Review
Cell Biology
Elisabetta Xue, Antonina Minniti, Tobias Alexander, Nicoletta Del Papa, Raffaella Greco
Summary: Systemic sclerosis is a disease characterized by autoimmune responses, vasculopathy, and tissue fibrosis. Currently available drugs have limited effects, so cellular therapies have become an important area of research.
Article
Psychology, Multidisciplinary
Xiaoyang Zhao, Changjun Yi, Chusheng Chen
Summary: This study, based on social identity theory and resource conservation theory, systematically investigates the impact of internal social capital on employees' innovative behavior. The results reveal that internal social capital has a positive effect on innovative behavior, and this effect is partly mediated by internal identity. Additionally, workplace friendship positively moderates the relationship between internal social capital and innovative behavior.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Oncology
Hiroyoshi Nishikawa, Shohei Koyama
Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Cell Biology
Abdul Fatah A. Samad, Mohd Farizal Kamaroddin
Summary: MicroRNA has the potential to regulate genetic pathways and has been explored as a therapeutic tool. However, there are challenges such as off-target effects, immunogenicity, and delivery platforms. Recently, innovative approaches have been developed to address these issues. Nevertheless, dosage remains an uncertainty for miRNA administration.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Mathematics
Peng Shao, Runhua Tan, Qingjin Peng, Wendan Yang, Fang Liu
Summary: This paper proposes an integrated method combining the technological evolution laws with back propagation neural network, international patent classification, and company's technological distance to forecast the potential states and directions of the new generation of products. By reducing the dependence on designers' experience and providing a systematic approach, the proposed method can stimulate innovative product design.
Review
Cell Biology
Biao Huang, Zipeng Zeng, Chennan C. Zhang, Megan E. Schreiber, Zhongwei Li
Summary: One out of seven people develop chronic kidney disease, and a shortage of donor kidneys for transplantation is a pressing issue. Innovative solutions are needed to address this problem.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Fatima Guerrero, Victoria Pulido, Said Hamad, Pedro Aljama, Alejandro Martin-Malo, Carolina Carrillo-Carrion
Summary: This study demonstrates the potential of zeolitic-imidazolate framework-8 nanoparticles to be incorporated within a renal scaffold while still retaining their ability to remove hydrophobic uremic toxins like p-cresol under flow conditions. This could lead to the development of novel adsorbents for dialysis and/or artificial kidneys in the future.
Review
Chemistry, Multidisciplinary
Pramila Patil, Sushil S. S. Sangale, Sung-Nam Kwon, Seok-In Na
Summary: Perovskite solar cells (PSCs) have rapidly advanced and achieved performance comparable to silicon solar cells. Semi-transparent PSCs (ST-PSCs) are a promising application that utilizes the tunable transmittance of perovskite photoactive layers. To overcome challenges, studies are focusing on band-gap tuning, high-performance charge transport layers, electrodes, and creating island-shaped microstructures. This review provides a summary of innovative approaches in ST-PSCs, including advancements in perovskite photoactive layers, transparent electrodes, device structures, and their applications in tandem solar cells (TSC) and building-integrated photovoltaics (BIPV).
Review
Cell Biology
Hafid Ait-Oufella, Jean-Remi Lavillegrand, Alain Tedgui
Summary: Research shows that chronic inflammation triggered by cholesterol-rich lipoproteins is crucial in atherosclerosis development. Effector Th1 cells are proatherogenic, while regulatory T cells (Tregs) protect against atherosclerosis. Understanding how Tregs affect atherosclerosis could lead to new targeted therapies against cardiovascular disease.
