Article
Chemistry, Medicinal
Sai-jia Ni, Zeng-Ying Yao, Xiaotong Wei, Xia Heng, Shu-Yue Qu, Xin Zhao, Yi-Yu Qi, Ping-Yuan Ge, Cai-Ping Xu, Nian-Yun Yang, Yi Cao, Hua-Xu Zhu, Rui Guo, Qi-Chun Zhang
Summary: This study explored the mechanism by which berberine improves neuroinflammation in cerebral ischemia by modulating microglia polarization. The results showed that berberine can enhance vagus nerve activity and stimulate the production of hydrogen sulfide (H2S) through the activation of the transient receptor potential vanilloid 1 (TRPV1) receptor. Sphingolipid metabolism may mediate the improvement of neuroinflammation following vagus afferent fiber activation.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Mengxiao Zhou, Lijuan Wang, Zihan Wang, Xiaotong Chang, Xiaobo Zhu
Summary: The spleen plays a crucial role in maintaining the vagal cholinergic anti-inflammatory activity, and this function involves the regulation of alpha 7 nicotinic acetylcholine receptor (alpha 7nAChR) expression in monocytes by the vagus nerve. The spleen is an indispensable site for this process.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yujing Zhang, Bing Xie, Xiaoyan Chen, Jiancheng Zhang, Shiying Yuan
Summary: The study showed that sleep deprivation exacerbates systemic inflammation after sepsis, with the involvement of the gut microbiota-vagus nerve axis and gut microbiota-spleen axis in modulating the inflammatory response.
Article
Biochemistry & Molecular Biology
Liping Zhang, Yilin Liu, Sanrong Wang, Lu Long, Qianwen Zang, Jingxi Ma, Lehua Yu, Gongwei Jia
Summary: The study found that VNS can promote M2 microglia polarization and inhibit M1 microglia polarization, alleviating brain injury in the acute stage of stroke by inhibiting the TLR4/MyD88/NF-kappa B pathway in microglia.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Pharmacology & Pharmacy
Shuxia Yao, Keith Maurice Kendrick
Summary: Intranasal administration of oxytocin and vasopressin has been widely used to modulate social cognition, but their effects are not consistent. The penetration of these neuropeptides into the brain following intranasal administration is debated. Different routes of administration and dose magnitude and frequency can lead to different functional outcomes. Understanding these factors is important for optimizing the desired effects of intranasal treatment.
Article
Medicine, Research & Experimental
Mojdeh Fattahi, Kiarash Eskandari, Esmail Riahi, Reza Khosrowabadi, Abbas Haghparast
Summary: The study aimed to investigate the potential efficacy of deep brain stimulation (DBS) in treating methamphetamine-conditioned place preference (CPP) in rats. The findings showed that both high-frequency stimulation (HFS) and low-frequency stimulation (LFS) significantly decreased methamphetamine place preference during the conditioning period. Only HFS could accelerate the extinction of reward-context associations and reduce methamphetamine-induced reinstatement of seeking behaviors during the extinction experiment.
Article
Cardiac & Cardiovascular Systems
Alicia D'Souza, Yanwen Wang, Cali Anderson, Annalisa Bucchi, Mirko Baruscotti, Serve Olieslagers, Pietro Mesirca, Anne Berit Johnsen, Svetlana Mastitskaya, Haibo Ni, Yu Zhang, Nicholas Black, Charlotte Cox, Sven Wegner, Beatriz Bano-Otalora, Cheryl Petit, Eleanor Gill, Sunil Jit R. J. Logantha, Halina Dobrzynski, Nick Ashton, George Hart, Rai Zhang, Henggui Zhang, Elizabeth J. Cartwright, Ulrik Wisloff, Matteo E. Mangoni, Paula A. Da Costa Martins, Hugh D. Piggins, Dario DiFrancesco, Mark R. Boyett
Summary: The circadian variation in heart rate is related to a local genomic regulation of the sinus node rather than neural influences. The rhythmic expression of ion channel gene HCN4 plays a key role in controlling the beating rate of the heart during day and night cycles. This study provides new insights into the regulation of heart rate and the mechanisms behind bradycardia during sleep.
