Review
Chemistry, Multidisciplinary
S. Arumugam, Y. Ju
Summary: The development of suitable bioactive scaffolds for bone tissue engineering is crucial to mimic the extracellular bone matrix, while the use of CNTs-reinforced composites in the biomedical field is increasing due to their outstanding properties.
MATERIALS TODAY CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Nurul Nadirah Suteris, Amina Yasin, Izan Izwan Misnon, Rasidi Roslan, Farah Hanani Zulkifli, Hanani Zulkifli, Mohd Hasbi Ab Rahim, Jayarama Reddy Venugopal, Rajan Jose
Summary: This study demonstrates the development of nanofibrous cloths loaded with curcumin for regenerative medicine applications. The optimized nanofiber scaffolds show improved swelling behavior and drug release properties, promoting fibroblast proliferation and actin expression for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Pharmacology & Pharmacy
Yolanda Diebold, Laura Garcia-Posadas
Summary: The conjunctiva, as a complex ocular tissue, plays a crucial role in protecting the ocular surface, but faces challenges in treatment. Cell therapy and tissue engineering techniques show promise in providing better treatment options for conjunctival diseases.
Review
Biochemistry & Molecular Biology
Mohammad Ehsan Taghavizadeh Yazdi, Simin Nazarnezhad, Seyed Hadi Mousavi, Mohammad Sadegh Amiri, Majid Darroudi, Francesco Baino, Saeid Kargozar
Summary: Gum tragacanth is a promising therapeutic substance in tissue engineering and regenerative medicine, as a polysaccharide extracted from various species of Astragalus. It is known for its biodegradability, non-allergenicity, non-toxicity, and stability against microbial, heat, and acid degradation. Further research is needed to define its applicability in biomedical engineering.
Review
Polymer Science
Jingzhi Fan, Keyvan Abedi-Dorcheh, Asma Sadat Vaziri, Fereshteh Kazemi-Aghdam, Saeed Rafieyan, Masoume Sohrabinejad, Mina Ghorbani, Fatemeh Rastegar Adib, Zahra Ghasemi, Kristaps Klavins, Vahid Jahed
Summary: The musculoskeletal system is crucial for movement, organ protection, support, hematopoiesis, and postural stability. Damage to or loss of musculoskeletal tissues greatly affects quality of life. Natural polymers have shown great potential in tissue engineering for musculoskeletal repair.
Review
Biochemistry & Molecular Biology
Courtney R. Lynch, Pierre P. D. Kondiah, Yahya E. Choonara
Summary: Tissue engineering involves various aspects of science, medicine, and engineering, focusing on promoting the growth of new cells and tissue components for severe tissue injury and damage treatment. Different biofabrication strategies, including hydrogels, 3D bioprinted scaffolds, and nanotechnology, are vital for this purpose. Biopolymers, specifically those with natural origins, have become increasingly popular due to their biocompatibility, biodegradability, and lack of immune response in the body.
Article
Engineering, Biomedical
Xifeng Liu, Emily T. Camilleri, Linli Li, Bipin Gaihre, Asghar Rezaei, Sungjo Park, A. Lee Miller Ii, Maryam Tilton, Brian E. Waletzki, Andre Terzic, Benjamin D. Elder, Michael J. Yaszemski, Lichun Lu
Summary: The study introduces a novel click-ON system for injectable polymer scaffolds without toxic initiators or catalysts, showing excellent bone formation and vascularization support in vivo. Additionally, an injectable porous click-ON cement was developed using salt leaching techniques to promote in vivo bone regeneration.
Review
Polymer Science
David Patrocinio, Victor Galvan-Chacon, J. Carlos Gomez-Blanco, Sonia P. Miguel, Jorge Loureiro, Maximiano P. Ribeiro, Paula Coutinho, J. Blas Pagador, Francisco M. Sanchez-Margallo
Summary: Tissue engineering focuses on developing 3D structures through bioprinting techniques using proteins and polysaccharides, but the rheological behaviors of these natural-based bioinks are the main challenge in the cell-laden printing process.