Article
Engineering, Biomedical
Leszek Pstras, Joanna Stachowska-Pietka, Malgorzata Debowska, Mauro Pietribiasi, Jan Poleszczuk, Jacek Waniewski
Summary: Haemodialysis and peritoneal dialysis are crucial kidney replacement therapies for patients with end-stage renal disease. Mathematical and computational models play an essential role in analyzing and predicting the complex transport and regulatory processes during dialysis. This article provides an overview of the important aspects and challenges of these therapies, along with examples of mathematical models used to study and optimize them.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Monica Mossenta, Davide Busato, Michele Dal Bo, Paolo Macor, Giuseppe Toffoli
Summary: This review article discusses the clinical features and common treatment approaches for hepatocellular carcinoma (HCC). Targeted nanoparticle-based therapies for HCC, which aim to improve drug delivery and overcome drug resistance, show promise by targeting glypican 3 (GPC3) as a tumor-associated antigen. The use of nanoparticles conjugated with anti-GPC3 agents may also reduce severe side effects caused by chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Enrico Cavarzerani, Isabella Caligiuri, Michele Bartoletti, Vincenzo Canzonieri, Flavio Rizzolio
Summary: High-grade serous ovarian cancer (HGSOC) requires new technologies for diagnosis and therapy improvement. Dynamic culture systems with patient-derived 3D microstructures could offer a new opportunity for exploring novel therapeutic approaches. In this study, a passive microfluidic platform with optimized conditions was utilized to improve the growth of cancer organoids, reduce the number of dead cells, and enhance drug penetration into the extracellular matrix (ECM).
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Chih-Yu Cheng, Yu-Sheng Wang, Zhong-Liang Wang, Sidra Bibi
Summary: This research increased the yield and quality of edible mushrooms by optimizing the morphology and culture medium formula of mycelial pellets, providing an alternative option for future food.
Article
Cell Biology
Bella Rossbach, Krithika Hariharan, Nancy Mah, Su-Jun Oh, Hans-Dieter Volk, Petra Reinke, Andreas Kurtz
Summary: This study investigates the immunological effects of hiPSC-derived cells and finds that their immune response varies depending on the stage of cell maturation. Autologous and allogeneic T cells tolerate early renal progenitors and mature renal epithelial cells, while NK cell responses are not suppressed and can effectively change NK cell activation status. These findings have important implications for the success of cell therapies.
Review
Chemistry, Medicinal
Qi Miao, Vilas D. Kadam, Ayan Mukherjee, Zhi Tan, Mingxing Teng
Summary: Chemically induced proximity-based targeted protein degradation has become a prominent paradigm in drug discovery, and additional E3 ubiquitin ligases are being harnessed to enrich the arsenal of this therapeutic approach to tackle drug resistance.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Surgery
Tim Pruimboom, Sander M. J. van Kuijk, Shan S. Qiu, Jacqueline van den Bos, Fokko P. Wieringa, Rene R. W. J. van der Hulst, Rutger M. Schols
SURGICAL INNOVATION
(2020)
Editorial Material
Engineering, Biomedical
Fokko P. Wieringa, Murray Sheldon
Article
Engineering, Biomedical
Bernardo Pereira Cabral, Joseph Bonventre, Fokko Wieringa, Fabio Batista Mota
Summary: Innovations in kidney replacement therapy are considered to lag behind other medical fields, but the majority of experts anticipate a revolution in kidney replacement therapies in the future, with implantable artificial kidneys and wearable artificial kidneys being the most likely approaches according to the surveyed experts.
