Article
Biochemical Research Methods
Carmen Mejias, Juan Luis Santos, Julia Martin, Irene Aparicio, Esteban Alonso
Summary: In this paper, a method for the determination of antibiotics and their metabolites in sewage sludge and agricultural soil was proposed. The method utilizes ultrasound-assisted extraction, dispersive solid-phase extraction clean-up, and liquid chromatography-tandem mass spectrometry. The method was validated and showed good accuracy and precision. The results revealed that macrolides and fluoroquinolones were the antibiotic classes found at the highest concentrations in all types of samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
Chee Xiang Chen, Azmi Aris, Ee Ling Yong, Zainura Zainon Noor
Summary: Advanced technologies have shown promising results in removing antibiotics from domestic wastewater, but improving the efficiency of activated sludge treatment would be more desirable. Understanding the mechanisms, kinetics, and factors affecting antibiotic removal in the activated sludge process is crucial for enhancing treatment performance. This review paper categorizes, discusses, and analyzes the removal of antibiotics in sewage through the activated sludge process, highlighting the different classes of antibiotics and factors affecting system performance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Akinranti S. Ajibola, Christian Zwiener
Summary: The occurrence of antibiotic residues in sewage sludge from two Nigerian hospital wastewater treatment plants was investigated. The highest concentrations were found in fluoroquinolone antibiotics. The majority of antibiotics presented low risk in sludge-amended soils, while only a few posed medium risk for aquatic ecological risk.
WATER AIR AND SOIL POLLUTION
(2022)
Article
Chemistry, Analytical
Alexandre Guironnet, Laure Wiest, Emmanuelle Vulliet
Summary: The use of beta-lactams in veterinary and human medicine has increased in the past decade, representing a significant portion of overall consumption. This study developed a modified QuEChERS method for extraction and analysis of beta-lactams from sewage treatment plant sludge, showing satisfactory performance for quantification and detection. Through optimization and validation, the method proved effective in extracting beta-lactams from solid environmental matrices.
Article
Environmental Sciences
Xiulei Fan, Weiliang Zhang, Yiming Liu, Shang Shi, Yue Cui, Ziyu Zhao, Jun Hou
Summary: The use of Cu/Zn-SBC as a catalyst to activate persulfate for the degradation of antibiotics was investigated in this study. The results showed that the Cu/Zn-SBC + PS system achieved a high removal rate of tetracycline (TC), with over 99% removal within 4 hours. The system was found to be dominated by radical and nonradical pathways, and the presence of Cu, hydroxyl groups, and carboxyl groups on the surface of Cu/Zn-SBC promoted the production of free radicals and non-free radicals. The study provides an ideal solution for the treatment of sewage sludge and offers a stable and efficient material for removing antibiotics from wastewater.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Pu Li, Yuru Wang, Bi Huang, Shengqi Guan, Tiangang Luan, Ge Lin, Ke Yuan
Summary: This study investigated the occurrence, removal, spatial distribution, and environmental risks of ten antibiotics in wastewater treatment plants in Guangdong province, China. The results showed that amoxicillin and ofloxacin were the predominant antibiotics with high detection rates and concentrations. The economic development of the region was found to positively affect the consumption of human antibiotics, while livestock-related factors affected the consumption of veterinary antibiotics. Additionally, no significant differences were observed in antibiotic removal efficiencies among the treatment processes. However, sulfamethazine and ofloxacin exhibited lower removal rates compared to other antibiotics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biotechnology & Applied Microbiology
Asmita Gupta, Madan Kumar, Radha Sharma, Ritu Tripathi, Vivek Kumar, Indu Shekhar Thakur
Summary: This study analyzed and tested the flocculation properties of extracellular polymeric substances (EPS) produced by the thermotolerant strain Bacillus sp. ISTVK1 in wastewater treatment. The results showed that the EPS exhibited the highest flocculating activity on the 6th day, at pH 6, temperature 32.7 degrees C, and with the presence of AlCl3 salt. The application of bacterial EPS in real wastewater also achieved significant reduction in organics and removal of certain aromatic contaminants.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Chemistry, Analytical
David Fabregat-Safont, Elisa Gracia-Marin, Maria Ibanez, Elena Pitarch, Felix Hernandez
Summary: The research on antibiotics occurrence in the aquatic environment has gained attention due to their potential negative effects, such as bacterial antibiotic-resistance. Antibiotic residues are not completely removed in wastewater treatment plants and end up in water bodies. Analytical methodologies are needed to determine antibiotics in influent and effluent wastewater for various purposes, such as environmental risk assessment and estimating removal efficiencies.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Environmental
Xinting Wang, Ning Huang, Jin Wang, Chunliu Lu, Guangying Li, Fang Li, Zaoshi Hu, Xiaoyu Bi, Lieshan Wu, Yan Tian
Summary: The occurrence and removal of 25 antibiotics in two sewage treatment plants in Guangxi Province, China were analyzed. It was found that tetracyclines were the main type of antibiotics present and the multistage composite mobile bed membrane bioreactor process showed better removal efficiency for sulfonamides, while the continuous-flow Intermission biological reactor process was better at removing tetracyclines and macrolides.
