Article
Geriatrics & Gerontology
Natalia Roberto, Maria J. Portella, Marta Marquie, Montserrat Alegret, Isabel Hernandez, Ana Mauleon, Maitee Rosende-Roca, Carla Abdelnour, Ester Esteban de Antonio, Juan P. Tartari, Liliana Vargas, Rogelio Lopez-Cuevas, Urszula Bojaryn, Ana Espinosa, Gemma Ortega, Alba Perez-Cordon, Angela Sanabria, Adelina Orellana, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Emilio Alarcon-Martin, Agustin Ruiz, Lluis Tarraga, Merce Boada, Sergi Valero
Summary: The study found that the Irritability and Apathy NPS clusters in MCI patients showed similar patterns of worsening in memory functioning, potentially serving as early prognostic markers for faster cognitive decline and aiding in the diagnostic process.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Miquel Aguilar-Barbera, Paquita Soler-Girabau, Ana Isabel Tabuenca-Martin, Laura Prieto-del Val
Summary: This study found that Fortasyn Connect, a nutritional supplement, can improve behavioral and psychological symptoms of dementia in patients with mild cognitive impairment and dementia, particularly symptoms of depression, anxiety, apathy, and irritability. The improvement is independent of patients' characteristics and treatment, but is more significant when the condition is severe and when treatment is initiated early.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychology, Clinical
Michael H. Connors, Armando Teixeira-Pinto, David Ames, Michael Woodward, Henry Brodaty
Summary: Apathy is a common symptom in patients with mild cognitive impairment (MCI) and may indicate progression to dementia. However, there is limited research on the longitudinal trajectory of apathy in MCI patients and its clinical correlates when controlled for depression, which can mimic apathy. This study aimed to address these issues.
INTERNATIONAL PSYCHOGERIATRICS
(2023)
Article
Neurosciences
Stefano Giuseppe Grisanti, Federico Massa, Andrea Chincarini, Stefano Pretta, Roberto Rissotto, Carlo Serrati, Fiammetta Monacelli, Gianluca Serafini, Pietro Calcagno, Andrea Brugnolo, Matteo Pardini, Flavio Nobili, Nicola Girtler
Summary: Apathy and awareness of apathy can predict the progression and timing of dementia in patients with amnesic mild cognitive impairment (aMCI).
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychology, Clinical
Alfonsina D'Iorio, Gabriella Santangelo
Summary: The information on neuropsychiatric symptoms associated with different subtypes of mild cognitive impairment (MCI) is insufficient. This study aimed to describe the behavioral and functional profile of patients with amnestic MCI (aMCI) and non-amnestic MCI (naMCI), and determine the association between apathy, depression, and functional autonomy. The findings support the clinical utility of distinguishing between aMCI and naMCI, as the two subtypes have different cognitive and behavioral profiles and may require different treatment approaches.
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
(2022)
Article
Clinical Neurology
Shawn D. X. Kong, Camilla M. Hoyos, Craig L. Phillips, Andrew C. McKinnon, Pinghsiu Lin, Shantel L. Duffy, Loren Mowszowski, Haley M. LaMonica, Ronald R. Grunstein, Sharon L. Naismith, Christopher J. Gordon
Summary: The study found that older adults with mild cognitive impairment (MCI) exhibited reduced parasympathetic function during non-rapid eye movement sleep, especially in those with amnestic MCI. This may serve as an early biomarker for dementia detection.
Article
Behavioral Sciences
Mickael Aubignat, Martine Roussel, Ardalan Aarabi, Chantal Lamy, Daniela Andriuta, Sophie Tasseel-Ponche, Malek Makki, Olivier Godefroy
Summary: Apathy occurs in approximately one third of people after stroke. The determinants of apathy have only been partially defined due to difficulties in disentangling it from comorbidities. This study aimed to examine the prevalence of apathy, identify confounding sources of hypoactivity, and define its neuroimaging determinants using mVLSM analyses.