Editorial Material
Engineering, Biomedical
Fokko P. Wieringa, Murray Sheldon, Stephen R. Ash, Thomas Groth, Jasper Boomker, Tom Oostrom, Raymond Vanholder
Article
Transplantation
Lucas Lindeboom, Seulki Lee, Fokko Wieringa, Willemijn Groenendaal, Carlo Basile, Frank van der Sande, Jeroen Kooman
Summary: Bioimpedance spectroscopy (BIS) is a promising non-invasive technique for fluid monitoring in haemodialysis patients, with the development of wearable devices opening up opportunities for unobtrusive longitudinal fluid status monitoring. This advancement may ultimately lead to improved fluid management, lower mortality rates, and enhanced quality of life for HD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Book Review
Engineering, Biomedical
Fokko P. Wieringa, Henning Sondergaard, Stephen Ash
Review
Urology & Nephrology
Raymond Vanholder, Lieven Annemans, Aminu K. Bello, Boris Bikbov, Daniel Gallego, Ron T. Gansevoort, Norbert Lameire, Valerie A. Luyckx, Edita Noruisiene, Tom Oostrom, Christoph Wanner, Fokko Wieringa
Summary: Kidney disease, including both chronic kidney disease and acute kidney injury, imposes a heavy burden on European population, affecting health, quality of life and economy. More research and investment are needed to address this growing issue.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Transplantation
Raymond Vanholder, John Agar, Marion Braks, Daniel Gallego, Karin G. F. Gerritsen, Mark Harber, Edita Noruisiene, Jitka Pancirova, Giorgina B. Piccoli, Dimitrios Stamatialis, Fokko Wieringa
Summary: This article emphasizes the mutual impact of climate change on kidney health and kidney care on ecology. It proposes a range of solutions, including measures to reduce water consumption, implement energy-neutral policies, waste triage, and material recycling, to address the ecological burden caused by nephrology care.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Raymond Vanholder, Paul T. Conway, Daniel Gallego, Eveline Scheres, Fokko Wieringa
Summary: The European Kidney Health Alliance is an advocacy organization that aims to defend the rights of kidney patients and the nephrological community. They have partnered with the American Association of Kidney Patients to launch the Decade of the Kidney initiative, advocating for innovation in kidney care. This article provides an overview of the medical and patient burden of kidney disease, the history and activities of EKHA, and the need for innovation in kidney care.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Chemistry, Analytical
Jorge Herranz Olazabal, Fokko Wieringa, Evelien Hermeling, Chris Van Hoof
Summary: This study compares the effects of integration time and light-source coherence on signal quality and waveform morphology for reflective and transmissive speckle plethysmography (SPG) and photoplethysmography (PPG). The results show that the signal quality of SPG and PPG varies under different light sources and coherence conditions.
Review
Engineering, Biomedical
Thomas Groth, Bernd G. Stegmayr, Stephen R. Ash, Janna Kuchinka, Fokko P. Wieringa, William H. Fissell, Shuvo Roy
Summary: Chronic kidney disease is a leading cause of early mortality worldwide, but access to kidney replacement therapy is limited due to various factors. Researchers from different fields are collaborating to develop wearable and/or implantable artificial kidneys that can provide long-term effective kidney functions. The goal is to create easily accessible and affordable options that can improve the quality of life and life expectancy for CKD patients.
Article
Biology
Eva de Vries, Lejla Alic, Rutger M. M. Schols, Kaj S. S. Emanuel, Fokko P. P. Wieringa, Nicole D. D. Bouvy, Gabrielle J. M. Tuijthof
Summary: This study assesses the spectral similarity between ex vivo porcine and in vivo human spectral data of nerve and adipose tissue, in order to generate large datasets for improved clinical classification.
Article
Biotechnology & Applied Microbiology
Jorge Herranz Olazabal, Fokko Wieringa, Evelien Hermeling, Chris Van Hoof
Summary: The objective of this study was to compare the Pulse Wave Morphology (PWM) and Pulse Arrival Time (PAT) of Speckle plethysmography (SPG) and Photoplethysmography (PPG) with non-invasive finger Arterial Pressure (fiAP). Healthy volunteers were connected to a Non-Invasive Blood Pressure (NIBP) monitor and other devices to record various signals. The results showed that SPG had a higher similarity to fiAP in terms of PWM compared to PPG, while there was no significant difference in PAT values between ECG-SPG and ECG-PPG.
BIOENGINEERING-BASEL
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Jorge Herranz Olazabal, Fokko Wieringa, Evelien Hermeling, Christopher Van Hoof
Summary: This study demonstrates that contactless camera-derived rSPG can obtain beat-to-beat intervals at least as good as routine clinical contact-mode transmissive finger clip PPG, potentially enabling innovative applications.
2021 COMPUTING IN CARDIOLOGY (CINC)
(2021)