WATER SCIENCE AND TECHNOLOGY
(2022)
Review
Environmental Sciences
Francesco Di Capua, Simona de Sario, Alberto Ferraro, Andrea Petrella, Marco Race, Francesco Pirozzi, Umberto Fratino, Danilo Spasiano
Summary: Phosphate rocks are essential for fertilizer production, but their availability is insufficient to meet agricultural demands. Wastewater treatment plants play a crucial role in phosphorus management by removing and recovering phosphorus, reducing eutrophication and meeting fertilizer demands. Recent studies have focused on improving phosphorus removal efficiency and reducing treatment costs through advancements in biological and material sciences. The development of processes for phosphorus recovery from wastewater and sludge has also been explored. This review provides updated information for the design and upgrading of wastewater treatment plants in anticipation of forthcoming regulations on phosphorus removal and recovery.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Ioanna Pantelaki, Dimitra Voutsa
Summary: An integrated study was conducted on the occurrence and fate of eleven organophosphate esters (OPEs) in two wastewater treatment plants (WWTPs) in Thessaloniki, Greece. The study found that biodegradation and sorption onto sludge were the main removal mechanisms for OPEs. The emissions of OPEs through effluents and sludge did not pose considerable risk to the aquatic and terrestrial environment.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Lucia Pittura, Alessia Foglia, Cagri Akyol, Giulia Cipolletta, Maura Benedetti, Francesco Regoli, Anna Laura Eusebi, Simona Sabbatini, Linda Y. Tseng, Evina Katsou, Stefania Gorbi, Francesco Fatone
Summary: The study found a high concentration of microplastics in a wastewater treatment plant, which were shown to have adverse effects on anaerobic processes. Further investigation is needed to fully understand the impact of microplastics on these processes.
