d-Serine, the Shape-Shifting NMDA Receptor Co-agonist

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

(2019) Justin M. Long et al.   CELL

Neurotoxic astrocytes express the d-serine synthesizing enzyme, serine racemase, in Alzheimer's disease

(2019) Darrick T. Balu et al.   NEUROBIOLOGY OF DISEASE

Astrocytes in primary cultures express serine racemase, synthesize d -serine and acquire A1 reactive astrocyte features

(2018) Suyan Li et al.   BIOCHEMICAL PHARMACOLOGY

Serine Racemase and D-serine in the Amygdala Are Dynamically Involved in Fear Learning

(2018) Darrick T. Balu et al.   BIOLOGICAL PSYCHIATRY

Astroglial CB 1 Receptors Determine Synaptic D-Serine Availability to Enable Recognition Memory

(2018) Laurie M. Robin et al.   NEURON

Alzheimer’s Disease (AD) therapeutics - 1: Repeated clinical failures continue to question the amyloid hypothesis of AD and the current understanding of AD causality

(2018) Kevin Mullane et al.   BIOCHEMICAL PHARMACOLOGY

The 1980s: d-AP5, LTP and a Decade of NMDA Receptor Discoveries

(2018) D. Lodge et al.   NEUROCHEMICAL RESEARCH

Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia

(2018) Ariel A. Jacobi et al.   NEUROSCIENCE LETTERS

Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness

(2018) Tomas Hökfelt et al.   Frontiers in Neural Circuits

Astrocytic IP3Rs: Contribution to Ca2+signalling and hippocampal LTP

(2017) Mark William Sherwood et al.   GLIA

Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function

(2017) Vanessa Morais Sardinha et al.   GLIA

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury

(2017) Enmanuel J. Perez et al.   JOURNAL OF CLINICAL INVESTIGATION

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex

(2017) Claire Meunier et al.   JOURNAL OF NEUROSCIENCE

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

(2017) Thomas Papouin et al.   NEURON

DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice

(2017) Chantelle E Terrillion et al.   NEUROPSYCHOPHARMACOLOGY

Astroglial Versus Neuronal D-Serine: Check Your Controls!

(2017) Herman Wolosker et al.   TRENDS IN NEUROSCIENCES

Astroglial versus Neuronal D-Serine: Fact Checking

(2017) Thomas Papouin et al.   TRENDS IN NEUROSCIENCES

D-serine released by astrocytes in brainstem regulates breathing response to CO2 levels

(2017) S. Beltrán-Castillo et al.   Nature Communications

Morphine-induced inhibition of Ca2+ -dependent d -serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens

(2016) Jian Wu et al.   ADDICTION BIOLOGY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

EphB3 signaling propagates synaptic dysfunction in the traumatic injured brain

(2016) Enmanuel J. Perez et al.   NEUROBIOLOGY OF DISEASE

The Rise and Fall of the d -Serine-Mediated Gliotransmission Hypothesis

(2016) Herman Wolosker et al.   TRENDS IN NEUROSCIENCES

D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability

(2016) Hong Lin et al.   Frontiers in Cellular Neuroscience

Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia

(2015) Guillermo Gonzalez-Burgos et al.   BIOLOGICAL PSYCHIATRY

Neuronal serine racemase regulates extracellular d-serine levels in the adult mouse hippocampus

(2015) Sayuri Ishiwata et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

Synaptic Integration of Adult-Born Hippocampal Neurons Is Locally Controlled by Astrocytes

(2015) Sébastien Sultan et al.   NEURON

Gliotransmission: focus on exocytotic release of L-glutamate and D-serine from astrocytes

(2015) Magalie Martineau   BIOCHEMICAL SOCIETY TRANSACTIONS

The serine shuttle between glia and neurons: implications for neurotransmission and neurodegeneration: Figure 1

(2015) Herman Wolosker et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

d-Serine and Serine Racemase are Localized to Neurons in the Adult Mouse and Human Forebrain

(2014) Darrick T. Balu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Serine Racemase Regulated by Binding to Stargazin and PSD-95

(2014) Ting Martin Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

(2014) T. Fujita et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Astrocytic adenosine: from synapses to psychiatric disorders

(2014) D. J. Hines et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus

(2014) Matildé Le Bail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Storage and Uptake of D-Serine into Astrocytic Synaptic-Like Vesicles Specify Gliotransmission

(2013) M. Martineau et al.   JOURNAL OF NEUROSCIENCE

Neuronal D-Serine and Glycine Release Via the Asc-1 Transporter Regulates NMDA Receptor-Dependent Synaptic Activity

(2013) D. Rosenberg et al.   JOURNAL OF NEUROSCIENCE

D-Serine in Glia and Neurons Derives from 3-Phosphoglycerate Dehydrogenase

(2013) J. T. Ehmsen et al.   JOURNAL OF NEUROSCIENCE

A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric A , and Frank Neuronal Loss

(2013) R. M. Cohen et al.   JOURNAL OF NEUROSCIENCE

Astrocytes release d-serine by a large vesicle

(2013) N. Kang et al.   NEUROSCIENCE

Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level

(2013) Yan Li et al.   Nature Communications

Synaptic and Extrasynaptic NMDA Receptors Are Gated by Different Endogenous Coagonists

(2012) Thomas Papouin et al.   CELL

Cell Selective Conditional Null Mutations of Serine Racemase Demonstrate a Predominate Localization in Cortical Glutamatergic Neurons

(2012) Michael A. Benneyworth et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion

(2012) T M Ma et al.   MOLECULAR PSYCHIATRY

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex

(2011) Pascal Fossat et al.   CEREBRAL CORTEX

Levels of d-serine in the brain and peripheral organs of serine racemase (Srr) knock-out mice

(2011) Mao Horio et al.   NEUROCHEMISTRY INTERNATIONAL

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Neuronal release of d-serine: a physiological pathway controlling extracellular d-serine concentration

(2010) Dina Rosenberg et al.   FASEB JOURNAL

Brain-specificPhgdhDeletion Reveals a Pivotal Role for l-Serine Biosynthesis in Controlling the Level of d-Serine, anN-methyl-d-aspartate Receptor Co-agonist, in Adult Brain

(2010) Jung Hoon Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase C activity regulates d-serine availability in the brain

(2010) Charles Vargas-Lopes et al.   JOURNAL OF NEUROCHEMISTRY

EphrinBs Regulate D-Serine Synthesis and Release in Astrocytes

(2010) Z. Zhuang et al.   JOURNAL OF NEUROSCIENCE

Long-term potentiation depends on release of d-serine from astrocytes

(2010) Christian Henneberger et al.   NATURE

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Gliotransmission: Exocytotic release from astrocytes

(2009) Vladimir Parpura et al.   BRAIN RESEARCH REVIEWS

Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures

(2009) Zongjun Shao et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Serine racemase is predominantly localized in neurons in mouse brain

(2008) Kazushi Miya et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior

(2008) A C Basu et al.   MOLECULAR PSYCHIATRY