Chromosomal translocation-derived aberrant Rab22a drives metastasis of osteosarcoma

The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases

(2019) Desirée García-Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials

(2019) Alexander Drilon et al.   LANCET ONCOLOGY

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials

(2019) Robert C Doebele et al.   LANCET ONCOLOGY

SmgGDS-607 Regulation of RhoA GTPase Prenylation Is Nucleotide-Dependent

(2018) Benjamin C. Jennings et al.   BIOCHEMISTRY

GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism

(2018) Hikaru Shimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors

(2018) Nathaniel D. Anderson et al.   SCIENCE

Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding

(2017) Hikaru Shimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel mutation in ATRX associated with intellectual disability, syndromic features, and osteosarcoma

(2017) Maria A. Smolle et al.   PEDIATRIC BLOOD & CANCER

Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer

(2016) Natasha S. Latysheva et al.   MOLECULAR CELL

Discovering and understanding oncogenic gene fusions through data intensive computational approaches

(2016) Natasha S. Latysheva et al.   NUCLEIC ACIDS RESEARCH

Sambamba: fast processing of NGS alignment formats

(2015) Artem Tarasov et al.   BIOINFORMATICS

Bone cancer incidence by morphological subtype: a global assessment

(2015) Patricia C. Valery et al.   CANCER CAUSES & CONTROL

Aspirin Suppresses the Growth and Metastasis of Osteosarcoma through the NF- B Pathway

(2015) D. Liao et al.   CLINICAL CANCER RESEARCH

Unscrambling the genomic chaos of osteosarcoma reveals extensive transcript fusion, recurrent rearrangements and frequent novel TP53 aberrations

(2015) Susanne Lorenz et al.   Oncotarget

Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma

(2014) Jennifer A. Perry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective Effect of Aspirin Associated with SNP

(2014)   Cancer Discovery

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

Chromoplexy: A New Category of Complex Rearrangements in the Cancer Genome

(2013) Michael M. Shen   CANCER CELL

WHO Classification of Soft Tissue and Bone, fourth edition

(2013) Andrew E. Rosenberg   CURRENT OPINION IN ONCOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Glycogen Synthase Kinase-3β, NF-κB Signaling, and Tumorigenesis of Human Osteosarcoma

(2012) Qing-Lian Tang et al.   JNCI-Journal of the National Cancer Institute

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

(2011) Brant Hamel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WWP2 is an E3 ubiquitin ligase for PTEN

(2011) Subbareddy Maddika et al.   NATURE CELL BIOLOGY

Splice Variants of SmgGDS Control Small GTPase Prenylation and Membrane Localization

(2010) Tracy J. Berg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coadministration of a Tumor-Penetrating Peptide Enhances the Efficacy of Cancer Drugs

(2010) K. N. Sugahara et al.   SCIENCE

MRI-visible polymeric vector bearing CD3 single chain antibody for gene delivery to T cells for immunosuppression

(2009) Guihua Chen et al.   BIOMATERIALS

Osteosarcoma incidence and survival rates from 1973 to 2004

(2009) Lisa Mirabello et al.   CANCER

Tissue-Penetrating Delivery of Compounds and Nanoparticles into Tumors

(2009) Kazuki N. Sugahara et al.   CANCER CELL

Establishment and characteristics of two syngeneic human osteosarcoma cell lines from primary tumor and skip metastases

(2008) Chang-ye ZOU et al.   ACTA PHARMACOLOGICA SINICA