Article
Engineering, Environmental
Chun-Kit Au, K. K. Jason Chan, Wan Chan, Xiangru Zhang
Summary: Through water sample analysis in rivers and coastal waters in Hong Kong, we have identified widespread PCMX pollution. Additionally, our research has demonstrated that the commonly used chemically enhanced primary treatment (CEPT) in wastewater treatment processes is not effectively removing PCMX. Furthermore, PCMX has been found to be relatively stable in water environments, posing a risk to aquatic organisms. These findings highlight the importance of increasing public awareness about the environmental impact of excessive use of PCMX-based disinfectants and the need to reevaluate wastewater treatment processes for PCMX removal.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Guodi Zheng, Bao Yu, Yuewei Wang, Chuang Ma, Tongbin Chen
Summary: The study revealed that TCC has a high biodegradation rate in sludge during wastewater treatment, and composting can further enhance the degradation of TCC. The discharged wastewater into city rivers was found to be safe, indicating effective removal of TCC and reduced ecological risk through composting.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Jing Zhang, Ziquan Liu, Shanjun Song, Junkai Fang, Lei Wang, Lei Zhao, Chenguang Li, Weixia Li, Hyang-Min Byun, Liqiong Guo, Penghui Li
Summary: This study examined antibiotic exposure and health risks in 102 adults in Tianjin. The detection rate of antibiotics in urine was high, but most antibiotics had hazard quotient values below one, indicating low risk. The study found a correlation between mtDNA methylation levels and certain antibiotics, suggesting potential health risks from persistent exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Adriana Osinska, Ewa Korzeniewska, Agnieszka Korzeniowska-Kowal, Anna Wzorek, Monika Harnisz, Piotr Jachimowicz, Martyna Buta-Hubeny, Wiktor Zielinski
Summary: This study aimed to determine the applicability of various methods for identifying E. coli strains in environmental samples. The results of gene sequencing and analysis could help in the selection of more accurate and reliable methods for the preliminary screening and precise identification of E. coli isolated from environmental samples.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Justyna Chojnacka, Agata Drobniewska, Wioletta Lenga, Joanna Misztal, Milena Wawryniuk, Grzegorz Nalecz-Jawecki
Summary: This study evaluated the effects of four antidepressants on the protozoan Spirostomum ambiguum, revealing that two of the drugs reduced the organism's feeding capacity.
Article
Biochemistry & Molecular Biology
Josko Osredkar, Kristina Kumer, Teja Fabjan, Maja Jekovec Vrhovsek, Jerneja Macek, Mojca Zupan, Barbara Bobrowska-Korczak, Paulina Gatarek, Angelina Rosiak, Joanna Giebultowicz, Geir Bjorklund, Salvatore Chirumbolo, Joanna Kaluzna-Czaplinska
Summary: Metabolic disorders and nutritional deficiencies in ASD children can be identified by analyzing levels of urinary-modified compounds. This study found elevated levels of O-methylguanosine and 7-methylguanosine, and significantly lower levels of 3-methyladenine, 1-methylguanine, 1-methyladenosine, 7-methylguanine, and 8-hydroxy-2'-deoxyguanosine in ASD children compared to controls. The results suggest that modified nucleosides/bases can play a role in the pathophysiology of ASD.
ACTA BIOCHIMICA POLONICA
(2023)
Article
Biochemistry & Molecular Biology
Josko Osredkar, Barbara Zvar Baskovic, Petra Finderle, Barbara Bobrowska-Korczak, Paulina Gatarek, Angelina Rosiak, Joanna Giebultowicz, Maja Jekovec Vrhovsek, Joanna Kaluzna-Czaplinska
Summary: Autism spectrum disorder (ASD) is a complex developmental disorder that affects communication and behavior. This study found higher levels of uremic toxins, p-cresyl sulphate (pCS) and indoxyl sulphate (IS), in the urine of children with ASD compared to healthy children. Additionally, lower levels of trimethylamine N-oxide (TMAO), symmetric dimethylarginine (SDMA), and asymmetric dimethylarginine (ADMA) were observed in ASD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
El zbieta Gniazdowska, Joanna Giebultowicz, Piotr J. Rudzki
Summary: Mass spectrometry coupled with liquid chromatography is a valuable tool for drug development and personalised drug therapy. The matrix effect is caused by enhancing or suppressing the analyte signal intensity by the interfering compounds of biological fluids. The matrix effect may influence the reliability of the quantitative results, thus its evaluation is critical in bioanalytical method validation.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2023)
Article
Nutrition & Dietetics
Joanna Rogulska, Sylwia Osowska, Katarzyna Zawada, Joanna Giebultowicz
