Article
Multidisciplinary Sciences
Lenuta Kloetzer, Alexandra Tucaliuc, Anca-Irina Galaction, Dan Cascaval
Summary: Fumaric, malic, and succinic acids were selectively separated from a mixture obtained by Rhizopus oryzae fermentation using reactive extraction. The extraction efficiency and selectivity of the acids were controlled by the concentration of the extractant and the polarity of the organic phase.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Chemical
Nguyen Thi Truc Loan, Dang Thanh Long, Pham Nguyen Dong Yen, Truong Thi Minh Hanh, Tri Nhut Pham, Dung Thuy Nguyen Pham
Summary: The study successfully extracted high-purity mangiferin from mango leaves and demonstrated its high antioxidant activity. However, no inhibitory action against common microbial strains was observed in the experiments.
Article
Multidisciplinary Sciences
Zakia Gueboudji, Dalila Addad, Kenza Kadi, Kamel Nagaz, Mansour Secrafi, Leila Ben Yahya, Belgacem Lachehib, Assia Abdelmalek
Summary: This study aimed to determine the cytotoxicity, antioxidant, anti-inflammatory, anti-hemolytic, and anticoagulant activities of phenolic compounds extracted from OMW. The results showed that OMW extract contains various phenolic compounds and exhibits good antioxidant, anti-inflammatory, and anticoagulant properties.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kulsoom Akhter, Azeem Bibi, Aamir Rasheed, Sadiq Ur Rehman, Urooj Shafique, Tariq Habib
Summary: The antioxidant capacity of different parts of Cucurbitaceae vegetables was evaluated using DPPH and ABTS methods. The peel extracts showed the highest total phenolic content and total flavonoid content, and the ABTS method provided the highest antioxidant potential in the peel extracts.
Review
Chemistry, Medicinal
Karim Naraki, Ramin Rezaee, Habibeh Mashayekhi-Sardoo, A. Wallace Hayes, Gholamreza Karimi
Summary: Mangiferin (MGF) is a polyphenolic compound extracted from mango trees, which has diverse effects such as antioxidant, antiapoptotic properties, and has been shown to modulate inflammatory pathways. MGF exerts protective effects against the toxic effects of pharmaceuticals, heavy metals, and environmental chemicals by suppressing lipid peroxidation, oxidative stress, inflammatory factors, and activating survival signaling pathways.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Applied
Haiyan Li, Yunxiang Ma, Xudong Gao, Guopeng Chen, Zhipeng Wang
Summary: In this study, four cinnamic acids were used to modify porous starch with esterification, confirming the ester linkage through various analyses. The modified starch maintained its porous structure, and exhibited different antioxidant capacities in vitro, with SA@PS showing the highest antioxidant activity due to the presence of phenolic hydroxyl groups. This research not only investigated the antioxidant mechanism of these modified starch derivatives but also provided insights for the synthesis of biodegradable antioxidant materials for the food industries.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Beatriz de la Fuente, Carlos Luz, Carla Puchol, Giuseppe Meca, Francisco J. Barba
Summary: It was found that orange-juice milk beverages are a good medium for the growth of L. brevis POM and L. plantarum (TR-71, TR-14), with higher antioxidant properties observed in the fermented beverages compared to the control ones.
Article
Pharmacology & Pharmacy
Maddalena Sguizzato, Francesca Ferrara, Paolo Mariani, Alessia Pepe, Rita Cortesi, Nicolas Huang, Fanny Simeliere, Paola Boldrini, Anna Baldisserotto, Giuseppe Valacchi, Elisabetta Esposito
Summary: This study described a formulative research for the development of vesicular systems for mangiferin based on phosphatidylcholine and the block copolymer pluronic, and compared their effect on mangiferin transdermal administration. The results showed that multilamellar vesicles retain mangiferin drugs more effectively than unilamellar ones, and the protective effect exerted by Plurethosomes and transethosomes suggests their possible application in enhancing cutaneous antioxidant defense.
Article
Biochemistry & Molecular Biology
Marcello Salvatore Lenucci, Riccardo Tornese, Giovanni Mita, Miriana Durante
Summary: This study aims to describe and compare the distribution of bioactive compounds, fatty acids profiles, and antioxidant activities in different fruit fractions of two mango cultivars. Our results provide valuable information on the distribution of nutraceuticals in different parts of mango fruit and highlight the potential value of peels and kernels as sources of novel ingredients. The study also emphasizes the importance of exploring green, novel biorefinery technologies to recover profitable byproducts from mango processing.
Article
Chemistry, Multidisciplinary
Alberto J. Nunez-Selles, Lauro Nuevas-Paz, Gregorio Martinez-Sanchez
Summary: This study found that metal-mangiferin complexes have good antioxidant and protection against protein oxidative damage effects in the adjuvant therapies of neurodegenerative diseases, cancer, diabetes, and cardiovascular disorders. The coordination complexes of Se (IV) and Zn (II) with mangiferin showed significantly improved antioxidant/protective effects compared to isolated mangiferin.