Article
Biochemistry & Molecular Biology
Noriyuki Mori, Tomomi Urata
Summary: Cinnamaldehyde can affect body temperature through TRPA1 activation, with the vagus nerve having a minor influence.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Sarah Hartley, Guillaume Bao, Ashley Russo, Marine Zagdoun, Sylvain Chevallier, Frederic Lofaso, Antoine Leotard, Eric Azabou
Summary: This study investigated the effectiveness of self-administered transauricular vagus nerve stimulation (taVNS) in patients with severe pharmacoresistant restless legs syndrome (RLS). The results showed that after 6 months of follow-up, patients experienced reduced symptoms severity, improved quality of life, and decreased anxiety and depression symptoms. The treatment was well tolerated.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Psychology, Biological
Siyu Zhu, Yanan Qing, Yingying Zhang, Xiaolu Zhang, Fangyuan Ding, Rong Zhang, Shuxia Yao, Keith M. Kendrick, Weihua Zhao
Summary: This study investigated the effects of transcutaneous electrical stimulation of the auricular branch of the vagus nerve (taVNS) on social cognition. The results showed that taVNS increased the proportion of time spent looking at socially salient facial features and also led to an increase in oxytocin release. This suggests that taVNS may have a positive impact on social cognition through the modulation of attention.
Article
Clinical Neurology
Rachel D. Penrod, Makoto Taniguchi, Angela M. Kearns, Jordan L. Hopkins, Carmela M. Reichel
Summary: This study investigates the roles of oxytocin receptors in drug use disorders and finds that their knockdown in the prefrontal cortex and nucleus accumbens core can reduce cued reinstatement of drug seeking. However, it has no effect on drug-primed reinstatement. The findings provide valuable insights for the development of oxytocin-based therapeutics to reduce drug relapse.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Jo-Ting Wu, Chia-Ling Sun, Tzu-Ting Lai, Chia-Wei Liou, Yuan-Yuan Lin, Jia-Ying Xue, Hong-Wen Wang, Laura Min Xuan Chai, Yen-Jung Lee, Shiou-Lan Chen, Alice Y. W. Chang, Jia-Horung Hung, Cheng-Chih Hsu, Wei-Li Wu
Summary: Anxiety is a pathological condition characterized by tension and worry, which can be regulated by the gut microbiota through the production of short-chain fatty acids (SCFA).
Article
Neurosciences
Jackson Brougher, Umaymah Aziz, Nikitha Adari, Muskaan Chaturvedi, Aryela Jules, Iqra Shah, Saba Syed, Catherine A. Thorn
Summary: The study compared the effects of right cervical vagus nerve stimulation (r-VNS) with traditional left VNS (l-VNS) on self-administration behavior and midbrain dopaminergic activation in rats. The results showed that rats stimulated with r-VNS exhibited significantly more lever presses and greater c-Fos expression in dopamine-related brain regions compared to l-VNS, suggesting a preferential activation of the midbrain dopaminergic system by targeting the right cervical nerve.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Yuya Kanauchi, Takeshi Yamamoto, Minako Yoshida, Yue Zhang, Jaemin Lee, Shusaku Hayashi, Makoto Kadowaki
Summary: This study investigates the role of alpha 7nAChRs on pDCs in the pathology of UC and finds that activation of alpha 7nAChRs can suppress pDC migration to achieve therapeutic effects on UC.
SCIENTIFIC REPORTS
(2022)
Article
Surgery
Robert C. Ross, Yanlin He, R. Leigh Townsend, Philip R. Schauer, Hans-Rudolph Berthoud, Christopher D. Morrison, Vance L. Albaugh
Summary: This study investigated the effects of bariatric surgery on obesity using a mouse model, focusing on the neuro-hormonal mechanisms. The results showed that nutrient signals in the duodenum significantly increased after bariatric surgery. This study suggests that bariatric surgery may alleviate obesity by altering cellular signaling mechanisms in the duodenum.