Summary: The aim of this study was to evaluate the effect of two different amino acid solutions used in different clinical situations on lipid peroxidation of three different lipid emulsions. The results showed that amino acid solutions influence the rate of lipid peroxidation.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Tzuyi L. Yang, Melpomeni Stogiannari, Sylwia Janeczko, Marva Khoshan, Yueyuan Lin, Abdullah Isreb, Rober Habashy, Joanna Giebu Ltowicz, Matthew Peak, Mohamed A. Alhnan
Summary: This study developed immediate-release hydrocortisone tablets using FDM 3D printing and assessed drug contents using near-infrared spectroscopy. The results demonstrated the feasibility of this method for determining drug content. Integration of non-destructive process analytical technology can accelerate the adoption of individualised dosing in a clinical setting.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Tzuyi L. Yang, Jakub Szewc, Lingu Zhong, Anna Leonova, Joanna Giebultowicz, Rober Habashy, Abdullah Isreb, Mohamed A. Alhnan
Summary: This study proposes the use of a low-cost and compact near-infrared (NIR) spectroscopy modality as a process analytical technology (PAT) to monitor drug content during and after 3D printing. The feasibility of the NIR model was demonstrated in caffeine tablets of different completion stages. Overall, this study showed the potential of a low-cost NIR model as a non-destructive, compact, and rapid analysis dose verification method for real-time release in 3D printing medicine production.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Analytical
Natalia Korytowska-Przybylska, Sylwia Michorowska, Aleksandra Wyczalkowska-Tomasik, Leszek Paczek, Joanna Giebultowicz
Summary: Chronic kidney disease (CKD) is diagnosed using serum creatinine or cystatin C levels, but more sensitive biomarkers are needed. This study aims to verify the correlation between saliva and serum levels of trimethylamine N-oxide (TMAO) in CKD patients. The results show a good correlation between TMAO levels in saliva and serum, suggesting that saliva can be used for non-invasive monitoring of renal failure in CKD.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Immunology
Albert Stec, Magdalena Maciejewska, Karolina Paralusz-Stec, Milena Michalska, Joanna Giebultowicz, Lidia Rudnicka, Mariusz Sikora
Summary: This study found that the concentration of the bacterial-derived metabolite TMAO is significantly increased in patients with systemic sclerosis (SSc), particularly in those with advanced organ involvement. This is the first study to evaluate plasma TMAO in SSc, and bacterial metabolites may be a link between dysbiosis and organ involvement in the disease course. Modulation of gut bacterial-derived metabolites may represent a new therapeutic approach in the management of systemic sclerosis.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Environmental Sciences
Justyna Chojnacka, Joanna Giebultowicz, Natalia Choinska, Agata Drobniewska, Grzegorz Nalecz-Jawecki
Summary: This study evaluated the photodegradation of the antidepressant duloxetine in the presence of four types of microplastics and found that its concentration decreased significantly under sunlight exposure, while its toxicity to protozoa decreased to a lesser extent. The presence of microplastics did not affect the photodegradation process or the toxicity of duloxetine. HPLC-MS/MS analysis revealed the presence of multiple photodegradation products, some of which were more toxic than duloxetine itself.
Article
Fisheries
Viktoriya Dzyuba, Joanna Giebultowicz, Borys Dzyuba, Ganna Fedorova, Vitaliy Kholodnyy, Rados law Kajetan Kowalski, Agnieszka Brzyszcz, Sergii Boryshpolets
Summary: This study used metabolome LC/MS analyses to explore potential metabolic markers of fish sperm quality and storage capability during refrigerated storage. The results showed a correlation between sperm motility and certain metabolites, suggesting potential markers. Using a methanol-containing buffer for sperm storage showed more promising results.
Article
Environmental Sciences
Magdalena Mecik, Martyna Buta-Hubeny, Lukasz Paukszto, Mateusz Mazdziarz, Izabela Wolak, Monika Harnisz, Ewa Korzeniewska
Summary: The application of poultry manure initially affects the diversity of soil microbiome and resistome, but the soil shows resilience over time, returning to its original state with most antibiotic resistance genes disappearing.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Environmental Sciences
Joanna Giebultowicz, Katerina Grabicova, Bryan W. Brooks, Roman Grabic
Summary: Metabolomics is a useful approach for characterizing environmental pollution gradients. This study investigated the influence of sampling delay and holding media on contaminants in fish plasma. The results showed rapid changes in the metabolome and exposome of fish plasma, with variations depending on the sample collection time. The study also identified a suitable method for non-lethal, low-volume blood sample collection.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
