knowledge. To investigate interhemispheric transmission of information, EEG data from 12 4-month-old infants were analyzed during a face-related oddball ERP protocol. The activity in the contralateral hemisphere showed differences between odd-same and odd-difference trials, with a weaker response in odd-different trials. This indicates that infants' contralateral hemisphere can recognize and discriminate odd familiar and odd-different stimuli. These findings provide insight into the connectivity and communication between the two hemispheres of the brain in the first year of life and contribute to understanding the functional integrity of the developing infant brain.
Article
Multidisciplinary Sciences
Yanjie Wang, Zhaonan Chen, Guofen Ma, Lizhao Wang, Yanmei Liu, Meiling Qin, Xiang Fei, Yifan Wu, Min Xu, Siyu Zhang
Summary: Lesions in the ACA cause visuospatial bias, which is mediated by a transcallosal inhibition loop. Activation of contralesional PV+ neurons improves contralesional detection and restores interhemispheric balance. Rating: 9/10.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
M. A. Sotgiu, G. Piga, V Mazzarello, I. R. Zarbo, A. Carta, L. Saderi, S. Sotgiu, M. Conti, L. Saba, P. Crivelli
Summary: In early MS patients, there is a significant increase in confluent CC lesions, particularly in the callosal body, associated with higher initial EDSS. Additionally, median CCR is significantly correlated with MS progression in the whole MS group regardless of initial EDSS. The measurement of CC body lesions and residual CC size is encouraged for therapeutic decisions and prognostic planning in early MS due to their significant association with disability.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Neurosciences
Diego Szczupak, Pamela Meneses Iack, Cirong Liu, Fernanda Tovar-Moll, Roberto Lent, Afonso C. Silva
Summary: The study identified direct interhemispheric corticothalamic connectivity from the orbital cortex for the first time, naming these crossing points thalamic commissures. Additionally, the research showed atypical and weaker interhemispheric corticothalamic communication in the Balb/c mouse model of dysgenesis of the corpus callosum (CCD) compared to the C57bl6/J mouse model.
Article
Neurosciences
Alberto Failla, Lauryna Filatovaite, Xiaowan Wang, Sampsa Vanhatalo, Jeroen Dudink, Linda S. de Vries, Manon Benders, Nathan Stevenson, Maria Luisa Tataranno
Summary: The study aimed to investigate the association between bursting interhemispheric synchrony (bIHS) and microstructural development of the corpus callosum (CC) in extremely preterm infants during the first week of life. Results indicated that early cortical synchrony may be affected by morphine, but is not associated with the microstructural development of the CC.
HUMAN BRAIN MAPPING
(2022)
Editorial Material
Clinical Neurology
Samar S. Ayache, Moussa A. Chalah
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Moussa A. Chalah, Christina Grigorescu, Tania Kumpfel, Jean-Pascal Lefaucheur, Frank Padberg, Ulrich Palm, Samar S. Ayache
Summary: Bifrontal tDCS intervention significantly improves daytime sleepiness in PwMS patients, but shows no significant effects on objective sleep measures. There may be a modest association between objective and subjective sleep measures, and modulating objective sleep measures may require more stimulation sessions or modulation of other cortical areas.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Oncology
Nicolas Serratrice, Joe Faddoul, Bilal Tarabay, Christian Attieh, Moussa A. Chalah, Samar S. Ayache, Georges N. Abi Lahoud
Summary: The objective of treatments for spinal metastasis is to achieve the best oncological and functional outcomes while minimizing side effects. The Spine Instability Neoplastic Score (SINS) has been widely used in the management of vertebral metastases over the past ten years. This review discusses the changes that have occurred with the SINS score and its utility in diagnosing and assessing the extent of spinal metastases. The reliability of SINS among different medical professionals is also examined, along with the latest advancements in surgery, radiotherapy, palliative care, and pain control for spinal metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Benjamin Bardel, Moussa A. Chalah, Alain Creange, Jean-Pascal Lefaucheur, Samar S. Ayache