Review
Chemistry, Organic
Shobhana Sharma, Anupama Singh
Summary: Graphene oxide is a nanomaterial obtained by the reaction of graphene with oxidants, and it has distinctive physicochemical properties. Biocompatibility is an important factor for its applications in tissue engineering. The catalytic activity of carbon-based catalysts is influenced by the surface chemistry of graphene oxide.
CURRENT ORGANIC CHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Marina Lopez-Paniagua, Ana de la Mata, Sara Galindo, Francisco Blazquez, Margarita Calonge, Teresa Nieto-Miguel
Summary: ATMPs are innovative and complex biological products for human use, including cell therapy, tissue engineering, gene therapy, and combined products with medical devices. The development of ATMPs for treating eye diseases has rapidly expanded in recent years, offering novel therapeutic approaches for incurable conditions.
Article
Engineering, Multidisciplinary
Payam Zarrintaj, Farzad Seidi, Mohamadreza Youssefi Azarfam, Mohsen Khodadadi Yazdi, Amir Erfani, Mahmood Barani, Narendra Pal Singh Chauhan, Navid Rabiee, Tairong Kuang, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Masoud Mozafari
Summary: Biomimetic scaffolds play an important role in tissue regeneration and have multifunctional characteristics. Biopolymers, with their unique biocompatibility and biodegradability, are ideal candidates for tissue engineering and regenerative medicine. This article reviews different types of biopolymers and their composites, as well as their interactions with specific cells and tissues. Cellular mechanisms in tissue regeneration are also considered, along with the challenges and improvements required for using biopolymer-based composites in tissue engineering.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Green & Sustainable Science & Technology
Francesca Scalera, Anna Grazia Monteduro, Giuseppe Maruccio, Laura Blasi, Francesca Gervaso, Elisabetta Mazzotta, Cosimino Malitesta, Clara Piccirillo
Summary: This study successfully developed an electroconductive scaffold using chitosan and an innovative filler obtained from cork, showing potential applications in tissue engineering.
SUSTAINABLE MATERIALS AND TECHNOLOGIES
(2021)
Review
Biotechnology & Applied Microbiology
Ipek Suntar, Sumeyra Cetinkaya, Ulku Selcen Haydaroglu, Solomon Habtemariam
Summary: Decades of research have led to advancements in sustainable bioproduction of high-value natural products, with recent developments in biotechnological production of NPs driven by new methodologies and omics technologies. High-throughput technologies like NGS and CRISPR/Cas9 have revolutionized the field, allowing for higher yields and production of complex molecules.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Cell & Tissue Engineering
Prasad Sawadkar, Nandin Mandakhbayar, Kapil D. Patel, Jennifer Olmas Buitrago, Tae Hyun Kim, Poojitha Rajasekar, Ferdinand Lali, Christos Kyriakidis, Benyamin Rahmani, Jeviya Mohanakrishnan, Rishbha Dua, Karin Greco, Jung-Hwan Lee, Hae-Won Kim, Jonathan Knowles, Elena Garcia-Gareta
Summary: The study focuses on using natural polymer scaffolds seeded with stem cells to improve soft tissue repair, finding that collagen-based materials exhibit good cell adhesion and proliferation in vitro, with superior adipogenic properties in vivo. In contrast, fibrin shows poor cellular and adipogenesis properties but higher angiogenesis. Elastin forms the most porous scaffold, with non-aggregated cell morphology in vitro, and degrades the fastest in vivo.
