Nanoparticle-Mediated Gene Silencing for Sensitization of Lung Cancer to Cisplatin Therapy

Non-Viral in Vitro Gene Delivery: It is Now Time to Set the Bar!

(2020) Nina Bono et al.   Pharmaceutics

Small interfering RNA from the lab discovery to patients' recovery

(2020) Marie Caillaud et al.   JOURNAL OF CONTROLLED RELEASE

Leading RNA Interference Therapeutics Part 1: Silencing Hereditary Transthyretin Amyloidosis, with a Focus on Patisiran

(2019) Simoneide S. Titze-de-Almeida et al.   Molecular Diagnosis & Therapy

Computer‐aided drug design of small molecule inhibitors of the ERCC1‐XPF protein–protein interaction

(2019) Francesco Gentile et al.   Chemical Biology & Drug Design

Leading RNA Interference Therapeutics Part 2: Silencing Delta-Aminolevulinic Acid Synthase 1, with a Focus on Givosiran

(2019) Pedro Renato de Paula Brandão et al.   Molecular Diagnosis & Therapy

Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer

(2018) Leena Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and characterization of synthetic viability with ERCC1 deficiency in response to interstrand crosslinks in lung cancer

(2018) Joshua Heyza et al.   CLINICAL CANCER RESEARCH

Targeting the DNA Repair Endonuclease ERCC1-XPF with Green Tea Polyphenol Epigallocatechin-3-Gallate (EGCG) and Its Prodrug to Enhance Cisplatin Efficacy in Human Cancer Cells

(2018) Joshua Heyza et al.   Nutrients

Microfluidic manufacturing improves polydispersity of multicomponent polymeric nanoparticles

(2018) Kathrin Abstiens et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

The impact of microfluidic mixing of triblock micelleplexes on in vitro $/$ in vivo gene silencing and intracellular trafficking

(2017) Daniel P Feldmann et al.   NANOTECHNOLOGY

Synthesis of Polymer-Lipid Nanoparticles by Microfluidic Focusing for siRNA Delivery

(2016) Yujing Li et al.   MOLECULES

Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells

(2016) Sanjeevani Arora et al.   Oncotarget

Folate Receptor Targeted Delivery of siRNA and Paclitaxel to Ovarian Cancer Cells via Folate Conjugated Triblock Copolymer to Overcome TLR4 Driven Chemotherapy Resistance

(2015) Steven K. Jones et al.   BIOMACROMOLECULES

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

(2015) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1–XPF

(2015) Timothy M. Chapman et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Inhibition of the ERCC1–XPF structure-specific endonuclease to overcome cancer chemoresistance

(2015) Ewan M. McNeil et al.   DNA REPAIR

Efficient and Tumor Targeted siRNA Delivery by Polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol)-folate (PEI–PCL–PEG–Fol)

(2015) Li Liu et al.   MOLECULAR PHARMACEUTICS

Phospholipid-modified PEI-based nanocarriers for in vivo siRNA therapeutics against multidrug-resistant tumors

(2014) S Essex et al.   GENE THERAPY

Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers

(2012) Mengyao Zheng et al.   BIOMATERIALS

Molecular Characteristics of ERCC1-Negative versus ERCC1-Positive Tumors in Resected NSCLC

(2011) L. Friboulet et al.   CLINICAL CANCER RESEARCH

Biophysical characterization of hyper-branched polyethylenimine-graft- polycaprolactone-block-mono-methoxyl-poly(ethylene glycol) copolymers (hy-PEI-PCL-mPEG) for siRNA delivery

(2011) Yu Liu et al.   JOURNAL OF CONTROLLED RELEASE

Progress Toward In Vivo Use of siRNAs-II

(2011) Garrett R Rettig et al.   MOLECULAR THERAPY

Downregulation of XPF–ERCC1 enhances cisplatin efficacy in cancer cells☆

(2010) Sanjeevani Arora et al.   DNA REPAIR

Nonviral siRNA Delivery to the Lung: Investigation of PEG−PEI Polyplexes and Their In Vivo Performance

(2009) Olivia M. Merkel et al.   MOLECULAR PHARMACEUTICS

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY