Journal
NATURE METHODS
Volume 17, Issue 6, Pages 609-+Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41592-020-0823-y
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Funding
- Burroughs Wellcome Fund Career Awards at the Scientific Interface
- Searle Scholars Program
- Packard Award in Science and Engineering
- NARSAD Young Investigator Award
- Institute for Basic Science [IBS-R026-D1]
- McKnight Foundation Technology Award
- National Science Foundation Graduate Research Fellowship [1122374]
- JPB Foundation (Picower Fellowship)
- NIA [P50 AG005134]
- JPB Foundation [PIIF, PNDRF]
- NCSOFT Cultural Foundation
- NIH [1-DP2-ES027992, U01MH117072]
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The ELAST technology renders large tissue samples elastic through embedding in hydrogel and facilitates sample handling and rapid molecular labeling. We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.
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