APPLIED SCIENCES-BASEL
(2022)
Article
Food Science & Technology
Pratik Pandit Potdar, Preetinder Kaur, Ruchika Zalpouri, Viruja Ummat
Summary: An experimental study compared the drying kinetics and retention of bioactive compounds in lemongrass shreds using convective drying (CD) and pulsed microwave drying (PMD). The results showed that PMD had the maximum retention of total chlorophyll, ascorbic acid, flavonoids, and antioxidant capacity. Additionally, microwave-assisted hydrodistillation (MAHD) yielded high-quality essential oil from the dried samples.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Food Science & Technology
Luan Gustavo Santos, Vilasia Guimaraes Martins
Summary: This study evaluated the influence of bio-based solvents on the extraction of compounds from purple onion peel and the effects of storage temperature on the degradation of anthocyanins and color stability. The results showed that the extract obtained with 60% ethanol had higher antioxidant and antibacterial activity, making it suitable for various industries.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Plant Sciences
Janice Mani, Joel Johnson, Holly Hosking, Beatriz E. Hoyos, Kerry B. Walsh, Paul Neilsen, Mani Naiker
Summary: This study selected five native Australian plants for screening, with Kakadu plum flesh extract showing the highest total phenolic content and antioxidant capacity. Extracts from Gumbi gumbi and Kakadu plum seeds exhibited significant cell inhibition in multiple cancer cell lines, indicating potential for further research.
Article
Biochemistry & Molecular Biology
Justina Kamarauskaite, Rasa Baniene, Lina Raudone, Gabriele Vilkickyte, Rimanta Vainoriene, Vida Motiekaityte, Sonata Trumbeckaite
Summary: This study focused on fractionating caffeoylquinic acids from cultivated wormwood and silver wormwood herb acetone extracts and evaluating their phytochemical profiles, antioxidant activities, and effects on kidney mitochondrial functions. The results showed that the silver wormwood extracts had the highest content of caffeoylquinic acids and exhibited the greatest radical scavenging and reducing activities, indicating their potential as antioxidants and cytochrome-c-reducing agents for the treatment of mitochondrial-pathway-associated pathologies.
Article
Materials Science, Multidisciplinary
Ying-Hong Xu, Xiao-Yu Li, Ming-Fei Li, Feng Peng, Jian-Feng Ma
Summary: Fractionating tetrahydrofurfuryl alcohol lignin with different acetone concentrations can produce homogeneous lignin with high antioxidant capacity. The study demonstrated that the lignin samples had strong antioxidant activity compared to commercial antioxidant butylated hydroxytoluene.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Applied
Ausra Sipailiene, Greta Slimaite, Sigita Jezniene, Petras Rimantas Venskutonis, Daiva Leskauskaite
Summary: The study demonstrates that double emulsion containing L. plantarum F1 cells and prebiotic mannitol, with lipophilic sea buckthorn pomace extract as an antioxidant, and alginate in the outer phase, has high encapsulation yield and cell survival rate, providing good protection during storage.
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Renata Baranauskiene, Petras Rimantas Venskutonis
Summary: The study developed a method for extracting fragrance substances from Narcissus poeticus using pure supercritical CO2 and a mixture of CO2 with 5% ethanol. The results showed that the extracts contained various volatile compounds, including benzyl benzoate, alpha-terpineol, and limonene. The findings are significant for the further extraction of fragrance substances from Narcissus poeticus using supercritical CO2.
Article
Plant Sciences
Gabriele Vilkickyte, Vilma Petrikaite, Audrius Pukalskas, Ausra Sipailiene, Lina Raudone
Summary: This study provides an in-depth investigation into the specialized metabolite profiling and biological activity of lingonberry crude extracts and isolated fractions. It identifies 59 compounds, mainly phenolics, which exhibit higher bioactivities in certain fractions compared to crude extracts. Trimeric and dimeric proanthocyanidins from lingonberry leaves and fruits are shown to have the strongest antimicrobial, antioxidant, and anti-inflammatory potential.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ausra Adomeniene, Petras Rimantas Venskutonis
Summary: This article provides a review on the antioxidant properties of Dioscorea plants and their relation to phytochemicals and health benefits. It found that leaf extracts demonstrated stronger antioxidant potential than tuber preparations.
Article
Virology
Laura Tamkute, Juliano G. Haddad, Nicolas Diotel, Philippe Despres, Petras Rimantas Venskutonis, Chaker El Kalamouni
Summary: In this study, it was found that Cranberry Pomace extract can block the infection of dengue virus and zika virus in human cells, showing good antiviral effects at non-cytotoxic concentrations. By directly acting on viral particles, the extract can prevent the attachment of viruses to the cell surface. Furthermore, it was also demonstrated to be safe and tolerable in a zebrafish model.
Correction
Multidisciplinary Sciences
Jessica Andries, Wildriss Viranaicken, Colette Cordonin, Charline Herrscher, Cynthia Planesse, Benedicte Roquebert, Marie Lagrange-Xelot, Chaker El-Kalamouni, Olivier Meilhac, Patrick Mavingui, David Couret, Gilles Gadea, Philippe Despres
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jessica Andries, Wildriss Viranaicken, Colette Cordonin, Charline Herrscher, Cynthia Planesse, Benedicte Roquebert, Marie Lagrange-Xelot, Chaker El-Kalamouni, Olivier Meilhac, Patrick Mavingui, David Couret, Gilles Gadea, Philippe Despres
Summary: In this study, synthetic peptide-based ELISA assays were used to identify linear B-cell epitopes in the spike protein that contribute to antibody response in individuals vaccinated with the Pfizer-BioNTech COVID-19 vaccine. The synthetic peptides S2P6 and S1P4 were recognized by the immune sera from vaccine recipients, suggesting their potential usefulness in measuring antibody response to COVID-19 mRNA vaccines. The S2P6 peptide has been shown to be immunogenic in mice, raising questions about its role in the protective efficacy of the vaccine.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Ausra Adomeniene, Audrius Pukalskas, Ona Ragazinskiene, Petras Rimantas Venskutonis
Summary: This study identified 41 compounds in the leaf and tuber hydroethanolic extracts of Dioscorea caucasica using UPLC-QTOF/MS. The main phytochemicals in the leaves were hydroxycinnamates and flavonoids, while steroidal glycosides, fatty acids, and carbohydrates were found in the tubers. The leaf extracts showed strong inhibitory activity against key enzymes, including alpha-amylase, alpha-glucosidase, acetylcholinesterase, and angiotensin-converting enzyme. These findings contribute to the development of new functional foods and nutraceuticals.
Article
Chemistry, Physical
Ramunas Tupciauskas, Kristine Meile, Daniela Godina, Janis Rizhikovs, Michail Syrpas, Petras Rimantas Venskutonis
Summary: This study investigated the emissions of volatile organic compounds (VOCs) from binder-less boards obtained from different raw lignocellulosics and SE-untreated suberinic acids-bonded particleboard. The results showed that the detected VOCs varied significantly depending on the raw lignocellulosic, board density, and post-treatment, decreasing over time.
Article
Chemistry, Medicinal
Fenia D. Ramiharimanana, Juliano G. Haddad, Maminiaina A. Andrianavalonirina, Cecile Apel, Florent Olivon, Nicolas Diotel, Philippe Despres, Voahangy Vestalys Ramanandraibe, Chaker El Kalamouni
Summary: Dengue and Zika viruses are identified as the most medically important arthropod-borne viral pathogens. In this study, extracts from two endemic plants from Madagascar, S. ericoides and S. inuloides, were found to have potential antiviral effects against dengue and Zika viruses without causing cytotoxicity in human cells or adverse effects in zebrafish. The analysis revealed the presence of specific phytocompounds in each plant species, suggesting their potential as sources for natural and safe antiviral phytocompounds against flaviviruses of medical concern.
Article
Biochemistry & Molecular Biology
Eva Ogire, Chaker El-Kalamouni, Philippe Despres, Marjolaine Roche
Summary: Dengue is a common viral disease transmitted by mosquitoes, and the NS1 protein of DENV-2 plays a crucial role in virus replication and infection. In this study, the impact of mutations at positions 272 and 324 on NS1 protein stability and secretion was investigated. It was found that replacing arginine with lysine at position 324 in the DES-14 strain resulted in decreased protein stability and secretion, leading to oxidative stress and pro-inflammatory cytokine activation in Huh7 cells. The ubiquitin-proteasome proteolytic pathway may be involved in the stability of DENV-2 protein containing a lysine residue at position 324.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Agricultural Engineering
Nora Emilia Nagybakay, Laura Sarapinaite, Michail Syrpas, Petras Rimantas Venskutonis, Vaida Kitryte-Syrpa
Summary: Silver birch leaves are a valuable plant material that can be used for the production of bioactive extracts with antioxidant properties. This study optimized the pressurized ethanol extraction parameters and analyzed the composition and antioxidant capacity of the extract. The optimized extract had high yield, rich phenolic and flavonoid content, strong in vitro antioxidant activity, and high sun protection factor, suggesting its potential applications in cosmetics, nutraceuticals, and pharmaceuticals.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Aya Jamaleddine, Pascale de Caro, Jalloul Bouajila, Philippe Evon, Juliano G. Haddad, Chaker El-Kalamouni, Akram Hijazi, Othmane Merah
Summary: This study isolated fractions from tomato pomace and found them to be rich in bioactive molecules with potential therapeutic effects such as antioxidant, anti-inflammatory, and anti-diabetic properties. Different solvents and pretreatment methods yielded extracts with varying levels of bioactive compounds, demonstrating the potential of tomato pomace as a source of beneficial molecules.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
