Exposure to gadolinium and neurotoxicity: current status of preclinical and clinical studies

Within-network brain connectivity in Crohn’s disease patients with gadolinium deposition in the cerebellum

(2020) Carlo A. Mallio et al.   NEURORADIOLOGY

MRI features suggestive of gadolinium retention do not correlate with Expanded Disability Status Scale worsening in Multiple Sclerosis

(2019) Sirio Cocozza et al.   NEURORADIOLOGY

Impact of Brain Irradiation, Chemotherapy, and Presence of Primary Brain Tumors on Changes in Signal Intensity after Exposure to Gadolinium-based Contrast Agents

(2019) Carlo Augusto Mallio et al.   RADIOLOGY

Absence of dentate nucleus resting-state functional connectivity changes in nonneurological patients with gadolinium-related hyperintensity on T1 -weighted images

(2019) Carlo A. Mallio et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

EDTA Chelation Therapy for the Treatment of Neurotoxicity

(2019) Fulgenzi Alessandro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gadolinium-Based MRI Contrast Agents Induce Mitochondrial Toxicity and Cell Death in Human Neurons, and Toxicity Increases With Reduced Kinetic Stability of the Agent

(2019) Danielle V. Bower et al.   INVESTIGATIVE RADIOLOGY

Diffusion-weighted imaging of the dentate nucleus after repeated application of gadolinium-based contrast agents in multiple sclerosis

(2019) Philipp Eisele et al.   MAGNETIC RESONANCE IMAGING

Fatal gadolinium-induced encephalopathy following accidental intrathecal administration: a case report and a comprehensive evidence-based review

(2019) David Anthony Provenzano et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Intrathecal Use of Gadobutrol for Glymphatic MR Imaging: Prospective Safety Study of 100 Patients

(2019) C.S. Edeklev et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in Multiple Sclerosis

(2019) Y. Forslin et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Cumulative gadodiamide administration leads to brain gadolinium deposition in early MS

(2019) Robert Zivadinov et al.   NEUROLOGY

Increased T1 Signal Intensity of the Anterior Pituitary Gland on Unenhanced Magnetic Resonance Images After Chronic Exposure to Gadodiamide

(2019) Carlo A. Mallio et al.   INVESTIGATIVE RADIOLOGY

Does serial administration of gadolinium‐based contrast agents affect patient neurological and neuropsychological status? Fourteen‐year follow‐up of patients receiving more than fifty contrast administrations

(2019) Josef Vymazal et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Effect of Long-Term Retention of Gadolinium on Metabolism of Deep Cerebellar Nuclei After Repeated Injections of Gadodiamide in Rats

(2019) Dounia El Hamrani et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study

(2018) Stefanie Fingerhut et al.   ACTA NEUROPATHOLOGICA

Effect of Age on High T1 Signal Intensity of the Dentate Nucleus and Globus Pallidus in a Large Population Exposed to Gadodiamide

(2018) Carlo Cosimo Quattrocchi et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-based Contrast Media, Cerebrospinal Fluid and the Glymphatic System: Possible Mechanisms for the Deposition of Gadolinium in the Brain

(2018) Toshiaki Taoka et al.   Magnetic Resonance in Medical Sciences

Gadolinium Retention: A Research Roadmap from the 2018 NIH/ACR/RSNA Workshop on Gadolinium Chelates

(2018) Robert J. McDonald et al.   RADIOLOGY

Absence of potential gadolinium toxicity symptoms following 22,897 gadoteric acid (Dotarem®) examinations, including 3,209 performed on renally insufficient individuals

(2018) Laura K. Young et al.   EUROPEAN RADIOLOGY

A Structured Survey on Adverse Events Occurring Within 24 Hours After Intravenous Exposure to Gadodiamide or Gadoterate Meglumine

(2018) Marco Parillo et al.   INVESTIGATIVE RADIOLOGY

Glymphatic Pathway of Gadolinium-Based Contrast Agents Through the Brain

(2018) Katerina Deike-Hofmann et al.   INVESTIGATIVE RADIOLOGY

Gadolinium retention after administration of contrast agents based on linear chelators and the recommendations of the European Medicines Agency

(2017) Ilona A. Dekkers et al.   EUROPEAN RADIOLOGY

Intrathecal Contrast-Enhanced Magnetic Resonance Imaging–Related Brain Signal Changes