Article
Neurosciences
Hannah Gardener, Bonnie Levin, Janet DeRosa, Tatjana Rundek, Clinton B. Wright, Mitchell S. Elkind, Ralph L. Sacco
Summary: The study suggests that social connections may have a protective effect on cognitive health, especially in disadvantaged populations.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Psychiatry
Zili Fan, Luchun Wang, Haifeng Zhang, Xiaozhen Lv, Lihui Tu, Ming Zhang, Ying Zhang, Caihua Yan, Xin Yu, Huali Wang
Summary: The presence of apathy in individuals with normal cognitive function is associated with a more than 2-fold increased risk of progressing to cognitive impairment. Future interventions targeting apathy management in the general population may reduce the risk of cognitive impairment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Maria del Carmen Carcelen-Fraile, Ana Maria Llera-DelaTorre, Agustin Aibar-Almazan, Diego Fernando Afanador-Restrepo, Mateo Baena-Marin, Fidel Hita-Contreras, Vania Brandao-Loureiro, Patricia Alexandra Garcia-Garro, Yolanda Castellote-Caballero
Summary: This study aimed to investigate the effects of a cognitive stimulation program on cognitive performance, anxiety, depression, and quality of life in individuals with mild cognitive impairment (MCI) aged > 70. The results showed that a 12-week cognitive stimulation program improved cognitive performance, anxiety, depression, and health-related quality of life in individuals with MCI aged > 70.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Cell Biology
Roopal Desai, Tim Whitfield, Glorianne Said, Amber John, Rob Saunders, Natalie L. Marchant, Joshua Stott, Georgina Charlesworth
Summary: The study found that anxiety or SCD-related worry significantly increased the risk of individuals with subjective cognitive decline progressing to objective cognitive impairment, while depressive symptoms did not increase this risk. Further research should explore whether psychological interventions targeting anxiety and worry can reduce the risk of clinical progression.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Kyoungjoo Cho
Summary: Cognitive impairment is a serious condition associated with aging and disruption of inflammation and innate immunity. Recent studies have shown that the innate immune system is prevalent in patients with Alzheimer's disease, and peripheral neutrophil markers can predict a decline in cognitive function in patients with mild cognitive impairment. Furthermore, altered levels of pro-inflammatory interleukins have been reported in patients with mild cognitive impairment, potentially playing a role in the progression from early cognitive impairment to dementia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychiatry
Madia Lozupone, Francesca D'Urso, Massimiliano Copetti, Rodolfo Sardone, Simona Arcuti, Fabio Castellana, Ilaria Galizia, Lucia Lofano, Federica Veneziani, Carla Piccininni, Maria Rosaria Barulli, Alessandra Grasso, Petronilla Battista, Rosanna Tortelli, Rosa Capozzo, Chiara Griseta, Fabrizio Doricchi, Nicola Quaranta, Emanuela Resta, Antonio Daniele, Davide Seripa, Vincenzo Solfrizzi, Antonello Bellomo, Giancarlo Logroscino, Francesco Panza
Summary: The prevalence of late-life depression varies depending on the sample and diagnostic methods used. The 30-item Geriatric Depression Scale (GDS-30) showed moderate accuracy in diagnosing late-life depression, with performance affected by educational level. Adjustments may be needed for more accurate diagnosis.
PSYCHIATRY RESEARCH
(2022)
Article
Nursing
Ying Zhou, Wei Han, Xiuyu Yao, JiaJun Xue, Zheng Li, Yingxin Li
Summary: This study aimed to develop a machine learning model to detect and distinguish depression, anxiety, and apathy based on speech and facial expressions. The results showed that this innovative approach combines text, audio, and video to provide objective methods for precise classification and remote monitoring of these symptoms.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2023)
Article
Neurosciences
Valerie Turcotte, Olivier Potvin, Mahsa Dadar, Carol Hudon, Simon Duchesne
Summary: This study examines the influence of birth cohorts and cognitive reserve (CR) on cognitive performance and structural brain health. The results show that recent birth cohorts, higher CR, and healthier brain structures are associated with better performance in verbal episodic memory, language and semantic memory, and attention capacities. The findings suggest that cohort differences in cognitive performance can be partly explained by proxies of CR.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Joel Macoir, Marie-Pier Tremblay, Maximiliano A. Wilson, Robert Laforce, Carol Hudon
Summary: The study aimed to investigate the role of semantic memory in emotion recognition of basic emotions conveyed by music in individuals with svPPA. Results showed that individuals with svPPA had preserved abilities to recognize familiar music but impaired performance on tasks involving semantic concepts and emotion recognition. Furthermore, recognition of basic emotions and association of musical excerpts with semantic concepts were better for familiar than non-familiar music excerpts in participants with svPPA.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Geriatrics & Gerontology
Helen-Maria Vasiliadis, Isabelle Pitrou, Sebastien Grenier, Djamal Berbiche, Carol Hudon
Summary: This study identified profiles of aging based on psychological distress, cognition, and functional disability, and explored their associated factors. The results showed that symptoms of anxiety and depression, as well as high burden of physical disorders, were associated with less favorable trajectories of aging. Additionally, modifiable lifestyle factors were found to have a significant impact on healthy aging.
CLINICAL GERONTOLOGIST
(2023)
Article
Psychology, Clinical
Francois Quesque, Antoine Coutrot, Sharon Cox, Leonardo Cruz de Souza, Sandra Baez, Juan Felipe Cardona, Hannah Mulet-Perreault, Emma Flanagan, Alejandra Neely-Prado, Maria Florencia Clarens, Luciana Cassimiro, Gada Musa, Jennifer Kemp, Anne Botzung, Nathalie Philippi, Maura Cosseddu, Catalina Trujillo-Llano, Johan Sebastian Grisales-Cardenas, Sol Fittipaldi, Nahuel Magrath Guimet, Ismael Luis Calandri, Lucia Crivelli, Lucas Sedeno, Adolfo M. Garcia, Fermin Moreno, Begona Indakoetxea, Alberto Benussi, Millena Vieira Brandao Moura, Hernando Santamaria-Garcia, Diana Matallana, Galina Pryanishnikova, Anna Morozova, Olga Iakovleva, Nadezda Veryugina, Oleg Levin, Lina Zhao, Junhua Liang, Thomas Duning, Thibaud Lebouvier, Florence Pasquier, David Huepe, Myriam Barandiaran, Andreas Johnen, Elena Lyashenko, Ricardo F. Allegri, Barbara Borroni, Frederic Blanc, Fen Wang, Monica Sanches Yassuda, Patricia Lillo, Antonio Lucio Teixeira, Paulo Caramelli, Carol Hudon, Andrea Slachevsky, Agustin Ibanez, Michael Hornberger, Maxime Bertoux
Summary: Measures of social cognition are essential in neuropsychology for diagnoses and rehabilitation. International collaborations help tackle global mental health challenges, but differences between countries should not be ignored.
Article
Geriatrics & Gerontology
Patrick J. Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, Philippe Voyer, Carol Hudon, Robert Laforce
Summary: The Montreal Cognitive Assessment (MoCA) is a widely used cognitive screening tool for older adults. However, interpreting its scores over time and distinguishing between age-associated cognitive decline and early neurodegeneration remains unclear. In this study, the researchers aimed to create cognitive charts using the MoCA for longitudinal evaluation of age-associated cognitive decline in clinical practice. They developed a linear regression model and validated it using two separate data sets. The Cognitive Charts-MoCA showed high validity and diagnostic accuracy, providing a valuable tool for identifying abnormal cognitive performance in older individuals and initiating appropriate investigation and treatment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Clinical Neurology
Elodie Marois, Sylvie Belleville, Olivier Potvin, Joel Macoir, Carol Hudon
Summary: This study aims to establish normative data for the story recall subtest of BEM-144, which can be used to evaluate and detect episodic memory impairment in middle-aged and older adults. The results show that sociodemographic variables such as age, sex, and education level significantly influence story recall performance.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Anne-Sophie Gaudreau, Joel Macoir, Carol Hudon
Summary: This study aimed to establish normative data for the Color Trails Test (CTT) in French-Quebec adults and elderly people, finding that age has an impact on test performance, education has a marginal effect, and sex does not play a role.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Psychology, Multidisciplinary
Joel Macoir, Pascale Tremblay, Carol Hudon
Summary: Verbal fluency tasks with high executive processing load may be useful in detecting cognitive deficits at the preclinical stage of AD, and their inclusion in assessment batteries should be considered to improve the detection of subtle cognitive impairment in preclinical major neurocognitive disorder populations.
