Journal
CHEMICAL RECORD
Volume 16, Issue 3, Pages 1216-1227Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201500265
Keywords
drug delivery; host-guest systems; nanostructures; stimuli responsiveness; supramolecular chemistry
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Funding
- National Natural Science Foundation of China [21202083, 21472089, 21572101]
- National Natural Science Foundation of Jiangsu [BK20140595]
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Supramolecular drug delivery systems (SDDSs), including various kinds of nanostructures that are assembled by reversible noncovalent interactions, have attracted considerable attention as ideal drug carriers owing to their fascinating ability to undergo dynamic switching of structure, morphology, and function in response to various external stimuli, which provides a flexible and robust platform for designing and developing functional and smart supramolecular nano-drug carriers. Pillar[n]arenes represent a new generation of macrocyclic hosts, which have unique structures and excellent properties in host-guest chemistry. This account describes recent progress in our group to develop pillararene-based stimuli-responsive supramolecular nanostructures constructed by reversible host-guest interactions for controllable anticancer drug delivery. The potential applications of these supramolecular drug carriers in cancer treatment and the fundamental questions facing SDDSs are also discussed.
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