JOURNAL OF TISSUE ENGINEERING
(2021)
Review
Biotechnology & Applied Microbiology
Naima Ahmed Omar, Joelle Amedee, Didier Letourneur, Jean-Christophe Fricain, Mathilde Fenelon
Summary: This systematic review presents the applications of pullulan and dextran-based biomaterials in bone tissue engineering (BTE). Different strategies have been developed to enhance their bone regeneration capacity, primarily through their fabrication processes and the addition of bioactive elements. The review highlights the potential and limitations of pullulan and dextran-based biomaterials for BTE applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yi-Hua Hung, Chun-Yen Liu, Wei-Chieh Chen, Jui-Hsiang Liu
Summary: This study demonstrates the synthesis of chiral amphitropic liquid crystals derived from cholesterol and investigates their thermal and optical properties. The synthesized CCM shows unique liquid crystal phases and can be used for developing temperature and solvent sensors. However, the loss of liquid crystalline properties was observed after polymerization, but the cholesteric structure of monomeric CCM was fixed via UV-polymerization.
Article
Polymer Science
Jui-Hsiang Liu, Yi-Hua Hung, Ssu-Ni Lin, Sergey A. Shvetsov, Vladimir Yu. Rudyak, Alexander V. Emelyanenko, Chun-Yen Liu
Summary: This study demonstrates the synthesis of recyclable polymer beads for Cu(2+) sensing using radially aligned liquid crystal assistance, achieving high sensitivity detection of metal ions in aqueous solutions through a spiro ring-opening mechanism. The fabricated polymeric LC beads were shown to change color in response to the presence of Cu2+ ions, and could be recycled by treating with aqueous ammonia, making it an easy method for metal ion detection in aqueous solutions.
Article
Polymer Science
Yi-Hua Hung, Chun-Yen Liu, Kai-Ti Chang, Yi-Ho Chen, Jui-Hsiang Liu
Summary: The study synthesized photonic films without a chiral dopant using a predesigned multiple photopolymerization process. These films can detect solvent changes and different kinds of mixed solvents through naked-eye observation and ultraviolet-visible spectroscopy. Furthermore, copolymerization with a rhodamine-derived monomer improved the sensing properties of the films.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Kai-Ti Chang, Chun-Yen Liu, Jui-Hsiang Liu
Summary: In this study, liquid crystal (LC) actuators were successfully fabricated with polydopamine (PDA) assistance to control order parameters, effectively converting thermal energy and photo-energy to mechanical power. Adding chiral dopant increased curling efficiency, and a hand-shaped actuator with gripping ability was prepared. Coating the surface with PDA enhanced the near-infrared light sensitivity of the LC networks.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Materials Science, Multidisciplinary
Kai Ti Chang, Chun Yen Liu, Jui Hsiang Liu
Summary: A tunable artificial iris made from liquid crystalline elastomers is demonstrated in this study, showing reversible pupil widening and closing in response to near-infrared light. The iris is synthesized using a stainless steel mold and coated with polydopamine to enhance photosensitivity. This fabricated artificial iris, with 2D radial motion, is the first example to show a tunable aperture size controlled by surrounding light intensity, and is expected to have potential applications in biomimicry and biomedical science.
MACROMOLECULAR MATERIALS AND ENGINEERING
(2021)
Article
Polymer Science
Chun-Yen Liu, Cheng-Chieh Chen, Chia-Ming Tu, Sheng-Chi Hung, Chia-Hui Chao
Summary: The research demonstrates the production of sliced polymeric films with different reflected colors through Bragg reflection, with the stability of reflected colors being influenced by the ratio of chiral dopants in the liquid crystal mixture. Colorful patterns can be easily created using cholesteric liquid crystal slices. Additionally, nanosized structural colorants can be prepared through femtosecond lasers for broader applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Chun-Yen Liu, Chien-Hsiang Chang, Thanh Tran Thi, Guan-Yi Wu, Chia-Ming Tu, Hung-Yi Chen
Summary: In this study, a series of cross-linked and interpenetrated poly(NIPAM-co-AM) hydrogel networks were synthesized to enhance the biocompatibility of artificial iris. The N3A1-N3A1 interpenetrated network hydrogel showed the best performance and was selected for the fabrication of thermally and light tunable iris-like actuators. The results demonstrated the feasibility of using poly(NIPAM-co-AM) IPN hydrogels for the design of thermal and light-responsive actuators.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Guan-Yi Wu, Kai-Ti Chang, Szu-Yin Ou, Chao-Hui Zhuang, Chun-Yen Liu