(2017) Ali Yusuf Öner et al.   INVESTIGATIVE RADIOLOGY

Histology and Gadolinium Distribution in the Rodent Brain After the Administration of Cumulative High Doses of Linear and Macrocyclic Gadolinium-Based Contrast Agents

(2017) Jessica Lohrke et al.   INVESTIGATIVE RADIOLOGY

Sodium MRI of T1 High Signal Intensity in the Dentate Nucleus due to Gadolinium Deposition in Multiple Sclerosis

(2017) Philipp Eisele et al.   JOURNAL OF NEUROIMAGING

Absence of clinical cerebellar syndrome after serial injections of more than 20 doses of gadoterate, a macrocyclic GBCA: a monocenter retrospective study

(2017) Gaetano Perrotta et al.   JOURNAL OF NEUROLOGY

Clearance of Gadolinium from the Brain with No Pathologic Effect after Repeated Administration of Gadodiamide in Healthy Rats: An Analytical and Histologic Study

(2017) Adrian P. L. Smith et al.   RADIOLOGY

Gadolinium Deposition in Human Brain Tissues after Contrast-enhanced MR Imaging in Adult Patients without Intracranial Abnormalities

(2017) Robert J. McDonald et al.   RADIOLOGY

25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives

(2016) Jessica Lohrke et al.   ADVANCES IN THERAPY

Penetration and distribution of gadolinium-based contrast agents into the cerebrospinal fluid in healthy rats: a potential pathway of entry into the brain tissue

(2016) Gregor Jost et al.   EUROPEAN RADIOLOGY

Association Between Gadolinium Contrast Exposure and the Risk of Parkinsonism

(2016) Blayne Welk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Gadolinium deposition disease: Initial description of a disease that has been around for a while

(2016) Richard C. Semelka et al.   MAGNETIC RESONANCE IMAGING

Gadolinium deposition within the dentate nucleus and globus pallidus after repeated administrations of gadolinium-based contrast agents—current status

(2016) Dragan Stojanov et al.   NEURORADIOLOGY

Effects of Gadolinium-Based Contrast Agents on Thyroid Hormone Receptor Action and Thyroid Hormone-Induced Cerebellar Purkinje Cell Morphogenesis

(2016) Winda Ariyani et al.   Frontiers in Endocrinology

Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy

(2015) Carlo Cosimo Quattrocchi et al.   INVESTIGATIVE RADIOLOGY

High-Signal Intensity in the Dentate Nucleus and Globus Pallidus on Unenhanced T1-Weighted Images

(2015) Alexander Radbruch et al.   INVESTIGATIVE RADIOLOGY

High Signal Intensity in Dentate Nucleus on Unenhanced T1-weighted MR Images: Association with Linear versus Macrocyclic Gadolinium Chelate Administration

(2015) Tomonori Kanda et al.   RADIOLOGY

Intracranial Gadolinium Deposition after Contrast-enhanced MR Imaging

(2015) Robert J. McDonald et al.   RADIOLOGY

Progressive Increase of T1 Signal Intensity of the Dentate Nucleus on Unenhanced Magnetic Resonance Images Is Associated With Cumulative Doses of Intravenously Administered Gadodiamide in Patients With Normal Renal Function, Suggesting Dechelation

(2014) Yuri Errante et al.   INVESTIGATIVE RADIOLOGY

Gadolinium triggers unfolded protein responses (UPRs) in primary cultured rat cortical astrocytes via promotion of an influx of extracellular Ca2+

(2010) Xu-Dong Feng et al.   CELL BIOLOGY AND TOXICOLOGY

Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C

(2010) Thomas Frenzel et al.   INVESTIGATIVE RADIOLOGY

Gadolinium-induced oxidative stress triggers endoplasmic reticulum stress in rat cortical neurons

(2010) Qing Xia et al.   JOURNAL OF NEUROCHEMISTRY

Impaired mitochondrial function and oxidative stress in rat cortical neurons: Implications for gadolinium-induced neurotoxicity

(2010) Xudong Feng et al.   NEUROTOXICOLOGY

Effect of Different Classes of Gadolinium-based Contrast Agents on Control and Nephrogenic Systemic Fibrosis–derived Fibroblast Proliferation

(2010) Michael Edward et al.   RADIOLOGY

Biodistribution of gadolinium-based contrast agents, including gadolinium deposition

(2009) Silvio Aime et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs

(2008) Teresa Cunha-Oliveira et al.   BRAIN RESEARCH REVIEWS

Gadolinium blocks proton-activated currents in isolated Purkinje cells

(2008) I. N. Sharonova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE