Article
Multidisciplinary Sciences
Steve Harakeh, Yousef Qari, Hanaa Tashkandi, Mohammed Almuhayawi, Saber H. Saber, Emad Aljahdali, Nagla El-Shitany, Soad Shaker, Filipa Lucas, Turki Alamri, Soad Al-Jaouni, Shaker Mousa
Summary: This study evaluated the protective effects of a novel nanoparticle encapsulating thymoquinone (THY) against cisplatin (CISP)-induced nephrotoxicity. The results showed that NP THY effectively prevented kidney toxicity, improved kidney function and pathology. It also ameliorated oxidative stress conditions and reduced inflammation induced by CISP in the kidney tissue.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yanting Yang, Xiuhong Zhu, Guohua Yu, Jinbo Ma
Summary: This study demonstrates that Pyxinol can mitigate cisplatin-induced renal injury by attenuating DNA damage response and tubular cell apoptosis. Furthermore, Pyxinol can enhance the in vivo anti-tumor efficacy of cisplatin against xenograft tumors in nude mice. The combination of Pyxinol with cisplatin may represent a beneficial adjunct therapy for cisplatin-based chemotherapeutic regimens in the clinic.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Heba Bassiony, Akmal A. El-Ghor, Taher A. Salaheldin, Salwa Sabet, Mona M. Mohamed
Summary: The study found that injection of magnetite nanoparticles induced histopathological changes and DNA damage in mice, with different administration routes leading to significant iron content changes in various organs. Injecting MNPs into tumors may have anticancer effects, but it is recommended to minimize adverse effects on healthy tissues.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Steve Harakeh, Mohammed S. Almuhayawi, Isaac O. Akefe, Saber H. Saber, Soad K. Al Jaouni, Torki Alzughaibi, Yousef Almehmadi, Soad Shaker Ali, Dhruba J. Bharali, Shaker Mousa
Summary: Pomegranate nanoparticles can effectively ameliorate cisplatin-induced nephrotoxicity without compromising its antitumor efficacy.
Article
Pharmacology & Pharmacy
Amr Ahmed WalyEldeen, Haidan M. El-Shorbagy, Hamdi M. Hassaneen, Ismail A. Abdelhamid, Salwa Sabet, Sherif Abdelaziz Ibrahim
Summary: This study evaluated the in vivo anticancer activity of a synthetic isoquinoline chalcone (CHE) in mice with solid carcinoma. The results showed that CHE treatment significantly inhibited tumor growth and induced apoptosis through oxidative stress and DNA damage. Additionally, CHE exhibited minimal toxicity on the liver and kidney.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzawa
Summary: LKB1 promotes p53 activation and apoptosis induced by cisplatin in human fibrosarcoma cells, while AMPK negatively regulates p53 activation and apoptosis. Furthermore, AMPK can suppress p53 activation through oxidative stress, as shown by the cancellation of apoptosis with antioxidants in AMPK DKO cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Asmaa Elsayed, Ashraf Elkomy, Reda Elkammar, Gehan Youssef, Ehab Yahya Abdelhiee, Walied Abdo, Sabreen Ezzat Fadl, Ahmed Soliman, Mohamed Aboubakr
Summary: The study demonstrates that administration of LP and NAC alone or in combinations can ameliorate hepatorenal toxicity and apoptosis induced by CP.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Pia Loren, Nicolas Saavedra, Kathleen Saavedra, Tomas Zambrano, Patricia Moriel, Luis A. Salazar
Summary: Cisplatin, an antineoplastic drug, is most notably known for its nephrotoxicity among various side effects. Recent research shows that epigenetic regulation plays a key role in cisplatin-induced nephrotoxicity by altering different signaling pathways leading to cell death. Despite the ongoing development in this field, it offers new strategies for the diagnosis and treatment of diseases.
Article
Biochemistry & Molecular Biology
Natalia A. A. Samoylova, Artem P. P. Gureev, Vasily N. N. Popov
Summary: Cisplatin, a platinum-based cytostatic drug used for cancer treatment, can cause nephrotoxicity by damaging renal mitochondria and mtDNA. This study found that exposure to cisplatin increased lipid peroxidation and induced damage to renal mtDNA. On the other hand, methylene blue protected kidney mitochondria by activating the Nrf2/ARE signaling pathway and promoting the expression of antioxidant genes and genes related to mtDNA repair. This research highlights the significance of using methylene blue to protect kidney mitochondria from cisplatin-induced damage in medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Barakat M. Alrashdi, Roaya A. Mohamed, Amal H. Mohamed, Feryal A. Samoul, Mazen I. Mohamed, Mohsen M. Moussa, Saad M. Alrashidi, Bassel Dawod, Ola A. Habotta, Ahmed E. Abdel Moneim, Shimaa S. Ramadan
Summary: This study found that turmeric conjugated with selenium nanoparticles effectively counteracted cisplatin-induced renal impairment in mice. Turmeric or turmeric-seNPs therapy significantly reduced renal dysfunction and inflammation, improved oxidative status, and inhibited renal apoptosis in cisplatin-treated mice.
BIOSCIENCE REPORTS
(2023)
Article
Oncology
Brian Geohagen, Elizabeth Zeldin, Kimberly Reidy, Tao Wang, Evripidis Gavathiotis, Yonatan Fishman, Richard LoPachin, David M. Loeb, Daniel A. Weiser
Summary: Cisplatin is an effective chemotherapeutic agent but causes irreversible systemic end-organ damage. We developed acetophenone-derived compounds that directly mitigate the side effects of cisplatin based on the hard-soft acid-base theory. Investigating organ-specific and generalized toxicity, we found that pre-treatment with acetophenones preserved normal organ function and prevented toxic effects induced by cisplatin.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hadar Golan Berman, Pooja Chauhan, Shira Shalev, Hiba Hassanain, Avital Parnas, Sheera Adar
Summary: The study identified that in a specific cell line system, cisplatin resistant cells had less damage but similar repair kinetics. Through mapping gene expression changes, 56 upregulated genes were identified that could potentially impact the response to cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yu-Li Su, Ling-Yi Xiao, Shih-Yu Huang, Chia-Che Wu, Li-Chung Chang, Yi-Hua Chen, Hao-Lun Luo, Chun-Chieh Huang, Ting-Ting Liu, Jei-Ming Peng
Summary: The combination of the Wee1 inhibitor AZD-1775 with cisplatin shows promising anticancer efficacy in urothelial carcinoma (UC) and represents an innovative therapeutic strategy for overcoming resistance to cisplatin-based chemotherapy in UC.
Article
Chemistry, Medicinal
Nahed Saleh, Tamer Allam, Reda M. S. Korany, Abdelfattah M. Abdelfattah, Ahmed M. Omran, Mabrouk Attia Abd Eldaim, Aziza M. Hassan, Nermeen Borai El-Borai
Summary: This study evaluates the antitumor efficacy of hesperidin (Hesp) versus cisplatin (Cis) in Ehrlich ascites carcinoma (EAC)-bearing mice, as well as its protective effect against Cis-triggered nephrotoxicity. The study found that hesperidin can alleviate the renal adverse side effects of cisplatin and has potential antitumor effects.
Article
Urology & Nephrology
Hirofumi Hamano, Yasumasa Ikeda, Mitsuhiro Goda, Keijo Fukushima, Seiji Kishi, Masayuki Chuma, Michiko Yamashita, Takahiro Niimura, Kenshi Takechi, Masaki Imanishi, Yoshito Zamami, Yuya Horinouchi, Yuki Izawa-Ishizawa, Licht Miyamoto, Keisuke Ishizawa, Hiromichi Fujino, Toshiaki Tamaki, Ken-ichi Aihara, Koichiro Tsuchiya
Summary: Research suggests that diphenhydramine may serve as a novel treatment for cisplatin-induced kidney toxicity by inhibiting cell death and reducing oxidative stress to alleviate kidney injury, with clinical evidence from patients supporting this finding.
KIDNEY INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Amr A. Abd-Elghany, Ebtesam A. Mohamad
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2020)
Article
Engineering, Biomedical
Haitham S. Mohammed, Hagar M. Hassan, Michael H. Zakhari, Hassan Mostafa, Ebtesam A. Mohamad
Summary: This study successfully detected seizures by recording ECoG signals from animals and extracting features, using an SVM classifier. Linear features performed better in terms of accuracy, and combining linear and non-linear features maximized the system's accuracy.
BIOMEDICAL ENGINEERING-BIOMEDIZINISCHE TECHNIK
(2021)
Article
Biology
Ebtesam A. Mohamad, Alyaa A. Elfky, Reem H. El-Gebaly, Amira Afify
Summary: The study showed that increasing the applied electrical field strength or the number of pulses significantly increased the mortality rates of mosquito larvae (P < .05), which was assessed using a bioassay system, SDS-PAGE for whole body proteins, enzyme analysis, and ultrastructural examination with TEM. The findings suggest that a low pulsed electric field can cause genotoxic effects in mosquito larvae, leading to changes in their body proteins which may impact their ability to survive. The increase in pulsed electric field parameters also induces oxidative stress in insect cells by disrupting enzyme secretion, potentially affecting mosquito capabilities in the future.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Ebtesam A. Mohamad, Monira M. Rageh, Mirhan Mostafa Darwish
Summary: The study successfully encapsulated sunscreen in CS-nio-aloe/PBSA polymer nanoparticles, which were completely deposited on the skin surface, providing skin protection and promoting sustained release of PBSA.
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
(2022)
Article
Chemistry, Multidisciplinary
Ebtesam A. Mohamad, Zahraa N. Mohamed, Mohammed A. Hussein, Mona S. Elneklawi
Summary: In this study, gallic acid nanoemulsion (GANE) was prepared by loading gallic acid onto niosomes using a green synthesis technique. GANE showed high encapsulation efficiency and cytotoxicity, and provided significant protection against LPS-induced pulmonary fibrosis. It exhibited antioxidant and anti-inflammatory effects.
Article
Materials Science, Multidisciplinary
Amr A. Abd-Elghany, Ebtesam A. Mohamad, Mohamed A. El-Sakhawy, Sofiene Mansouri, Sameh H. Ismail, Mona S. Elneklawi
Summary: This study aimed to enhance the mechanical properties of chitosan films by doping niosomal sage nanoparticles (NS-SagNPs) at various concentrations. The doped films showed improved mechanical properties, particularly in tensile strength and elasticity, when the NS-SagNPs loading was increased to 300 μg.
MATERIALS RESEARCH EXPRESS
(2022)
Article
Biology
Ebtesam A. Mohamad, Marwa A. Ramadan, Marwa M. Mostafa, Mona S. Elneklawi
Summary: This study aims to reduce the activity and growth characteristics of Staphylococcus aureus using nanoparticles and extremely low frequency electric fields. The results show that the combination of nanoparticles with ELF-EF at 0.8 Hz enhances bacterial inhibition efficiency.
ELECTROMAGNETIC BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ebtesam A. Mohamad, Kawkab A. Ahmed, Haitham S. Mohammed
Summary: The study investigated the efficacy of Annona squamosa leaf extract (A.S.L.E) and its niosomal-entrapped preparation in protecting skin from UVA irradiation. Results showed that the niosomal-entrapped A.S.L.E was more effective than the native plant leaf extract in protecting skin from the damaging effects of UVA, suggesting its potential as an effective sunscreen against UVA radiation.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Amr A. Abd-Elghany, Ebtsam A. Mohamad
Summary: The research demonstrated that iron oxide nanoparticles have significant antitumor activity against Ehrlich carcinoma in mice, with in vivo experiments showing therapeutic efficacy and toxicity assessment using FTIR spectroscopy and DNA comet assay.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ebtesam Abdelghany Mohamad, Heba Mohamed Fahmy
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Food Science & Technology
Ebtesam A. Mohamad, Walaa N. Ali, Omar S. Desouky, Seham M. El-Marakby, Wael M. Elshemey
ANNALS OF THE UNIVERSITY DUNAREA DE JOS OF GALATI, FASCICLE VI-FOOD TECHNOLOGY
(2019)