Summary: This article presents a novel design of liquid crystal displays using predesigned radially constructed polydopamine particles. The results show that the radially constructed particles greatly enhance the performance of cholesteric liquid crystal devices, leading to higher contrast, lower threshold voltage, and faster response time.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Engineering, Chemical
Chia-Ming Tu, Chia-Hui Chao, Sheng-Chi Hung, Szu-Yin Ou, Chao-Hui Zhuang, Chun-Yen Liu
Summary: A series of photonic polymers and butterfly-shaped LC actuators were fabricated using a laser cutter, showing reversible curling and color variations simultaneously. The synthesis of photonic polymers via one-step polymerization was achieved, demonstrating color variation and thermal actuation. The butterfly-shaped LC actuators, with planar-co-focal-conic layers, have great potential for applications in soft robotics and optical devices.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Polymer Science
Chia-Hui Chao, Wei-Chuan Chen, Chung-Yu Kuo, Chun-Yen Liu
Summary: In this study, a predesigned method was used to fabricate rolling direction controllable asymmetrically constructed cylindrical liquid crystal elastomers (CLCEs). The CLCEs were fabricated by Michael addition and stretched uniaxially with a twisted angle before fixing with UV polymerization. The created CLCEs showed asymmetric gravity center and thermal actuation. The location of the gravity center was estimated in order to achieve rolling direction control.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Chemical
Yi-Hua Hung, Kai -Ti Chang, Zi-Yun Chiu, Jia-Ying Chang, Kai -Ting Yen, Chun -Yen Liu
Summary: In this study, a novel liquid crystalline acrylic chiral dopant was synthesized and incorporated into dual frequency cholesteric liquid crystal, resulting in a bistable display material with a high transmittance of 97.6% and a fast response time of 1.5 ms. The material can maintain the transparent ON and opaque OFF states without the bias of a continuous electric field.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Engineering, Biomedical
Kai-Ti Chang, Yi-Hua Hung, Zi-Yun Chiu, Jia-Ying Chang, Kai-Ting Yen, Chang Yen Liu
Summary: Inspired by human muscle tissues, preconstructed porous liquid crystalline (LC) scaffolds were fabricated using a two-step polymerization and salt leaching method. These biocompatible scaffolds provide enough space for cell growth and can be implanted into the human body to improve mechanical properties. In vitro experiments confirmed the good biocompatibility of the LC scaffolds and the enhancement of cell growth with the addition of gelatin. The scaffolds also induced the growth direction of smooth muscle cells and showed potential for tissue engineering in biomedical and research fields.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Hung-Yi Chen, Bing-Han Wu, Szu-Yin Ou, Chao-Hui Zhuang, Chun-Yen Liu
Summary: This study demonstrates the preparation of a secondary energy conversion device based on cylindrical liquid crystal elastomers (CLCE) that can convert near-infrared energy to electric power. By coating the surface with polydopamine, the sensitivity to near-infrared is enhanced. The CLCE actuators were combined with a hydrogel-assembled triboelectric nanogenerator to create a photomechanical-electrical secondary energy conversion device.
ACS APPLIED ELECTRONIC MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Chun-Yen Liu, Chi-Feng Yen, Yi-Hua Hung, Chia-Min Tu, Guan-Yi Wu, Hung-Yi Chen
Summary: By synthesizing chiral ferroelectric liquid crystals to induce the formation of cholesteric liquid crystal phase, stable bistable cholesteric liquid crystal devices were fabricated with efficient energy-saving switching. Further stabilization of the devices was achieved through polymer matrixes, and reliable one-step voltage switching was demonstrated, showcasing potential for energy-saving green liquid crystal displays and related smart devices.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)
Article
Nanoscience & Nanotechnology
Jui-Hsiang Liu, Yi-Hua Hung, Kai-Ti Chang, Chun-Yu Kao, Yu-Ting Lin, Chun-Yen Liu
ACS APPLIED BIO MATERIALS
(2020)