BEHAVIORAL SCIENCES
(2022)
Article
Clinical Neurology
Mariane Landry, Marie-Michele Champagne, Charlotte Labrecque, Phylicia Verreault, Joel Macoir, Carol Hudon
Summary: This study aimed to provide normative data for the 12-item Buschke memory test in the Quebec-French population aged 50 and older. Results showed that age, years of formal education, and sex were associated with performance on the test. Normative data were provided in the form of Z-scores equations and percentiles. These findings are important for improving clinicians' accuracy in detecting verbal episodic memory impairments in Quebec's aging population.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Clinical Neurology
Joel Macoir, Carol Hudon
Summary: The aim of this study was to provide normative data for the verb fluency test in the adult population of French Quebec and to assess its discriminant validity and test-retest reliability. The results showed that age, sex, and education level were significantly related to performance on the test. The test was effective in distinguishing between healthy individuals and participants with mild cognitive impairment, and demonstrated good stability over time.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Clinical Neurology
Carol Hudon, Alexandre St-Hilaire, Mariane Landry, Florence Belzile, Joel Macoir
Summary: The present study aimed to establish normative data for the Drexel version of the Tower of London (ToL) among French-Quebec people aged 50 years and over. Results indicated that Total Execution Time was associated with age, whereas the Total Type II Errors and Total Rule Violation score were associated with both age and education level. Normative data are presented in the form of percentile ranks.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Psychology, Clinical
Joel Macoir, Carol Hudon
Summary: This study introduces two new verbal fluency tests, namely, extradimensional alternating fluency (EAF) and extradimensional orthographic constraint semantic fluency (EOCSF). The aim of Study 1 was to establish normative data for the tests in the adult and elderly population of French Quebec. The aim of Study 2 was to determine their psychometric value. Both tests proved to be useful in distinguishing healthy individuals from those with cognitive impairments.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Psychology, Clinical
Carol Hudon, Sylvie Belleville, Florence Belzile, Mariane Landry, Hannah Mulet-Perreault, Corinne Trudel, Joel Macoir
Summary: The present study aimed to establish normative data for the Judgment of Line Orientation (JLO) Test of Benton and found that JLO performance was positively associated with years of formal education and male sex, whereas it was negatively associated with age. The generated normative data will ease the detection of visuospatial impairment in French-Quebec middle-aged and older adults.
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2023)
Article
Neuroimaging
Marie-Eve Martineau-Dussault, Claire Andre, Veronique Daneault, Andree-Ann Baril, Katia Gagnon, Helene Blais, Dominique Petit, Jacques Y. Montplaisir, Dominique Lorrain, Celyne Bastien, Carol Hudon, Maxime Descoteaux, Arnaud Bore, Guillaume Theaud, Cynthia Thompson, Julie Legault, Guillermo E. Martinez Villar, Alexandre Lafreniere, Chantal Lafond, Danielle Gilbert, Julie Carrier, Nadia Gosselin
Summary: The study found that the association between obstructive sleep apnea (OSA) severity and medial temporal lobe volumes is influenced by sex, age, cognitive status, and free-water fraction correction. Further research is needed to investigate whether the increase in medial temporal subregion volumes leads to neuronal death in untreated OSA patients.
NEUROIMAGE-CLINICAL
(2022)
Article
Neurosciences
Laurence Caron, Marie-Christine Ouellet, Carol Hudon, David Predovan, Marie-Josee Sirois, Elaine de Guise, Marie-Eve Lamontagne, Marcel Emond, Natalie Le Sage, Simon Beaulieu-Bonneau
Summary: This study investigated the objective and subjective cognitive functioning of older adults with TBI at the age of 65 or over. The results showed that subjective cognitive functioning was significantly associated with mental health-related quality of life.