Article
Neurosciences
Sarah J. Baracz, Katherine J. Robinson, Amanda L. Wright, Anita J. Turner, Iain S. McGregor, Jennifer L. Cornish, Nicholas A. Everett
Summary: Early life stress (ELS) is associated with disrupted neural development and increased vulnerability to mental health disorders, including addiction. ELS disrupts the oxytocin system, which modulates addiction susceptibility, and adolescent oxytocin treatment can reduce ELS-induced psychopathology and addiction vulnerability.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Paige I. Webb, Timothy J. Hill, Nicholas A. Everett, Jade L. Thornton, Jennifer L. Cornish, Sarah J. Baracz
Summary: Adolescent social isolation stress alters various methamphetamine addiction-like behaviors in female rats.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Laisa S. Umpierrez, Priscila A. Costa, Eden A. Michelutti, Sarah J. Baracz, Melanie Sauer, Anita J. Turner, Nicholas A. Everett, Jonathon C. Arnold, Iain S. McGregor, Jennifer L. Cornish
Summary: This study aimed to determine whether CBD or CBDA attenuate METH-induced sensitisation of locomotor hyperactivity in rats. The results showed that CBD, but not CBDA, reduced METH sensitisation of locomotor activity in rats at pharmacologically effective doses.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Katherine J. Robinson, Nicholas A. Everett, Sarah J. Baracz, Jennifer L. Cornish
Summary: The abuse of METH alters the function of GABAergic interneurons, disrupting the excitatory/inhibitory balance in the brain.
PSYCHOPHARMACOLOGY
(2022)
Article
Neurosciences
Erin Lynch, Bowen Dempsey, Christine Saleeba, Eloise Monteiro, Anita Turner, Peter G. R. Burke, Andrew M. Allen, Roger A. L. Dampney, Cara M. Hildreth, Jennifer L. Cornish, Ann K. Goodchild, Simon McMullan
Summary: The deep superior colliculus (dSC) plays a crucial role in integrating multisensory inputs and activating neural pathways responsible for orienting behaviors. This study identifies a monosynaptic pathway between the dSC and the medullary gigantocellular reticular nucleus (GiA), which coordinates autonomic and locomotor components of orienting. The findings suggest that this pathway may mediate the physiological aspects of orienting responses independently of emotional stress.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Behavioral Sciences
Melanie Porter, Polina Gavria, Jessica Reeve, Michael Green, Sarah Baracz, Adriana Rossi, Kelsie Boulton
Summary: Individuals with Williams Syndrome and Downs Syndrome are often described as hypersociable, friendly and overly trusting of others. This study aimed to investigate the potential neuroanatomical and neuropsychological correlates of hypersociability in these conditions. Results provide potential biological explanations for the hypersociability seen in WS and DS.
Article
Clinical Neurology
Joel S. Raymond, Nicholas A. Everett, Anand Gururajan, Michael T. Bowen
Summary: The study examined the effects of oxytocin on sleep-wake behavior and found that intraperitoneal administration of oxytocin promoted quiet wakefulness and suppressed active wakefulness, non-rapid eye movement (NREM) sleep, and rapid eye movement (REM) sleep. The sleep-wake effects of oxytocin were mediated by oxytocin receptor binding. In contrast, intranasal administration of oxytocin did not affect sleep-wake outcomes.
Article
Multidisciplinary Sciences
Harry Carey, Michael Pegios, Lewis Martin, Chris Saleeba, Anita J. Turner, Nicholas A. Everett, Ingvild E. Bjerke, Maja A. Puchades, Jan G. Bjaalie, Simon Mcmullan
Summary: Registration of data to a common frame of reference is crucial in analyzing and integrating diverse neuroscientific data. The traditional methods for registration are time-consuming and rely on expertise. However, using the neural network DeepSlice, we were able to significantly improve the speed while maintaining the accuracy of registering mouse brain histological images to the Allen Brain Common Coordinate Framework.
NATURE COMMUNICATIONS
(2023)
Meeting Abstract
Substance Abuse
C. J. Perry, T. M. Ferella, A. Lin, J. L. Cornish, A. J. Lawrence
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Priscila Costa, Laisa Umpierrez, Anita Turner, Nicholas Everett, Christina Perry, Sarah Baracz, Jennifer Cornish
JOURNAL OF NEUROCHEMISTRY
(2022)