Proteinase-Activated Receptor 4 Activation Triggers Cell Membrane Blebbing through RhoA and β-Arrestin

Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)

(2020) Pierre E. Thibeault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of beta-arrestin signaling in the absence of active G proteins

(2018) Manuel Grundmann et al.   Nature Communications

KIF13A‐regulated RhoB plasma membrane localization governs membrane blebbing and blebby amoeboid cell migration

(2018) Xiaowei Gong et al.   EMBO JOURNAL

Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling

(2018) Laurel A. Grisanti et al.   Theranostics

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

(2018) Rachel A. Rigg et al.   PLATELETS

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function

(2017) Rithwik Ramachandran et al.   MOLECULAR PHARMACOLOGY

Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding

(2017) Pancras C. Wong et al.   Science Translational Medicine

A RhoA and Rnd3 cycle regulates actin reassembly during membrane blebbing

(2016) Kana Aoki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrestins regulate cell spreading and motility via focal adhesion dynamics

(2015) Whitney M. Cleghorn et al.   MOLECULAR BIOLOGY OF THE CELL

Characterization of UBO-QIC as a Gαqinhibitor in platelets

(2015) Vaishali Inamdar et al.   PLATELETS

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Met-induced membrane blebbing leads to amoeboid cell motility and invasion

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Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Rho GTPases in platelet function

(2012) J. E. ASLAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Targeting proteinase-activated receptors: therapeutic potential and challenges

(2012) Rithwik Ramachandran et al.   NATURE REVIEWS DRUG DISCOVERY

Vorapaxar in the Secondary Prevention of Atherothrombotic Events

(2012) David A. Morrow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neurokinin 1 Receptor Mediates Membrane Blebbing and Sheer Stress-Induced Microparticle Formation in HEK293 Cells

(2012) Panpan Chen et al.   PLoS One

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

High Glucose Enhances Thrombin Responses via Protease-Activated Receptor-4 in Human Vascular Smooth Muscle Cells

(2010) Seema Dangwal et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Arrestin-2 Differentially Regulates PAR4 and ADP Receptor Signaling in Platelets

(2010) Dongjun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Biased Allosteric Compound Inhibitor of Parturition Selectively Impedes the Prostaglandin F2α-mediated Rho/ROCK Signaling Pathway

(2010) Eugénie Goupil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestin 1 Inhibits the GTPase-Activating Protein Function of ARHGAP21, Promoting Activation of RhoA following Angiotensin II Type 1A Receptor Stimulation

(2010) D. F. Anthony et al.   MOLECULAR AND CELLULAR BIOLOGY

The Angiotensin II Type 1 Receptor Induces Membrane Blebbing by Coupling to Rho A, Rho Kinase, and Myosin Light Chain Kinase

(2010) C. M. Godin et al.   MOLECULAR PHARMACOLOGY

Regulation of RhoGEF proteins by G12/13-coupled receptors

(2009) Sandra Siehler   BRITISH JOURNAL OF PHARMACOLOGY

Agonist-Biased Signaling via Proteinase Activated Receptor-2: Differential Activation of Calcium and Mitogen-Activated Protein Kinase Pathways

(2009) R. Ramachandran et al.   MOLECULAR PHARMACOLOGY

Role of cortical tension in bleb growth

(2009) J.-Y. Tinevez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell motility through plasma membrane blebbing

(2008) Oliver T. Fackler et al.   JOURNAL OF CELL BIOLOGY

A short history of blebbing

(2008) G.T. CHARRAS   JOURNAL OF MICROSCOPY

PDK1 regulates cancer cell motility by antagonising inhibition of ROCK1 by RhoE

(2008) Sophie Pinner et al.   NATURE CELL BIOLOGY

Blebs lead the way: how to migrate without lamellipodia

(2008) Guillaume Charras et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Life and Times of a Cellular Bleb

(2007) Guillaume T. Charras et al.   BIOPHYSICAL JOURNAL

Cytokine upregulation of proteinase-activated-receptors 2 and 4 expression mediated by p38 MAP kinase and inhibitory kappa B kinase β in human endothelial cells

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