Summary: This study found that patients with multiple sclerosis (MS) exhibit prolonged movement preparation compared to healthy controls, especially in certain brain regions. Additionally, MS patients showed larger readiness potential amplitudes during performance tasks. Furthermore, the study also revealed a significant correlation between BP1 latency and disease duration as well as performance on executive function tests.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Clinical Neurology
Samar S. Ayache, Nicolas Serratrice, Georges N. Abi Lahoud, Moussa A. Chalah
Summary: Fatigue is a common and debilitating symptom in multiple sclerosis (MS), affecting the patients' quality of life. It exhibits motor, cognitive, and psychosocial facets, and can be differentiated from perceived fatigue and fatigability. Despite existing literature, the pathophysiology and management of MS fatigue remain challenging.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Christina Grigorescu, Moussa A. Chalah, Samar S. Ayache, Ulrich Palm
Summary: Alexithymia, a multidimensional construct of personality, is characterized by difficulties in identifying and describing another's emotions. It is prevalent in multiple sclerosis (MS) patients and has been associated with anxiety, depression, fatigue, and some aspects of social cognition. However, its relationship with clinical and cognitive variables has been rarely evaluated, calling for further research.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2023)
Editorial Material
Neurosciences
Ulrich Palm, Samar S. Ayache, Moussa A. Chalah
Review
Surgery
Nicolas Serratrice, Sarkis Taifour, Christian Attieh, Joe Faddoul, Bilal Tarabay, Yassine Yachou, Moussa A. Chalah, Samar S. Ayache, Georges Naim Abi Lahoud
Summary: This case report describes a female patient with pelvic and lumbar radicular cysts who experienced acute progression of a cyst and painful sciatica after delivery. CT-guided puncture and aspiration resulted in complete symptom relief, suggesting that percutaneous cyst aspiration is an effective and safe treatment for Tarlov cysts.
FRONTIERS IN SURGERY
(2022)
Review
Oncology
Nicolas Serratrice, Imene Lameche, Christian Attieh, Moussa A. Chalah, Joe Faddoul, Bilal Tarabay, Rabih Bou-Nassif, Youssef Ali, Joseph G. Mattar, Francois Nataf, Samar S. Ayache, Georges N. Abi Lahoud
Summary: Meningiomas are common benign tumors that arise from arachnoidal cap cells of the meninges. Spinal meningiomas can be diagnosed through MRI and can be classified into different grades based on histology. Surgery is the best treatment option and advances in surgical techniques have improved outcomes. Adjuvant therapy plays a role in subtotal resection and tumor recurrence cases.
FRONTIERS IN ONCOLOGY
(2023)
Article
Clinical Neurology
Naji Riachi, Moussa A. Chalah, Rechdi Ahdab, Feroza Arshad, Samar S. Ayache
Summary: Fibromyalgia is a chronic pain condition that is difficult to treat with medication alone. This study evaluated the use of a new transcutaneous electrical stimulation device, which showed temporary analgesic effects in patients with fibromyalgia.
NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY
(2023)
Review
Medicine, General & Internal
Youssef Rizk, Nour Saad, Wassim Arnaout, Moussa A. Chalah, Stephanie Farah
Summary: This review sheds light on primary hyperparathyroidism (PHPT) in older adults, including its prevalence, clinical manifestations, management options, and post-operative complications. The prevalence of PHPT in the elderly is approximately 1%, with female predominance. Clinical symptoms vary with age and may include osteoporosis, fractures, and neuropsychiatric symptoms. Parathyroidectomy (PTX) has been demonstrated to be a safe and effective treatment option in the older population, improving symptoms and quality of life.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Samar S. Ayache, Benjamin Bardel, Jean-Pascal Lefaucheur, Moussa A. Chalah
Summary: Fatigue, affective manifestations, cognitive deficits, and pain are common and debilitating symptoms in patients with multiple sclerosis (MS), which may have a complex pathophysiology and challenging management. Neurofeedback (NFB) could potentially improve outcomes by modulating brain activity in specific electroencephalographic bands, but further research is needed to explore its utility. Different NFB protocols and comprehensive evaluation may help optimize interventions for specific symptoms and potentially combine with other approaches to enhance management of MS symptoms.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)